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作者： REYES BATISTA ESTEPHANY del carmen（任巴缇）中南大学

学位级别：硕士

对材料特性的研究在研究和工业领域进行,作为获得材料的优势和寻找潜在应用的工具。因此,生物启发材料领域有助于结构的设计和材料的制造,目的是将已知的自然结构与特定的材料相结合。毫无疑问,对具有改进的机械性能的结构和材料的需求... 详细信息

对材料特性的研究在研究和工业领域进行,作为获得材料的优势和寻找潜在应用的工具。因此,生物启发材料领域有助于结构的设计和材料的制造,目的是将已知的自然结构与特定的材料相结合。毫无疑问,对具有改进的机械性能的结构和材料的需求正在上升,以及为提高抗震性和内部缓冲而提供定制性能的材料组合。本文介绍的吸能结构的一些应用,将在下文中说明。根据Lu和Yu书,吸能结构/材料的主要应用可以归纳为以下五个方面。提高车辆耐撞性的结构,用于道路安全的结构,用于保护工作中的事故的结构,用于个人保护的结构和用于商品包装的结构.有许多关于这种结构的科学研究,也有多个模型经过测试和优化,以实现拯救生命和减少损失的目的。这项研究旨在测试新的生物启发设计。大自然作为一个伟大的灵感来源,已经进化了数百万年。将对薄壁模型进行分析。这些可以在用于能量吸收应用的结构领域进行评估。在Lazarus等人的研究中,总结了生物材料的一般特征,如分层、复合、多孔和界面。另一方面,还介绍了在抗冲击生物材料中发现的具体结构:它们是分层、梯度、管状、夹层和缝合。这样的研究解释了在自然界中发现的许多管状型材料由于典型的塑性变形和裂纹偏转机制而增强了抗冲击性。通过这种方式,这项研究希望了解和理解在自然界发现的特定植物的主要结构特征,以模仿其结构并在三维建模软件的帮助下进行模拟,使我们能够分析和评估生物启发的薄壁结构的能量吸收。为了实现目的和目标,首先回顾了现有的科学研究,然后从巴拿马和美洲大陆的植被中获取灵感,以确定、解释、设计、验证和优化用于吸收能量的薄壁结构(直管)。这就是我们如何在以前的研究基础上着手验证FE方法,以便能够应用这种方法。然后,我们生成了受巴拿马椰树启发的薄壁圆管和方管的模型,在轴向和斜向载荷下进行数值试验,通过这些试验评估防撞性能,观察可用于能量吸收应用的替代结构的变形模式。本研究在第二章中介绍了一些基本知识,以及在薄壁结构设计中使用生物灵感的研究,特别是对圆形和方形结构。根据Lu&Yu的观点,无论应用何种结构设计来吸收能量,都有一些基本原则需要考虑,因为它们是一种指导原则。其中包括。不可逆的能量转换,受限和恒定的反作用力,长效冲击,稳定和可重复的变形模式,轻质和高比能量吸收能力以及简单和低成本的安装。有了生物启发设计的定义,下一步就是管子的制造、实验测试和数值分析。所查阅的科学文献研究中使用的实验方法包括不同的制造方法,如传统方法(车床加工、深拉工艺、成型、激光切割/雕刻、精密铸造工艺和线放电加工技术)、增材制造(使用3D打印技术)、层压,和其他新的制造技术。关于机械测试或试验的性能,我们可以提到蠕变和应力测试、准静态测试、低和高应变动态测试和冲击测试等方法。这些测试在生物启发设计领域的应用对于验证天然材料和由生物启发设计制造的材料的机械性能至关重要。科学文献中报道的数值分析方法包括使用有限元分析(FEA)工具,如Abaqus,ANSYS,Cosmos Works,Deform和LS-DYNA。关于数值模拟,已知的情况如下。当评估测试方法的类型以测量生物启发设计的能量吸收时,根据Lazarus等人,有不同的静态和动态方法。这些方法根据结构的可实现的变形率进行分组,即变形量对时间的变化。静态和准静态方法的应变速率小于100s-1,动态方法则高于这个范围。在决定方法时,区别在于要考虑到在动态试验中,载荷在短时间内快速施加,导致结构振动,必须考虑到结构的惯性力。而在静态和准静态试验中,载荷是缓慢施加的,它不依赖于时间,惯性力可以忽略不计。为了评估薄壁管的能量吸收特性(在轴向和斜向载荷下),在类似的研究中,很常见的是利用载荷-位移曲线评估这种结构在某些防撞标准下的性能,其中有以下几种:能量吸收(EA),比能量吸收(SEA),平均压溃力(MCF),峰值破碎力(PCF),压碎力效率(CFE).本研究的灵感来自于椰子树(Cocos nucifera)的茎。Fathi进行了一项研究,调查椰子树、油棕榈树和枣树木材的结构和机械/物理特性的关系。椰子树在整个巴拿马境内非常普遍;因此,这种植物被选为生物启发设计的对象。椰树茎的稳定性和椰树茎材料机械性能测试的良好结果,主要是由于维管束和实质细胞的组合,它们共同作为加固材料。在下一章中,首先解释了灵感的过程,圆柱形和方形的薄壁结构的设计,其几何形状,管子材料的机械性能,以及用于模拟的方法。然后介绍了有限元方法的验证结果。最后,介绍了每种设计的图表和模拟结果,绘制了不同的防撞标准,并比较了圆柱形和方形管在轴向破碎力和斜向冲击力下的设计效率。在一个名为***的免费在线工具上搜索植物管理结构力的生物策略,我发现树木和那些用于获得木材的树木都是实心圆柱体,因为它们有强大的维管束分布在茎中。这些维管束在外缘具有较高的强度和密度。椰

关键词：轴向挤压能量吸收生物启发设计耐撞性椰子树结构斜向冲击血管束

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Mallory-Weiss syndrome from giant gastric trichobezoar: A case report

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World Journal of Gastrointestinal Surgery 2023年第5期15卷 972-977页

作者： Eva Lieto Annamaria Auricchio maria Paola Belfiore Giovanni del Sorbo Gabriele De Sena Vincenzo Napolitano Alessio Ruggiero Gennaro Galizia Francesca Cardella Department of Translational Medical Sciences University of Campania L.VanvitelliNapoli 80138CampaniaItaly Department of Precision Medicine University of Campania L.VanvitelliNapoli 80138CampaniaItaly

BACKGROUND Mallory-Weiss syndrome(MWS),representing a linear mucosal laceration at the gastroesophageal junction,is a quite frequent cause of upper gastrointestinal bleeding,usually induced by habitual *** subsequent cardiac ulceration in this condition is likely due to the concomitance of increased intragastric pressure and inappropriate closure of the gastroesophageal sphincter,collectively inducing ischemic mucosal ***,MWS is associated with all vomiting conditions,but it has also been described as a complication of prolonged endoscopic procedures or ingested foreign *** SUMMARY We described herein a case of upper gastrointestinal bleeding in a 16-year-old girl with MWS and chronic psychiatric distress,the latter of which deteriorated following her parents’*** patient,who was residing on a small island during the coronavirus disease 2019 pandemic lockdown period,presented with a 2-mo history of habitual vomiting,hematemesis,and a slight depressive ***,a huge intragastric obstructive trichobezoar was detected and discovered to be due to a hidden habit of continuously eating her own hair;this habit had persisted for the past 5 years until a drastic reduction in food intake and corresponding weight loss *** relative isolation in her living status without school attendance had worsened her compulsory *** hair agglomeration had reached such enormous dimensions and its firmness was so hard that its potential for endoscopic treatment was judged to be *** patient underwent surgical intervention instead,which culminated in complete removal of the *** According to our knowledge,this is the first-ever described case of MWS due to an excessively large trichobezoar.

关键词： Mallory-Weiss syndrome Upper gastrointestinal bleeding Trichobezoar Ringworm Psychiatric distress Case report

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Tolerance of Chrysantemum maximum to heavy metals:The potential for its use in the revegetation of tailings heaps

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Journal of Environmental Sciences 2013年第2期25卷 367-375页

作者： Ma.del carmen A.Gonzlez-Chvez Rogelio Carrillo-Gonzlez Colegio de Postgraduados Programa de EdafologíaCarr.Mxico-Texcocokm 36.5MontecilloTexcoco estado de Mxico 56230Mxico

To find if ornamental plants are applicable to the remediation of metal-polluted areas, the tolerance of chrysanthemum plants （Chysanthemum maximum） var. Shasta to different metals under hydroponic conditions was studied. Their responses as influenced by the mycorrhizal fungus Glomus mosseae （Nicol. ＆ Gerd.） Gerdemann ＆ Trappe BEG25 on substrates containing mine residues were also investigated. Our results showed that chrysanthemum is a metal-tolerant plant under hydroponic conditions, plants behaving as Pb-excluders, whereas Cd, Cu and Ni were accumulated in roots. Low accumulation in flowers was observed for Cd and Cu but it was concentration-dependent. Ni and Pb were not translocated to flowers. Shoot biomass was not significantly affected by the different rates of mine residue addition for both mycorrhizal and non-mycorrhizal plants. Mycorrhizal plants accumulated less Pb and Cu in both shoots and roots than non-mycorrhizal plants. Chysanthemum could be a prospective plant for revegetation of tailings and the use of inoculation may decrease plant metal accumulation in polluted soils.

关键词： mine residues ornamental plants phytostabilization urban remediation

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From landslide characterization to nature reserve management:The“Scialimata Grande di Torre Alfina”landslide Geosite(Central Apennines,Italy)

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山地科学学报（英文） 2023年第3期20卷 585-606页

作者： Gianluca TRONTI Francesca VERGARI Irene maria BOLLATI Filippo BELISARIO Maurizio delMONTE Manuela PELFINI Paola FREDI Earth Sciences Department"Ardito Desio" University La StataleMilan 20133(MI)Italy Monte Rufeno Nature Reserve Acquapendente 01021(VT)Italy Earth Sciences Department University La SapienzaRome 00185(RM)Italy

Italy is characterized by widespread geomorphological instability,among which landslides leave impressive marks on the ***,landslide bodies may represent key sites for thematic and educational itineraries,especially in protected areas,where their management becomes an important *** study focuses on the"Monte Rufeno Nature Reserve"(Central Apennines,Italy),where iconic landslides are ***,the"Scialimata Grande di Torre Alfina"landslide(SGTA)is listed in the regional Geosite *** work aims to propose a multiscale procedure for landslide analysis,in terms of both hazard sources but also educational and geoheritage enhancement opportunities in natural *** performing a Landslide Susceptibility conditional Analysis(LSA)for the reserve territory,attention was focused on the SGTA,to define properly its features and morphodynamics.A multi-disciplinary approach was adopted,by applying both remote sensing(UAV structure from motion,Photointerpretation)and field survey(geomorphological and GPS monitoring).From the LSA,based on drainage density,curvature,and slope triggering factors,the road and trail susceptibility maps were derived,as base tools for future risk assessments and trail paths management within the *** the SGTA scale,the monitoring showed a displacement of up to 23 m during the time interval between 2015 and *** landslide dynamics seem to be driven by alternating dry and extremely wet periods;moreover,leaks from the aqueduct in the detachment area and piping effects through clays may have also decreased the substrate *** SGTA complex influence on the Paglia River valley geometry was also hypothesized,underlining the action of landslide through different spatial scales(on-site and off-site)and on different environment features(sediment connectivity,hydrology).Finally,the SGTA appears highly representative of the geomorphic dynamics within the Nature Reserve(i.e.,scientific value)and it could be

关键词： Landslides Geoheritage Geosites Nature reserves management UAV structure from motion Landslides conditional analyses

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Effect of Water Stress Induced by Polyethylene Glycol on Growth, Proline Accumulation in Agave americana L.

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Phyton-International Journal of Experimental Botany 2023年第2期92卷 629-643页

作者： Alfaro-Corres Arnoldo Enrique Lecona-Guzman Carlos Alberto Gutiérrez-Miceli Federico Antonio Martínez-Esteves Manuel Silverio-Gómez María del carmen Medina-Lara María de Fátima Ruiz-Lau Nancy Laboratorio de Biotecnología vegetal Instituto Tecnológico de Tuxtla GutiérrezTuxtla Gutiérrez29050México Centro de Investigación Científica de Yucatán Unidad de Bioquímica y Biología Molecular de PlantasMérida97205México Insituto Nacional de Investigaciones Forestales Agrícolas y PecuariasHuimanguilloTabasco86400México CONACYT-Tecnológico Nacional de México/Instituto Tecnológico de Tuxtla Gutiérrez Tuxtla Gutiérrez29050México

The effect of water deficit was determined on both in vitro and soil seedling as well as in cells in suspension of Agave americana *** order to do the establishment of cells,the formation of callus was induced;for it two auxins were evaluated:2,4-dichlorophenoxyacetic acid(2,4-D)and 4-mino-3,5,6-trichloropicolinic acid(picloram)at three concentrations(0.25,0.5 and 0.75 mg L−1)in three explants(leaf,root and meristems)cultured in MS semisolid *** callogenesis response was related to the type and section of the explant,as well as the regulator used,and a cell suspension was established using 0.5 mg L−1 naphthaleneacetic acid(NAA)+0.5 mg L−1 Benzylaminopurine(BAP).Seedlings were exposed to polyethyleneglycol(15%and 30%w/v)with a water potential of−0.87 and−2.67 MPa,respectively,under soil *** stress was applied through restricted *** weight,root system growth,and chlorophyll concentration were some of the parameters that were affected by the effect of water deficit on *** *** concentration values were significantly decreased by 15 at 30%PEG(19.6 SPAD units)compared to the control *** in vitro plants,the highest concentration of proline was found in the roots,being the treatment with 30%polyethylene glycol where the highest concentration of this osmoregulator was obtained(62.5 mg g−1 DW).Under restricted irrigation conditions,an increase in proline concentration was observed both in the aerial part(2.2μg 100 g−1 DW)and in the root system(1.8μg 100 g−1 DW).However,the concentrations found were approximately ten times greater,less than those found under in vitro ***,the accumulation of proline can be considered an indicator of stress in Agave Americana *** in vitro.

关键词： Agave americana water deficit proline

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Evaluation of ^(177)Lu-Dotatate treatment in patients with metastatic neuroendocrine tumors and prognostic factors

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World Journal of Gastroenterology 2020年第13期26卷 1513-1524页

作者： Estephany Abou Jokh Casas Virginia Pubul Núnez Urbano Anido-Herranz María del carmen Mallón Araujo maria del carmen Pombo Pasín Miguel Garrido Pumar José Manuel Cabezas Agrícola José Manuel Cameselle-Teijeiro Ashraf Hilal álvaro Ruibal Morell Department of Nuclear Medicine Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Oncology Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Endocrinology Santiago de Compostela′s University HospitalSantiago de Compostela15706A CorunaSpain Department of Pathology Santiago de Compostela′s University HospitalSantiago de Compostela 15706A CorunaSpain Department of Statistics University of Santiago de CompostelaSantiago de Compostela 15706A CorunaSpain

BACKGROUND^177Lu peptide receptor radionuclide therapy(PRRT)is a recently approved therapy in Spain that has been demonstrated to be a well-tolerated therapy for positive somatostatin receptor advanced gastroenteropancreatic neuroendocrine *** To determine the impact of PRRT on quality of life,radiologic and metabolic response,overall survival,prognostic factors and *** Thirty-six patients treated with^177Lu-PRRT from 2016 to 2019 were *** most frequent location of the primary tumor was the gastrointestinal tract(52.8%),pancreas(27.8%),and nongastropancreatic neuroendocrine tumor(11.1%).The liver was the most common site of metastasis(91.7%),followed by distant nodes(50.0%),bone(27.8%),peritoneum(25.0%)and lung(11.1%).Toxicity was evaluated after the administration of each *** efficacywas evaluated by two parameters:stable disease and disease progression in response evaluation criteria in solid tumors 1.1 criterion and prognostic factors were *** From 36 patients,55.6%were men,with a median age of 61.1±11.8 *** previous treatments,55.6%of patients underwent surgery of the primary tumor,100%of patients were treated with long-acting somatostatin analogues,66.7%of patients were treated with everolimus,27.8%of patients were treated with tyrosine kinase inhibitor,and 27.8%of patients were treated with *** patient received radioembolization,three patients received chemoembolization,six patients received *** toxicity was registered in 14 patients(G1-G2:55.5%and G3:3.1%).Other events presented were intestinal suboclusion in 4 cases,cholestasis in 2 cases and carcinoid crisis in 1 *** median follow-up time was 3 ***,24 patients completed *** are alive with stable disease,two have disease progression,eight have died,and nine are still receiving *** median overall survival was 12.5 mo(95%confidence interval range:9.8–15.2),being inversely p

关键词： Peptide receptor radionuclide therapy Gastropancreatic neuroendocrine tumors Radiological response Metabolic response

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Bowman-Birk inhibitors from legumes as colorectal chemopreventive agents

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World Journal of Gastroenterology 2014年第30期20卷 10305-10315页

作者： Alfonso Clemente maria del carmen Arques Department of Physiology and Biochemistry of Nutrition Estación Experimental del Zaidín (CSIC)18008 GranadaSpain

Aberrant functioning of serine proteases in inflammatory and carcinogenic processes within the gastrointestinal tract(GIT)has prompted scientists to investigate the potential of serine protease inhibitors,both natural and synthetic,as modulators of their proteolytic *** inhibitors of the Bowman-Birk type,a major protease inhibitor family in legume seeds,which inhibit potently and specifically trypsin-and chymotrypsin-like proteases,are currently being investigated as colorectal chemopreventive *** relevant amounts of Bowman-Birk inhibitors(BBI)can reach the large intestine in active form due to their extraordinary resistance to extreme conditions within the *** in animal models have proven that dietary BBI from several legume sources,including soybean,pea,lentil and chickpea,can prevent or suppress carcinogenic and inflammatory processes within the *** the therapeutic targets and the action mechanism of BBI have not yet been elucidated,the emerging evidence suggests that BBI exert their preventive properties via protease inhibition;in this sense,serine proteases should be considered as primary targets in early stages of *** validation of candidate serine proteases as therapeutic targets together with the identification,within the wide array of natural BBI variants,of the most potent and specific protease inhibitors,are necessary to better understand the potential of this protein family as colorectal chemopreventive agents.

关键词： Bowman-Birk inhibitors Cell proliferation Chemopre

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Molecular markers of systemic therapy response in urothelial carcinoma

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Asian Journal of Urology 2021年第4期8卷 376-390页

作者： Francesco Claps maria carmen Mir Homayoun Zargar Department of Urology Fundacion Instituto Valenciano de OncologiaValenciaSpain Urological Clinic Department of MedicineSurgery and Health SciencesUniversity of TriesteTriesteItaly Department of Urology Royal Melbourne HospitalMelbourneVictoriaAustralia Department of Surgery University of MelbourneMelbourneVictoriaAustralia

Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer *** carcinoma is a very heterogeneous disease and responses to systemic therapies,and outcomes after radical cystectomy are difficult to *** in molecular biology such as next generation sequencing and whole genome or transcriptomic analysis provide promising platforms to achieve a full understanding of the biology behind the disease and can identify emerging predictive ***,the ability to categorize patients’risk of recurrence after curative treatment,or even predict benefit from a conventional or targeted therapies,represents a compelling challenge that may reshape both selection for tailored treatment and disease *** has been made but currently no molecular biomarkers are used in the clinical setting to predict response to systemic agents in either neoadjuvant or adjuvant settings highlighting a relevant unmet ***,we aim to present the emerging role of molecular biomarkers in predicting response to systemic agents in urothelial carcinoma.

关键词： Urothelial carcinoma Biomarkers Neoadjuvant chemotherapy Adjuvant chemotherapy Targeted therapies Precision oncology

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A Novel Method to Improve Quality of Drinking Water, Based on the Eye’s Biology

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Journal of Water Resource and Protection 2022年第4期14卷 318-333页

作者： Arturo Solís Herrera María del carmen Arias Esparza Martha Patricia Solís Arias Human Photosynthesis^TM Research Centre Aguascalientes México

Water represents a critical nutrient, the absence of which will be lethal within days. Water’s importance for the prevention of nutrition-related noncommunicable diseases has received more attention recently. There are major gaps in knowledge related to the measurement of total fluid intake and hydration status at the population level. It is poorly understood the effects of chronic mild dehydration and fluid consumption on specific health outcomes including obesity. Urolithiasis is the only disorder that has been consistently associated with chronic low daily water intake. Water is an essential nutrient required for life, but until now, it was considered mainly as a universal solvent, which served to prepare the broth of life inside the cells, but the function of water now takes unusual importance with our discovery of the unsuspected ability of the human body to transform the power of light into chemical energy by dissociating the molecule from water, as it happens in plants. The process that we replicated in the laboratory for the first time in 2007, represents a light at the end of the tunnel, in the growing and serious problem of contamination of the mysterious and vital liquid that we call water.

关键词： Drinking Water Hydrogen Oxygen Dissolved Oxygen Pollution Human Eye

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Households as Sources Contributing the Most to Urban Solid Wastes Production:Implications for a Better Management and Disposal

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Journal of Environmental Protection 2019年第8期10卷 1072-1084页

作者： Otoniel Buenrostro delgado maria del Consuelo hernandez Berriel Ivan Yassmany hernandez Paniagua maria del Consuelo Manon Salas Instituto de Investigaciones en Ciencias de la Tierra Universidad Michoacana de San Nicolas de HidalgoCiudad UniversitariaMoreliaMexico Sociedad Mexicana de Ciencia y Tecnologia Aplicada a los Residuos Solidos A.C.(SOMERS)Ciudad de MexicoMexico Tecnologico Nacional de Mexico Instituto Tecnologico de TolucaDivision de Estudios de Posgrado e InvestigacionMetepecMexico CONACYT-Consorcio CENTROMET QueretaroMexico

Households are the sources contributing the most to the production of urban solid wastes in developing countries. The present study analyses the generation of domestic solid wastes in a settlement in Mexico in two different years. The goals were to compare composition and rates of generation into the periods to assess changes and the influence of socioeconomic variables. In 1998 and 2004, wastes from households were sampled of three socioeconomic levels randomly selected, and a survey was applied. Data obtained were analyzed with descriptive and multivariate analysis. Results of generation rate and composition of domestic solid wastes showed a negative correlation between generation and income in the first one, but positive in the second one;in both, composition did not show correlation. Rates of per capita generation, per household, population and density of inhabitants per dwelling increased, and the generation of wastes were more with respect to population growth, which emphasizes the influence of economic and demographic variables. This study corroborates that households are the principal sources of urban solid wastes and it is emphasized that management strategies must preponderate households to be successful. In addition, this information is important to establish strategies for an integral management of urban solid wastes in developing countries.

关键词： Waste Dwellings Management Recycling Survey

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