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T follicular helper expansion and humoral-mediated rejection are independent of the HVEM/BTLA pathway

Cellular & Molecular Immunology 2017年第6期14卷 497-510页

作者： Jose-Ignacio Rodriguez-Barbosa Carlos Fernandez-Renedo Ana maria Bravo Moral Leo Biihler maria-luisa del rio Transplantation Immunobiology Section Institute of Biomedicine University of Leon and Castilla and Leon Regional Transplantation Coordination Leon University Hospital Leon Spain Department of Veterinary Clinical Sciences University of Santiago de Compostela Veterinary Faculty Lugo Spain Visceral and Transplantation Surgery Department of Surgery University Hospitals of Geneva and Faculty of Medicine Geneva Switzerland

The molecular pathways contributing to humoral-mediated allograft rejection are poorly defined. In this study, we assessed the role of the herpesvirus entry mediator/B- and T-lymphocyte attenuator （HVEM/BTLA） signalling pathway in the context of antibody-mediated allograft rejection. An experimental setting was designed to elucidate whether the blockade of HVEM/BTLA interactions could modulate de novo induction of host antidonor-specific antibodies during the course of graft rejection. To test this hypothesis, fully allogeneic major histocompatibility complex-mismatched skin grafts were transplanted onto the right flank of recipient mice that were treated with isotype control, anti-CD40L or modulatory antibodies of the HVEM/BTLA signalling pathway. The frequencies of CD4 T follicular helper （Tfh） cells （B220-, CD4＋ CXCR5＋ PD-lhigh）, extrafollicular helper cells （B220-, CD4＋ CXCR5- PD-1＋ and PD-1-） and germinal centre （GC） B cells （B220＋Fas＋ GL7＋） were analysed by flow cytometry in draining and non-draining lymph nodes at day 10 post transplantation during the acute phase of graft rejection. The host antidonor isotype-specific humoral immune response was also assessed. Whereas blockade of the CD40/CD40L pathway was highly effective in preventing the allogeneic humoral immune response, antibody-mediated blockade of the HVEM/BTLA-interacting pathway affected neither the expansion of Tfh cells nor the expansion of GC B cells. Consequently, the course of the host antidonor antibody-mediated response proceeded normally, without detectable evidence of impaired development. In summary, these data indicate that HVEM/BTLA interactions are dispensable for the formation of de novo host antidonor isotype-specific antibodies in transplantation.

关键词： BTLA (CD272) humoral immunity HVEM (TNFRSF14, CD270) T follicular helper cells transplantation

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HVEM,a cosignaling molecular switch,and its interactions with BTLA,CD160 and LIGHT

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Cellular & Molecular Immunology 2019年第7期16卷 679-682页

作者： Jose Ignacio Rodriguez-Barbosa Pascal Schneider Andreas Weigert Kyung-Mi Lee Tae-Jin Kim Jose-Antonio Perez-Simon maria-luisa del rio Transplantation Immunobiology Section Research Institutes of the University of LeonCampus of Vegazana s/n24071 LeonSpain Leon Regional Transplantation Coordination Center Leon University HospitalLeonSpain Acción Estratégica en Salud Consorcio CIBER-ONCSevilleSpain Department of Biochemistry University of Lausanne1066 EpalingesSwitzerland Institute of Biochemistry I Faculty of MedicineGoethe-University Frankfurt60590 FrankfurtGermany Department of Biochemistry and Molecular Biology Korea University College of MedicineSeoul 02841Republic of Korea Department of Biomedical Engineering Center for Bio-Integrated ElectronicsSimpson Querrey Institute for BioNanotechnologyNorthwestern UniversityEvanstonIL 60208USA Department of Hematology Virgen del Rocio University HospitalBiomedical Institute of SevillaSevillaSpain

Temporal and spatial expression of cosignaling receptors and their ligands regulates the early stages of T-cell activation(signal 1,T-cell receptor(TCR)signaling and signal 2,costimulation/coinhibition),clonal expansion and T-cell survival during their differentiation towards effector T *** the inflammatory stimulus is eliminated,effector T cells return to homeostasis after undergoing a contraction phase by activation-induced cell death and the intervention of ligands for coinhibitory receptors,leaving a population of long-term memory T *** expression of ligands for coinhibitory receptors on hematopoietic cells and,more importantly,on non-hematopoietic cells of peripheral tissues is a key process in tuning the functional activity of effector T cells to prevent excess tissue inflammation that may lead to immunopathology and subsequent tissue dysfunction.

关键词： stimulation homeostasis inflammation

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Correction to: T follicular helper expansion and humoralmediated rejection are independent of the HVEM/BTLA pathway

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Cellular & Molecular Immunology 2019年第3期16卷 314-314页

作者： Jose-Ignacio Rodriguez-Barbosa Carlos Fernandez-Renedo Ana María Bravo Moral Leo Bühler maria-luisa del rio Transplantation Immunobiology Section Institute of BiomedicineUniversity of Leon and Castilla and Leon Regional Transplantation CoordinationLeon University HospitalLeonSpain Department of Veterinary Clinical Sciences University of Santiago de CompostelaVeterinary FacultyLugoSpain Visceral and Transplantation Surgery Department of SurgeryUniversity Hospitals of Geneva and Faculty of MedicineGenevaSwitzerland

In this article,one of the grating agencies requested us to incorporate the information,Spanish Government and co-funded by European Union ERDF/ESF,“Investing in your future”,in the acknowledgments *** correct acknowledgement is as follows:“This work has been supported by grants of the Spanish Ministry of Health(Fondo de Investigaciones Sanitarias,PI13/00029,Spanish Government and co-funded by European Union ERDF/ESF,“Investing in your future”),Department of Education of Castilla and Leon Regional Government(Grant#LE093U13)and Mutua Madrileña Foundation(Basic research grants 2012)to J.I.R.B.;by Miguel Servet National Program(Ministry of National Health)CP12/03063 and by Gerencia Regional de Salud GRS963/A/2014 to *** are particularly grateful to *** Alaiz for outstanding animal husbandry.”The authors regret the errors.

关键词： section. expansion husbandry

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A deep learning framework to emulate density functional theory

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npj Computational Materials 2023年第1期9卷 687-695页

作者： Beatriz G.del rio Brandon Phan Rampi Ramprasad Departamento de Física Teórica Atómica yÓpticaUniversidad de ValladolidPaseo de Belén 747011 ValladolidSpain School of Materials Science and Engineering Georgia Institute of Technology771 Ferst Drive NWAtlantaGA 30332USA

Density functional theory(DFT)has been a critical component of computational materials research and discovery for ***,the computational cost of solving the central Kohn–Sham equation remains a major obstacle for dynamical studies of complex phenomena ***,we propose an end-to-end machine learning(ML)model that emulates the essence of DFT by mapping the atomic structure of the system to its electronic charge density,followed by the prediction of other properties such as density of states,potential energy,atomic forces,and stress tensor,by using the atomic structure and charge density as *** deep learning model successfully bypasses the explicit solution of the Kohn-Sham equation with orders of magnitude speedup(linear scaling with system size with a small prefactor),while maintaining chemical *** demonstrate the capability of this ML-DFT concept for an extensive database of organic molecules,polymer chains,and polymer crystals.

关键词： functional theory system

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Selective suspension of single layer graphene mechanochemically exfoliated from carbon nanofibres

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Nano Research 2014年第7期7卷 963-972页

作者： Antonio Esau del rio-CastilloI Cesar Merino Enrique Diez-Barra Ester Vazquez Departamento de Quimica Orgdnica Facultad de Ciencias y Tecnologfas Qufmicas-IRICA Universidad de Castilla-La Mancha 13071 Ciudad Real Spain Grupo Antolin Ingenieria S.A. Burgos E09007 Spain

This paper presents the first report of the successful ball-milling exfoliation of graphitic filaments （GANF~ carbon nanofibres） into single layer graphene. The addition of small amounts of solvent during the milling process makes it possible to enhance the intercalation of the exfoliating agent （melamine） between the graphene layers, thus promoting exceptional exfoliation. Advantage has also been taken of the fact that the Hansen solubility parameters of graphene are different from those of carbon fibres, which allows single and few-layer graphene to be suspended in a particular solvent, thus discriminating them from poorly exfoliated carbon nanofibres.

关键词： carbon fibre graphene ball-milling exfoliation Hansen solubilityparameters

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Interpretation of Data in Psychology： A False Problem, a True Issue

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Journal of Philosophy Study 2015年第1期5卷 54-62页

作者： maria del rio Carral Marie Santiago-delefosse University of Lausanne

In psychology, the concept of interpretation has been namely associated to the subjectivist paradigm underpinning qualitative approaches, rather than the objectivist paradigm charactefising quantitative research. In this article, we challenge this belief by showing how interpretation concerns psychology as a whole. To do this, the authors will first consider some dominant tendencies characterising the psychological field in general, such as the ＂empiricist illusion＂ and the ＂trap of scientism＂（Vygotsky 1999）. Moreover, they will introduce the cultural perspective in psychology, pertinent to deconstruct several assumptions regarding research within the discipline. Stemming from this approach, ＂indirect methods＂ will be presented with regard to their potential to analyse psychological phenomena both qualitatively and scientifically. They will conclude by describing a set of principles that can be implemented when doing qualitative research as to ensure the quality and the adequacy of interpretation.

关键词： qualitative research interpretation empiricist illusion indirect methods critical psychology

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Recent Advances on Early-Stage Fire-Warning Systems: Mechanism, Performance, and Perspective

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Nano-Micro Letters 2022年第12期14卷 106-136页

作者： Xiaolu Li Antonio Vazquez-Lopez Jose Sanchez del rio Saez De-Yi Wang IMDEA Materials Institute C/Eric Kandel228906 GetafeMadridSpain E.T.S.de Ingenieros de Caminos Universidad Politecnica de MadridCalle Profesor Aranguren 328040 MadridSpain Departamento de Ingenieria Electrica Electronica Automatica y Fisica AplicadaETSIDIUniversidad Politecnica de MadridRonda de Valencia 328012 MadridSpain

Early-stage fire-warning systems(EFWSs)have attracted significant attention owing to their superiority in detecting fire situations occurring in the pre-combustion *** progress on EFWSs has been achieved recently,and they have presented a considerable possibility for more evacuation time to control constant unintentional fire hazards in our daily *** review mainly makes a comprehensive summary of the current EFWSs,including the working mechanisms and their *** to the different working mechanisms,fire alarms can be classified into graphene oxide-based fire alarms,semiconductor-based fire alarms,thermoelectric-based fire alarms,and fire alarms on other working ***,the challenge and prospect for EFWSs are briefly provided by comparing the art of state of fire *** work can propose a more comprehensive understanding of EFWSs and a guideline for the cutting-edge development direction of EFWSs for readers.

关键词： Smart thermosensitive fire sensors Working mechanism Response time Signal conversion

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在KLOE/KLOE-2实验中寻找暗传播子（英文）

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中国科学技术大学学报 2016年第7期46卷 587-593页

作者： PEREZ del rio Elena 无弗拉斯卡蒂国家实验室-核物理研究所意大利弗拉斯卡帝00044 kloe-2合作组

一个新的矢量玻色子的存在已经在不同的背景下被提出,这个新矢量玻色子与标准模型粒子的耦合可以通过动力学混合,对U玻色子,或者通过耦合到重子数,对B玻色子.暗物质传播子的直接寻找可以在加速器上进行.DANEΦ-工厂中的KLOE探测器大... 详细信息

一个新的矢量玻色子的存在已经在不同的背景下被提出,这个新矢量玻色子与标准模型粒子的耦合可以通过动力学混合,对U玻色子,或者通过耦合到重子数,对B玻色子.暗物质传播子的直接寻找可以在加速器上进行.DANEΦ-工厂中的KLOE探测器大量研究了U玻色子参与的两种过程:介子的达利兹衰变,即伴随→ηU,U→e+e-过程,以及连续统事件e+e-→Uγ过程.在所有这些过程中,对于质量区间在4 Me V/c2

关键词：暗物质暗能量 U玻色子 A’ 希格斯辐射 h’ 上限

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Treatment modalities for early gastric cancer

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World Journal of Gastrointestinal Endoscopy 2015年第12期7卷 1062-1069页

作者： Jesús Espinel Eugenia Pinedo Vanesa Ojeda maria Guerra del rio Department of Digestive Diseases Hospital Universitario de León Department of Radiodiagnosis Hospital Universitario de León Department of Digestive Diseases Hospital Universitario Dr.Negrín Las Palmas de Gran Canaria Burton Hospitals NHS Foundation Trust Burton on TrentStaffordshire DE13 0RB United Kingdom

Different treatment modalities have been proposed in the treatment of early gastric cancer(EGC). Endoscopic resection(ER) is an established treatment that allows curative treatment, in selected cases. In addition, ER allows for an accurate histological staging, which is crucial when deciding on the best treatment option for EGC. Recently, endoscopic mucosal resection(EMR) and endoscopic submucosal dissection(ESD) have become alternatives to surgery in early gastric cancer, mainly in Asian countries. Patients with "standard" criteria can be successfully treated by EMR techniques. Those who meet "expanded" criteria may benefit from treatment by ESD, reducing the need for surgery. Standardized ESD training system is imperative to promulgate effective and safe ESD technique to practices with limited expertise. Although endoscopic resection is an option in patients with EGC, surgical treatment continues to be a widespread therapeutic option worldwide. In this review we tried to point out the treatment modalities for early gastric cancer.

关键词： Early gastric cancer Endoscopic submucosal dissect

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Endoscopic management of adenomatous ampullary lesions

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World Journal of Methodology 2015年第3期5卷 127-135页

作者： Jesús Espinel Eugenia Pinedo Vanesa Ojeda maria Guerra del rio Department of Digestive Diseases Hospital Universitario de León Department of Radiodiagnosis Hospital Universitario de León Department of Digestive Diseases Hospital Universitario Dr. Negrín Consultant Gastroenterologist Burton Hospitals NHS foundation trust

Lesions of the ampulla of Vater represent an uncommon group of gastrointestinal malignancies. The majority of lesions of the ampulla of Vater are either adenomas or adenocarcinomas. Ampullary lesions are often incidental findings. Accurate preoperative diagnosis and staging of ampullary tumors is imperative for predicting prognosis and determining the most appropriate therapeutic approach. Endoscopic ampullectomy is a safe and efficacious therapeutic procedure that can obviate the need for potentially major surgical intervention. This review will provide the framework for the diagnosis and management of ampullary lesions from the perspective of the practicing gastroenterologist. Strategies for safe and successful endoscopic ampullectomy with a focus on accurate preoperative diagnosis and staging, resection technique, and management of complications are presented.

关键词： Papillary tumors Endoscopic ampullectomy Endoscopic ultrasound Ampullary adenoma Pancreatitis

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