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Importance of complementary data to histopathological image analysis of oral leukoplakia and carcinoma using deep neural networks

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Intelligent Medicine 2023年第4期3卷 258-266页

作者： Leandro Muniz de Lima maria clara falcão ribeiro de assis Júlia Pessini Soares Tânia Regina Grão-Velloso Liliana Aparecida Pimenta de Barros Danielle Resende Camisasca Renato Antonio Krohling Nature-inspired Computing Lab Federal University of Espirito SantoVitoriaBrazil Graduate Program in Computer Science Federal University of Espirito SantoVitoriaBrazil School of dentistry Departamento de Clinica OdontologicaFederal University of Espirito SantoVitoriaBrazil Graduate Program in Clinical dentistry Federal University of Espirito SantoVitoriaBrazil

Background oral cancer is one of the most common types of cancer in men causing mortality if not *** recent years,computer-aided diagnosis(CAD)using artificial intelligence techniques,in particular,deepneural networks have been investigated and several approaches have been proposed to deal with the automateddetection of various pathologies using digital *** studies indicate that the fusion of images with thepatient’s clinical information is important for the final clinical *** such dataset does not yet exist fororal cancer,as far as the authors are aware,a new dataset was collected consisting of histopathological images,demographic and clinical *** study evaluated the importance of complementary data to histopathologicalimage analysis of oral leukoplakia and carcinoma for *** A new dataset(NDB-UFES)was collected from 2011 to 2021 consisting of histopathological imagesand *** 237 samples were curated and analyzed by oral pathologists generating the gold standardfor ***-of-the-art image fusion architectures and complementary data(Concatenation,MutualAttention,MetaBlock and MetaNet)using the latest deep learning backbones were investigated for 4 distincttasks to identify oral squamous cell carcinoma,leukoplakia with dysplasia and leukoplakia without *** evaluate them using balanced accuracy,precision,recall and area under the RoC curve *** Experimental results indicate that the best models present balanced accuracy of 83.24%using images,demographic and clinical information with MetaBlock fusion and ResNetV2 *** represents an improvement in performance of 30.68%(19.54 pp)in the task to differentiate samples diagnosed with oral squamous cellcarcinoma and leukoplakia with or without *** This study indicates that cured demographic and clinical data may positively influence the performance of artificial intelligence models in automated classification of

关键词： Leukoplakia Squamous carcinoma Pathology deep learning Transfer learning

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Immune response to inactivated bacterial vector carrying the recombinant K39 antigen of Leishmania infantum in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第5期14卷 199-206页

作者： Lucelina S.Araújo Bruno B.Silva Eduarda N.F.N.Santos Arnaldo S.Bezerra Samuel S.Frota assis R.Montenegro Eridan o.P.T.Florean Maurício Fvan Tilburg maria Izabel F.Guedes Laboratory of Biotechnology and Molecular Biology Northeast Biotechnology NetworkState University of CearáFortalezaBrazil Faculty of Veterinary Medicine State University of CearáFortalezaBrazil

objective:To evaluate the immunological response elicited by an inactivated bacterial vector carrying the K39 antigen of Leishmania infantum,and a purified ***:Mice were subjected to the following treatments:(1)Purified recombinant K39(rK39)protein at a 20μg dose with complete Freund’s adjuvant;(2)Inactivated Escherichia coli(BL21 de3)carrying the K39 protein at an equivalent total protein content of 200μg;(3)Inactivated bacteria lacking the K39 protein;(4)Non-immunized control *** monitoring was *** groups were challenged by intraperitoneal injection of 10^(7) Leishmania infantum *** euthanasia,the liver and spleen were collected to analyze the levels of TNF,IFN-γ,IL-12,IL-4,and ***:Mice immunized with purified rK39 or the inactivated bacterial vector carrying the K39 antigen of Leishmania infantum showed a long-lasting immune response with high levels of polyclonal antibodies specifically recognizing the recombinant *** IgG1 subclass was the predominant immunoglobulin;however,the induction of IgG2a and the profile of cytokines produced were indicative of the induction of a mixed-type ***:The inactivated bacterial vector carrying the K39 antigen,as well as the purified antigen can induce a long-lasting immune response in immunized mice,predominantly favouring a Th2 profile response.

关键词： Visceral leishmaniasis K39 Inactivated bacterial vector Vaccine Immune response Th1 Th2 Leishmania infantum

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Impacts of land use and land cover changes on hydrological processes and sediment yield determined using the SWAT model

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International Journal of Sediment Research 2022年第1期37卷 54-69页

作者： Edivaldo Afonso de oliveira Serr?o Madson Tavares Silva Thomás Rocha Ferreira Lorena Concei??o Paiva de Ataide Cleber assis dos Santos Aline maria Meiguins de Lima Vicente de Paulo Rodrigues da Silva Francisco de assis Salviano de Sousa denis José Cardoso Gomes Academic Unit of Atmospheric Sciences Federal University of Campina Grande department of Physics Center for Natural and Exact Sciences Federal University of Santa Maria Institute of Technology Civil Engineering Graduate Program Federal University of Pará Earth System Science Center National Institute of Space Research Institute of Geosciences Federal University of Pará

Land use and land cover (LULC) changes strongly affect local hydrology and sediment *** current study focused on a basin in the Brazilian Amazon and had the following three objectives:(1) to perform an effective diagnosis of flow and sediment yield,(2) to evaluate the impacts of LULC changes over the last 40 years on the hydro-sedimentological variables,and (3) to investigate the impacts of the possible trends or breaking points in the flow,surface runoff,and sediment yield *** Soil and Water Assessment Tool (SWAT) model validation showed that the simulated results were consistent with the data measured in the dynamic reproduction of flow ***,changes in LULC altered surface runoff,sediment yield,and flow according to the Mann-Kendall and Pettitt non-parametric *** was also observed that the sub-basins in which pastureland is predominant are more susceptible to increased surface runoff and sediment *** to trend and homogeneity tests,these sub-basins had break points in the time series of these *** the other hand,in the sub-basins whose land cover is predominantly forest,the time series is homogeneous and *** current study highlighted the impacts that 40 years of LULC changes in an Amazonian basin had on hydro-sedimentological variables,which,in turn,can play an important role in changing the hydrological cycle,consequently these changes can also impact diverse human activities in the region,such as agribusiness,livestock,energy production,food security,and public water ***,it is concluded that the SWAT model is a good estimator of hydro-sedimentological processes in Amazonian basins and can be used by decision makers in the management of water and environmental resources.

关键词： Hydrological modeling Sediment yield Amazon basin SWAT model

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Clinicopathological description of a Chronic Lymphocytic Leukemia in a Dog

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open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： maria clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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Exclusive breastfeeding greater than 50%, success of education in a university hospital in Bogotá: Case-control study

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World Journal of Clinical Pediatrics 2024年第1期13卷 23-30页

作者： Marcela Murillo Galvis Sofia ortegon ochoa clara Eugenia Plata García maria Paula Valderrama Junca Dayanna Alejandra Inga Ceballos Daniel Mauricio Mora Gómez Claudia M Granados Martin Rondón department of Pediatrics Hospital Universitario San IgnacioBogotá110111Colombia department of Clinical Epidemiology and Biostatistics Pontifica Universidad JaverianaBogotá110111Colombia

BACKGRoUND Maintenance rates of exclusive breastfeeding(EBF)worldwide are low,thus,one of the objectives of the summary of policies on breastfeeding(BF)in world nutrition goals for 2025 are that at least 50%of infants under six months of age receive EBF that *** objective of this study is to document the rates of EBF in children born in San Ignacio University Hospital(HUSI)and identify factors associated with *** To document the percentages of EBF in those that were born at HUSI and identify factors associated to their *** This is a study of cases and controls in an analytic,retrospective cohort that took children born alive between January 2016 and January 2019 at HUSI located in the city of Bogotá,*** Receiving information about BF at HUSI was able to maintain EBF up until 4 mo(oR=1.65;95%CI:1.02-2.66).The presence of gynecologic and obstetric comorbidities(oR=0.32;95%CI:0.12-0.83),having mastitis(oR=0.56;95%CI:0.33-0.94),and receiving information from mass media(oR=0.52;95%CI:0.31-0.84)are factors associated with not maintaining *** Receiving education at a Women-and Child-Friendly Institution was the only significant factor to achieve EBF until 4 mo,with a frequency greater than the one reported in the country,which matches multiple studies where counseling and individualized support on BF achieve this *** about BF and early detection of obstetric/gynecologic complications must be strengthened among the healthcare staff in charge of mothers during ***,strategies must be promoted to continue BF such as creating milk banks with the objective of increasing BF rates even when mothers return to work.

关键词： Breastfeeding Women-and Child-Friendly Institutional Strategy Strategies Adherence Education

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Case report of a criminal dismemberment in Northeast Brazil

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Forensic Sciences Research 2022年第4期7卷 637-642页

作者： Evelyne Pessoa Soriano maria do Socorro Dantas de Araújo Francisca de assis Nascimento Pereira Francisca Divina Silveira de Melo Cristiane Helena da Silva Barbosa Freire Marcus Vitor Diniz de Carvalho Medico-legal Institute of João Pessoa ParaíbaBrazil Faculty of dentistry(FoP) Center for Studies in Forensic Anthropology(CEAF)University of Pernambuco(UPE)RecifeBrazil

Several decomposed body parts were received for examination by the Forensic Anthropology section of the Medico-legal Institute of João Pessoa,Paraíba,*** portions of the lower and upper limbs,ribs,vertebrae,and a skull were thoroughly *** biological profile indicated a male individual with an estimated age range between 23 and 57 years and a mean age of 35.2 years(SD=9.4;phase IV,Suchey-Brooks).The skeleton showed injuries caused by sharp force and sharp-blunt force trauma that affected all body ***,the lesions are mainly in the diaphyseal segments of the long bones,sacrum,pelvis,mandible,maxilla,scapulae,sternum,vertebrae,the distal epiphysis of the left fibula,and the distal epiphysis of the left tibia displayed characteristics compatible with injuries produced *** was not possible to determine the cause of *** resulted in a positive *** of common difficulties faced in forensic practice,it is often not possible for forensic anthropologists to go to the crime scene,X-ray or body scanners are frequently unavailable,and the victim’s medical and/or dental records are sometimes *** difficulties make identification ultimately depend on genetic analysis,which is more time-consuming than other identification *** this,bone fragment examination in dismemberment cases is a complex *** Anthropology can shed light on cases involving the identification of dismembered remains,which are challenging because of the number of traumatic injuries,as well as different injury patterns,on bones.

关键词： Forensic sciences forensic anthropology dismemberment human identification

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Antioxidant and Cytotoxic Activities of Clove oil Nanoparticles and Evaluation of Its Size and Retention Efficiency

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Materials Sciences and Applications 2022年第1期13卷 39-53页

作者： clara Teixeira de oliveira maria Inês Bruno Tavares Institute of Macromolecules Professor Eloisa Mano Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil

A derivation of the nanoprecipitation technique without the presence of surfactants to reduce the nanoparticle size is herein proposed. The absence of surfactant in the nanoprecipitation technique allows capturing particles with a smaller diameter than nanoparticles containing surfactants, facilitating the migration of antioxidant nanoparticles in film packaging. Biodegradable PLA nanoparticles with clove oil were produced and characterized by dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, retention efficiency, cytotoxicity, and antioxidant activity. The particle sizes obtained were smaller than those commonly produced by nanoprecipitation, monodispersed and stable for 6 months. The antioxidant activity showed that the encapsulated form of clove oil had greater antioxidant activity than unencapsulated clove oil. The addition of PLA nanoparticles decreased the cytotoxic action of eugenol, the main antioxidant component of clove oil.

关键词： Nanoprecipitation PLA Clove oil Antioxidant

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Growth and nutrient accumulation of Brazil nut trees(Bertholletia excelsa) in agroforestry at different fertilizer levels

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Journal of Forestry Research 2015年第2期26卷 347-353页

作者： Gotz Schroth maria do Socorro Souza da Mota maria Elizabeth de assis Elias C.P. 513 Santarem PA 68109-971 Brazil Centro de Estudos Avanqados de Promoqao Social e Ambiental Av. Mendonqa Furtado 3979 Santarem PA 68040-050 Brazil Universidade Federal do Amazonas Manaus AM 69077-000Brazil

The Brazil nut tree（Bertholletia excelsa） is a frequent component of agroforestry systems in the Amazon because of its adaptation to nutrient-poor upland soils and multiple *** investigated the aboveground biomass production（kg dry weight）,nutrient uptake and requirements（N,P,Ca,Mg,K） of Brazil nut trees of different sizes grown under agroforestry conditions and fertilized at different *** of 70 experimental trees with different size were harvested and stem,branches and leaves were *** contents were determined for three trees of varying *** tree growth was fast,but variability was high,suggesting considerable potential for the improvement of this economically important *** trees responded to increased levels of fertilizer and lime with significantly increased foliar nutrient contents and growth,probably because of the improved availability of Mg and Ca for which the species seems to have a relatively high *** contrast to Brazil nut trees grown in forest or dense plantations,the agroforestry trees invested a substantial part of their biomass and nutrients in large branches and developed spreading *** improve stem form,reduce competition with associated crops for light and recycle nutrients,regular pruning of lower branches or planting arrangements that favor self-pruning are *** measures would also increase the recycling of Ca and Mg,large quantities of which are contained in the branches.

关键词： Allometric equation Amazon Nutrient competition Nutrient recycling Plant mineral nutrition Soil fertility Silviculture

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Impact of tacrolimus intra-patient variability in adverse outcomes after organ transplantation

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World Journal of Transplantation 2023年第5期13卷 254-263页

作者： maria clara Morais maria Eduarda Soares Gabriela Costa Laura Guerra Nayana Vaz Liana Codes Paulo Lisboa Bittencourt School of Medicine Bahiana School of Medicine and Public HealthSalvador 40290-000BahiaBrazil School of Medicine Federal University of BahiaSalvador 40110-100BahiaBrazil Unit of Gastroenterology and Hepatology Portuguese HospitalSalvador 40130-030BahiaBrazil

Tacrolimus(Tac)is currently the most common calcineurin-inhibitor employed in solid organ *** intra-patient variability(IPV)of Tac(Tac IPV)has been associated with an increased risk of immune-mediated rejection and poor outcomes after kidney *** data are available concerning the impact of high Tac IPV in non-kidney ***,even in kidney transplantation,there is still a controversy whether high Tac IPV is indeed detrimental in respect to graft and/or patient *** may be due to different methods employed to evaluate IPV and distinct time frames adopted to assess graft and patient survival in those reports published up to now in the *** is also known about the influence of high Tac IPV in the development of other untoward adverse events,update of the current knowledge regarding the impact of Tac IPV in different outcomes following kidney,liver,heart,lung,and pancreas tran-splantation to better evaluate its use in clinical practice.

关键词： Tacrolimus Intra-patient variability Rejection organ transplantation Graft survival outcomes

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Reinforcement of Hydroxypropylcellulose Films by Cellulose Nanocrystals in the Presence of Surfactants

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Chinese Journal of Polymer Science 2016年第11期34卷 1301-1301,1302-1310页

作者： Noor Rehman maria Inez G.de Miranda Simone M.L.Rosa clara I.D.Bica Instituto de Quimica Universidade Federal do Rio Grande do Sul 91501-970 Porto Alegre/RS Brazil department of Chemistry Shaheed Benazir Bhutto University 18000 Sheringal Dir (Upper) KPK Pakistan Instituto de Ciencias Exatas e Tecnologicas Universidade FEEVALE Campus Ⅱ 93525-075 Novo Hamburgo/RS Brazil

Hydroxypropylcellulose（HPC） films were prepared by casting with cellulose nanocrystals in the presence of anionic surfactant sodium dodecylsulphate（SDS） and cationic surfactant hexadecyltrimethyl ammonium bromide（CTAB）. The cellulose nanocrystals were isolated from maize straw, a biomass source produced in huge quantities as an agrowaste in Brazil. These bionanocomposite films had good transparency and their surface hydrophilic character was evidenced by static contact angle measurements. Thermogravimetry（TGA） measurement revealed that nanocrystals and surfactants changed the thermal stability of the HPC films. Dynamic mechanical analysis（DMA） showed that the tensile storage and loss moduli of the HPC films increased by increasing the contents of cellulose nanocrystals and surfactants, especially in the case of CTAB. This good reinforcing effect of HPC matrix can be explained as due to electrostatic attractive interactions brought about by the presence of CTAB and the nanocrystals.

关键词： surfactant attractive hydrophilic cellulose reinforcing modulus cationic electrostatic tensile ammonium

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