检索结果-南通市图书馆

Immediate virological response predicts the success of shortterm peg-interferon monotherapy for chronic hepatitis C

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2010年第12期16卷 1506-1511页

作者： Masayoshi Yada Akihide Masumoto Naoki Yamashita Kenta Motomura Toshimasa Koyanagi Shigeru sakamoto Department of Hepatology Iizuka Hospital

AIM:To investigate the efficacy of short-term peginterferon(PEG-IFN)monotherapy for chronic hepatitis C patients who achieved an immediate virological ***:Defining an"immediate virological response(IVR)"as the loss of serum hepatitis C virus(HCV) RNA 7 d after the first administration of PEG-IFNα,we conducted a 12-wk course of PEG-IFNα2a monotherapy without the addition of ribavirin for 38 patients who had low pretreatment HCV RNA load and exhibited *** patients included 21 men and 17 women,whose ages ranged from 22 to 77 years(mean±SD:52.0±17.8 years).There were 4 patients with HCV genotype 1b,23 patients with genotype 2a and 4 patients with genotype *** genotype was not determined for the remaining 7 *** were categorized into a sustained virological response(SVR)group,if serum HCV RNA remained negative for 24 wk after the end of treatment,or into a relapse ***:Based on the intention-to-treat analysis,35 patients(92.1%)achieved *** patient(2.6%)relapsed with serum HCV RNA 12 wk after the end of *** patients(5.3%)withdrew from the study during the 24-wk follow-up *** regard to the HCV RNA genotype,the SVR rates were 100%(4/4) for genotype 1b,95.7%(22/23)for genotype 2a and 100%(4/4)for genotype *** SVR rate in 7 patients,whose HCV RNA genotypes were not determined,was 71.4%(5/7).CONCLUSION:Short-term PEG-IFNα2a monotherapy is highly effective for chronic hepatitis C patients who have low pretreatment HCV RNA load and exhibit IVR.

关键词： Chronic hepatitis C Immediate virological response Interferon therapy

Prognostic value of postoperative complication for early recurrence after curative resection of hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2018年第4期17卷 323-329页

作者： Masataka Amisaki Hiroaki Saito Naruo Tokuyasu Teruhisa sakamoto Soichiro Honjo Yoshiyuki Fujiwara Division of Surgical Oncology Department of SurgerySchool of MedicineTottori University Faculty of Medicine

Background: Postoperative complications may adversely affect oncological outcomes. The aim of this study was to evaluate the impact of postoperative complications on early-phase recurrence after curative resection for hepatocellular carcinoma(HCC).Methods: We included 145 HCC patients who underwent initial and curative resection between January2004 and December 2013. Postoperative complications of grade III or higher based on Clavien–Dindo classification were defined as clinically relevant postoperative complications. Recurrence within two years after hepatectomy was defined as early-phase ***: Thirty-eight patients(26%) developed postoperative complications. The only predictive factor for postoperative complication was longer operative duration(P = 0.037). The disease-specific survival rate of patients with complication was lower than that of patients without complications(P = 0.015). Earlyphase recurrence was observed in 20/38(53%) patients who suffered postoperative complications and36/107(34%) patients with no complications, which was statistically significant(P = 0.039). Multivariate analysis identified four factors contributing to early-phase recurrence: high serum AFP level(P = 0.042),multiple tumors(P < 0.001), poor differentiation(P = 0.036) and presence of postoperative complication(P = 0.039).Conclusions: Postoperative complication is an independent prognostic factor for early-phase recurrence after curative resection of HCC. Close observation of patients with postoperative complications may be a necessary treatment strategy for HCC.

关键词： Neoplasm metastasis Complications Risk factors Hepatocellular carcinoma

Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2022年第3期14卷 646-653页

作者： Shintaro Akiyama Taku sakamoto Joshua M Steinberg Yutaka Saito Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaIbaraki 305-8575Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

Magnifying endoscopy is a useful technique to differentiate neoplasia from non-neoplastic lesions. Data regarding the clinical utility of magnifying endoscopy for neoplasia in patients with inflammatory bowel disease(IBD) has been *** Kudo’s pit pattern types Ⅲ-Ⅴ are findings suggestive of neoplasia in non-IBD patients, these pit patterns are predictive of IBD-associated neoplasia as ***, active chronic inflammatory processes, particularly regenerative changes, can mimic neoplastic pit patterns and may affect a meticulous evaluation of pit pattern diagnosis in patients with IBD. The clinical evidence regarding the utility of magnifying endoscopy with narrow band imaging or endocytoscopy has also been evolving in regard to the diagnosis of IBD-associated neoplasia. These advanced endoscopic techniques are promising for multiple reasons;not only for making an accurate diagnosis of neoplasia, but also in determining if endoscopic resection is appropriate for such lesions in patients with IBD. In this review, we discuss the diagnostic accuracy and limitations of magnifying endoscopy in assessing IBD-associated neoplasia and examine the feasibility and outcomes of endoscopic resection for these lesions.

关键词： Magnifying endoscopy Neoplasia Ulcerative colitis Inflammatory bowel disease Endoscopic resection

Multidisciplinary management of acute mesenteric ischemia:Surgery and endovascular intervention

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2021年第8期13卷 806-813页

作者： Takashi sakamoto Tadao Kubota Hiraku Funakoshi Alan Kawarai Lefor Department of Clinical Epidemiology and Health Economics School of Public HealthThe University of TokyoTokyo 1130033Japan Department of Surgery Tokyo Bay Urayasu Ichikawa Medical CenterChiba 2790001Japan Department of Interventional Radiology Tokyo Bay Urayasu Ichikawa Medical CenterChiba 2790001Japan Department of Surgery Jichi Medical UniversityTochigi 3290498Japan

Acute mesenteric ischemia(AMI)is a rare cause of the“acute abdomen”,characterized by impaired blood flow to the *** principle of treatment is restoration of perfusion to ischemic bowel and resection of any necrotic *** and endovascular intervention are two complementary approaches to mesenteric *** intervention is not an alternative to the surgical approach,but it has the potential to improve the prognosis of patients with AMI when judiciously combined with a surgical *** to the need for emergent treatment of patients with acute mesenteric ischemia,the treatment strategy needs to be modified for each *** review aims to highlight cutting-edge studies and provide reasonable treatment strategies for patients with acute mesenteric ischemia based on available evidence.

关键词： Acute mesenteric ischemia Endovascular intervention Acute mesenteric arterial embolism Acute mesenteric arterial thrombosis

Knowledge,attitudes and practices towards avian influenza A(H5N1) among Cambodian women:A cross-sectional study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 727-734页

作者： Mav Khun Chantha Heng Md.Harun-Or-Rashid Hideki Kasuya Junichi sakamoto Young Leaders' Program in Healthcare Administration Nagoya University Graduate School of MedicineNagoyaJapan Communicable Disease Control Rapid Response TeamKampot Provincial Health DepartmentKampot ProvinceCambodia Department of Surgery Ⅱ Nagoya University Graduate School of MedicineNagoyaJapan

Objective:To measure highly pathogenic avian influenza(HPAI)-related knowledge,attitudes, and practices(KAPs) among Cambodian ***:This cross-sectional study selected 246 married women aged between 18-55 years who had backyard poultry and lived at least one year in the areas of the survey through multi-stage cluster *** average score of correct answers was generated to evaluate respondents’ knowledge(Good/Poor).attitudes(Positive/ Negative),and practices(Good/Bad).Results:We reported that about half of the respondents had good knowledge and good practices and four-fifth of them had positive attitudes towards *** ratios(ORs) and 95%confidence intervals(CIs) were estimated through a logistic regression model to explore contributing factors that raise their KAP *** of the sources were significant in increasing knowledge of the respondent,like television(OR=l.6.95%CI=1.0- 2.7),radio(OR=2.5.95%CI=l.3-4.9).leaflets/booklets(OR=2.1,95%CI=1.2-3.9),school students (OR=18.4.95%CI=2.4-142.9).village health volunteers(OR=4.5.95%CI=2.2-10.9) *** such as television(OR=3.7.95%CI=2.1-6.4).leaflets/booklets(OR=2.6,95%CI7=1.4-5.1).and public health staff(OR=2.2,95%CI=1.2-4.1) had similar influence on ***,we found similar effect on raising the attitudes of the responded,it was not ***: We report a satisfactory level of positive attitudes,and moderate level of knowledge and practices related to HPAI among Cambodian *** KAPs through television,radio and other medias may be more efficient than using usual information,education and communication materials to prevent HPAI.

关键词： Highly pathogenic avian influenza Knowledge Attitudes Practices Kampot Cambodia

Non-ossifying fibromas: Case series, including in uncommon upper extremity sites

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2017年第7期8卷 561-566页

作者： Akio sakamoto Ryuzo Arai Takeshi Okamoto Shuichi Matsuda Department of Orthopaedic Surgery Graduate School of Medicine Kyoto University

AIM To investigate non-ossifying fibromas(NOFs) common fibrous bone lesions in children that occur in bones of the lower *** We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities(1 proximal humerus, 1 distal radius) and the lower extremities(25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas).RESULTS Three cases had NOFs in multiple anatomical locations(femur and fibula in 1 case, femur and tibia in 2 cases). Overall, larger lesions > 4 cm and lesion expansion at the cortex were seen in 21% and 32% of cases, respectively. Multiple lesions with bilateral symmetry in the lower extremities suggest that these NOFs were developmental bone defects. Two patients suffered from fracture and were treated without surgery, one in the radius and one in the femur. Lesions in the upper extremities(i.e., humerus of a 4-year-old female and radius of a 9-year-old male) expanded at the cortex and lesion size increased with slow *** NOFs in the lower extremity had fewer clinical problems, regardless of their size and expansiveness. In these two upper extremity cases, the NOFs had aggressive biological features. It seems that there is a site specific difference, especially between the upper extremity and the lower extremity. Furthermore, NOFs in the radius are predisposed to fracture because of the slender structure of the radius and the susceptibility to stress.

关键词： Non-ossifying fibroma Humerus Radius Fibula Upper extremity

Effect of dietary docosahexaenoic acid on lipogenesis and lipolysis in black sea bream,Acanthopagrus schlegeli

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2007年第1期26卷 112-121页

作者： JI Hong OM Ahamd Daud YOSHIMATSU Takao UMINO Testuya NAKAGAWA Heisuke FURUHASHI Makoto sakamoto Shuichi College of Animal Science and Technology Northwest Agriculture and Forestry University Shaanxi 712100 China Graduate School of Biosphere Science Hiroshima University Higashi - hiroshima 739 - 8528 Japan Marine Finfish Production and Research Center Terengganu 22200 Malaysia Farming System Division National Research Institute of Aquaculture Fisheries Research Agency Mie 516 -0913 Japan Oriental Yeast Co Ltd Chiba 281 -0002 Japan

Hatchery-roared juvenile black sea breams are characterized by a low level of highly unsaturated fatty acids in their bodies, as compared with wild fish. To assess the effect of docosahaxaenoic acid （DHA） on lipegenic and lipelysis enzymes, one-year fish were roared on a casein-based purified diet and a DHA fortified diet （ 1.5% DHA ethyl ester/kg diet） for 60 d, followed with a period of 55 d for starvation. Dietary DHA was effectively incorporated into the fish body. Fortification of DHA depressed activities of glucose-6-phosphate dehydrogenase and NADP-isocitrate dehydrogenase as lipogenic enzymes in the hepatopancroas and intraperitoneal fat body. Carnitine palmitoyltransferase as lipolysis enzyme in the hepatopancreas was active in the DHA fortified fish. Starvation after feeding experiment induced increased carnitine palmitoyltransferase activity in both control and DHA fortified fish and the activity remained higher in the DHA fortified fish, while the monoenes were selectively consumed prior to highly unsaturated fatty acids. These results indicated that dietary DHA depressed lipogenesis and activated lipolysis.

关键词： DHA enzyme lipogenesis lipolysis black sea bream

Quantitative index calculated by ^(99m)Tc-GSA scintigraphy

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2014年第6期26卷 641-643页

作者： Morikatsu Yoshida Shinya Shiraishi Noriko Tsuda Fumi sakamoto Seiji Tomiguchi Yasuyuki Yamashita Department of Diagnostic Radiology Graduate School of Life Sciences Kumamoto University Department of Diagnostic Medical Imaging School of Health Faculty of Life Sciences Kumamoto University

99mTc-galactosyl human serum albumin（GSA） scintigraphy is useful to evaluate hepatic function and hepatic functional reserve. A reliable SPECT and CT integrated system is now commercially available. Using this system, we can obtain 99mTc-GSA SPECT/CT fused imaging with a small registration error. Therefore, the 99mTc-GSA scintigraphy techniques prove more useful in clinical practice than have been previously reported. In the latest Annals of Surgical Oncology on Oct 2014, the uptake index（UI） values calculated from 99mTc-GSA scintigraphy are reported to be useful for predicting the functional reserve of the future remnant liver. In this paper, we describe the usefulness of 99mTc-GSA scintigraphy as well as some cautions that are necessary as regards using the system.

关键词： 99mTc-GSA scintigraphy SPECT/CT uptake index(UI)

Clinical characteristics and mutation analysis of propionic acidemia in Thailand

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2014年第1期10卷 64-68页

作者： Nithiwat Vatanavicharn Somporn Liammongkolkul Osamu sakamoto Mahattana Kamolsilp Achara Sathienkijkanchai Pornswan Wasant Division of Medical Genetics Department of PediatricsFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Pediatrics Tohoku University School of MedicineSendaiJapan Department of Pediatrics Phramongkutklao HospitalBangkokThailand

Background:Propionic acidemia(PA)is caused by a deficiency of propionyl CoA carboxylase.A characteristic urine organic acid profile includes 3-hydroxypropionate,methylcitrate,tiglylglycine,and *** diagnosis of PA is confirmed by detection of mutations in the PCCA or PCCB *** herein report the clinical and molecular findings of four Thai patients with ***:Clinical findings of four Thai patients with PA were retrospectively *** organic acids were analyzed by gas chromatography-mass ***-sequencing analyses of encoding exons and intron/exon boundaries of the PCCA and PCCB genes were ***:All patients had neonatal onset of *** patient died of cardiomyopathy,and another one of pneumonia and metabolic *** remainder experienced significant neurocognitive *** analysis of the PCCA gene identified homozygous c.1284+1G>A in patient 1,c.230G>A(p.R77Q)and c.1855C>T(p.R619X)in patient 2,homozygous c.2125T>C(p.S709P)in patient 3,and only one mutant allele,c.231+1G>T in patient *** PCCB mutation was *** mutations including c.230G>A,c.231+1G>T,c.1855C>T,and c.2125T>C have not been reported ***:The clinical and molecular study of these Thai patients provided additional knowledge of the genotype and phenotype characteristics of *** results of the study suggested that PCCA mutations in Asian populations were distinct from those of other populations.

关键词： mutations propionic acidemia Thailand