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vaccination coverage in children with juvenile idiopathic arthritis,inflammatory bowel diseases,and healthy peers:Cross-sectional electronic survey data

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World Journal of Clinical Pediatrics 2023年第2期12卷 45-56页

作者： Elizaveta Makarova Aygul Khabirova Natalia volkova Tatiana Gabrusskaya Natalia ulanova Larisa Sakhno maria Revnova Mikhail Kostik Department of Polyclinic Pediatrics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Hospital Pediatrics Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia Department of Pediatric GI Saint-Petersburg State Pediatric Medical UniversitySaint-Petersburg 194100Russia

BACKGROUND Patients with immune-mediated diseases,such as juvenile idiopathic arthritis(JIA)and inflammatory bowel disease(IBD)are at increased risk of developing infections,due to disease-related immune dysfunction and applying of immunosuppressive *** To evaluate vaccine coverage in patients with IBD and JIA,and compare it with healthy *** In the cross-sectional study we included the data from a questionnaire survey of 190 Legal representatives of children with JIA(n=81),IBD(n=51),and healthy children(HC,n=58).An electronic online questionnaire was created for the *** There were female predominance in JIA patients and younger onset *** of JIA had higher education *** level and family status were similar in the three studied *** with JIA and IBD had lower vaccine coverage,without parental rejection of vaccinations in IBD,compare to JIA and healthy *** main reason for incomplete vaccination was medical conditions in IBD and *** patients had a lower rate of normal vaccine-associated reactions compared to JIA and *** encouraging role of physicians for vaccinations was the lowest in JIA *** patients had more possibilities to check antibodies before immune-suppressive therapy and had more supplementary vaccinations compared to JIA and *** JIA and IBD patients had lower vaccine coverage compared to ***'encouragement of vaccination and the impossibility of discus about future vaccinations and their outcomes seemed the main factors for patients with immune-mediated diseases,influencing vaccine *** investigations are required to understand the reasons for incomplete vaccinations and improve vaccine coverage in both groups,especially in rheumatic disease *** approaches that stimulate vaccination in healthy children are not always optimal in children with immunemediated *** is necessary to provide personalized vaccine-encouraging strategie

关键词： vaccines Juvenile idiopathic arthritis Inflammatory bowel diseases vaccine coverage Immune-mediated diseases

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Dendritic spine degeneration:a primary mechanism in the aging process

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Neural Regeneration Research 2025年第6期20卷 1696-1698页

作者： Gonzalo Flores Leonardo Aguilar-Hernández Fernado García-Dolores Humberto Nicolini Andrea Judith vázquez-Hernández Hiram Tendilla-Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencias Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Nacional de Medicina Genómica(INMEGEN) Mexico CityMexico

Recent reports suggest that aging is not solely a physiological process in living beings;instead, it should be considered a pathological process or disease(Amorim et al., 2022). Consequently, this process involves a wide range of factors, spanning from genetic to environmental factors, and even includes the gut microbiome(GM)(Mayer et al., 2022). All these processes coincide at some point in the inflammatory process, oxidative stress, and apoptosis, at different degrees in various organs and systems that constitute a living organism(Mayer et al., 2022;AguilarHernández et al., 2023).

关键词： aging process stress

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN D.SINGH R.vAISH v.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： finite element method (FEM) nonlinear Green-Lagrange inverse hyperbolic shear deformation theory (IHSDT) bio-inspired composite plate helicoidal O322

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Stable oligonucleotide-functionalized gold nanosensors for environmental biocontaminant monitoring

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Journal of Environmental Sciences 2017年第12期29卷 49-59页

作者： maria v.Riquelme Weinan Leng Marcos Carzolio Amy Pruden Peter vikesland via Department of Ciuil ancl Environmental Engineering Virginia TechBlacksburgVA 24061United States Department of Statistics Virginia TechBlacksburgVA 24061United States

The global propagation of environmental biocontaminants such as antibiotic resistant pathogens and their antibiotic resistance genes（ARGs） is a public health concern that highlights the need for improved monitoring strategies. Here, we demonstrate the environmental stability and applicability of an oligonucleotide-functionalized gold nanosensor. The mec A ARG was targeted as model biocontaminant due to its presence in clinically-relevant pathogens and to its emergence as an environmental *** A-specific nanosensors were tested for antibiotic resistance gene（ARG） detection in ARG-spiked effluent from four wastewater treatment plants（WWTPs）. The mec A-specific nanosensors showed stability in environmental conditions and in high ionic strength（[MgCl_2] 〈 50 m M）, and high selectivity against mismatched targets. Spectrophotometric detection was reproducible with an LOD of 70 pM（≈ 4 × 10~7 genes/μL）, even in the presence of interferences associated with non-target genomic DNA and complex WWTP effluent. This contribution supports the environmental applicability of a new line of cost-effective, field-deployable tools needed for wide-scale biocontaminant monitoring.

关键词： Stable oligonucleotide-functionalized gold nanosensors for environmental biocontaminant monitoring LOD DNA

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Ion-conducting Membranes Based on Bacterial Cellulose Nanofibers Modified by Poly(sodium acrylate-co-2-acrylamido-2-methylpropanesulfonic acid)

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Chinese Journal of Polymer Science 2024年第3期42卷 333-343,I0007页

作者： Elizaveta v.Batishcheva Nikolay N.Smirnov Natalya v.Bobrova maria P.Sokolova Michael A.Smirnov Institute of Macromolecular Compounds Russian Academy of SciencesBolshoy pr.31Saint Petersburg 199004Russia

Green method for preparation of ion-conducting membranes(ICM) based on bacterial cellulose nanofibers(CNF) modified by a copolymer of sodium acrylate and 2-acrylamido-2-methylpropanesulfonic acid was elaborated. FTIR and NMR data confirmed grafting of polyacrylate onto cellulose surface. Formation of porous structure of the ICM was controlled by SEM and AFM. The maximal ionic conductivity of the membranes reaches 1.5 and 3.1 mS·cm^(-1)(60 ℃ and 98% relative humidity) when they are saturated with water or H_2SO_4(1 mol·L^(-1)) electrolyte,respectively. Prepared ICM was tested as a separator in a symmetrical supercapacitor with electrodes based on polyaniline hydrogel. The assembled cell demonstrate ability to operate at high current density up to 100 A·g^(-1) maintaining specific capacitance 165 F·g^(-1). Maximal specific capacitance of 289 F·g^(-1) was achieved at current density 1 A·g^(-1). Retaining of 90% of initial capacitance after 10000 of charge-discharge cycles proves high electrochemical stability of prepared ICM.

关键词： Bacterial cellulose Ion conductivity Porous membrane Supercapacitor

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Histological assessment in peripheral nerve tissue engineering

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Neural Regeneration Research 2014年第18期9卷 1657-1660页

作者： víctor Carriel Ingrid Garzón Miguel Alaminos maria Cornelissen Department of Histology (Tissue Engineering Group) Faculty of MedicineUniversity of Granadaand Instituto de Investigación Biosanitariaibs Department of Basic Medical Sciences (Histology and Tissue Engineering Group) Faculty of MedicineGhent University

The histological analysis of peripheral nerve regeneration is one of the most used methods to demonstrate the success of the regeneration through nerve conduits. Nowadays, it is possible to evaluate different parameters of nerve regeneration by using histological, histochemical, immunohistochemical and ultrastructural techniques. The histochemical methods are very sensible and are useful tools to evaluate the extracellular matrix remodeling and the myelin sheath, but they are poorly specific. In contrast, the immunohistochemical methods are highly specific and are frequently used for the identification of the regenerated axons, Sehwann cells and proteins associated to nerve regeneration or neural linage. The ultrastructural techniques offer the possibility to perform a high resolution morphological and quantitative analysis of the nerve regeneration. However, the use of a single histological method may not be enough to assess the degree of regeneration, and the combination of different histological techniques could be necessary.

关键词： peripheral nerve regeneration histology, histochemistry immunohistochemistry quantitative histology

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Flat Absorber Phosphorous Black Nickel Coatings for Space Applications

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Journal of Materials Science & Technology 2012年第2期28卷 118-124页

作者： v.maria Shalini P.Arockiasamy R.Uma Rani A.K.Sharma Thermal Systems Group ISRO Satellite CentreVimanapura PostBangalore-560 017India

A new process of flat absorber black nickel alloy coating tion from a bath containing nickel, zinc and ammonium was developed on stainless steel by electrodeposi- sulphates; thiocyanate and sodium hypophosphite for space applications. Coating process was optimized by investigating the effects of plating parameters, viz concentration of bath constituents, current density, temperature, pH and plating time on the optical properties of the black deposits. Energy dispersive X-ray spectroscopy showed the inclusion of about 6% phosphorous in the coating. The scanning electron microscopy studies revealed the amorphous nature of the coating. The corrosion resistance of the coatings was evaluated by the electrochemical impedance spectroscopy （EIS） and linear polarization （LP） techniques. The results revealed that, phosphorous addition confers better corro- sion resistance in comparison to conventional black nickel coatings. The black nickel coating obtained from hypophosphite bath provides high solar absorptance （αs） and infrared emittance （εIR） of the order of 0.93. Environmental stability to space applications was established by the humidity and thermal cycling tests.

关键词： Phosphorous black nickel alloy Electrochemical impedance spectroscopy Linear polarization Solar absorptance Infrared emittance

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Carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

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World Journal of Clinical Cases 2025年第2期13卷 14-20页

作者： Aikaterini Mastoraki maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos Ero Mouchtouri Christiana Panagi Evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Medical Oncology Hygeia HospitalAthens 15123Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Surgery Athens Metropolitan HospitalAthens 15562Greece

Carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

关键词： Carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters

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Temperature and precipitation,but not geographic distance,explain genetic relatedness among populations in the perennial grass Festuca rubra

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Journal of Plant Ecology 2019年第4期12卷 730-741页

作者： mariaŠurinová věroslava Hadincová vigdis vandvik Zuzana Münzbergová Department of Botany Faculty of ScienceCharles UniversityPragueCzech Republic Institute of Botany Academy of Sciences of the Czech RepublicPrůhoniceCzech Republic Department of Biology University of BergenBergenNorway Bjerknes Centre for Climate Research BergenNorway

Aims Knowledge of genetic structure of natural populations and its determinants may provide key insights into the ability of species to adapt to novel *** many genetic studies,the effects of climate could not be disentangled from the effects of geographic *** aimed to understand the effects of temperature and moisture on genetic diversity of populations and separate these effects from the effects of geographic *** also wanted to explore the patterns of distribution of genetic diversity in the system and assess the degree of clonality within the *** also checked for possible genome size variation in the *** We studied genetic variation within and among 12 populations of the dominant grass Festuca rubra distributed across a unique regional-scale climatic grid in western Norway,Europe and explored the importance of temperature,precipitation and geo-graphic distance for the observed *** also explored the distribution of genetic diversity within and among popula-tions,identified population differentiation and estimated degree of *** analyses used microsatellites as the genetic *** analyses were supplemented by flow cytometry of all the *** Findings All the material corresponds to hexaploid cytotype,indicating that ploidy variation does not play any role in the *** results indicate that temperature and precipitation were better predictors of genetic relatedness of the populations than geographic distance,suggesting that temperature and precipitation may be important determinants of population *** addition,precipitation,alone and in interaction with temperature,strongly affected population genotypic diversity suggesting increased clonality towards the coldest and especially the coldest wettest *** the same time,individuals from the coldest and wettest climates also had the high-est individual genetic diversity,suggesting that only the most hetero-zygous

关键词： AMOvA hexaploid isolation by distance isolation by environment microsatellites Poaceae fuzzy clustering

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K-Corruption Intermittent Attacks for violating the Codiagnosability

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 159-172页

作者： Ruotian Liu Yihui Hu Agostino Marcello Mangini maria Pia Fanti IEEE the Department of Electrical and Information Engineering Polytechnic University of Bari the School of Automation Xi'an University of Posts and Telecommunications

In this work, we address the codiagnosability analysis problem of a networked discrete event system under malicious attacks. The considered system is modeled by a labeled Petri net and is monitored by a series of sites, in which each site possesses its own set of sensors, without requiring communication among sites or to any coordinators. A net is said to be codiagnosable with respect to a fault if at least one site could deduce the occurrence of this fault within finite steps. In this context, we focus on a type of malicious attack that is called stealthy intermittent replacement attack. The stealthiness demands that the corrupted observations should be consistent with the system's normal behavior, while the intermittent replacement setting entails that the replaced transition labels must be recovered within a bounded of consecutive corrupted observations(called as K-corruption intermittent attack). Particularly, there exists a coordination between attackers that are separately effected on different sites, which holds the same corrupted observation for each common transition under attacks. From an attacker viewpoint, this work aims to design Kcorruption intermittent attacks for violating the codiagnosability of systems. For this purpose, we propose an attack automaton to analyze K-corruption intermittent attack for each site, and build a new structure called complete attack graph that is used to analyze all the potential attacked paths. Finally, an algorithm is inferred to obtain the K-corruption intermittent attacks, and examples are given to show the proposed attack strategy.

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