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Impact of Standardized Scheme on the Detection of Chest X-Ray Abnormalities and Radiographic Diagnosis of Pulmonary Tuberculosis in Adult

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Open Journal of Medical Imaging 2014年第1期4卷 23-30页

作者： marie laure gharingam Boniface Moifo Eric Walter Pefura Yone André Pascal Kengne Jean Roger Moulion Tapouh Annick laure Edzimbi Georges Nguefack-Tsague Samuel Nko’o Amvene Department of Medical Imaging and Radiation Therapy The University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaounde Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaounde Cameroon Department of Internal Medicine and Specialties The University of Yaoundé I Yaoundé Cameroon Service of Pulmonology Yaounde Jamot Hospital Yaounde Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaounde Cameroon Department of Medical Imaging and Radiation Therapy The University of Yaoundé I Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaoundé I Yaounde Cameroon Department of Public Health The University of Yaoundé I Yaoundé Cameroon South African Medical Research Council & University of Cape Town Cape Town South Africa

Purpose: The complexity of chest radiography (CXR) is a source of variability in its interpretation. We assessed the effect of an interpretation grid on the detection of CXR anomalies and radio- graphic diagnosis of tuberculosis in an endemic area for tuberculosis. Methods: The study was conducted in Yaounde (Cameroon). Six observers (2 pulmonologists, 2 radiologists and 2 senior residents in medical imaging) interpreted 47 frontal CXR twice two months apart without (R1) and with (R2) the aid of an interpretation grid. We focused on the detection of micro nodules (n = 16), cavitations (n = 12), pleural effusion (n = 6), adenomegaly (n = 6), and diagnosis of tuberculosis (n = 23) and cancer (n = 7). Results: The average score for accurate detection of elementary lesions was 40.4% [95%CI: 25% - 58.3%] in R1 and 52.1% [36.9% - 65.3%] in R2. The highest im- provement was observed for micro nodules (19.8%). Cavitations had the highest proportions of accurate detections (58.3% in R1 and 65.3% in R2). The average score of accurate diagnosis was 46.1% in R1 and 57.4% in R2. Accurate diagnosis improved by 3.6% for tuberculosis and 19% for cancer between R1 and R2. Intra-observer agreement was higher for the diagnosis of cancers (0.22 ≤ k ≤ 1) than for diagnosing tuberculosis (0.21 ≤ k ≤ 0.68). Inter-observer agreement was highly variable with a modest improvement for the diagnosis of tuberculosis in R2. Conclusion: Standardized interpretation scheme improved the detection of CXR anomalies and diagnosis of tuberculosis. It significantly improved inter-observer’s agreement in diagnosing tuberculosis but not in detecting most lesions.

关键词： Chest Radiography Interpretation Scheme Tuberculosis Micro Nodules Cavitations Agreement

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Inter-Observer Variability in the Detection and Interpretation of Chest X-Ray Anomalies in Adults in an Endemic Tuberculosis Area

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Open Journal of Medical Imaging 2015年第3期5卷 143-149页

作者： Boniface Moifo Eric Walter Pefura-Yone Georges Nguefack-Tsague marie laure gharingam Jean Roger Moulion Tapouh André-Pascal Kengne Samuel Nko’o Amvene Faculty of Medicine and Biomedical Sciences (FMBS) The University of Yaoundé I Yaoundé Cameroon Department of Radiology and Radiation Oncology FMBS Yaoundé Cameroon Department of Internal Medicine and Specialties’ FMBS Yaoundé Cameroon Service of Pneumology A Jamot Hospital of Yaoundé Yaoundé Cameroon Department of Public Health FMBS Yaoundé Cameroon South African Medical Research Council & University of Cape Town Cape Town South Africa

Purpose: To assess the inter-observer agreement in reading adults chest radiographs (CXR) and determine the effectiveness of observers in radiographic diagnosis of pulmonary tuberculosis (PTB) in a tuberculosis endemic area. Methods: A quasi-observational study was conducted in the Pneumology Department of Yaounde Jamot Hospital (Cameroon) from January to March 2014. This included six observers (two chest physicians, two radiologists, two end-training residents in medical imaging) and 47 frontal CXRs (4 of diffuse interstitial lung disease, 6 normal, 7 of lung cancers, 7 of bacterial pneumonia, 23 of PTB). The sample size was calculated on the basis of an expected 0.47 Kappa with a spread of 0.13 (α = 5%, CI = 95%) for six observers and five diagnostic items. The analysis of concordance was focused on the detection of nodules, cavitary lesions, pleural effusion, adenomegaly and diagnosis of PTB and lung cancer. These intervals of kappa coefficient were considered: discordance (0.81). Results: The average score for the detection of caverns was the highest (58.3%) followed by that of the correct diagnosis of tuberculosis (49.3%). Pneumologists had the highest proportions of correct diagnosis of tuberculosis (69.6% and 73.9%) and better inter-observer agreement (k = 0.71) for PTB diagnosis. Observers were more in agreement for the detection of nodules (0.32 - 0.74), adenomegalies (0.43 - 0.69), and for the diagnosis of cancer (0.22 - 1) than for the diagnosis of tuberculosis (0.19 - 0.71). Disagreements were more frequent for the detection of pleural effusions (-0.08 - 0.73). Conclusion: The inter-observer agreement varies with the type of lesions and diagnosis. Pneumologists were most effective for the diagnosis of pulmonary tuberculosis. Observers were more in agreement for the detection of nodules and the diagnosis of cancer than for the diagnosis of pulmonary tuberculosis.

关键词： Inter-Observer Variability Concordance Pulmonary Tuberculosis Nodules Caverns Lung Cancer Chest Radiography Kappa

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Application of Sigma Metric Analysis to Evaluate the Performance of the Biochemistry Analytical System in a Medical Biology Laboratory in Côte d’Ivoire

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Journal of Analytical Sciences, Methods and Instrumentation 2024年第1期14卷 14-21页

作者： Koffi Akissi Joelle Kouakou Francisk Kouadio Charlotte Yeo Karna Ahiboh Hugues Hauhouot-Attoungbré marie-laure Biochemistry and Clinical Chemistry Unit CeDReS University Hospital of Treichville Abidjan Ivory Coast Department of Biochemistry Clinical Chemistry and Molecular Biology Faculty of Pharmaceutical and Biological Sciences University Felix Houphouet-Boigny Abidjan Ivory Coast

Introduction: The Six Sigma methodology is an opportunity for a better understanding of the performance of analytical methods and for a better adaptation of the quality control management policy of the medical biology laboratory. Using the sigma metric, this study assessed the performance of the Biochemistry analytical system of a medical biology laboratory in Côte d'Ivoire. Methods: Six Sigma methodology was applied to 3 analytes (alanine aminotransferase, glucose and creatinine). Performance indicators such as measurement imprecision and bias were determined based on the results of internal and external quality controls. The sigma number was calculated using the total allowable error values proposed by Ricos et al. Results: For both control levels, ALT had a sigma number greater than 6 (7.6 for normal control and 7.9 for pathological control). However, low sigma numbers, less than or equal to 2 for creatinine (1.4 for normal control and 2 for pathological control) and less than 1 for glucose were found. Conclusion: This study revealed good analytical performance of ALT from the point of view of 6 sigma analysis. However, modifications to the overall quality control procedure for glucose and creatinine are needed to improve their analytical performance. The study should be extended to the entire laboratory’s analytes in order to modify the strategies of quality control procedures based on metric analysis for an overall improvement in analytical performance.

关键词： Six Sigma Qualities Controls Bias Imprecision Total Allowable Error

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祖母绿与西方世界的面面观:历史、文化与象征

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中国宝石 2024年第4期 132-143页

作者： marie-laure Cassius-Duranton L'ECOLE珠宝艺术中心

如今,对矿物种类的判定主要取决于其化学成分与原子结构。祖母绿是一种含铬和(或)钒的绿柱石。然而,在矿物学成为一门真正的学科之前,人们会使用其他方式来区分宝石,其中最重要的因素便是颜色。在西方历史和文化中,人们对祖母绿的想象... 详细信息

如今,对矿物种类的判定主要取决于其化学成分与原子结构。祖母绿是一种含铬和(或)钒的绿柱石。然而,在矿物学成为一门真正的学科之前,人们会使用其他方式来区分宝石,其中最重要的因素便是颜色。在西方历史和文化中,人们对祖母绿的想象与其颜色密切相关。尽管绿色具有丰富的象征意义,但在西方文明中,蓝色、红色等其他颜色要比绿色更为重要。

关键词：祖母绿矿物种类绿柱石矿物学原子结构化学成分西方文明宝石

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The Support Systems and Coping Strategies of Infertile Women Attending the Out-Patient Consultation Unit of CHRACERH Yaoundé, Cameroon: A Cross-Sectional Study

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 869-887页

作者： Emenguele Pascale Mpono Fidelia Mbi Kobenge Gabrielle laure Mengne Etienne Belinga Jean marie Kasia Thomas Obinchemti Egbe Department of Obstetrics and Gynecology CHRACERH Yaound Yaound Cameroon Department of Obstetrics and Gynecology Faculty of Medicine and Biomedical Sciences University of Yaound 1 Yaound Cameroon Department of Obstetrics and Gynecology Faculty of Health Sciences University of Bamenda Bamenda Cameroon Department of Obstetrics and Gynecology Douala General Hospital Douala Cameroon Department of Obstetrics and Gynecology Faculty of Health Sciences University of Buea Buea Cameroon

Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psychosocial aspects of the disease. Objectives: This study aimed to identify the support systems and coping strategies of infertile women attending the outpatient consultation unit of the Gynaecological Endoscopic Surgery and Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methods: A hospital-based cross-sectional study was conducted from the 14th of March to the 6th of April 2023 at CHRACERH Yaoundé. A total of 190 participants were recruited using a convenience sampling method. Data regarding socio-demographic characteristics, support systems and coping strategies were collected using a pretested questionnaire. Descriptive and analytic statistics were conducted using SPSS version 25. Results: The mean age of participants was 39.52 ± 7.64 years. The majority 78.9% of participants were workers (public, private sector, or traders) and were Christians 95.8%. The most common source of psychological support was from family 76.8 and husbands 72.63%. Most of the participants 89.5% resorted to prayer and getting busy 48.4% as a coping strategy. There was no statistically significant relationship between coping strategies and psychological disorders p > 0.05. Conclusion: The main support system of participants was family, husband, and friends. Prayer, getting busy and adoption were the most common coping strategies. There is a need for the Ministry of Public Health and other stakeholders to put in place other support systems and coping strategies (FELICIA) used elsewhere and provide adequate health education and infection control to prevent infertility in Cameroon.

关键词： Infertility Coping Strategies Support Systems Mental Health Women

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Prevalence of Work-Aggravated Asthma among Bakery Workers in Abidjan (Cote d’Ivoire)

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Health 2024年第3期16卷 204-217页

作者： Loukou Leandre Konan Esme marie laure Essis Brou Michel Kouassi Marius Kedote Julius Fobil William Yavo Ossey Bernard Yapo Issaka Tiembre National Institute of Public Health Abidjan Cote d’Ivoire Interuniversity Doctoral Program Cotonou Benin Medical Sciences Training and Research Unit Department of Public Health and Biostatistics Felix Houphouet Boigny University Abidjan C&#244te d’Ivoire Global Environmental Occupational Health (GEOHealth) Accra Ghana UFR of Pharmaceutical and Biological Sciences Department of Public Health Felix Houphou&#235t Boigny University Abidjan Cote d’Ivoire Nangui Abrogoua University Abidjan C&#244te d’Ivoire National Institute of Public Hygiene Abidjan C&#244te d’Ivoire

Introduction: Work-aggravated asthma is pre-existing or concomitant asthma whose symptoms are aggravated by the work environment. The aim of this study was to determine the prevalence of this pathology and its associated factors among bakery workers in Abidjan. Materials and Methods: This descriptive and analytical cross-sectional study was conducted over a period of four (4) months from 18 December 2019 to 18 April 2020. Two questionnaires were used, one on employees and the other on the indoor environment of bakeries. In addition, a spirometry test was performed on all bakery workers. Statistical analysis was performed using stata 15.1 software. Results: A total of 599 bakery employees, including bakers (59.73%), sales assistants/ cashiers (23.52%), cleaners (6.34%) and administrative staff (10.18%), were investigated. The mean age was 30.8 ± 8 years, with a sex ratio (M/F) = 2.2. Asthma symptoms were found in 95 (15.86%) employees, of whom 74 (77.9%) had work-related asthma and 11 (14.9%) had asthma aggravated by work. The factors associated with work-aggravated asthma were personal or family history of allergy or atopy [ORa = 3.75;CI95%: 1.56 - 8.93;p = 0.003], exposure to dust [ORa = 5.01;CI95%: 1.43 - 7.50;p = 0.011] and humidity level (60% - 70%) [ORa = 1.80;CI 95%: 0.99 - 3.28;p = 0.05]. Conclusion: Work-aggravated asthma is a reality in bakeries in Abidjan, with an estimated prevalence of 14.9%. Two of the three factors associated with this condition suggest a link with indoor air pollution. Combating air pollution in these establishments must therefore be a priority for the relevant authorities, in order to provide employees with a working environment that protects their health.

关键词： Work-Aggravated Asthma Occupational Asthma Work-Related Asthma Bakeries Abidjan Ivory Coast

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Building the Capacity of Health Professionals in Monitoring and Evaluation in a Public Health Institution: Experience of the National Institute of Public Health (NIPH) of Côte d’Ivoire

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Health 2024年第8期16卷 731-749页

作者： Esme marie laure Essis N’guetta Mathilde Manouan Anna-Corine Estell Liema Bissouma Ethmonia Kouamé Ekissi Orsot Tetchi Sagou Olivier Yayo Stephane Claon Yao Eugene Konan William Yavo Agbaya Stephane Oga Tenenan Jean marie Yeo Joseph Aka National Institute of Public Health Abidjan Cte dIvoire Cellule de Recherche en Sant de la Reproduction de Cte dIvoire (CRESAR-CI) Abidjan Cte dIvoire Department of Public Health and Biostatistics UFR of Medical Sciences Felix Houphout Boigny University Abidjan Cte dIvoire Department of Public Health UFR of Pharmaceutical and Biological Sciences Felix Houphout Boigny University Abidjan Cte dIvoire

Background: In the context of the fight against HIV, a lack of skills in monitoring and evaluating the personnel in charge of activities has been identified at the national level. It was the subject of a priority axis of the national plan for monitoring and evaluating the fight against HIV (2006-2010) that was aimed at strengthening the capacities of actors in this area. To increase the critical mass of competent human resources in the short term, the National Institute of Public Health (NIPH) of Côte d’Ivoire organized monitoring and evaluation training sessions for healthcare professionals from 2011 to 2016. Methods: A single case study with multiple levels of analysis was carried out, combining a qualitative survey and a literature review. An evaluation was carried out six months after each training session. In addition, the results of the pre- and post-tests and of the daily and final evaluations that accompanied the various training sessions were used to provide further information. The qualitative data collected were analyzed using INVIVO 15 software. Results: Some 89 health professionals (69% men and 31% women) working at the national level (51% at the central level, including 58% in health programs) and in development partner agencies (37%) participated in this capacity building program. Most participants were senior health managers (56%), data managers (23%), and statisticians and computer scientists (10%). Almost all the trainings were financed by 16 technical and financial partners (85%), mainly the MEASURE Evaluation project (27%). Conclusion: M&E training, despite all its imperfections, has made it possible to identify M&E training needs at the national level and to increase the critical mass of national skills and to have some culture in M&E.

关键词： Short-Term Training Capacity Building Monitoring and Evaluation Health Professional Africa Côte d’Ivoire

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Deep Morphea in an Immunosuppressed Patient With Anti-U1RNP Myositis:A Case Report

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International Journal of Dermatology and Venereology 2024年第2期7卷 111-114页

作者： Ahmad Berjawi laure L.Irani Jinane R.El Khoury Department of Dermatology Gilbert and Rose Marie Chagoury School of MedicineLebanese American UniversityBeirut 1100Lebanon Department of Rheumatology Division of Internal MedicineGilbert and Rose Marie Chagoury School of MedicineLebanese American University Medical CenterBeirut 1100Lebanon

Introduction:Morphea is an inflammatory skin disease characterized by skin thickening due to increased collagen deposition in the dermis or subcutaneous ***-U1RNP myositis is a newly described entity characterized by myositis,arthritis,interstitial lung disease,and Raynaud *** present a case of a unique combination of deep morphea in a patient with anti-U1RNP *** presentation:A 64-year-old male with 5-year history of proximal muscle weakness,polyarthritis,Raynaud phenomenon,and dyspnea on multiple immunosuppressives presented with localized infiltrated,tight,and hyperpigmented plaques over the posterior thighs and mid-to-lower back developing over the last 2 years and limiting his *** workup revealed a positive ANA,anti-U1RNP antibody,anti-Jo1 antibody,and anti-Ro52 *** workup showed restrictive lung disease,kidney disease,and *** was diagnosed with anti-U1RNP *** biopsy of the back lesion showed deep ***:Association of deep morphea with anti-U1RNP myositis is not described prior in the *** of morphea is challenging since the patient is already on immunosuppressive *** patient failed methotrexate prior and is currently on Mycophenolate mofetil and Deflazacort which are reported as potential treatment for ***,physical therapy plus topical Tacrolimus were suggested as an initial measure to preserve the range of motion of his posterior thighs and *** is a case of progressive deep morphea developing in a patient with a unique autoimmune profile on immunosuppressive ***:Anti-U1RNP myositis is a challenging diagnosis and should be always thought of in patients with positive anti-U1RNP,myositis,interstitial lung disease,arthritis,kidney disease,and Raynaud ***,deep morphea treatment in immunosuppressed patients is challenging and different measures should be considered.

关键词： deep morphea immunosuppression anti-U1RNP myositis case report

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凡尔赛宫中的中国

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紫禁城 2024年第3期350卷 24-45页

作者：玛丽-劳尔·德·罗什布吕内法国巴黎凡尔赛宫博物馆

自十七世纪中期开始,中法两国建立起了长达一个世纪的特殊外交关系,为了与中国建立长久贸易关系,路易十四个人出资支持耶稣会士前往中国。这些耶稣会士凭借自己的数学、医学和天文学知识取得了康熙皇帝的信任,影响着中国宫廷,为中法双... 详细信息

自十七世纪中期开始,中法两国建立起了长达一个世纪的特殊外交关系,为了与中国建立长久贸易关系,路易十四个人出资支持耶稣会士前往中国。这些耶稣会士凭借自己的数学、医学和天文学知识取得了康熙皇帝的信任,影响着中国宫廷,为中法双方了解彼此做出了贡献。

关键词：耶稣会士康熙皇帝路易十四凡尔赛宫十七世纪外交关系

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On a fractional stochastic Hodgkin-Huxley model

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International Journal of Biomathematics 2018年第5期11卷 1-16页

作者： laure Coutin Jean-Marc Guglielmi Nicolas marie Institut de Mathematiques de Toulouse Toulouse France American Hospital of Paris NeuiUy-sur-Seine France Laboratoire Modal'X Universite Paris 10 Nanterre France ESME Sudria Paris France

The model studied in this paper is a stochastic extension of the so-called neuron model introduced by Hodgkin and Huxley. In the sense of rough paths, the model is perturbed by a multiplicative noise driven by a fractional Brownian motion, with a vector field satisfying the viability condition of Coutin and marie for R× [0, 1]3. An application to the modeling of the membrane potential of nerve fibers damaged by a neuropathy is provided.

关键词： Hodgkin-Huxley model stochastic differential equations fractional Brownian motion viability theorem.

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