Cross-talk between microRNAs,long non-coding RNAs and p21^(Cip1)in glioma:diagnostic,prognostic and therapeutic roles
作者机构：School of PharmacyUniversity of CamerinoCamerino 62032Italy Department of Molecular MedicineUniversity of Rome SapienzaRome 00161Italy Medical Oncology UnitHospital of MacerataMacerata 62100Italy School of Biosciences and Veterinary MedicineUniversity of CamerinoCamerino 62032Italy
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2020年第6卷第1期
页 面：225-238页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：PRIN 2017 and Fondazione Umberto Veronesi(Post-doctoral Fellowship 2019 to Morelli MB)
主 题：Glioma microRNA long non-coding RNA p21^(Cip1) glioma stem cells
摘 要：Glioblastoma multiforme is considered one of the most common malignant primary intracranial *** treatment with a combination of surgery,chemotherapy and radiotherapy,patients with glioblastoma multiform have poor *** has been widely accepted that the occurrence,progression,and even recurrence of glioblastoma multiforme strictly depends on the presence of glioma cancer stem *** presence of glioma stem cells reduces the efficacy of standard therapies,thus increasing the imperative to identify new targets and therapeutic strategies in glioblastoma *** this regard,the p21^(Cip1)pathway has been found to play an important role in the maintenance of the glioma stem *** has been shown that this pathway regulates cancer stem cell pool by preventing hyperproliferation and ***,endogenous small non-coding RNAs,and long non-coding RNAs,regulate post-transcription gene *** are not only altered in glioma,but also in other cancer types,and are involved in tumor development and ***,they have also been shown to modulate the expression of proteins in the p21^(Cip1)signaling *** review highlights the extent and complexity of cross-talk between microRNAs,long non-coding RNAs and the p21^(Cip1)pathway,and demonstrates how such interplay orchestrates the regulation of protein expression and functions in glioma and glioma stem cells.
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