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Seropositivity for Hepatitis B Virus, Vaccination Status and Response to Vaccine in a Cohort of Dental Students

Open Journal of Preventive Medicine 2017年第2期7卷 32-39页

作者： Monica Lamberti Elpidio maria Garzillo maria rosaria muoio Antonio Arnese Albert Nienhaus Elia Abbondante Gabriella Di Giuseppe Paola Pedata Alfredo De Rosado Department of Experimental Medicine Section of Hygiene Occupational Medicine and Forensic Medicine Second University of Naples Naples Italy Institute for Health Services Research in Dermatology and Nursing University Medical Center Hamburg-Eppendorf Hamburg Germany Institution for Statutory Accident Insurance and Prevention in Healthcare and Welfare Services Hamburg Germany ASL Napoli 1 Naples Italy Department of Orthodontics Second University of Naples Naples Italy

Background: The development of a vaccine against hepatitis B virus (HBV) has been a major achievement in terms of prevention of HBV infection. To evaluate the immunological status against HBV of dental-profession students, we analysed the long-term immunogenicity and effectiveness of HBV vaccination in Italian dental students with different work seniorities, determining the influence of epidemiological variables on the immune response. Methods: This study, carried out from January 2014 to April 2016, involved 361 under- and post-graduate dental students attending the Second University of Naples. HBV serum markers were determined and multivariate logistic regression analysis was used to identify factors associated with the level of long-term immunogenicity. Results: Of the 361 subjects evaluated, 15 (4.2%) declared no history of vaccination. All vaccinated subjects were HBsAg/anti-HBc negative, with 86 (24.9%) having an anti-HBs titre <10 IU/L. The latter were younger, more likely to be attending undergraduate dental school, and more likely to have been vaccinated in infancy. Conclusion: The findings of this study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful to identify small numbers of unvaccinated subjects or vaccinated subjects with low antibody titre, all of whom should be referred for a booster series of vaccinations.

关键词： HBV Infection HBV Vaccination Anti-HBs Titre Dental Students

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Iron and Heart Failure: Current Concepts and Emerging Pharmacological Paradigms

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World Journal of Cardiovascular Diseases 2024年第4期14卷 195-216页

作者： maria rosaria De Pascale maria Beatrice Rondinelli Flora Ascione Vincenzo Maffei Chiara Di Lorenzo Sarah Scagliarini Raffaella Faraonio Antonio Faiella Immunohematology and Transfusion Medicine Unit Cardarelli Hospital Naples Italy Immunohematology and Transfusion Medicine Unit San Camillo-Forlanini Hospital Rome Italy Health Management Office Cardarelli Hospital Naples Italy Anesthesiology Unit Cardarelli Hospital Naples Italy Department of Medical and Translational Sciences University of Naples Federico II Naples Italy Oncology Unit Cardarelli Hospital Naples Italy Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy

Background: Emerging evidence has recognized that anemia and iron deficiency are recurrent comorbidities in chronic heart failure (HF) and several trials have established that iron administration improves myocardial asset and clinical scenario in HF. Purpose: Recent acquisitions suggest that iron deficiency represents a concrete bias in the pathogenetic mechanism of chronic HF, so we have investigated the putative role of the hepcidin/ferroportin axis in the cardiovascular setting to advocate novel pharmacological and clinical approaches. Methods: Here, after an excursus on iron metabolism, we first reviewed the ongoing studies on novel iron targeted compounds. Then, we summarize large clinical interventional studies conducted on patient suffering from iron deficiency and HF which have tested the effects of drugging iron regard QoL, hospitalizations and cardiovascular death. Results: Novel compounds such as hepcidin agonist (PTG 300), synthetic human hepcidin (LJPC-401) and anti FPN (Vamifeport) are ongoing in iron overloaded patients, while the hepcidin blocker (PRS-080) is under investigation in anemic patients. Noteworthy, novel insights could arise from the results of a Phase IV interventional study regarding the modification of hepcidin pathway in a large cohort of HF patients (n = 1992) by sodium glucose cotransporter 2 inhibitors. To date, several studies highlight the beneficial effect of iron administration in cardiovascular setting and latest evidences consider hepcidin level as a novel biomarker of cardiac injury and atherosclerosis. Conclusions: We advocate that data from ongoing studies will suggest novel iron targeted therapies for diagnosis, prognosis and therapy transferable in selected heart failed patients.

关键词： Heart Failure Iron Anemia Iron Deficiency Hepcidin

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Potential application of the Kampo medicine goshajinkigan for prevention of chemotherapy-induced peripheral neuropathy

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Journal of Integrative Medicine 2017年第2期15卷 77-87页

作者： Marco Cascella maria rosaria Muzio Division of Anesthesia Department of Anesthesia and Pain Medicine Istituto Nazionale Tumori "Fondazione G. Pascale"--IRCCS via Mariano Semmola Naples 80131 Italy Division of Infantile Neuropsychiatry UOMI-Maternal and Infant Health Asl NA 3 SUD Torre del Greco via Marconi Naples 80059 Italy

Chemotherapy-induced peripheral neuropathy （CIPN） is one of the most common and severe adverse effects related to cancer treatment. Unfortunately, although several agents and protocols have been proposed, no prophylactic strategies have yet to be proven useful. Therefore, new alternative therapies have been considered for CIPN prevention. Herbal medicine in Japan, called Kampo medicine, is derived from traditional Chinese medicine. Goshajinkigan （GJG） is a Kampo medicine, that is comprised of ten herbs. The aim of this work is to analyse the results of pre-clinical and clinical studies on the potential applications of GJG in CIPN prevention.

关键词： chemotherapy peripheral neuropathies herbal medicine alternative medicine natural products

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Groups with Cyclic Outer Automizers

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Algebra Colloquium 2014年第3期21卷 381-398页

作者： maria rosaria Celentani Giovanni Cutolo Antonella Leone Dipartimento di Matematica e Applieazioni 'R .Caccioppoli' Universita degli Studi di Napoli 'Federico II' Via Cintia Monte S. Angelo 1-80126 Napoli Italy

We consider groups G such that NG（H）/HCG（H） is cyclic for all H ≤ G. More specifically, we characterise locally nilpotent and supersoluble groups with this property.

关键词： automizers locally nilpotent supersoluble soluble groups

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Personality traits and emotional patterns in irritable bowel syndrome

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World Journal of Gastroenterology 2016年第28期22卷 6402-6415页

作者： maria rosaria A Muscatello Antonio Bruno Carmela Mento Gianluca Pandolfo Rocco A Zoccali Psychiatry Unit Department of Biomedical and Dental Sciences and Morphofunctional Imaging University of Messina

The review focuses on those personality traits(neuroticism, extraversion, openness to experience, agreeableness, and conscientiousness), constructs(alexithymia and distressed- Type D personality) and emotional patterns(negative and positive) that are of particular concern in health psychology, with the aim to highlight their potential role on the pathogenesis, onset, symptom clusters, clinical course, and outcome of irritable bowel syndrome(IBS). Personality traits and emotional patterns play key roles in affecting autonomic, immune, inflammatory, and endocrine functions, thus contributing not only to IBS clinical expression and symptomatic burden, but also to disease physiopathology. In this sense, psychological treatments should address those personality traits and emotional features that are constitutive of, and integral to IBS. The biopsychosocial model of illness applied to IBS acknowledges the interaction between biological, psychological, environmental, and social factors in relation to pain and functional disability. A holistic approach to IBS should take into account the heterogeneous nature of the disorder, and differentiate treatments for different types of IBS, also considering the marked individual differences in prevalent personality traits and emotional patterns. Beyond medications, and lifestyle/dietary interventions, psychological and educational treatments may provide the optimal chance of addressing clinical symptoms, comorbid conditions, and quality of life in IBS patients.

关键词： Alexithymia Depression Anxiety Anger Conscientiousness Irritable bowel syndrome Emotions Personality Neuroticism Extraversion

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Role of negative affects in pathophysiology and clinical expression of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第24期20卷 7570-7586页

作者： maria rosaria A Muscatello Antonio Bruno Giuseppe Scimeca Gianluca Polfo Rocco A Zoccali Psychiatry Unit Department of NeurosciencesUniversity of Messina98125 MessinaItaly

Irritable bowel syndrome(IBS)is regarded as a multifactorial disease in which alterations in the brain-gut axis signaling play a major *** biopsychosocial model applied to the understanding of IBS pathophysiology assumes that psychosocial factors,interacting with peripheral/central neuroendocrine and immune changes,may induce symptoms of IBS,modulate symptom severity,influence illness experience and quality of life,and affect *** present review focuses on the role of negative affects,including depression,anxiety,and anger,on pathogenesis and clinical expression of *** potential role of the autonomic nervous system,stress-hormone system,and immune system in the pathophysiology of both negative affects and IBS are taken into *** comorbidity and subclinical variations in levels of depression,anxiety,and anger are further discussed in relation to the main pathophysiological and symptomatic correlates of IBS,such as sensorimotor functions,gut microbiota,inflammation/immunity,and symptom reporting.

关键词： Depression Anxiety Anger Mood disorders Irritable bowel syndrome Neuroticism Stress Brain-gut axis Microbiota Hypothalamic-pituitary-adrenal axis

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Gallbladder hemorrhage–An uncommon surgical emergency:A case report

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World Journal of Clinical Cases 2022年第27期10卷 9734-9742页

作者： maria rosaria Valenti Andrea Cavallaro maria Di Vita Antonio Zanghi Giovanni Longo Trischitta Alessandro Cappellani Department of Surgery University of Catania Medical SchoolUniversity of CataniaCatania 95123Italy

BACKGROUND Gallbladder hemorrhage is a life-threatening ***(accidental or iatrogenic such as a percutaneous biopsy or cholecystectomy surgery),cholelithiasis,biliary tract parasitosis,vasculitis,vascular malformations,autoimmune and neoplastic diseases and coagulopathies have been described as causes of hemorrhage within the lumen of the *** use of nonsteroidal anti-inflammatory drugs and anticoagulants may represent a risk *** SUMMARY We report the case of a 76-year-old male *** urgent contrast computed tomography scan demonstrated relevant distension of the gallbladder filled with hyperdense non-homogeneous *** gallbladder walls were of regular *** the anterior wall a focus of suspected active bleeding was *** to the progressive decrease in hemoglobin despite three blood transfusions,this was an indication for urgent *** Early diagnosis of this potentially fatal pathology is essential in order to plan a strategy and eventually proceed with urgent surgical treatment.

关键词： Gallbladder Hemorrhage Anticoagulants Cholecystectomy Surgery Case report

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Early and long-term postoperative management following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

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World Journal of Gastrointestinal Oncology 2010年第1期2卷 36-43页

作者： Dario Baratti Shigeki Kusamura Barbara Laterza maria rosaria Balestra Marcello Deraco Department of Surgery National Cancer Institute Via Venezian 1

Peritoneal surface malignancies have been traditionally regarded as end-stage conditions amenable to merely palliative options. The combination of aggressive cytoreductive surgery (CRS), involving peritonectomy procedures and multivisceral resections, with intra-operative hyperthermic intra-peritoneal chemotherapy (HIPEC) and/or early postoperative intra-peritoneal chemotherapy (EPIC) to treat the microscopic residual tumor is a new concept. In recent years, promising results have been reported for peritoneal mesothelioma and carcinomatosis of gastrointestinal and gynaecologic origin treated by this combined protocol. However, CRS with HIPEC and/or EPIC is a complex procedure associated with high rates of potentially life-threatening complications. Furthermore, disease progression following comprehensive treatment is not uncommon and represents a relevant cause of treatment failure. The present paper reviews the available information on early postoperative management and long-term follow-up in patients treated with CRS and intraperitoneal chemotherapy. The peculiar clinical and biological alterations that can be expected during an uncomplicated postoperative course, as compared to standard digestive surgery, are discussed. Early recognition and appropriate management of the most common adverse events are addressed, in order to minimize the impact of treatment-related morbidity on survival and quality of life results. Since re-operative surgery with additional HIPEC, has proven to be useful in selected patients with recurrent disease, long-term surveillance aiming at early detection of postoperative disease progression has become a relevant issue. Current results on follow-up investigations are presented.

关键词： Peritoneal surface malignancies Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Hyperthermic intra-peritoneal chemotherapy Follow-up

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International transferability of macro-level safety performance functions: a case study of the United States and Italy

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Transportation Safety and Environment 2019年第1期1卷 68-78页

作者： Jaeyoung Lee Mohamed Abdel-Aty maria rosaria de Blasiis Xuesong Wang Ilaria Mattei Department of Civil Environmental and Construction EngineeringUniversity of Central Florida.4000 Central Florida Blvd.OrlandoFlorida 32816USA Department of Engineering Roma Tre University.Via Vito Volterra 6200146 RomaItaly School of Transportation Engineering Tongji University.4800 Cao’an RoadJiading DistrictShanghai 201804China Ferrovie dello Stato Italiano.Piazza della Croce Rossa 100161 RomaItaly School of Traffic and Transportation Engineering Central South University.22 Shaoshan South RoadChangsha Hunan 410075 China

Safety performance functions(SPFs),or crash-prediction models,have played an important role in identifying the factors contributing to crashes,predicting crash counts and identifying *** a great deal of time and effort is needed to estimate an SPF,previous studies have sought to determine the transferability of particular SPFs;that is,the extent to which they can be applied to data from other *** many efforts have been made to examine micro-level SPF transferability,few studies have focused on macro-level SPF *** has been little transferability analysis of macro-level SPFs in the international context,especially between western *** study therefore evaluates the transferability of SPFs for several states in the USA(Illinois,Florida and Colorado)and for *** SPFs were developed using data from counties in the United States and provincias in Italy,and the results revealed multiple common significant variables between the two *** indexes were then calculated between the *** showed that the Italy SPFs for total crashes and bicycle crashes were transferable to US data after calibration factors were applied,whereas the US SPFs for total and bicycle crashes,with the exception of the Colorado SPF,could not be transferred to the Italian *** the other hand,none of the pedestrian SPFs developed was transferable to other *** paper provides insights into the applicability of macro-level SPFs between the USA and Italy,and shows a good potential for international SPF ***,further investigation is needed of SPF transferability between a wider range of countries.

关键词： safety performance function(SPF) crash prediction model negative binomial model transferability transferability index international transferability macro-level safety macroscopic safety

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Regression of liver metastases of occult carcinoid tumor with slow release Lanreotide therapy

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World Journal of Gastroenterology 2005年第13期11卷 2041-2044页

作者： Marta Bondanelli maria rosaria Ambrosio maria Chiara Zatelli Luigi Cavazzini Laura Al Jandali Rifa'y Ettore C.degli Uberti Department of Biomedical Sciences and Advanced Therapies-Section of Endocrinology Department of Experimental and Diagnostic Medicine

Few clinical studies have demonstrated an anti-proliferative activity of somatostatin (SST) analogs in carcinoids. We report the case of a woman with liver metastases of neuroendocrine tumor and no evidence of the primary tumor. The liver metastases were characterized by high proliferation index, immunoreactiviy for somatostatin receptor (SSTR)-l, 2, 3 and 5 and positive octreoscan. Urinary 5-hydroxyindolacetic acid, serum serotonin and chromogranin A were elevated. Slow release lanreotide (SR-LAN) therapy for 3 mo controlled clinical and biochemical signs of carcinoid tumor and caused a clear-cut reduction in the diameter of two liver metastases and disappearance of another lesion, with further reduction after 6 and 18 mo. We demonstrated a clear-cut long-lasting anti-proliferative effect of SR-LAN on liver metastases of occult carcinoid with high proliferation index and immunoreactivity for SSTR-1, 2, 3, and 5. Immunohistochemistry for SSTRs could be a suitable method for the selection of patients with metastatic carcinoid that may benefit from SST analog therapy.

关键词： Carcinoid Somatostatin analogs Somatostatin receptors

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