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Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano De Santis Giulia d’Amati Silvia Nardelli Alessandra Spagnoli Arianna Di Rocco Lorenzo Ridola oliviero Riggio Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly Department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

Determinants of prognosis in cirrhosis:a new outlook

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 759-761页

作者： Lorenzo Ridola Stefania Gioia Jessica Faccioli Silvia Nardelli oliviero Riggio Department of Translational and Precision Medicine “Sapienza”University of RomeRomeItaly

The metanalysis by Tantai and collaborators highlights the role of sarcopenia in cirrhosis by demonstrating that the presence of muscular alterations is independently related with a mortality(HR 2.61)(1).Sarcopenia is confirmed as a condition with high prevalence in patients with cirrhosis(37.5%),being more representative in males than females(41.9%vs.37.8%)and in subjects with alcoholic etiology(49.6%)or with more advanced degree of liver disease(Child Pugh C 46.7%).Interestingly,authors demonstrate that sarcopenia was associated with mortality in subjects with MELD15(HR 2.34)as well evaluating only on studies that excluded patients with hepatocellular carcinoma(HCC),risk of mortality was similar to that of the main analysis(2.35)(1).

关键词： cirrhosis mortality alterations

Non-invasive tests for fibrosis detection: still in search for the best way

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Hepatobiliary Surgery and Nutrition 2022年第6期11卷 920-923页

作者： Lorenzo Ridola Danila Capoccia Gloria Guarisco oliviero Riggio Frida Leonetti Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Medical-Surgical Sciences and Biotechnologies Sapienza University of RomeRomeItaly

Eilenberg and colleagues’paper highlights the importance of non-invasive detection by using vibration controlled transient elastography(VCTE)and controlled attenuation parameter(CAPTM)for the assessment of fibrosis,s... 详细信息

关键词： invasive obesity transient

Hepatocellular carcinoma metastatic to the kidney mimicking renal oncocytoma

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Hepatobiliary & Pancreatic Diseases International 2010年第5期9卷 550-552页

作者： Antonio D'Antonio Alessia Caleo oliviero Caleo maria Addesso Amedeo Boscaino Department of Pathologic Anatomy A.O."San Giovanni di Dio e Ruggi d'Aragona"via S.LeonardoSalernoItaly Department of Biomorphological and Functional Science University of Medicine "Federico II"NaplesItaly Department of Pathologic Anatomy ASL SA1Hospital "Scarlato"Scafati(SA) Unit of Pathologic Anatomy A.O.R.N."Cardarelli"via A.Cardarelli 980131 NaplesItaly

BACKGROUND:Renal metastases of hepatocellular carcinoma(HCC) are very *** our knowledge only five cases have been reported to the present;all had a well-known primary ***:We describe the clinico-pathological features of a rare case of HCC metastatic to the kidney in which the renal mass was the clinical debut of *** patient was a 54-year-old woman previously submitted to orthotopic liver transplantation,who underwent left nephrectomy for a renal ***:Histologically,the tumor was composed mainly of epithelioid cells with homogeneous acidophilic cytoplasm resembling oncocytoma or primary renal carcinoma with oncocytic features.A correct diagnosis was made on the basis of positive immunostaining for hepatocyte paraffin ***:Metastasis to the kidney is a rare complication that should be considered whenever a renal mass is present in patients with *** HCC may histologically resemble primary renal tumors such as oncocytoma,pathologists must be aware of this possibility above all in patients referred for liver transplantation and treated with immunosuppressant *** is particularly helpful to establish a precise diagnosis in cases of doubt.

关键词： renal metastasis hepatocellular carcinoma immunohistochemistry differential diagnosis

Ascitic fluid analysis for diagnosis and monitoring of spontaneous bacterial peritonitis

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World Journal of Gastroenterology 2009年第31期15卷 3845-3850页

作者： oliviero Riggio Stefania Angeloni Department of Clinical Medicine "Sapienza" University of Rome

Polymorphonuclear (PMN) cell count in the ascitic fluid is essential for the diagnosis and management of spontaneous bacterial peritonitis (SBP). To date, PMN cell count is routinely performed by traditional manual counting. However, this method is time-consuming, costly, and not always timely available. Therefore, considerable efforts have been made in recent years to develop an alternative test for a more rapid diagnosis and monitoring of SBP. The use of urinary reagent strips was proposed to achieve an "instant" bedside diagnosis of SBP. A series of reports evaluated the urine strip test for SBP diagnosis and reported promising results. However, a recent large multicenter study revealed a surprising lack of diagnostic effi cacy of the urine screening test for SBP diagnosis. Another method, more recently proposed as an alternative to the manual PMN count, is the measurement of lactoferrin in ascitic fluid, but the data available on the diagnostic value of this test are limited to a single study. However, both urinary reagent strips and ascitic lactoferrin tests are qualitative methods and need, therefore, to be further confirmed by standard cytology of the ascitic fluid. To date, the only quantitative method proposed as a valid alternative to manual PMN counting is automated blood cell counters, commonly used in all laboratories for blood cell counting. Data available in the literature on the diagnostic performance of this method are limited but very promising, and this tool seems to have the potential to replace the manual counting method.

关键词：腹膜炎细菌性水分析监测诊断

Fabulous Glamping Destinations in Georgia

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空中英语教室（高级版．彭蒙惠英语） 2022年第5期 11-13,40,41页

作者： Helena oliviero 徐佩仪(译) 不详

现在正是享受户外的美好季节一外出踏青、烤棉花糖,也许睡在星空下也很宜人:对于想要摆脱电子产品而重新投入大自然怀抱,却又(丝毫)不想吃苦头的人而言,“豪华露营”也许正投其所好:佐治亚州有若干个目的地可以让你依偎在大自然的怀抱,... 详细信息

现在正是享受户外的美好季节一外出踏青、烤棉花糖,也许睡在星空下也很宜人:对于想要摆脱电子产品而重新投入大自然怀抱,却又(丝毫)不想吃苦头的人而言,“豪华露营”也许正投其所好:佐治亚州有若干个目的地可以让你依偎在大自然的怀抱,又不必牺牲家的舒适。下面就来看看其中四个景点:奇克莫加的烛光森林树屋。

关键词：佐治亚州棉花糖投其所好电子产品

Controlling infestation of a chocolate factory by Plodia interpunctella by combining mating disruption and the parasitoid Habrobracon hebetor

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Insect Science 2017年第3期24卷 503-510页

作者： Pasquale Trematerra Annachiara oliviero Sara Savoldelli Matthias Scholler Department of Agricultural Environmental and Food Sciences University of Molise Via De Sanctis 86100 Campobasso Italy Department of Food Environmental and Nutritional Sciences Universit& degli Studi di Milano Via Celoria 2 20133 Milan Italy Faculty of Life Sciences Humboldt-Universit#t zu Berlin Lentzeallee 55/57 14195 Berlin Germany

A field experiment of 4 years＇ duration was carried out to evaluate the ef- ficacy of combining the mating disruption （MD） formulation Dismate ZETA （（9Z,12E）- tetradecadienyl acetate）, with the parasitoid Habrobracon hebetor against the Indianmeal moth Plodia interpunctella in a chocolate factory. The experimental period began early in 2011 and ended in late 2014. Begane Dismate dispensers were placed in the facility from 2011 to 2014 and H. hebetor was released in 2014. Pheromone-baited traps were used to monitor the flight activity of the male moths and oviposition Petri dish traps were placed to assess the progeny production ofP. interpunctella females. Following the start of MD, a decrease in the number ofP. interpunctella males caught in monitoring traps was observed from 2011 to 2013. A further decline in the moth population was noted in 2014, when MD was combined with the release of parasitoids. The presence of larvae in the oviposition cups was occasionally observed throughout the monitoring period, from 2011 to 2014. This study demonstrates that the combined system of MD and parasitoids is an effective and reliable technique that can be used to successfully control P. interpunctella.

关键词： control food processing integrated pest management mating disruption parasitoid Plodia interpunctella

Cross-talk between microRNAs,long non-coding RNAs and p21^(Cip1)in glioma:diagnostic,prognostic and therapeutic roles

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Journal of Cancer Metastasis and Treatment 2020年第1期6卷 225-238页

作者： Giorgio Santoni maria Beatrice Morelli Massimo Nabissi Federica Maggi oliviero Marinelli Matteo Santoni Consuelo Amantini School of Pharmacy University of CamerinoCamerino 62032Italy Department of Molecular Medicine University of Rome SapienzaRome 00161Italy Medical Oncology Unit Hospital of MacerataMacerata 62100Italy School of Biosciences and Veterinary Medicine University of CamerinoCamerino 62032Italy

Glioblastoma multiforme is considered one of the most common malignant primary intracranial *** treatment with a combination of surgery,chemotherapy and radiotherapy,patients with glioblastoma multiform have poor *** has been widely accepted that the occurrence,progression,and even recurrence of glioblastoma multiforme strictly depends on the presence of glioma cancer stem *** presence of glioma stem cells reduces the efficacy of standard therapies,thus increasing the imperative to identify new targets and therapeutic strategies in glioblastoma *** this regard,the p21^(Cip1)pathway has been found to play an important role in the maintenance of the glioma stem *** has been shown that this pathway regulates cancer stem cell pool by preventing hyperproliferation and ***,endogenous small non-coding RNAs,and long non-coding RNAs,regulate post-transcription gene *** are not only altered in glioma,but also in other cancer types,and are involved in tumor development and ***,they have also been shown to modulate the expression of proteins in the p21^(Cip1)signaling *** review highlights the extent and complexity of cross-talk between microRNAs,long non-coding RNAs and the p21^(Cip1)pathway,and demonstrates how such interplay orchestrates the regulation of protein expression and functions in glioma and glioma stem cells.

关键词： Glioma microRNA long non-coding RNA p21^(Cip1) glioma stem cells

Quality of life in patients with minimal hepatic encephalopathy

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World Journal of Gastroenterology 2018年第48期24卷 5446-5453页

作者： Lorenzo Ridola Silvia Nardelli Stefania Gioia oliviero Riggio Department of Medico-Surgical Sciences and Biotechnologies Sapienza University of Rome Department of Clinical Medicine Sapienza University of Rome

Minimal hepatic encephalopathy(MHE) represents the mildest type of hepatic encephalopathy(HE). This condition alters the performance of psychometric tests by impairing attention, working memory, psychomotor speed, and visuospatial ability, as well as electrophysiological and other functional brain measures. MHE is a frequent complication of liver disease, affecting up to 80% of tested patients, depending of the diagnostic tools used for the diagnosis. MHE is related to falls, to an impairment in fitness to drive and the development of overt HE, MHE severely affects the lives of patients and caregivers by altering their quality of life(QoL) and their socioeconomic status. MHE is detected in clinically asymptomatic patients through appropriate psychometric tests and neurophysiological methods which highlight neuropsychological alterations such as video-spatial orientation deficits, attention disorders, memory, reaction times, electroencephalogram slowing, prolongation of latency evoked cognitive potentials and reduction in the critical flicker frequency. Several treatments have been proposed for MHE treatment such as non-absorbable disaccharides, poorly absorbable antibiotics such rifaximin, probiotics and branched chain amino acids. However, because of the multiple diagnosis methods, the various endpoints of treatment trials and the variety of agents used in trials, to date the treatment of MHE is not routinely recommended apart from on a case-by-case basis. Aim of this review is analyze the burden of MHE on QoL of patients and provide a brief summary of therapeutic approaches.

关键词： Cirrhosis Minimal hepatic encephalopathy Covert hepatic encephalopathy Health related quality of life