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Neural Regeneration Research 2018年第9期13卷 1619-1621页

作者： Damiana Scuteri maria Roberta Garreffa Stefania Esposito Giacinto Bagetta maria Diana Naturale maria Tiziana Corasaniti Preclinical and Translational Pharmacology Department of Pharmacy Health Science and NutritionUniversity of Calabria Pharmacy Unit "Mater Domini" University Hospital Department of Health Sciences University "Magna Graecia" of Catanzaro

During the clinical course of dementia,beside cognitive impairment and memory loss,a very complex challenge is posed by the neuropsychiatric symptoms（NPSs）.Accurate evaluation and treatment of pain impacts positively the agitation of demented patients aged ≥ 65 *** gather information on the utilization of pain killers in demented patients a preliminary survey has been conducted in collaboration with the Calabrian Pharmacovigilance Territorial Service of the health district of Catanzaro（Italy）.The study has taken into consideration the prescriptions of acetylcholinesterase inhibitors and memantine during the period ranging from July 2015 to June 2016 and the percentage of patients treated against pain with non steroidal antinflammatory drugs,opioids,and anticonvulsants have been *** latter have been evaluated statistically for difference between the treatment before（pre） and after（post） the settlement of acetylcholinesterase inhibitors（ACh EI） or memantine *** results do support accuracy in painkillers utilization in the course of dementia in the regional population of Calabria（Italy）.

关键词： Alzheimer's disease dementia neuropsychiatric symptoms pain appropriate prescriptions aromatherapy opioids α2δ-1 ligands

Comparison of PM_(10) concentrations and metal content in three different sites of the Venice Lagoon: An analysis of possible aerosol sources

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Journal of Environmental Sciences 2012年第11期24卷 1954-1965页

作者： Daniele Contini Franco Belosi Andrea Gambaro Daniela Cesari Angela maria Stortini maria Chiara Bove Institute of Atmospheric Sciences and Climate ISAC-CNRLecceItaly Institute of Atmospheric Sciences and Climate ISAC-CNRBolognaItaly Department of Environmental Sciences Informatics and StatisticsUniversity Ca'Foscari of VeniceVeneziaItaly Institute of Atmospheric Sciences and Climate ISAC-CNRLecceItaly. Institute for the Dynamics of Environmental Processes IDPA-CNRVeneziaItaly

The Venice Lagoon is exposed to atmospheric pollutants from industrial activities, thermoelectric power plants, petrochemical plants, incinerator, domestic heating, ship traffic, glass factories and vehicular emissions on the mainland. In 2005, construction began on the mobile dams （MOSE）, one dam for each channel connecting the lagoon to the Adriatic Sea as a barrier against high tide. These construction works could represent an additional source of pollutants. PM10 samples were taken on random days between 2007 and 2010 at three different sites： Punta Sabbioni, Chioggia and Malamocco, located near the respective dam construction worksites. Chemical analyses of V, Cr, Fe, Co, Ni, Cu, Zn, As, Mo, Cd, Sb, T1 and Pb in PM10 samples were performed by Inductively coupled plasma- quadrupole mass spectrometry （ICP-QMS） and results were used to identify the main aerosol sources. The correlation of measured data with meteorology, and source apportionment, failed to highlight a contribution specifically associated to the emissions of the MOSE construction works. The comparison of the measurements at the three sites showed a substantial homogeneity of metal concentrations in the area. Source apportionment with principal component analysis （PCA） and positive matrix factorization （PMF） showed that a four principal factors model could describe the sources of metals in PM10. Three of them were assigned to specific sources in the area and one was characterised as a source of mixed origin （anthropogenic and crustal）. A specific anthropogenic source of PM10 rich in Ni and Cr, active at the Chioggia site, was also identified.

关键词： MOdulo Sperimentale Elettromeccanico metals Venice Lagoon PM10 principal component analysis positive matrixfactorization

Glutamate receptors and glutamatergic signalling in the peripheral nerves

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Neural Regeneration Research 2020年第3期15卷 438-447页

作者： Ting-Jiun Chen maria Kukley Center for Neuroscience Research Children’s Research InstituteChildren’s National Medical CentreWashingtonDCUSA Group of Neuron Glia Interaction University of TübingenTübingenGermany Research Institute of Ophthalmology Tübingen University HospitalTübingenGermany

In the peripheral nervous system,the vast majority of axons are accommodated within the fibre bundles that constitute the peripheral *** within the nerves are in close contact with myelinating glia,the Schwann cells that are ideally placed to respond to,and possibly shape,axonal *** mechanisms of intercellular communication in the peripheral nerves may involve direct contact between the cells,as well as signalling via diffusible *** glutamate has been proposed as a candidate extracellular molecule mediating the cross-talk between cells in the peripheral *** types of experimental findings support this idea:first,glutamate has been detected in the nerves and can be released upon electrical or chemical stimulation of the nerves;second,axons and Schwann cells in the peripheral nerves express glutamate ***,the studies providing direct experimental evidence that intercellular glutamatergic signalling takes place in the peripheral nerves during physiological or pathological conditions are largely ***,in the central nervous system,axons and myelinating glia are involved in glutamatergic *** signalling occurs via different mechanisms,the most intriguing of which is fast synaptic communication between axons and oligodendrocyte precursor *** receptors and/or synaptic axon-glia signalling are involved in regulation of proliferation,migration,and differentiation of oligodendrocyte precursor cells,survival of oligodendrocytes,and re-myelination of axons after *** synaptic signalling exist between axons and Schwann cells in the peripheral nerves?What is the functional role of glutamate receptors in the peripheral nerves?Is activation of glutamate receptors in the nerves beneficial or harmful during diseases?In this review,we summarise the limited information regarding glutamate release and glutamate receptors in the peripheral nerves and speculate about possible mechanisms of

关键词： AMPA receptors axons glutamate metabotropic glutamate receptors myelination nerve injury NMDA receptors peripheral nervous system PNS Schwann cells synaptic signalling

Composition of Fractional Orlicz Maximal Operators and A1-weights on Spaces of Homogeneous Type

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Acta Mathematica Sinica,English Series 2010年第8期26卷 1509-1518页

作者： Ana L. BERNARDIS Gladis PRADOLINI maria LORENTE maria Silvina RIVEROS IMAL ( CONICET)-FIQ (UNL) Guemes 3450 (3000) Santa Fe Argentina Departamento de Analisis Matemdtico Facultad de CienciasUniversidad de Malaga 29071-Malaga Spain FaMAF Universidad Nacional de Cordoba CIEM ( CONICET) 5000 Cordoba Argentina

For a Young function θ with 0 ≤α 〈 1, let Mα,θ be the fractional Orlicz maximal operator defined in the context of the spaces of homogeneous type （X, d, μ） by Mα,θf（x） = supx∈（B）α ｜｜f｜｜θ,B, where ｜｜f｜｜θ,B is the mean Luxemburg norm of f on a ball B. When α= 0 we simply denote it by Me. In this paper we prove that if Ф and ψare two Young functions, there exists a third Young function θ such that the composition Mα,ψ o MФ is pointwise equivalent to Mα,θ. As a consequence we prove that for some Young functions θ, if Mα,θf 〈∞a.e. and δ ∈（0,1） then （Mα,θf）δ is an A1-weight.

关键词： Orlicz maximal function spaces of homogeneous type weights

γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential

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Signal Transduction and Targeted Therapy 2018年第1期3卷 90-95页

作者： maria Alvarado-Kristensson Molecular Pathology DepartmentofTranslationalMedicineLundUniversitySkåneUniversityHospitalMalmö20502Sweden

Knowledge ofγ-tubulin is increasing with regard to the cellular functions of this protein beyond its participation in microtubule nucleation.γ-Tubulin expression is altered in various malignancies,and changes in the TUBG1 gene have been found in patients suffering from brain *** review recapitulates the known functions ofγ-tubulin in cellular homeostasis and discusses the possible influence of the protein on disease development and cancer.

关键词： homeostasis cancer. therapeutic

Conductivity improvement of Ce_(0.8)Gd_(0.2)O_(1.9) solid electrolyte

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Journal of Rare Earths 2009年第4期27卷 655-660页

作者： Sebastian Molin maria Gazda Piotr Jasinski Faculty of Electronics Telecommunications and Informatics Gdansk University of Technology ul.Narutowicza 11/12 80-952 Gdansk Poland Faculty of Applied Physics and Mathematics Gdansk University of Technology ul.Narutowicza 11/12 80-952 Gdansk Poland

Solid oxide fuel cells based on doped cefia electrolytes offer operating temperatures of -600℃. During recent years much atten- tion was aimed at successful powder preparation with high sinter activity and high conductivity. The properties of ceria electrolyte are very sensitive to impurities introduced during powder and electrolyte fabrication. One of the most successful and commercially available processes for the production of clean powders is based on the addition of several percent metallic cations that will react with impurities and segregate into the triple points of grain boundaries. In this work the results obtained from doping of CGO20 by 2% Ca and prepared by different routes were presented. The way of introducing Ca seemed to play an important role.

关键词： rare earth solid elecllolyte electrical properties impedance spectroscopy fuel cell solid oxide fuel cells (SOFC)

Vedolizumab for inflammatory bowel disease:from randomized controlled trials to real-life evidence

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World Journal of Gastroenterology 2018年第23期24卷 2457-2467页

作者： maria Lia Scribano IBD Unit Azienda Ospedaliera San Camillo-forlanini

The biologic antitumor necrosis factor alpha(anti-TNFα) agents have revolutionised the treatment of inflammatorybowel disease(IBD). However,some patients experience primary nonresponse,loss of response,or intolerance. Therefore,introducing a newer class of therapy with a mechanism of action that acts on different inflammatory pathways involved in IBD pathogenesis is appealing. Vedolizumab is a fully humanised monoclonal antibody that selectively targets α4β7 integrin. Based on the results of the pivotal clinical GEMINI trials,vedolizumab was approved for the treatment of adult patients with moderately to severely active ulcerative colitis(UC) and Crohn's disease(CD) refractory or intolerant to either conventional therapy or TNFα inhibitors. This review describes the efficacy,safety,and tolerability of vedolizumab reported in both randomized,controlled,clinical trials and from real-world experience in patients with UC and CD in order to identify its place in treatment algorithms for IBD.

关键词： Vedolizumab Crohn’s disease Real-world Efficacy Ulcerative colitis Controlled trial Effectiveness Safety

Analysis of hydrodynamic effects on biofilm thickness in fluidized-bed tapered bioreactors

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Particuology 2021年第5期19卷 48-57页

作者： Daniela maria Koerich Leonardo Machado da Rosa Chemical Engineering Department University of Blumenau(FURB)3250 Sao Paulo Street89030-000 BlumenauSanta CatarinaBrazil

Fluidized beds in tapered geometries provide advantages such as a broad range of optimum operating ***,the dynamics of the flow inside these bioreactors is significantly more complex,as they promote non-uniform bioparticles *** this end,the CFD technique can give a detailed description of the flow in the ***,the aim of this work is to assess the influence of the hydrodynamic on the steady-state biofilm thickness through numerical simulations of liquid–solid fluidized *** geometries of tapered bioreactors in the operating conditions used to develop *** were run to solve the two-phase RANS equations using the open-source software OpenFOAM in *** SST k−ω model was used to estimate the turbulent features of the *** and bioparticles distribution inside the reactor were analyzed for different inlet velocities,while bioparticles collision frequency and shear stresses were evaluated for various operating *** comparison between the turbulent kinetic energy and the granular temperature indicated that the fluid flow is more turbulent than the bioparticles *** hydrodynamics influence on the steady-state biofilm thickness was assessed,and results led to the conclusion that biofilm is more sensitive to hydrodynamic shear stress than bioparticles collisions.

关键词： Liquid-solid fluidization Shear stress Particles collisions Computational fluid dynamics Biofilm Tapered bioreactors

Predetermination of potential plastic hinges on reinforced concrete frames using GFRP reinforcement

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Frontiers of Structural and Civil Engineering 2022年第5期16卷 624-637页

作者： Dominik KUERES Dritan TOPUZI maria Anna POLAK Department of Civil and Environmental Engineering University of WaterlooWaterlooON N2L 3G1Canada Schoeck Canada Inc. OttawaON K1P 5G3Canada

In the past,glass fiber-reinforced polymer(GFRP)-reinforcement has been successfully applied in reinforced concrete(RC)structures where corrosion resistance,electromagnetic neutrality,or cuttability were *** investigations suggest that the application of GFRP in RC structures could be advantageous in areas with seismic activity due to their high deformability and ***,especially the low modulus of elasticity of GFRP limited its wide application as GFRP-reinforced members usually exhibit considerably larger deformations under service loads than comparable steel-reinforced *** overcome the aforementioned issues,the combination of steel and GFRP reinforcement in hybrid RC sections has been investigated in the *** on this idea,this paper presents a novel concept for the predetermination of potential plastic hinges in RC frames using GFRP *** analyze the efficiency of the concept,nonlinear finite element simulations were *** results underscore the high efficiency of hybrid steel-GFRP RC sections for predetermining potential plastic hinges on RC *** results also indicate that the overall seismic behavior of RC structures could be improved by means of GFRP as both the column base shear force during the seismic activity as well as the plastic deformations after the earthquake were considerably less pronounced than in the steel-reinforced reference structure.

关键词： glass fiber-reinforced polymer GFRP hybrid section plastic hinge seismic design reinforced concrete

Carbon sequestration in a bamboo plantation:a case study in a Mediterranean area

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Journal of Forestry Research 2024年第3期35卷 231-238页

作者： Tommaso Chiti Emanuele Blasi maria Vincenza Chiriaco Department for Innovation in Biological Agro-Food and Forest Systems(DIBAF)University of TusciaVia San C.De Lellis snc01100 ViterboItaly Foundation Euro-Mediterranean Center on Climate Change(CMCC) Division on Climate Change Impacts on AgricultureForests and Ecosystem Services(IAFES)Via Garbini5101100 ViterboItaly

In the Mediterranean region,despite bamboo being an alien species that can seriously alter plant and ani-mal biocoenosis,the area occupied by bamboo plantations continues to increase,especially for the purpose to seques-ter carbon(C).However,the C dynamics in the soil-plant system when bamboo is grown outside its native area are poorly *** we investigated the C mitigation potential of the fast-growing Moso bamboo(Phyllostachys edulis)introduced in Italy for climate-change *** analyzed aboveground(AGB)and belowground(as root/shoot ratio)biomass,litter and soil organic C(SOC)at O-15-and 15-30-cm depths in a 4-year-old bamboo plantation in comparison with the former annual cropland on which the bamboo was *** have an idea of the maximum C stored at an ecosystem level,a natural forest adjacent the two sites was also *** the plantation,C accumulation as AGB was stimulated,with 14.8±3.1 Mg C ha^(-1) stored in 3 years;because thinning was done to remove culms from the first year,the mean sequestration rate was 4.9 Mg C ha^(-1) a^(-1).The sequestration rates were high but comparable to other fast-growing tree species in Italy(e.g.,Pinus nigra).SOC was significantly higher in the bamboo plantation than in the cropland only at the 0-15 cm depth,but SOC stock did not *** 4 years were not enough time for a clear increase in SOC,or the high nutrient uptake by bamboos might have depleted the soil nutrients,thus inhibiting the soil organic matter formation by *** comparison,the natural forest had significantly higher C levels in all the *** C dynamics at an ecosystem level,the bamboo plantation on the former annual cropland led to substantial C removal from the atmosphere(about 12 Mg C ha^(-1) a^(-1)).However,despite the promising C sequestration rates by bamboo,its introduction should be carefully considered due to potential ecological problems caused by this species in overexploited environments such as the Med

关键词： Carbon sequestration Climate change mitigation Mediterranean area Moso bamboo Soil organic carbon