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PML nuclear bodies:new players in familial amyotrophic lateral sclerosis-frontotemporal dementia?

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Neural Regeneration Research 2024年第9期19卷 1875-1876页

作者： Anand Goswami serena Carra Institute of Neuropathology RWTH Aachen University HospitalAachenGermany Department of Neurology Eleanor and Lou Gehrig ALS CenterColumbia UniversityNew YorkNYUSA Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly

Amyotrophi c lateral s c lerosis(ALS)and frontotemporal dementia(FTD)are two closely related disorders with overlapping clinical,genetic,and neuropathological features,forming a continuous disease spectrum(Ling et al.,2013).The major pathological hallmark of ALS and FTD are the depletion from the nucleus of the RNA-binding proteins TAR DNA‐binding protein 43(TDP-43)and FUsed in Sarcoma(FUS)and their abnormal accumulation in ubiquitin-positive cytoplasmic inclusions(Ling et al.,2013).

关键词： clinical familial

Different behavioral profles between invasive and native nudibranchs:means for invasion success?

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Current Zoology 2024年第3期70卷 406-417页

作者： Armando Macali Sara Ferretti serena Scozzafava Elia Gatto Claudio Carere Ichthyogenic Experimental Marine Centre(CISMAR) Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Department of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Department of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior is predicted to be a primary determinant of the success of the invasion process during the early phases of *** invaders with sympatric native species may provide a good approach to unravel behavioral traits involved in an invasion *** this study,we carried out an experimental simulation of the introduction and the acclimatization phase into a new environment and assessed the expression of activity,alertness,and habituation in an invasive Mediterranean population of the South African nudibranch Godiva quadricolor comparing its profles with those of the sympatric Mediterranean native nudibranchs Cratena peregrina and Caloria *** of these 3 species were subjected to 3 behavioral tests:spontaneous activity,carried out in the introduction phase(immediately after sampling)and after a week of acclimatization;alert test,in which a potential threat was simulated by means of a tactile stimulus,and habituation test,in which the same alert test stimulus was repeated 5 times at 30-min *** invasive *** showed higher levels of exploration activity,thigmotaxis,alertness,and sensitization than the native *** behavioral traits may represent pivotal drivers of the ongoing invasion process.

关键词： biological invasion invasive phenotype invertebrate cognition molluscs personality.

Relative peripheral refraction in school children with different refractive errors using a novel multispectral refraction topographer

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1477-1482页

作者： Hui-Ling Hu serena Zhe-Chuang Li Ai-Ying Feng Hao-Xi Zhong Jing-Feng Mu Mei-Zhou Liu Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina NIMO Ophthalmology Research Institute Beijing 100176China

AIM:To compare relative peripheral refraction(RPR)in Chinese school children with different refractive errors using multispectral refraction topography(MRT).METHODS:A total of 713 eyes of primary school children[172 emmetropia(E),429 low myopia(LM),80 moderate myopia(MM),and 32 low hypermetropia(LH)]aged 10 to 13y were *** were measured using MRT without *** results showed RPR at 0-15°(RPR 0-15),15°-30°(RPR 15-30),and 30°-45°(RPR 30-45)annular in the inferior(RPR-I),superior(RPR-S),nasal(RPR-N),and temporal(RPR-T)*** equivalent(SE)was detected and calculated using an ***:There were significant differences of RPR 15-30 between groups MM[0.02(-0.12;0.18)]and LH[-0.13(-0.36;0.12)](P<0.05),MM and E[-0.06(-0.20;0.10)](P<0.05),and LM[-0.02(-0.15;0.15)]and E(P<0.05).There were also significant differences of RPR 30-45 between groups MM[0.45(0.18;0.74)]and E[0.29(-0.09;0.67)](P<0.05),and LM[0.44(0.14;0.76)]and E(P<0.001).RPR values increased from the hyperopic to medium myopic group in each *** were significant differences of RPR-S between groups MM[-0.02(-0.60;0.30)]and E[-0.44(-0.89;-0.04)](P<0.001),and LM[-0.28(-0.71;0.12)]and E(P<0.05).There were also significant differences of RPR-T between groups MM[0.37(0.21;0.78)]and LH[0.14(-0.52;0.50)](P<0.05),LM[0.41(0.06;0.84)]and LH(P<0.05),and LM and E[0.29(-0.10;0.68),P<0.05].A Spearman’s correlation analysis showed a negative correlation between RPR and SE in the 15°-30°(P=0.005),30°-45°(P<0.05)annular(P=0.002),superior(P<0.001),and temporal(P=0.001)***:Without pupil dilation,values for RPR 15-30,30-45,RPR-S,and T shows significant differences between myopic eyes and emmetropia,and the differences are negatively correlated with SE.

关键词： relative peripheral refraction myopia school children multispectral refraction topography

Brain-derived neurotrophic factor in main neurodegenerative diseases

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Neural Regeneration Research 2023年第3期18卷 554-555页

作者： serena Camuso Sonia Canterini Division of Neuroscience Department of PsychologyUniversity La SapienzaRomeItaly PhD Program in Behavioral Neuroscience Sapienza University of RomeRomeItaly

Discovered in pig brains in 1982,the brain-derived neurotrophic factor(BDNF)is one of the most studied and characterized neurotrophins in the central nervous *** recent years,BDNF has received considerable attention for its importance in the development and maintenance of normal brain *** is because BDNF plays an important role in crucial functions of the nervous system,such as the survival,differentiation,and maturation of neurons and glial cells as well as the actions of neuroprotection in adverse conditions,such as glutamatergic overstimulation,cerebral ischemia,hypoglycemia,and neurotoxicity(Kowiański et al.,2018).

关键词： stimulation diseases

Mapping the quality of prenatal and postnatal care and demographic differences on child mortality in 26 low to middle-income countries

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World Journal of Pediatrics 2023年第9期19卷 835-850页

作者： Kelly Lin serena Chern Jing Sun School of Medicine and Dentistry Griffith UniversityParkland DriveGold CoastQLD4215Australia Institute for Integrated and Intelligent Systems Griffith UniversityGold Coast4222Australia Menzies Health Institute Queensland Griffith UniversityGold CoastAustralia

Background Closing the gap between child mortality in low-and middle-income countries(LMICs)and high-income countries is a priority set by the WHO in sustainable development goals(SDGs).We aimed to examine poor nutrition and prenatal and postnatal care that could increase the risk of child mortality in *** The Demographic and Health Survey(DHS)was used to examine data from 26 countries to compare prenatal,postnatal,nutritional,and demographic factors across *** of child death was classified into death before one month of age,between 1 to 11 months,between one to two years,between three to five years,and overall death before five ***-square analyses identified differences in prenatal care,postnatal care,nutrition,and demographic factors between children who died and those who *** regression identified factors that increased child mortality *** The majority of deaths occurred before the ages of one month and one *** poorer quality of prenatal care,postnatal care,and nutrition were found in low-income and low-middle-income countries in the contemporary *** child mortality and poor quality of prenatal and postnatal care coincide with low *** in LMICs were exposed to less vitamin A-rich foods than children in higher-middle-income *** use of intestinal parasite drugs and the absence of postpartum maternal vitamin A supplementation significantly increased child mortality *** socio-demographic risk factors were associated with an increased mortality rate in children,including lack of education,maternal marital status,family wealth index,living rurally,and financial problems hindering access to *** Poor nutrition remains a vital factor across all LMICs,with numerous children being exposed to foods low in iron and vitamin ***,most deaths occur in neonates and infants,indicating an urgent need to address risk factors associated with early chil

关键词： Child mortality Low-and middle-income countries Postnatal care Prenatal care

Lipid catabolism and mitochondrial uncoupling are stimulated in brown adipose tissue of amyotrophic lateral sclerosis mouse models

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Genes & Diseases 2023年第2期10卷 321-324页

作者： Fabio Ciccarone serena Castelli Giacomo Lazzarino Silvia Scaricamazza Renata Mangione Sergio Bernardini Savina Apolloni Nadia D'Ambrosi Alberto Ferri maria Rosa Ciriolo Department of Biology University of Rome “Tor Vergata”00133 RomeItaly IRCCS San Raffaele Roma 00166 RomeItaly UniCamillus-Saint Camillus International University of Health Sciences 00131 RomeItaly IRCCS Fondazione Santa Lucia 00179 RomeItaly Department of Basic Biotechnological Sciences Intensive and Perioperative ClinicsCatholic University of Rome00168 RomeItaly Fondazione Policlinico Universitario A. Gemelli IRCCS 00168 RomeItaly Institute of Translational Pharmacology IFT-CNR 00133 RomeItaly

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease typically leading to death within 5 years from symptom onset. ALS familial forms are associated with mutations in several genes, including Superoxide Dismutase 1 (SOD1) and Fused in Sarcoma (FUS). Although genes linked to ALS participate in disparate biological processes, ALS genetic variants largely trigger shared pathogenic events such as oxidative stress, protein aggregation and defects in RNA processing. Moreover, ALS patients show systemic hypermetabolism that leads to increased energy expenditure at rest and thus weight loss during the disease course.1 ALS hypermetabolic phenotype and weight loss have been extensively characterized in mice bearing the G93A substitution in SOD1 protein (SOD1-G93A), which exhibit skeletal-muscle metabolic reprogramming before disease onset.

关键词： Lipid metabolism aggregation

Genotyping ex situ trees of Abies nebrodensis translocated from the original Sicilian population to enrich the gene pool

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Journal of Forestry Research 2023年第4期34卷 1095-1106页

作者： Anna De Rogatis Fulvio Ducci serena Guerri Angela Teani Roberta Proietti CREA Research Centre for Agriculture and EnvironmentVia di Saliceto 8040123 BolognaItaly CREA Research Centre for Forestry and WoodViale Santa Margherita 8052100 ArezzoItaly Comprehensive Institute Venturino Venturi of Loro Ciuff enna Arezzo Via Genova 1252024 Loro Ciuff enna(AR)Italy

As a dynamic ex situ conservation strategy,a clonal seed orchard was started in a nursery in Pomaio(POM)in central Italy in 1993 for an assisted migration experiment of Abies nebrodensis(Lojac.)*** artifi cial ex situ populations were planted with this gene pool:a seedling arboretum in Pieve Santo Stefano(PSS)and a small dendrological collection in Papiano(PAP),both originating from the Sicilian relict ***,using AFLP markers,we estimated the relatedness among the relocated genotypes of the three collections to check whether the three collections had suffi cient genetic variability to be considered as additional sources of variability to the original gene pool for the assisted migration *** individual genetic variability was found in the collections;each plant had a diff erent genotype and was confi rmed to belong to its population of *** and PSS trees were shown to be only from the original population of *** species and were derived from a limited set of maternal fertile *** on the Sicilian fi r population inventory,nursery production in Sicily,and structure clustering analysis,close genetic relationships among POM,PAP and several PSS trees(1–35)were ***,the PSS group(36–78)was genetically close to tree 1 of POM and in a lesser proportion to plants 7 and 9 of *** sampling of seedlings used to form batches in the nursery might have infl uenced the structure of the resultant *** genotypes will be useful for enriching the original gene pool.

关键词： Sicilian fir Genotyping Ex situ conservation Gene pool Assisted migration

Operando electrochemical SERS monitors nanoparticle reactions by capping agent fingerprints

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Nano Research 2022年第5期15卷 4517-4524页

作者： Kevin Wonner Steffen Murke serena RAlfarano Pouya Hosseini Martina Havenith Kristina Tschulik Chair of Analytical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany Chair of Physical Chemistry Ⅱ Faculty of Chemistry and BiochemistryRuhr University BochumBochum 44801Germany

Nanomaterials are frequently employed in daily life goods,including health,textile,and food industry.A comprehensive picture is lacking on the role of the capping agents,added ligand molecules,in case of nanoparticle reactions and degradation in aqueous solutions,like surface waters or ***,we aim to elucidate the capping agent influence on nanoparticle reactivity probing two commonly employed capping agents citrate and polyvinylpyrrolidone(PVP).Their influence on silver nanoparticle(AgNP)transformation is studied,which is particularly important due to its application as an antimicrobial *** induce oxidation and reduction processes of AgNPs in halide solutions and we monitor the associated transformations of particles and capping agents by spectro-electrochemical surface-enhanced Raman spectroscopy(SERS).Raman bands of the capping agents are used here to track chemical changes of the nanoparticles under operando *** sparingly soluble and non-plasmon active silver salts(AgBr and AgCl)are formed under potential *** addition,we spectroscopically observe plasmon-mediated structural changes of citrate to cis-or trans-aconitate,while PVP is *** different behavior of the capping agents implies a change in the physical properties on the surface of AgNPs,in particular with respect to the surface ***,we showcase that reactions of the capping agents induced by different external stimuli,such as applied bias or laser irradiation,can be *** results demonstrate how SERS of capping agents can be exploited to operando track nanoparticle conversions in liquid *** approach is envisaged to provide a more comprehensive understanding of nanoparticle fates in complex liquid environments and varied redox conditions.

关键词： capping agent electrochemical surface-enhanced Raman spectroscopy silver nanoparticle nanoparticle reaction

The effect of temperature on the wear behaviour of dental composites

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Biosurface and Biotribology 2022年第4期8卷 329-336页

作者： Joseph A.Arsecularatne serena Tran Mark J.Hoffman School of Materials Science and Engineering UNSW SydneySydneyNew South WalesAustralia School of Mechanical and Manufacturing Engineering UNSW SydneySydneyNew South WalesAustralia School of Engineering University of NewcastleCallaghanNew South WalesAustralia

Despite numerous published studies on the wear of dental composites,few have considered the influence of temperature on the two-body wear ***,no previous work has considered the influence of temperature on dominant wear mecha-nisms during the consumption of hot substances,hence the focus of this ***-rocating wear tests were carried out at varying artificial saliva lubricant temperatures(37 and 57℃)and material loss was quantified using *** wear tracks were analysed using FIB/SEM/*** reveal that the wear rate of a dental composite can significantly increase with temperature,with fatigue/delamination and ploughing acting as dominant mechanisms.

关键词： dental composite temperature tribological performance wear mechanism