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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda Ribeiro Ramos lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-Juan Mario Villa Irene Benito-Cuesta lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain Department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden Departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNED) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(Dikic and Elazar,2018).Different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

Creation of an oxygen-enriched environment during synthesis as an effective way to improve luminescent properties of Y_(2)O_(3):Eu^(3+)

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Journal of Rare Earths 2025年第1期43卷 21-29,I0001页

作者： Aleksandr A.Nashivochnikov Anton I.Kostyukov mariana I.Rakhmanova Lidiya S.Kibis Svetlana V.Cherepanova Evgenii A.Suprun Novosibirsk State University Pirogova Str.2630090NovosibirskRussia Boreskov Institute of Catalysis SB RAS 5 Lavrentiev Ave630090NovosibirskRussia Nikolaev Institute of Inorganic Chemistry SB RAS 3 Lavrentiev Ave630090NovosibirskRussia

The growing demand for luminescent nanomaterials intended for various applications increases the necessity to develop and improve approaches to the creation of highly efficient nanosized *** current study,an approach to enhancing the efficiency of red luminescence of monoclinic Y_(2)O_(3):Eu^(3+)with the particle size of~20 nm by creating the oxygen-enriched environment during the gas-phase synthesis was *** investigate the effect of oxygen amount during the synthesis on characteristics of the phosphor,a series of nano structured Y_(2)O_(3):Eu^(3+)with the addition of 0-40 vol%O_(2) to the main buffer gas Ar was synthesized by laser *** is shown that the amount of added O_(2) exerts virtually no effect on the phase composition and particle size,but significantly improves the luminescent characteristics of Y_(2)O_(3):Eu^(3+).Thus,the addition of 30 vol%O_(2) leads to virtually a 20-fold growth in the photoluminescence(PL)intensity caused by ^(5)D_(0)→^(7)F_(0-4) transitions in Eu^(3+)and an increase in the absolute PL quantum yield from 3%to 53%(λex=395 nm)compared to the sample synthesized without O_(2).The addition of oxygen also improves the emission color coordinates from(0.571,0.320)to(0.630,0.322)due to the removal of a considerable fraction of oxygen *** synthesized nanopowders are shown to be highly stable:upon storage under ambient conditions for two *** yield(QY)of the samples decreases by less than 2%.It is expected that the key features underlying the proposed approach will be useful for various methods used to synthesize oxide nanophosphors.

关键词： Photoluminescence Quantum yield Laservaporization Y_(2)0_(3):Eu^(3+) Monoclinic Y_(2)0_(3) Rareearths

Combined Effect of Honey from Central West Brazil on Bacterial Membrane Permeability

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Journal of Biosciences and Medicines 2025年第1期13卷 316-337页

作者： mariana Lenina Menezes Aleixo Joziane da Cruz Mendonça Rafael Bruno Rocha Benevides Larissa Maria Scalon Lemos Carla Galbiati Graduate Program in Environmental Sciences (PPGCA) Office of Research and Graduate Studies State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Faculty of Agrarian Sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil Departament of Nursing Faculty of Health Sciences State University of Mato Grosso (UNEMAT) Cceres Mato Grosso Brazil

Honey, an apicultural product with a complex chemical composition, contains numerous bioactive compounds with potential antimicrobial effects. This study investigated the effect of Apis mellifera honey from Brazil’s Central-West Region, combined with antibiotics, on bacterial membrane permeability, exploring the contributions of bioactive compounds and the botanical origin of honey. Six fresh Apis mellifera honey samples and their fractions (hexane and ethyl acetate) were analyzed, for a total of 18 samples. The bacteria Staphylococcus epidermidis, Helicobacter pylori and Enterococcus faecalis were used for antibacterial activity tests, which included minimum inhibitory concentration (MIC) determination and synergistic effect (checkerboard) assays. The total polyphenol and flavonoid contents were quantified, and the botanical origin was determined based on pollen analysis. The tested honey samples significantly affected bacterial membrane permeability when combined with rifampicin and clarithromycin. Although many honey-derived bioactive compounds, when isolated, did not exhibit significant activity against these bacteria, the additive or synergistic effect of multiple compounds acting on different targets appears to potentiate the antibacterial action. Descriptive statistical analysis, including means and 95% confidence intervals, confirmed the relevance of the findings. This study has provided an important discovery: Honey has an effect on bacterial membrane permeability, although the specific mechanisms involved in this process require further investigation.

关键词： Honey Mechanism of Action Antibacterial Bacterial Membrane Permeability Bioactive Compounds

Effect of magnesium on the aluminothermic reduction rate of zinc oxide obtained from spent alkaline battery anodes for the preparation of Al–Zn–Mg alloys

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International Journal of Minerals,Metallurgy and Materials 2016年第4期23卷 458-465页

作者： Rocio ochoa Alfredo Flores Jesus Torres Cinvestav-Saltillo

The aluminothermic reduction of zinc oxide（ZnO） from alkaline battery anodes using molten Al may be a good option for the elaboration of secondary 7000-series alloys. This process is affected by the initial content of Mg within molten Al, which decreases the surface tension of the molten metal and conversely increases the wettability of ZnO particles. The effect of initial Mg concentration on the aluminothermic reduction rate of ZnO was analyzed at the following values： 0.90wt%, 1.20wt%, 4.00t%, 4.25wt%, and 4.40wt%. The ZnO particles were incorporated by mechanical agitation using a graphite paddle inside a bath of molten Al maintained at a constant temperature of 1123 K and at a constant agitation speed of 250 r/min, the treatment time was 240 min and the ZnO particle size was 450？500 mesh. The results show an increase in Zn concentration in the prepared alloys up to 5.43wt% for the highest initial concentration of Mg. The reaction products obtained were characterized by scanning electron microscopy and X-ray diffraction, and the efficiency of the reaction was measured on the basis of the different concentrations of Mg studied.

关键词： aluminothermic reduction alkaline batteries zinc oxide waste utilization aluminum zinc magnesium alloys

Efficient Gaussian process regression for prediction of molecular crystals harmonic free energies

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npj Computational Materials 2021年第1期7卷 1552-1561页

作者： Marcin Krynski mariana Rossi Fritz Haber Institute of the Max Planck Society Faradayweg 4-614195 BerlinGermany Faculty of Physics Warsaw University of TechnologyKoszykowa 7500-662 WarsawPoland MPI for the Structure and Dynamics of Matter Luruper Chaussee 14922765 HamburgGermany

We present a method to accurately predict the Helmholtz harmonic free energies of molecular crystals in high-throughput *** is achieved by devising a computationally efficient framework that employs a Gaussian Process Regression model based on local atomic *** cost to train the model with ab initio potentials is reduced by starting the optimization of the framework parameters,as well as the training and validation sets,with an empirical *** is then transferred to train the model based on density-functional theory potentials,including *** benchmarked our framework on a set of 444 hydrocarbon crystal structures,comprising 38 polymorphs and 406 crystal structures either measured in different conditions or derived from these *** performance and high prediction accuracy,with mean absolute deviation below 0.04 kJ mol^(−1) per atom at 300 K is achieved by training on as little as 60 crystal ***,we demonstrate the predictive efficiency and accuracy of the developed framework by successfully calculating the thermal lattice expansion of aromatic hydrocarbon crystals within the quasi-harmonic approximation,and predict how lattice expansion affects the polymorph stability ranking.

关键词： harmonic crystal Gaussian

Response of bioaerosol cells to photocatalytic inactivation with ZnO and TiO_(2)impregnated onto Perlite and Poraver carriers

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Frontiers of Environmental Science & Engineering 2021年第3期15卷 137-149页

作者： mariana Valdez-Castillo Sonia Arriaga Environmental Science Department Institute for Scientific and Technological Research of San Luis PotosiIPICYT.Camino Presa San Jose 2055Lomas 4a SeccionCP 78216San Luis PotosiMexico

Bioaerosols are airborne microorganisms that cause infectious sickness,respiratory and chronic health *** have become a latent threat,particularly in indoor *** is a promising process to inactivate completely bioaerosols from ***,in systems treating a continuous air flow,catalysts can be partially lost in the gaseous *** avoid such phenomenon,supporting materials can be used to fix *** the present work,four photocatalytic systems using Perlite or Poraver glass beads impregnated with ZnO or TiO_(2)were *** inactivation mechanism of bioaerosols and the cytotoxic effect of the catalysts to^bioaeros^ls were *** plug flow photocatalytic reactor treated a bioaerosol flow of 460×10^(6)cells/m^(3)_(air)with a residence time of 5.7 *** Cytometry(FC)was used to quantify and characterize bioaerosols in terms of dead,injured and live *** most efficient system was ZnO/Perlite with 72%inactivation of bioaerosols,maintaining such inactivation during 7.5 h due to the higher water retention capacity of Perlite(2.8 mL/gpcriite)in comparison with Poraver(1.5 mL/gperiite).However,a global balance showed that Ti0_(2)/Poraver system triggered the highest level of cytotoxicity to bioaerosols retained on the support after 96 h with 95%of dead *** and FC analyses showed that the mechanism of inactivation with ZnO was based on membrane damage,morphological cell changes and cell lysis;whereas only membrane damage and cell lysis were involved with Ti0_(2).Overall,results highlighted that photocatalytic technologies can completely inactivate bioaerosols in indoor environments.

关键词： Immobilized catalysts Continuous flow Photocatalysis Bioaerosols Cytotoxicity Inactivation mechanism

Burden,stress and depression in caregivers of cirrhosis patients before and after liver transplantation

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World Journal of Transplantation 2025年第2期15卷 276-287页

作者： Adriano Virches mariana B Claudino Maria C Miyazaki Eliane T Miyazaki Renato F Silva Rita C Silva Heitor B Farias Neide A Domingos Randolfo Santos Jr Patricia S Fucuta Department of Psychology School of Medicine of São Josédo Rio Preto(FAMERP/Faculdade de Medicina de São Josédo Rio Preto)São Josédo Rio Preto 15090-000São PauloBrazil Department of Surgery and Study Group of Liver Tumors-GETF and Liver and Small Intestine Transplantation Unit School of Medicine of São Josédo Rio Preto and Base HospitalSão Josédo Rio Preto 15090-000São PauloBrazil Department of Gastroenterology and Liver and Small Intestine Transplantation Unit School of Medicine of São Josédo Rio Preto and Base HospitalSão Josédo Rio Preto 15090-000São PauloBrazil Stricto Sensu Graduate Program in Psychology Pontifical Catholic University of Minas GeraisBelo Horizonte 32604-115Minas GeraisBrazil Stricto Sensu Graduate Program in Psychology and Health School of Medicine of São Josédo Rio PretoSão Josédo Rio Preto 15090-000São PauloBrazil Department of Medicine Faceres Medical SchoolSão Josédo Rio Preto 15090-305São PauloBrazil

BACKGROUND Family caregivers of cirrhosis patients(CPs)often experience burden,stress,and *** whether these conditions improve following the patient undergoing liver transplantation(LT)is crucial,as it would elucidate the compre-hensive benefits of the procedure and demonstrate the positive impacts not only on the patients but also on their caregivers and *** To compare the levels of burden,stress and depression among family caregivers of cirrhotic and liver transplant *** This cross-sectional observational study evaluated caregivers of CPs and LT recipients at a quaternary Brazilian *** included identification cards,interview scripts,the caregiver burden scale Inventory,Lipp’s Stress Symptom Inventory,and the Beck Depression Inventory-Second *** analyses involved confirmatory factor analysis and calculation of McDonald’s omega and composite *** scores were compared with the Mann-Whitney U test,with effect size as the rank-biserial correlation coefficient(r).Statistical analysis was performed with R software(P<0.05).RESULTS Seventy-seven CP caregivers and 65 LT recipient caregivers were *** were female(CP:85.7%vs LT:84.6%)and the patients’spouses(76.6%vs 63.1%).The median age and caregiving duration were 55.4(23.3-76.3)vs 54.6(25.7-82.1)and 3.9(1-20)vs 8(1.5-24)years,respectively(P=0.001).LT caregivers were less likely to be at risk of overload(21.5%vs 49.4%),to be under stress(33.8%vs 36.4%)and to show symptoms of depression(15.4%vs 35.1%).Compared with LT caregivers,CP caregivers had greater median factor scores for burden(general tension,P=0.012;isolation,P=0.014;disappointment,P=0.004),depression(P=0.008),and stress(P=0.047),with small to moderate effect *** disappointment(r=0.240)and depression(r=0.225)dimensions had the largest effect *** Family caregivers of LT recipients are less likely to exhibit symptoms of burden,stress,and depression,su

关键词： Mental disorders Caregiver burden Psychological stress Depressive disorder Chronic disease Liver cirrhosis Transplant recipients Liver transplantation

In Vitro Propagation, Isolation and Expression Studies of Suaeda edulis Genes Involved in the Osmoprotectants Biosynthesis

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Phyton-International Journal of Experimental Botany 2020年第3期89卷 715-726页

作者： Gloria Viviana Cerrillo-Rojas mariana Tiscareno-Andrade Ana Erika ochoa-Alfaro Eugenio Perez-Molphe Balch Ruth Elena Soria-Guerra Jose Francisco Morales-Dominguez Departamento de Quimica Universidad Autonoma de AguascalientesCentro de Ciencias BasicasCiudad UniversitariaAguascalientes20131Mexico Facultad de Quimica Universidad Autonoma de San Luis PotosiZona UniversitariaSan Luis Potosi78210Mexico

Halophytes are an excellent choice for the study of genes conferring salt tolerance to salt-sensitive plants and,they are suitable for reclamation and remediation of saline *** develop an in vitro plant propagation protocol and studies of genes involved with GB and Pro biosynthesis in Suaeda *** buds were used as explants and cultured in different treatments on Murashige and Skoog(MS)medium supplemented with different concentrations and combinations of plant growth *** highest number of multiple shoots was on MS medium containing 1 mg/L Benzyladenine(BA)and/or 2 g/L activated carbon with 5.5±06 shoots per *** identification and expression analysis of genes involved in glycine betaine(GB)biosynthesis were S-adenosyl-methionine synthetase(SAMS),choline monooxygenase(CMO)and betaine alde-hyde dehydrogenase(BADH),and for proline(Pro)was pyrroline 5-carboxylate synthetase(P5CS).These sequences shared 90–95%of identity with others plant homologous in public *** amino acids sequence analysis showed that all these peptides contain some of the conserved motifs of those kinds of *** qRT-PCR analysis revealed a higher expression of SeBADH,SeCMO,and,SeP5CS genes in the roots and leaves from plants collected in the field in contrast with from in vitro ***,the expression level of SeSAMS was higher only in the leaves of plants collected in the field when com-pared to those cultivated in vitro.

关键词： Axillary buds halophyte proline glycine betaine salt-resistant