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Colorectal Cancer Surgery in Extreme Elderly Population

j.urnal of Cancer Therapy 2015年第1期6卷 12-20页

作者： j.vier Gallego Plazas Elena Asensio j.an C. Navalon Inmaculada Lozano j.se M. Navarro Guillermo Ricote Montse Olcina Almudena Cotes Henry M. Ore Alej.ndra Magdaleno maria C. Ors maria j. escudero Miguel A. Morcillo Servicio de Oncología Médica Hospital General Universitario de Elche-Hospital Vega Baja Alicante Espana Servicio de Cirugía General Hospital Vega Baja Alicante Espana

Background: Colorectal cancer surgery in extreme elderly population (380 years) is a growing problem and a subj.ct in question. Experiences and results in this scenario are limited. Methods: Medical records of patients?380 years old hospitalized in General Surgery Department in Vega Baj. Hospital between j.nuary 1st 2008 and December 31st 2012 were retrospectively reviewed. Patients diagnosed with colorectal cancer (CRC) were selected. Data regarding comorbidities, treatment performed, complications and survival were collected. Results: 95 patients (74 colon, 21 rectum) were identified: median age 83.0 years (80 - 93), 64.2% males. 93.7% of patients were operated on: median hospital and post-operative stay of 11 and 9 days, respectively;curative intention surgery 82.1%. 4.2% of patients were treated with interventionist procedures, and 2.1% of patients in a conservative way. 17.9% and 4.2% of patients came up with early and late complications, respectively. Early and late mortality occurred in 9.5% and 3.2% of patients, respectively. By March 2014, with a median follow up of 43.8 months, median overall survival for colorectal cancer patients was 2.7 years (95%IC, 2.0 - 3.2). Univariaye Cox Regresion analysis revealed the presence of cardiomyopathy (p = 0.024), the presence of chornic kidney disease (p = 0.025), the presence of comorbidities (vs absence) (0.026), the number of comorbidities (0.034), type of admission (p = 0.001), treatment with surgery (p = 0.001) and the incidence of early (p = 0.004) or late complications (p = 0.023) associated to overall survival with statically significance. Multivariate Cox Regression analysis showed number of comorbidities (HR = 1.104;95%CI: 0.851 - 1.431;p = 0.456), treatment with surgery (HR = 4.928;95%CI: 1.815 - 13.385;p = 0.002), programmed admission into hospital (HR = 2.316;95%CI: 1.298 - 4.133;p = 0.004), and the incidence of late complications (HR = 4.629;95%CI: 1.279 - 16.750;p = 0.020) independently associated with o

关键词： Colorectal Cancer Surgery Elderly

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Phase Transformation under Continuous Cooling Conditions in Medium Carbon Microalloyed Steels

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j.urnal of Materials Science & Technology 2014年第5期30卷 511-516页

作者： Manuel Gomez Lucia Rancel Esther escudero Sebastian F.Medina National Centre for Metallurgical Research CENIM-CSICAv.Gregorio del Amo 828040 MadridSpain

Several 35CrMo4 and 38MnV7 steels with different additions of Ti and V were manufactured by electroslag remelting. The influence of the alloying and microalloying elements on phase transformation at different cooling rates was studied and the continuous cooling transformation diagrams were plotted. In order to optimize the heat treatment and improve the mechanical properties, the range of cooling rates leading to a fully bainitic microstructure （without ferrite, pearlite and especially without martensite） was determined. Bainite and martensite transformation start temperatures （Bs, Ms） were also established and compared with the values predicted by empirical equations. The important role of precipitates （especially V carbonitride particles） on final microstructure and mechanical properties was assessed.

关键词： Microalloyed steel Phase transformation Precipitation Dilatometry Continuous cooling transformation diagram

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Therapeutic potential of insulin-like growth factor 2 in Huntington's disease: controlling proteostasis to alleviate the load of misfolded protein

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Neural Regeneration Research 2021年第8期16卷 1564-1565页

作者： Paulina Troncoso-escudero Claudio Hetz Rene L.Vidal Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Center for Geroscience Brain Health and MetabolismSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesUniversity of ChileSantiagoChile Center for Integrative Biology Faculty of SciencesUniversity MayorChile Buck Institute for Research on Aging NovatoCAUSA

Huntington's disease(HD) is an inherited autosomal dominant neurodegenerative disorder characterized by the development of adult-onset motor dysfunction,psychiatric disturbances and intellectual *** is associated with an expansion of CAG repeat sequence in the huntingtin gene(Htt).Exon 1 of Htt normally contains between 6 to 35 CAG repeats,whereas in patients affected with HD it contains more than 40 trinucleotides.

关键词： Huntington Therapeutic stasis

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Pharmacogenetics of hepatocellular carcinoma and cholangiocarcinoma

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Cancer Drug Resistance 2019年第3期2卷 680-709页

作者： Marta Alonso-Peña Anabel Sanchez-Martin Paula Sanchon-Sanchez Meraris Soto-Muñiz Ricardo Espinosa-escudero j.se j.G.Marin Experimental Hepatology and Drug Targeting(HEVEFARM) IBSALUniversity of SalamancaSalamanca 37007Spain Center for the Study of Liver and Gastrointestinal Diseases(CIBERehd).Carlos III National Institute of Health Madrid 28029Spain.

Primary liver cancers constitute the fourth most deadly group of *** poor prognosis is due in part to the pre-existence and/or development,often during treatment,of powerful mechanisms accounting for the poor response of cancer cells to antitumor *** include both impaired gene expression and the appearance of spliced variants,polymorphisms and mutations,affecting the function of genes leading to the reduction in intracellular concentrations of active agents,changes in molecular targets and survival pathways,altered tumor microenvironment and phenotypic *** present review summarizes available information regarding the role of germline and somatic mutations affecting drug transporters,enzymes involved in drug metabolism,organelles and signaling molecules related to liver cancer chemoresistance.A more complete picture of the actual complexity of this problem is urgently needed for carrying out further pharmacogenomic studies aimed to improve the management of patients suffering from hepatocellular carcinoma or cholangiocarcinoma.

关键词： Anticancer drug chemoresistance chemotherapy cholangiocarcinoma germline mutation hepatoma liver cancer somatic mutation

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Implementation outcomes of a sensory integration therapy program with computerized dynamic posturography in patients with balance and sensory dysfunction

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j.urnal of Otology 2023年第1期18卷 26-32页

作者： Francisco j.vier Gonzalez Eslait Paola Andrea escudero Trivino Yaidy Viviana Giraldo Vergara Monica Andrea Morales Garcia Vanessa Fernanda Lucero Gutierrez Universidad del Valle Audiological and Otological Balance CenterImbanaco Clinic-Grupo Quiron SaludCaliColombia Research Institute.Imbanaco Clinic-Grupo Quiron Salud CaliColombia

Obj.ctive:We describe the first-year implementation experience of an Instrumented Sensory Integration Therapy Program in Audiological&Balance Center ***:This is a retrospective descriptive *** included Seventy-three adults with diagnoses of acute,episodic,or chronic vestibular *** were classified into the following two groups:group 1 included 46 individuals treated with ISIT plus VRT,and group 2 included 27 individuals treated only with ***:The Sensory Organization Test(SOT)for both groups showed a statistical significance for all three sensory inputs;visual systems(G1:p=0.0003;G2:p=0.0337),vestibular system(G1:p<0.0001;G2:p=0.0003),and balance as demonstrated by compound balance score(G1:p<0.0001;G2:p=0.0035),and balance percentage deficit(G1:p<0.0001;G2:p=0.0078).Conclusions:The severity and complexity of functional neurological disorders in the context of vestibular syndromes seem to require between 10 and 20 therapy sessions,and combined ISIT plus VRT appears to be more effective than ISIT as a monotherapy.

关键词： Posturography Vestibular rehabilitation therapy Dizziness handicap inventory

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尿道超声成像的优化:钳夹法

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国际医学放射学杂志 2018年第4期 488-489页

作者： j.de Dios Berná-Mestre T.Balmaceda D.Martínez j.F.escudero G.Martínez j.A.García 郑孝飞 Department of Radiology Virgen de la Arrixaca University Hospital

目的描述经会阴入路行逆行超声造影(RSUG)和增强排尿超声造影(CE-VSUG)的钳夹方法。方法在2011年—2015年期间通过对接受经尿道超声造影钳夹方法证实为尿道狭窄的113例男性(14～86岁)进行了前瞻性研究。计算定量变量的特征参数并采用McN... 详细信息

目的描述经会阴入路行逆行超声造影(RSUG)和增强排尿超声造影(CE-VSUG)的钳夹方法。方法在2011年—2015年期间通过对接受经尿道超声造影钳夹方法证实为尿道狭窄的113例男性(14～86岁)进行了前瞻性研究。计算定量变量的特征参数并采用McNemar测试对定性变量进行比较分析。结果所有病例(113例)均成功进行了RSUG检查,共检出49例前尿道狭窄,其中5例(10.2%)近端球部狭窄未在逆行尿道造影(RUG)中观察到(P<0.05)。CE-VSUG手术成功97例,后尿道狭窄82例,其中6例(7.3%)膀胱颈狭窄未在排尿膀胱尿道造影(VCUG)中观察到(P<0.05)。逆行膀胱充盈约6 min内完成。结论该钳夹方法使RSUG和CE-VSUG能够由1名操作员简单、有效和无痛地完成。它还可以评估尿道口改变(狭窄、尿道下裂和切开术)的病例。

关键词：超声造影 CE 尿道狭窄

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半化学谷草浆的制造和无硫木素的回收,一种清洁和可盈利的方法

半化学谷草浆的制造和无硫木素的回收,一种清洁和可盈利的方法

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1999中国造纸学会学术报告会

作者： Enrique escudero 秦文焕

谷草浆的利用在生态及工艺领域占有重要的地位,但在西方已大为减少,实际上已不再使用谷草浆。主要原因是价格问题,而且谷草制浆不可避免地会产生废水处理问题。本文分析了价格因素,虽然谷草浆的价格比回收纸浆高出很多,但是可以找到降...

谷草浆的利用在生态及工艺领域占有重要的地位,但在西方已大为减少,实际上已不再使用谷草浆。主要原因是价格问题,而且谷草制浆不可避免地会产生废水处理问题。本文分析了价格因素,虽然谷草浆的价格比回收纸浆高出很多,但是可以找到降低价格的办法。同时还介绍了废水处理方法。采用这些方法可生产出销路好并可回收的产品,降低纸浆的整体价格。最后残留的灰份易于排除。而且提取的蒸馏水绝对无害,可100％再利用。

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RES:定制材料成形

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世界建筑导报 2015年第4期30卷 38-40页

作者： Andre Felipe escudero Dimitrij. Miletic Giovanni Parodi Dimitar Pouchnikovl Robert Stuart-Smith

该研究策略性地执行了场外和现场施工流程,从而创造出一种能够将浪费最小化的设计和施工方法,无需在现场使用大量脚手架,并能带来成形生产工艺所固有的新的设计潜力。该项目设计了一座采用轻型纤维复合材料的宜居桥梁。桥梁预制件切自... 详细信息

该研究策略性地执行了场外和现场施工流程,从而创造出一种能够将浪费最小化的设计和施工方法,无需在现场使用大量脚手架,并能带来成形生产工艺所固有的新的设计潜力。该项目设计了一座采用轻型纤维复合材料的宜居桥梁。桥梁预制件切自工厂的平面纤维材料,然后将其裁剪组合成三维构件,这种方式类似于对大块布料的操作方式。

关键词：纤维复合材料 RES 纤维材料在现场施工方法 factory 生产工艺 costly 结构分析 fibre

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用促性腺激素释放激素拮抗剂与重组卵泡刺激素行卵巢刺激患者的血清黄体生成素水平及其与周期结局的关系

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世界核心医学期刊文摘（妇产科学分册） 2006年第3期2卷 40-40页

作者： Bosch E. escudero E. Crespo j. A. Pellicer 李跃萍 Instituto Valenciano de Infertilidad Plaza Polica Local 3 46015 Valencia Spain Dr.

The serum LH was determined on days 3, 6, and 8 of stimulation and on the day of hCG in 110 normogonadotropic patients undergoing controlled ovarian hyperstimulation (COH) for IVF induced with GnRH antagonists and recombinant FSH, creating three groups of patients according to Tukey’s hinges (percentiles 25 and 75) for each determination. No differences were observed between the number of oocytes recovered or the fertilization, implantation, and pregnancy rates (PR) of the groups, although patients with high serum LH levels during stimulation showed significantly higher serum E2 levels on the day of hCG.

关键词：卵巢刺激卵泡刺激素黄体生成素控制性超排卵体外受精种植率拮抗剂

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颈动脉血管成形和支架置入术后神经元的兴奋性中毒

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国际医学放射学杂志 2013年第5期 484-484页

作者： F.Nombela M.Blanco N.Pérez de la Ossa j.L.Caniego T.Sobrino D.escudero 谢菲 Stroke Unit Departments of Neurology and NeuroradiologyHospital Universitario La PrincesaPrincesa Health Research Institute

摘要目的缺血性梗死和短暂缺血性发作可导致血浆谷氨酸含量升高,但引起其升高所需的缺血时间尚无研究报道。本研究评估颈动脉血管成形和支架置入术(CAS)后血浆谷氨酸含量是否会升高。材料与方法所有病人或其亲属都已签署知情同意书。本... 详细信息

摘要目的缺血性梗死和短暂缺血性发作可导致血浆谷氨酸含量升高,但引起其升高所需的缺血时间尚无研究报道。本研究评估颈动脉血管成形和支架置入术(CAS)后血浆谷氨酸含量是否会升高。材料与方法所有病人或其亲属都已签署知情同意书。本研究使用高效液相色谱法测定74例CAS术后病人的血浆谷氨酸含量。经动脉和外周静脉置入导管抽取术前及术后的血液标本,其中静脉血标本分别于CAS

关键词：颈动脉血管成形术后病人血浆 CAS 支架置入术谷氨酸 α-氨基戊二酸神经递体

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