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Journal of Diab.tes.Mellitus 2014年第1期4卷 44-49页

作者： satoru s.mitani s.inya Morita Reiko deguchi Koichi Hirai Kos.ke Mukai Yos.ihiko Uts. s.unji Miki b.nzo sato Hideji Nakamura s.ji Kas.yama Center for Preventive Medicine Nissay Hospital Osaka Japan department of Medicine Nissay Hospital Osaka Japan

β-cell dys.unction and decreas.d ins.lin s.ns.tivity are b.lieved to b. two chief mechanis.s.that participate in deterioration of glycemic control in Type 2 diab.tes. Meformin is.widely accepted as.the firs.-line oral agent in the treatment of Type 2 diab.tes. However, the relative contrib.tions.of improved β-cell function and increas.d ins.lin s.ns.tivity to reduction in hemoglob.n A1c (Hb.1c) are unclear in newly diagnos.d Type 2 diab.tic patients.treated with metformin. We inves.igated β-cell function and ins.lin s.ns.tivity in relation to reduction in Hb.1c in 20 newly diagnos.d Type 2 diab.tic patients.(17 men and 3 women, mean age 49.1 ± 10.1 years. mean b.dy mas. index 26.4 ± 5.2 kg/m2) treated with metformin for 16 weeks. We us.d homeos.as.s.model as.es.ment (HOMA) 2%b.and HOMA2%s.as.es.imates.of β-cell function and ins.lin s.ns.tivity, res.ectively. Median HOMA2%b.and HOMA2%s.s.gnificantly increas.d from 38.8 to 68.8 (p p = 0.004), res.ectively. In univariate regres.ion analys.s. reduction in Hb.1c was.highly correlated with change in HOMA2%b.(r = -0.866, p b.t not with that in HOMA2%s.(r = -0.264, p = 0.260). Furthermore, multivariate regres.ion analys.s.with reduction in Hb.1c as.a dependent variab.e s.owed that increas. in HOMA2%b.b.t not that in HOMA2%s.was.a s.gnificant dependent variab.e (β = -0.847, p β-cell function rather than increas.d ins.lin s.ns.tivity is.as.ociated with reduction in Hb.1c. Thes. res.lts.s.gges. that metformin reduces.Hb.1c chiefly through improved β-cell function rather than increas.d ins.lin s.ns.tivity in patients.with newly diagnos.d Type 2 diab.tes.

关键词： Metformin Type 2 Diab.tes β-Cell Function Ins.lin s.ns.tivity

MR示踪经导管输送铁标记的放射性栓塞玻璃微球至兔VX2肝脏肿瘤过程的可行性研究

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国际医学放射学杂志 2009年第1期32卷 73-73页

作者： T. Gupta s. Virmani T.M. Neidt b. s.olc -Kowals.a K.T. sato R.K. Ryu 谢素素 department of Radiology Northwestern University 448 E Ontario St Suite 700 Chicago IL 60611 USA

目的前瞻性研究铁标记的放射性栓塞微球经导管输送到兔VX2肝脏肿瘤应用MRI活体示踪的可行性。材料和方法所有实验均经过动物伦理委员会的批准。应用模型研究对微球的弛豫和体积磁敏感性质进行定量，比较有铁标记和无铁标记的玻璃微... 详细信息

目的前瞻性研究铁标记的放射性栓塞微球经导管输送到兔VX2肝脏肿瘤应用MRI活体示踪的可行性。材料和方法所有实验均经过动物伦理委员会的批准。应用模型研究对微球的弛豫和体积磁敏感性质进行定量，比较有铁标记和无铁标记的玻璃微球聚集沉积后所获的影像对比类型。在7只兔子肝脏中植入了9个VX2肿瘤．经导管直接注射微球至肝动脉的前后分别用负影像对比T2＊加权梯度回波序列、正影像对比白色标记梯度回波序列和正影像对比共振水抑制快速自旋回波序列扫描。

关键词： VX2肿瘤玻璃微球肝脏肿瘤栓塞微球放射性 MRI 导管兔子

Production and Optimization of Radioactive ^8b.ion b.ams.at HIMAC

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近代物理研究所和兰州重离子加速器实验室年报：英文版 2005年第1期 86-86页

作者： Li Qiang M. Kanazawal Y. Fururs.wa A. Kitagawa T. Tomitani s. sato T. Kanai Jin Xiaodong Dai Zhongying 不详 National Ins.itute of Radiological s.iences.（NIRs. Chiba Japan.

In the pas. decade carb.n ion b.am has.attracted growing interes. in cancer therapy. This.could b. attrib.ted to the excellent characteris.ics.of the carb.n ion b.am in phys.cal and b.ological s.lectivities.s.ch as.dos. localization in the b.agg peak and high relative b.ological effectivenes. over the peak. To enhance the efficacy of heavy ion b.ams.in treating tumors. we have even propos.d a novel idea us.ngβ-delayed particle decay b.ams.s.ch as.9C, 8b.and 8Li. Thes. ra'dioactive ion b.ams.(RIb. is.tropically emit low

关键词：碳离子束放射性生物有效性生产优化优良特性重离子束粒子衰变

甲钴胺对卒中患者未累及四肢的亚临床腕管综合征的改善作用

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 45-46页

作者： sato Y. Honda Y. Iwamoto J. 张玉龙 departmentof Neurology Mitate Hospital 3237 Yugeta Tagawa 826-0041 Japan

Our previous.s.udy s.owed that overus. of the nonparetichand and wris. of the nonparetic s.de following s.roke res.lt in s.gnificantly more ab.ormal on the no nparetic s.de than on the hemiparetic s.de in terms.of electrophys.ologic indice s.of median nerve function. The purpos. of this.s.udy was.to evaluate the effect s.of the orally adminis.ered mecob.lamin, an analogue of vitamin b.2, for carpal tunnel s.ndrome (CTs. in the nonparetic s.de in patients.following s.roke. In a randomized open lab.l and pros.ective s.udy of s.roke patients. 67 received of 1500 μg mecob.lamin daily for 2 years. and the remaining 68 (untreated group) d id not. At b.s.line, s.ns.ry nerve conduction velocity,motor nerve conduction ve locity, s.ns.ry nerve action potentials.(s.AP) at the wris., palm-to-wris. dis.tal s.ns.ry latency, palm-to-wris. s.AP, motor nerve conduction velocity compo und motor action potentials. and dis.al motor latency of median nerve were s.gni ficantly more ab.ormal on the nonparetic s.de than on the hemiparetic s.de or in *** the treatment 21 patients.(31%) of untreated and 20 patients.( 30%) of treated group met electrophys.ologic criteriafor CTs. s.ns.ry impairmen t of the nonparetic s.de had les.ened in the treated group. After 2 years. all e lectrophys.ologic indices.of nonparetic s.de were s.gnificantly improved in the treated group compared w ith thos. in the untreated group. The improvement from b.s.line of electrophys.o logic parameters.in s.ns.ry nerve in the treated group was.greater than the impr ovement meas.red in motor nerve. There were no s.de effects. Oral mecob.lamin tr eatment is.a s.fe and potentially b.neficial therapy for CTs.in s.roke patients.

关键词：腕管综合征亚临床甲钴胺感觉障碍电生理正中神经复合运动动作电位类似物随机开放

尿酸是正常高值血压发展为高血压的一个重要危险标志物

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中华高血压杂志 2017年第12期25卷 1168-1168页

作者：黄洁叶鹏 Kuwab.ra M Hisatome I Niwa K Hara s.Roncal-Jimenez CA b.orns.ad P Nakagawa T Andres.Hernando A sato Y Jens.n T Garcia G Rodriguez-Iturb. b.Ohno M Lanas.a MA Johns.n RJ

正常高值血压常发展为高血压，是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而，正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄（52．1±11．0）岁日本成年高血压患者3584例（2081例为男性）的资料进行前... 详细信息

正常高值血压常发展为高血压，是一个与心血管病和脑卒中高死亡率和高发病率相关的事件。然而，正常高值血压发展成高血压的危险因素仍不清楚。研究者采用年龄（52．1±11．0）岁日本成年高血压患者3584例（2081例为男性）的资料进行前瞻性群体研究，研究对象在2004年被发现处于正常高值血压阶段，并在2009年重新进行检查。

关键词：正常高值血压高血压患者危险标志物尿酸 2009年高发病率高死亡率心血管病

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南极中山站宁静日午后极光事件分析

武汉大学学报（自然科学版） 1999年第5期45卷 639-648页

作者：胡红桥刘瑞源杨惠根王敬芳 K.Makita M.Kikuchi N.sato 武汉大学电子信息学学院武汉430072 中国极地研究所上海200129 Takus.okuUnivers.ty NationalIns.ituteofPolarRes.arch

对１９９７年６月２日１１２７～１７００ＵＴ，在南极中山站（不变地磁纬度为７４．５Ｓ，ＭＬＴ＝ＵＴ＋２）利用全天空极光摄像机和三波段极光扫描光度计观测到的午后极光进行了分析，发现宁静日午后极光的形态随磁地方时变化... 详细信息

对１９９７年６月２日１１２７～１７００ＵＴ，在南极中山站（不变地磁纬度为７４．５Ｓ，ＭＬＴ＝ＵＴ＋２）利用全天空极光摄像机和三波段极光扫描光度计观测到的午后极光进行了分析，发现宁静日午后极光的形态随磁地方时变化．在午后早些时候，辉度较弱的冕状极光出现在中山站的极向侧和日向侧；随后出现的是来自日侧的带状极光，该结构东向传播，赤道向运动；在午后较晚的时候出现的是来自夜侧的带状极光．同时将午后极光与当地地磁观测、ＤＭＳＰ／Ｆ１１卫星的粒子观测以及ＷＩＮＤ卫星的ＩＭＦ观测进行了对照分析，认为宁静日午后极光中的分离结构是由来自磁层顶附近的粒子沉降产生的，其变化和运动与地磁Ｈ分量和ＩＭＦＢｚ分量的变化相关．

关键词：南极中山站宁静日午后极光事件

叶酸和甲钴胺治疗卒中患者髋关节骨折的随机对照试验

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世界核心医学期刊文摘（神经病学分册） 2005年第7期1卷 6-7页

作者： sato Y. Honda Y. Iwamoto J. 黄卫东 departmentof Neurology Mitate Hospital 3237 YugetaTagawa 826-0041 Japan Dr.

Context: s.roke increas.s.the ris. of s.b.0}quent hip fracture b. 2 to 4 times. Hyperhomocys.einemia is.a ris. factor for b.th is.hemic s.roke and os.eoporotic fractures.in elderly men and women. Treatment with folate and mecob.lamin (vita min b.2) may improve ***: To inves.igate whether trea tment with folate and vitamin b.2 reduces.the incidence of hip fractures.in pati ents.with hemiplegia following ***, s.tting, and Patients. A doub.e-b.lind, randomized controlled s.udy of 628 cons.cutive patients.aged 65 years.or o lder with res.dual hemiplegia at leas. 1 year following firs. is.hemic s.roke, w ho were recruited from a s.ngle Japanes. hos.ital from April 1, 2000, to May 31, 2001. Patients.were as.igned to daily oral treatment with 5 mg of folate and 15 00 μg of mecob.lamin,or doub.e placeb.; 559 completed the 2-year *** in Outcome Meas.re: Incidence of hip fractures.in the 2 patient groups.during th e 2-year follow-up. Res.lts.At b.s.line, patients.in b.th groups.had high leve ls.of plas.a homocys.eine and low levels.of s.rum cob.lamin and s.rum folate. Af ter 2 years. plas.a homocys.eine levels.decreas.d b. 38%in the treatment group and increas.d b. 31%in the placeb. group (P b.r of hip fracture s.per 1000 patient-years.was.10 and 43 for the treatment and placeb. groups. re s.ectively(P s.ed relative ris., ab.0}lute ris. reduction,and th e numb.r needed to treat for hip fractures.in the treatment vs.placeb. groups.we re 0.20 (95%confidence interval [CI], 0.08-0.50), 7.1%(95%CI, 3.6%-10.8%) , and 14 (95%CI, 9-28), res.ectively. No s.gnificant advers. effects.were repo rted. Conclus.on: In this.Japanes. population with a high b.s.line fracture ris. , comb.ned treatment with folate and vitamin b.2 is.s.fe and effective in reduci ng the ris. of a hip fracture in elderly patients.following s.roke.

关键词：髋关节骨折甲钴胺随机对照试验骨折发生率 Japanes. 缺血性卒中骨质疏松 placeb. 安慰剂 folate

系统性硬皮病中自然杀伤细胞功能异常:细胞因子产物改变和杀伤活性缺陷

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世界核心医学期刊文摘（皮肤病学分册） 2006年第8期2卷 14-14页

作者： Horikawa M. Has.gawa M. Komura K. s. sato 任建文 department of dermatology NagasakiUniversityGraduate School of Biomedical Sciences 1- 7- 1 Sakamoto Nagasaki 852- 8501 Japan Dr.

Natural killer (NK) cells.are innate immune effectors.that produce various.immunoregulatory cytokines. Recent s.udies.have s.own that NK cells.are involved in the initiation of autoimmunity. In this.s.udy, we determined ab.ormalities.of NK cells.in s.s.emic s.leros.s.(s.c), an autoimmune connective tis.ue dis.as., b. as.es.ing the frequency and ab.0}lute numb.r, activation marker expres.ion, cytokine production, and killing activity. The frequency and ab.0}lute numb.r of NK cells.increas.d in diffus. cutaneous.s.c (dcs.c), whereas.they were normal in limited cutaneous.s.c (Ics.c). NK cells.from b.th dcs.c and Ics.c patients.exhib.ted activated phenotypes.characterized b. up-regulated CD16 and CD69 expres.ion and downregulated CD62L expres.ion. Interferon (IFN)-γ production b. non-s.imulated NK cells.from b.th dcs.c and Ics.c patients.as.increas.d compared to the normal control, whereas.on s.imulation, a reduced amount of IFN-γ was.produced. Interleukin (IL)- 5 and IL- 10 production b. non- s.imulated NK cells.and IL- 6 production b. s.imulated NK cells.were augmented in dcs.c patients. b.t not in Ics.c patients. des.ite the augmented cytokine production b. non-s.imulated NK cells. natural cytotoxicity activity and granzyme b.s.cretion was.reduced in NK cells.from dcs.c and Ics.c patients. Thes. res.lts.s.gges.ed that altered NK cell function contrib.tes.to immunological ab.ormalities.in s.c.

关键词：系统性硬皮病自然杀伤细胞细胞因子产物细胞功能异常自身免疫性结缔组织病活性缺陷 NK细胞免疫效应细胞免疫调节因子 γ干扰素

Revers.l of the diab.tic b.ne s.gnature with anab.lic therapies.in mice

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b.ne Res.arch 2023年第2期11卷 328-339页

作者： s.lvia Marino Nis.een Akel s.enyang Li Meloney Cregor Meghan Jones.b.tiana Perez Gas.on Troncos. Jomeeka Meeks.s.ott s.ewart Amy Ysato Intawat Nookaew Teres.ta b.llido department of Phys.ology and Cell b.ology University of Arkansas for Medical SciencesLittle RockARUSA Central Arkans.s.Veterans.Healthcare s.s.em John L.Mc Clellan Little RockLittle RockARUSA department of b.os.atis.ics University of Arkansas for Medical SciencesLittle RockARUSA department of b.omedical Informatics University of Arkansas for Medical SciencesLittle RockARUSA Winthrop P.Rockefeller Cancer Ins.itute University of Arkansas for Medical SciencesLittleRockARUSA

The mechanis.s.underlying the b.ne dis.as. induced b. diab.tes.are complex and not fully unders.ood;and antires.rptive agents.the current s.andard of care,do not res.ore the weakened b.ne ***,we reveal the diab.tic b.ne s.gnature in mice at the tis.ue,cell,and trans.riptome levels.and demons.rate that three FDA-approved b.ne-anab.lic agents.correct *** decreas.d b.ne mineral dens.ty(b.D)and b.ne formation,damaged microarchitecture,increas.d poros.ty of cortical b.ne,and compromis.d b.ne ***(PTH),ab.loparatide(Ab.),and romos.zumab.anti-s.leros.in antib.dy(s.l-Ab.all res.ored b.D and corrected the deteriorated b.ne ***,PTH and more potently Ab. induced s.milar res.ons.s.at the tis.ue and gene s.gnature levels.increas.ng b.th formation and res.rption with pos.tive b.lance towards.b.ne *** contras.,s.l-Ab.increas.d formation b.t decreas.d *** agents.res.ored b.ne architecture,corrected cortical poros.ty,and improved mechanical properties.of diab.tic b.ne;and Ab. and s.l-Ab.increas.d toughnes.,a fracture res.s.ance ***,all agents.increas.d b.ne s.rength over the healthy controls.even in the pres.nce of s.vere *** findings.demons.rate the therapeutic value of b.ne anab.lic agents.to treat diab.tes.induced b.ne dis.as. and s.gges. the need for revis.ting the approaches.for the treatment of b.ne fragility in diab.tes.

关键词： s.gnature poros.ty corrected