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Automatic target tracking on multi-resolution terrain

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第7期7卷 1275-1281页

作者： WAN Ming ZHANG Wei MURRAY marie O. KAUFMAN Ariet The Boeing Company P.O. Box 3707 MC 7L-40 Seattle W.4 98124-2207 USA Department of Computer Setence and Center for Visual Computing State University of New York at Stony BrookStony Brook NY 11794-4400 USA

We propose a high-performance path planning algorithm for automatic target tracking in the applications of real-time simulation and visualization of large-scale terrain datasets, with a large number of moving objects （such as vehicles） tracking multiple moving targets. By using a modified Dijkstra＇s algorithm, an optimal path between each vehicle-target pair over a weighted grid-presented terrain is computed and updated to eliminate the problem of local minima and losing of tracking. Then, a dynamic path re-planning strategy using multi-resolution representation of a dynamic updating region is proposed to achieve high-performance by trading-off precision for efficiency, while guaranteeing accuracy. Primary experimental results showed that our algorithm successfully achieved l0 to 96 frames per second interactive path-replanning rates during a terrain simulation scenario with 10 to 100 vehicles and multiple moving targets.

关键词： Target tracking Path planning Dijkstra's algorithm Voxel-based modeling Multi-resolution terrain Real-timevisualization and simulation

Design and implementation of platform for embedded Ethernet control system

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仪器仪表学报 2008年第6期29卷 1121-1128页

作者： Zhu Lingbo Lin-Shi Xue-Fang Dai Guanzhong Rétif Jean-marie College of Automation Northwestern Polytechnical University Xi＇an 710072 China l＇Ecole Doctorale： Electronique Electrotechnique Automatique (EEA) Institute National des Sciences Appliquées de Lyon Villeurbanne 69621 France

A platform named EMECS based on embedded Ethernet control system is implemented.A PC running Fedora 6(Linux2.6)works as a central controller.A kit running Linux 2.4 based on Samsung2410A(ARM920t core)works as a remote controller and a DC motor(ESCA P28HSL18-219/204)made by Portescap Company works as a ***,system modeling is presented by analyzing the characteristics of Ethernet and the plant,based on a proposed delay measurement ***,implementation of the system including program and hardware is described in *** then the delay is measured and the control results of the system are tested in three cases with different network loads as *** platform is proved to have flexibility of running different control algorithms and extensibility of adding *** results demonstrate the validity of the system.

关键词：以太网控制系统设计方案平台

A time fractional model to represent rainfall process

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Water Science and Engineering 2014年第1期7卷 32-40页

作者： Jacques GOLDER Maminirina JOELSON marie-Christine NEEL Liliana DI PIETRO Department of Physics University of Avignon Mediterranean Environment and Agro-Hydro System Modelisation Laboratory French National Institute for Agricultural Research

This paper deals with a stochastic representation of the rainfall process. The analysis of a rainfall time series shows that cumulative representation of a rainfall time series can be modeled as a non-Gaussian random walk with a log-normal jump distribution and a time-waiting distribution following a tempered a-stable probability law. Based on the random walk model, a fractional Fokker-Planck equation （FFPE） with tempered a-stable waiting times was obtained. Through the comparison of observed data and simulated results from the random walk model and FFPE model with tempered a-stable waiting times, it can be concluded that the behavior of the rainfall process is globally reproduced, and the FFPE model with tempered a-stable waiting times is more efficient in reproducing the observed behavior.

关键词： rainfall process heavy-tailed probability distribution tempered a-stable probability law log-normal law Hurst exponent continuous time random walk model fractional Fokker-Planck equation

Unveiling the lamellar structure of the human cornea over its full thickness using polarization-resolved SHG microscopy

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Light(Science & Applications) 2023年第9期12卷 1782-1794页

作者： Clothilde Raoux Anatole Chessel Pierre Mahou Gaël Latour marie-Claire Schanne-Klein Laboratory for Optics and Biosciences Ecole PolytechniqueCNRSINSERMInstitut Polytechnique de Paris91128 PalaiseauFrance UniversitéParis-Saclay 91190 Gif-sur-YvetteFrance

A key property of the human cornea is to maintain its curvature and consequently its refraction capability despite daily changes in intraocular *** is closely related to the multiscale structure of the corneal stroma,which consists of 1-3µm-thick stacked lamellae made of thin collagen ***,the distribution,size,and orientation of these lamellae along the depth of the cornea are poorly characterized up to *** this study,we use second harmonic generation(SHG)microscopy to visualize the collagen distribution over the full depth of 10 intact and unstained human corneas(500-600µm thick).We take advantage of the small coherence length in epi-detection to axially resolve the lamellae while maintaining the corneal physiological ***,as raw epi-detected SHG images are spatially homogenous because of the sub-wavelength size of stromal collagen fibrils,we use a polarimetric approach to measure the collagen orientation in every *** a careful validation of this approach,we show that the collagen lamellae(i)are mostly oriented along the inferior-superior axis in the anterior stroma and along the nasal-temporal axis in the posterior stroma,with a gradual shift in between and(ii)exhibit more disorder in the anterior *** results represent the first quantitative characterization of the lamellar structure of the human cornea continuously along its entire thickness with micrometric *** also shows the unique potential of P-SHG microscopy for imaging of collagen distribution in thick dense tissues.

关键词： structure curvature resolved

Increased mortality in elderly heart failure patients receiving infusion of furosemide compared to elderly heart failure patients receiving bolus injection

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Journal of Geriatric Cardiology 2020年第6期17卷 359-364页

作者： Rana Sager Isak Lindstedt Lars Edvinsson marie-Louise Edvinsson Department of Emergency and Internal Medicine Lund University Hospital of SkåneSweden Department of Medicine Institute of Clinical Sciences in LundLund UniversitySweden

Heart failure(HF)is a condition of cardiac dysfunction and fluid *** activation via the reninangiotensin-aldosterone system and the sympathetic nervous system are the pathophysiological cornerstones.[1]Furthermore,HF is a disorder widely associated with grave adverse outcomes and poor prognosis.[2]A loop diuretic is the fundamental drug used to prevent multiorgan failure and improve symptoms in these patients.[3]

关键词： Furosemide Heart failure Infusion Injection Mortality

Asthma-associated polymorphisms in 17q12-21 locus modulate methylation and gene expression of GSDMA in naive CD4^+ T cells

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Journal of Genetics and Genomics 2020年第3期47卷 171-174页

作者： Anne-marie Madore Lucile Pain Anne-marie Boucher-Lafleur Andréanne Morin Jolyane Meloche marie-Michelle Simon Bing Ge Tony Kwan Warren A.Cheung Tomi Pastinen Catherine Laprise Departement des sciences fondamentales Universite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada Department of Human Genetics McGill UniversityMontrealQuebecH3A 0C7Canada Department of Human Genetics University of ChicagoIL60637USA McGill University and Genome Quebec Innovation Centre MontrealQuebecH3A 0G1Canada Center for Pediatric Genomic Medicine Kansas CityMO64108USA Centre intersectoriel en sante durable Universite du Quebec a ChicoutimiSaguenayQuebecG7H 2B1Canada

The 17q12-21 locus harboring ORMDL sphingolipid biosynthesis regulator 3(ORMDL3)and Gasdermin B(GSDMB)genes exhibits one of the most significant and replicated associations with asthma[MIM:600807](Stein et al.,2018).Several studies explored the complex interactions between SNPs,gene expression and epigenetic modifications at this locus,primarily focusing on the levels of expressed ORMDL3 and GSDMB(Stein et al.,2018).Given that DNA methylation and gene expression signals are cell-type specific(Reinius et al.,2012),isolated materials such as lymphocytes from blood and,to a lesser extent,bronchial epithelial cells from biopsies of bronchi or bronchoalveolar lavages have been used in a number of studies to investigate such interactions(Stein et al.,2018).

关键词： FDR T cells Asthma-associated polymorphisms gene expression of GSDMA

Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France

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Asian Journal of Andrology 2012年第4期14卷 584-590页

作者： Cendrine Geoffroy-Siraudin Anderson Dieudone Loundou Fanny Romain Vincent Achard Blandine Courbibre marie-He1ene Perrard Philippe Durand marie-Roberte Guichaoua Reproduction Biology Laboratory Conception Hospital AP-HM Marseille 13005 France Aix-Marseille University UMR CNRS IMBE 7263 Faculty of medicine of Marseille Marseille 13005 France Department of medical information Conception Hospital AP-HM Marseille 147 Bd Baille Marseille 13005 France Health Laboratory Faculty of Medicine of Marseille Marseille 13005 France Centre of Assisted Reproductive Technique (CPMA) Conception Hospital AP-HM Marseille 13005 France Functional Genomic Institute of Lyon CNRS INRA ENS of Lyon Lyon 69007 France

Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille （France） between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration （〉~ 40 million per ejaculate）. The whole population demonstrated declining trends in sperm concentration （1.5% per year）, total sperm count （1.6% per year）, total motility （0.4% per year）, rapid motility （5.5% per year） and normal morphology （2.2% per year）. In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the auality of semen decreased in this population over the study period.

关键词： environment male infertility regional differences semen quality sperm parameters

Single Mutations in the Transmembrane Domains of Maize Plasma Membrane Aquaporins Affect the Activity of Monomers within a Heterotetramer

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Molecular Plant 2016年第7期9卷 986-1003页

作者： marie C. Berny Dimitri Gilis Marianne Rooman Francois Chaumont Institut des Sciences de la Vie University catholique de Louvain 1348 Louvain-la-Neuve Belgium Bioinformatique genomique et structurale Universite Libre de Bruxelles 1050 Brussels Belgium

Aquaporins are channels facilitating the diffusion of water and/or small uncharged solutes ecross biological membranes. They assemble as homotetramers but some of them also form heterotetramers, especially in plants. In Zea mays, aquaporins belonging to the plasma membrane intrinsic protein （PIP） subfamily are clustered into two groups, PIP1 and PIP2, which exhibit different water-channel activities when expressed in Xenopus oocytes. When PIP1 and PIP2 isoforms are co-expressed, they physically interact to modulate their subcellular localization and channel activity. Here, we demonstrated by affinity chromatography purification that, when co-expressed in Xenopus oocytes, the maize PIP1;2 and PIP2;5 isoforms assemble as homo- and heterodimers within heterotetramers. We built the 3D structure of such heterotetramers by comparative modeling on the basis of the spinach SoPIP2;1 X-ray structure and identified amino acid residues in the transmembrane domains which putatively interact at the interfaces between monomers. Their roles in the water-channel activity, subcellular localization, protein abundance, and physical interac- tion were investigated by mutagenesis. We highlighted single-residue substitutions that either inactivated PIP2;5 or activated PIP1;2 without affecting their interaction. Interestingly, the Phe220Ala mutation in the transmembrane domain 5 of PIP1 ;2 activated its water-channel activity and, at the same time, inactivated PIP2;5 within a heterotetramer. Altogether, these data contribute to a better understanding of the interaction mechanisms between PIP isoforms and the role of heterotetramerization on their water-channel activity.

关键词： aquaporin heterotetramer mutation oligomerization water-channel activity

Aging and menopause reprogram osteoclast precursors for aggressive bone resorption

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Bone Research 2020年第3期8卷 333-342页

作者： Anais marie Julie Moller Jean-marie Delaisse Jacob Bastholm Olesen Jonna Skov Madsen Luisa Matos Canto Troels Bechmann Silvia Regina Rogatto Kent Soe Clinical Cell Biology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Department of Regional Health Research University of Southern Denmark5230 Odense MDenmark Department of Clinical Biochemistry and Immunology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Clinical Cell Biology Department of PathologyOdense University Hospital5000 Odense CDenmark Department of Clinical Research University of Southern Denmark5230 Odense MDenmark Department of Molecular Medicine University of Southern Denmark5230 Odense MDenmark Department of Clinical Genetics Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark Department of Oncology Lillebaelt HospitalUniversity Hospital of Southern Denmark7100 VejleDenmark OPEN Odense Patient data Explorative NetworkOdense University Hospital5000 Odense CDenmark

Women gradually lose bone from the age of〜35 years,but around menopause,the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels,rendering these individuals more prone to developing *** increased osteoclast activity has been linked to a reduced estrogen level and other hormonal ***,it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast ***,we set up a protocol in which CD14f blood monocytes were isolated from 49 female donors(40-66 years old).Cells were differentiated into osteoclasts,and data on differentiation and resorption activity were *** multiple linear regression analyses combining in vitro and in vivo data,we found the following:(1)age and menopausal status correlate with aggressive osteoclastic bone resorption in vitro;(2)the type I procollagen N-terminal propeptide level in vivo inversely correlates with osteoclast resorption activity in vitro;(3)the protein level of mature cathepsin K in osteoclasts in vitro increases with age and menopause;and(4)the promoter of the gene encoding the dendritic cell-specific transmembrane protein is less methylated with *** conclude that monocytes are"reprogrammed"in vivo,allowing them to"remember"age,the menopausal status,and the bone formation status in vitro,resulting in more aggressive *** discovery suggests that this may be mediated through DNA *** suggest that this may have clinical implications and could contribute to understanding individual differences in age-and menopause-induced bone loss.

关键词： osteoclast menopause osteoporosis