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α,β-amyrin, a natural triterpenoid ameliorates L-arginine-induced acute pancreatitis in rats

World Journal of Gastroenterology 2010年第34期16卷 4272-4280页

作者： Caroline Mouro Melo Karine maria Martins Bezerra Carvalho Julliana Catharina de Sousa Neves Talita Cavalcante Morais Vietla Satyanarayana Rao Flávia Almeida santos Gerly Anne de Castro Brito mariana Helena Chaves Department of Physiology and Pharmacology Biomedical Institute of Brazilian Semiarid Faculty of Medicine Federal University of Ceará Department of Morphology Faculty of Medicine Federal University of Ceará Department of Organic and Inorganic Chemistry Federal University of Piauí

AIM: To study the benef icial effects of triterpene α,β-amyrin and the underlying mechanisms in an experimental pancreatitis model. METHODS: Acute pancreatitis was induced in five groups of rats (n = 8) by L-arginine (2 × 2.5 g/kg, intraperitoneal, 1 h apart) and 1 h later, they received a single oral dose of α,β-amyrin (10, 30 and 100 mg/kg),methylprednisolone (30 mg/kg) and vehicle (3% Tween 80). A saline (0.9% NaCl) treated group served as a normal control. Efficacy was assessed at 24 h by determination of serum levels of amylase, lipase and proinflammatory cytokines [tumor necrosis factor (TNF)-α and interleukin (IL)-6], pancreatic myeloperoxidase (MPO) activity, lipid peroxidation [thiobarbituric acid reactive substances (TBARS)], nitrate/nitrite levels, and the wet weight/body weight ratio. Tissue histology and the immunoreactivity for TNF-α and inducible nitric oxide synthetase (iNOS) were performed. RESULTS: α,β-amyrin and methylprednisolone treatments significantly (P < 0.05) attenuated the L-arginine-induced increases in pancreatic wet weight/body weight ratio, and decreased the serum levels of amylase and lipase, and TNF-α and IL-6, as compared to the vehicle control. Also, pancreatic levels of MPO activity, TBARS, and nitrate/nitrite were signifi cantly lower. Histological f indings and TNF-α and iNOS immunostaining further confirmed the amelioration of pancreatic injury by α,β-amyrin. CONCLUSION: α,β-amyrin has the potential to combat acute pancreatitis by acting as an anti-in? ammatory and antioxidant agent.

关键词： Acute pancreatitis L-arginine Cytokines Lipid peroxidation α,β-amyrin

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Eco-efficient Earth Plasters:Influence of Clay Content,Sand Particle Size,and Support

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Journal of World Architecture 2018年第6期2卷 1-12页

作者： Tania santos maria Idália Gomes Flávia Coelho Paulina Faria CERIS IST1049-001 LisbonPortugal Department of Civil Engineering ISELPolytechnic Institute of Lisbon1959-007 LisbonPortugal Department Civil Engineering FCTNOVA University of Lisbon2829-516 CaparicaPortugal

Earth construction,including the use of earth mortars,has been extensively used in the ***,with the appearance of hydraulic binders,the use of earth strongly decreased for new construction and even to repair old earth buildings,whose best solution would be the use of compatible materials such as earth *** to the innumerable advantages of earth and with the growing concern on eco-efficient construction,the interest on earth construction has resurfaced,namely on earth *** optimize the composition of an earth plastering mortar made with a defined clayish earth and two siliceous sands with different particle sizes,six compositions were *** with different volumetric ratios were applied in two different supports(on the back of a tile and on a brick)and planar specimens were also *** characteristics were assessed,such as their visual appearance,shrinkage,surface cohesion,surface hardness,dry abrasion resistance,ultrasonic velocity,adhesive strength,and thermal *** is possible to conclude that a higher clay content in the earth mortar composition increases the shrinkage and occurrence of cracking,the use of fine sand promotes high mass loss by abrasion,and the same mortar applied in different supports behaves differently in terms of durability.

关键词： clayish earth formulation mortar optimization shrinkage non-destructive test

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Assessment of the Risk of Violence in Portuguese Psychiatric Settings Using the Broset Violence Checklist

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Sociology Study 2015年第5期5卷 360-370页

作者： maria Isabel Marques Aida Bessa Licinia santos Sara Carvalho Goreti Neves Nursing School of Coimbra Portugal University Hospital of Coimbra Portugal Community Health Center in Figueira da Foz Portugal

The risk of violence in psychiatric settings implies the assessment of dynamic predictors to adjust nursing interventions. So as to identify the pattern of aggressive behaviors, assess the dynamic predictors of violence in hospitalized patients, and analyze the predictive qualities of the Brcset Violence Checklist （BVC）, an exploratory/descriptive study was conducted in psychiatric wards in Coimbra, Portugal. The instruments used were： the staff observation aggression scale-revised （SOAS-R）, visual analogue scale （VAS）, and the BVC. For the period of a month, 64 patients with a mean age of 29 years, unemployed, and with psychotic disorders were observed. In this group, 13 people displayed 15 aggressive behaviors of moderate severity, which had consequences for nurses; they were triggered by the denial of something through verbal aggression and controlled by non-restrictive measures. The most common predictors of violence were irritability and boisterousness. It was also concluded that the BVC shows good predictive characteristics （sensitivity and specificity） of violence, thus, it may be considered as a useful and effective instrument to assess the risk of violence and, consequently, to adjust nursing interventions to prevent this phenomenon.

关键词： Risk assessment violence patients psychiatry

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New variola(mpox)in Brazil:Epidemiological update and perspectives

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Asian Pacific Journal of Tropical Medicine 2022年第12期15卷 525-528页

作者： Ana Caroline Edwiges Evangelista maria Eduarda Queiroz santos Bandeira Larissa Martins de Sena Williana de Paula Marli do Carmo Cupertino Andréia Patrícia Gomes Rodrigo Siqueira-Batista School of Medicine Faculdade Dinâmica do Vale do PirangaPonte NovaMinas GeraisBrazil Departament of Medicine and Nursing Universidade Federal de ViçosaViçosaMinas GeraisBrazil

New variola(NV)-mpox(monkeypox)-is a zoonosis caused by the mpox virus,which belongs to the genus Orthopoxvirus in the family *** disease,in the present year(2022),has caused several cases and deaths around the world,including Brazil[1].The group of poxviruses,in which the species that causes NV is included,consists of agents widely distributed in *** to their considerably large size,they were among the first viruses to be microscopically *** Poxviridae family is capable of infecting epithelial and connective tissue ***,such a viral family is classified as a genome lineage composed of doublestranded DNA,completely independent of the host nucleus[1].

关键词： Brazil belongs considerably

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Traps and trumps from adjacent-to-tumor samples in gastric cancer research

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Chinese Journal of Cancer Research 2018年第5期30卷 564-567页

作者： Paulo Pimentel de Assumpcao Andre Salim Khayat Taissa Maira Thomaz Araujo Williams Fernandes Barra Geraldo Ishak Mine maria Pereira Cruz Ramos Sidney Emanuel Batista dos santos Andrea Kely Campos Ribeiro dos santos Samia Demachki Paula Barauna de Assumpcao Danielle Queiroz Calcagno Ney Pereira Carneiro dos santos Monica Barauna de Assumpcao Fabiano Cordeiro Moreira Andre Mauricio Ribeiro dos santos Carolina Barauna de Assumpcao Gregory Joseph Riggins Rommel Mario Rodriguez Burbano Oncology Research Center Federal University of Para Belem 66075-110 Brazil PhD Program in Genetics and Molecular Biology Federal University of Para Belem 66075-110 Brazil Gastrointestinal Endoscopy Service Joao de Barros Barreto University Hospital Belem 66073-000 Brazil Department of Surgical Oncology Oswaldo Cruz Germany Hospital Sao Paulo 01327-001 Brazil Department of Neurosurgery Johns Hopkins University Baltimore 21287 USA Laboratory of Molecular Biology Ophir Loyola Hospital Belem 66060-281 Brazil

The search for cancer biomarkers is frequently based on comparisons between tumors and adjacent-to-tumor samples. However, even after histological confirmation of been free of cancer cells, these adjacent-to-tumor samples might harbor molecular alterations which are not sufficient to cause them to look like cancer, but can differentiate these cells from normal cells. When comparing them, potential biomarkers are missed, and mainly the opportunity of finding initial aberrations presents in both tumors and adjacent samples, but not in true normal samples from non-cancer patients, resulting in misinterpretations about the carcinogenic process. Nevertheless, collecting adjacent-to-tumor samples brings trumps to be explored. The addition of samples from non-cancer patients opens an opportunity to increase the finds of the molecular cascade of events in the carcinogenic process. Differences between normal samples and adjacent samples might represent the first steps of the carcinogenic process. Adding samples of non-cancer patients to the analysis of molecular alterations relevant to the carcinogenic process opens a new window of opporttmides to the discovery of cancer biomarkers and molecular targets.

关键词： Adjacent-to-tumor trumps traps

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Pró-Saúde and PET-Saúde in the Context of Reorientation Policy of Health Professions Training

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Health 2015年第13期7卷 1800-1805页

作者： Ana maria Gomes dos santos maria José Medeiros da Fonseca Fernanda Fayane C. Belarmino Adriana Vitória dos santos Fábia Barbosa de Andrade City Health Department Municipal Government Santa Cruz Brazil Faculty of Health Sciences of Trairi (FACISA) Federal University of Rio Grande do Norte (UFRN) Santa Cruz Brazil

The health education has been a topic discussed throughout Brazil, as the country is experiencing a period of expansion of higher education and it needs to give quality. So they were implanted two federal programs to allow that health students to approach their professional reality to make them capable of full mode. The paper aims to discuss the experience of the participating members of these programs for professional reorientation. The study is exploratory and descriptive conducted with participants of the programs in the city of Santa Cruz, Rio Grande do Norte, Brazil, in the year 2014. This study aims to present an experience report from the experience of the mentors in Reorientation National Program for Health Professional Training (Pró-Saúde), associated with the Labor Education Program for Health (PET-Saúde) at the Federal University of Rio Grande do Norte (UFRN)/Sciences College of Trairi (FACISA), with emphasis on the reorientation of professional practice, provided by integrating teaching-service and community as well as exchange of knowledge between tutors, mentors and students participating in the project, from the development of interdisciplinary activities, giving the opportunity to reflect on these actions and services offered based on the epidemiological analysis provided by research, intervening in this reality.

关键词： Health Education Education Community Learning Students Family Health

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Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice

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Neural Regeneration Research 2021年第4期16卷 780-786页

作者： maria Eduarda Ziani Gutierrez Anne Suély Pinto Savall Edina da Luz Abreu Kelly Ayumi Nakama Renata Bem Dos santos Marina Costa Monteiro Guedes Daiana SilvaÁvila Cristiane Luchese Sandra Elisa Haas Caroline Brandão Quines Simone Pinton Postgraduation Program in Biochemistry Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Pharmaceutical Science Federal University of Pampa(UNIPAMPA)UruguaianaRSBrazil Postgraduation Program in Biochemistry and Bioprospecting Federal University of Pelotas(UFPEL)Capão do LeãoRSBrazil

Alzheimer’s disease is a progressive brain disorder and complex mechanisms are involved in the physiopathology of Alzheimer’s ***,there is data suggesting that inflammation plays a role in its development and ***,some non-steroidal antiinflammatory drugs,such as meloxicam,which act by inhibiting cyclooxygenase-2 have been used as neuroprotective agents in different neurodegenerative disease *** purpose of this study was to investigate the effects of co-nanoencapsulated curcumin and meloxicam in lipid core nanocapsules(LCN)on cognitive impairment induced by amyloid-beta peptide injection in *** were prepared by the nanoprecipitation *** Swiss mice received a single intracerebroventricular injection of amyloid-beta peptide aggregates(fragment 25–35,3 nmol/3μL)or vehicle and were subsequently treated with curcumin-loaded LCN(10 mg/kg)or meloxicam-loaded LCN(5 mg/kg)or meloxicam+curcumin-co-loaded LCN(5 and 10 mg/kg,respectively).Treatments were given on alternate days for 12 days(i.e.,six doses,once every 48 hours,by intragastric gavage).Our data showed that amyloid-beta peptide infusion caused long-term memory deficits in the inhibitory avoidance and object recognition tests in *** the inhibitory avoidance test,both meloxicam and curcumin formulations(oil or co-loaded LCN)improved amyloid-beta-induced memory impairment in ***,only meloxicam and curcumin-co-loaded LCN attenuated non-aversive memory impairment in the object recognition ***,the beneficial effects of meloxicam and curcuminco-loaded LCN could be explained by the anti-inflammatory properties of these drugs through cortical cyclooxygenase-2 *** study suggests that the neuroprotective potential of meloxicam and curcumin co-nanoencapsulation is associated with cortical cyclooxygenase-2 *** study was approved by the Committee on Care and Use of Experimental Animal Resources,the Federal University of Pampa,Brazil(app

关键词： Alzheimer’s disease curcumin cyclooxygenase-2 lipid core nanocapsules meloxicam memory rats inflammation

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Epidemiological and clinical characteristics of COVID-19 in a Brazilian public hospital

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World Journal of Clinical Cases 2023年第8期11卷 1761-1770页

作者： Fillipe Dantas Pinheiro Luana Weber Lopes Rafael santos Dantas Miranda Dórea Glauber Rocha Lima Araújo Filipe Antônio França da Silva Breno Bittencourt de Brito maria Luísa Cordeiro santos Geovani Moreno santos Júnior maria Teresa Araújo de Lorenzo Barcia Renata de Amorim Marques AndréBezerra Botelho Anna Carolina Saúde Dantas Davi Tanajura Costa Adriano Fernandes Teixeira Cláudio Lima Souza Lucas Miranda Marques Guilherme Barretos Campos Márcio Vasconcelos Oliveira Dulciene maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Hospital Geral de Vitória da Conquista Vitória da Conquista 45030-160BahiaBrazil Departamento de Ciências da Saúde Universidade Estadual do Sudoeste da Bahia(UESB)Vitória da Conquista 45083-900BahiaBrazil Faculdade de Medicina Universidade Federal de Minas GeraisBelo Horizonte 31270-901Minas GeraisBrazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has become a major health concern *** that context,the understanding of epidemiological and clinical features associated with the disease and its severity is crucial for the establishment of strategies aimed at disease control and *** To describe epidemiological features,signs,symptoms,and laboratory findings among severely ill COVID-19 patients from an inten-sive care unit in northeastern Brazil as well as to evaluate predictor factors for disease *** This is a prospective single-center study that evaluated 115 patients admitted to the intensive care unit in a northeastern Brazilian *** The patients had a median age of 65.60±15.78 *** was the most frequent symptom,affecting 73.9%of the patients,followed by cough(54.7%).Fever was reported in approximately one-third of patients and myalgia in 20.8%of the *** least two comorbidities were found in 41.7%of the patients,and hypertension was the most prevalent(57.3%).In addition,having two or more comorbidities was a predictor of mortality,and lower platelet count was positively associated with *** and vomiting were two symptoms that were predictors of death,and the presence of a cough was a protective *** This is the first report of a negative correlation between cough and death in severely ill severe acute respiratory syndrome coronavirus 2-infected *** associations between comorbidities,advanced age,and low platelet count and the outcomes of the infection were similar to the results of previous studies,highlighting the relevance of these features.

关键词： COVID-19 Epidemiology Symptoms Comorbidities Laboratory parameters

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Biochar produced from Amazonian agro-industrial wastes:properties and adsorbent potential of Cd^(2+) and Cu^(2+)

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Biochar 2019年第4期1卷 389-400页

作者： Yan Nunes Dias Edna santos Souza Hercilia Samara Cardoso da Costa Leônidas Carrijo Azevedo Melo Evanise Silva Penido Cristine Bastos do Amarante Orivan maria Marques Teixeira Antonio Rodrigues Fernandes Institute of Agricultural Sciences Federal Rural University of Amazon(ICA-UFRA)C.P.917BelemPara 66077-530Brazil Department of Soil Science Federal University of LavrasCP 3037Campus UFLALavrasMinas Gerais 37200-000Brazil Department of Chemistry Federal University of LavrasCP 3037Campus UFLALavrasMinas Gerais 37200-000Brazil Museu Paraense Emílio Goeldi Coordination of Earth Sciences and EcologyBelémPará66077-830Brazil Soil and Plant Laboratory Brazilian Agricultural Research Corporation-Embrapa Eastern AmazoniaBelémPará66000-000Brazil

In the Amazon region,several residues that have been misused can serve as feedstocks for biochar production with the aim of recovering soils contaminated by heavy ***,these biochars need to be firstly tested for their adsorption capacity as well as their physicochemical attributes prior to field ***,this study aimed to characterize and evaluate the adsorption capacities of Cd^(2+) and Cu^(2+) of biochars produced from acai(BA),Brazil nut(BN),and palm kernel cake(BK)*** were produced by slow pyrolysis at four different temperatures(400,500,600,and 700℃).The physicochemical properties of the biochars,such as cation exchange capacity,ash,recalcitrance index,and aromaticity were enhanced with increased pyrolysis *** adsorption capacities of Cd^(2+) and Cu^(2+) showed high correlations with the physicochemical properties of biochar,indicating the importance of these characteristics in the adsorption ***,the adsorption of Cd^(2+) and Cu^(2+) also increased with the increase in the pyrolysis *** a competitive system,Cd^(2+)exhibited higher adsorption capacity than Cu^(2+) for all *** general,BN showed the highest adsorption capacity,followed by BK and *** produced from the Amazonian residues have the potential to improve soil quality when used as amendments in the recovery of soils contaminated with Cd and Cu,representing an environmentally sound technology for the reuse of these residues.

关键词： Pyrolysis Environmental contamination Adsorption

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Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives

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World Journal of Clinical Pediatrics 2022年第2期11卷 105-119页

作者： maria Luísa Cordeiro santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Campus Vitória da Conquista Universidade Estadual do Sudoeste da BahiaVitória da Conquista 45083-900BahiaBrazil

Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use.

关键词： Functional abdominal pain disorder Pediatrics Rome IV Behavioral intervention Nonpharmacological treatment Complementary medicine

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