Seropositivity for Hepatitis B Virus, Vaccination Status and Response to Vaccine in a Cohort of Dental Students

作     者：Monica Lamberti Elpidio Maria Garzillo Maria Rosaria Muoio Antonio Arnese Albert Nienhaus Elia Abbondante Gabriella Di Giuseppe Paola Pedata Alfredo De Rosado 

作者机构：Department of Experimental Medicine Section of Hygiene Occupational Medicine and Forensic Medicine Second University of Naples Naples Italy Institute for Health Services Research in Dermatology and Nursing University Medical Center Hamburg-Eppendorf Hamburg Germany Institution for Statutory Accident Insurance and Prevention in Healthcare and Welfare Services Hamburg Germany ASL Napoli 1 Naples Italy Department of Orthodontics Second University of Naples Naples Italy 

出 版 物：《Open Journal of Preventive Medicine》 (预防医学期刊（英文）)

年 卷 期：2017年第7卷第2期

页      面：32-39页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：HBV Infection HBV Vaccination Anti-HBs Titre Dental Students 

摘      要：Background: The development of a vaccine against hepatitis B virus (HBV) has been a major achievement in terms of prevention of HBV infection. To evaluate the immunological status against HBV of dental-profession students, we analysed the long-term immunogenicity and effectiveness of HBV vaccination in Italian dental students with different work seniorities, determining the influence of epidemiological variables on the immune response. Methods: This study, carried out from January 2014 to April 2016, involved 361 under- and post-graduate dental students attending the Second University of Naples. HBV serum markers were determined and multivariate logistic regression analysis was used to identify factors associated with the level of long-term immunogenicity. Results: Of the 361 subjects evaluated, 15 (4.2%) declared no history of vaccination. All vaccinated subjects were HBsAg/anti-HBc negative, with 86 (24.9%) having an anti-HBs titre 10 IU/L. The latter were younger, more likely to be attending undergraduate dental school, and more likely to have been vaccinated in infancy. Conclusion: The findings of this study suggest that assessment of HBV serum markers in workers potentially exposed to hospital infections is useful to identify small numbers of unvaccinated subjects or vaccinated subjects with low antibody titre, all of whom should be referred for a booster series of vaccinations.