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Oral Cancer:Health Promotion and Visual Screening—A Study Report

Journal of Cancer Therapy 2013年第8期4卷 1313-1320页

作者： Augusta P.Silveira Augusta Marques Miguel Pavao Eurico Monteiro Gabriela Pereira Joaquim Goncalves Luís Castro maria ines guimaraes Bernardete Carvalho Claudia Ribeiro Teresa Sequeira Faculty of Heath Sciences Fernando Pessoa UniversityPortoPortugal Centre of Health Studies and Research Coimbra UniversityCoimbraPortugal Non-Governmental Organization(NGO):Mundo A Sorrir PortoPortugal Portuguese Institute for Oncology PortoPortugal Instituto Politecnico do Cavado e do Ave BarcelosPortugal Porto Portugal Well Medical Spa PortoPortugal Health Sciences Department Portuguese Catholic UniversityViseuPortugal

Background: Oral cancer presents a heterogeneous geographic incidence. Annually, more than 275,000 new cases are diagnosed worldwide. In spite of the easy accessibility of oral cavity during physical examination, most malignancies are not diagnosed until late stages of disease. Methods: Oral health promotion was our main objective, risk factors were identified and oral cavity self-examination was promoted. The population considered (n = 1117) was divided in two main age groups—a youngest (individuals under 25 years old) mostly targeted for oral cancer awareness and oral cavity self examination promotion, and an older group having accumulated potential risk exposure. Results: The results obtained revealed smoking habits and fruits-vegetables consumption deficit as the highest risks factors found. Considering a Risk Factor Exposure Index analysis, individuals with secondary level of instruction and living in sub-urban areas assumed the highest risk exposure. Alcohol consumption had also contributed as a significant risk exposure. Conclusions: Some of these risk factors work as biological reward of quality of life deficit. A wide comprehension of the problem requires a multidisciplinary approach necessarily involving Health and Social Sciences in order to target the core of oral cancer health promotion. An effective epidemiological strategy must thus support three major aspects: population knowledge, sensitization and visual screening.

关键词： Oral Cancer Visual Screening Oral Health Promotion Epidemiological Strategies

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Long noncoding RNAs:a missing link in osteoporosis

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Bone Research 2019年第1期7卷 25-40页

作者： Andreia Machado Silva Sara Reis Moura JoseHenrique Teixeira Mario Adolfo Barbosa Susana Gomes Santos maria ines Almeida i3S-Instituto de Investigacao e Inovacao em Sau.de University of PortoPortoPortugal INEB-Instituto de Engenharia Biomedica University of PortoPortoPortugal ICBAS-Instituto de Ciências Biomedicas Abel Salazar University of PortoPortoPortugal

Osteoporosis is a systemic disease that results in loss of bone density and increased fracture risk,particularly in the vertebrae and the *** condition and associated morbidity and mortality increase with population *** noncoding(lnc)RNAs are transcripts longer than 200 nucleotides that are not translated into proteins,but play important regulatory roles in transcriptional and post-transcriptional *** contribution to disease onset and development is increasingly ***,we present an integrative revision on the studies that implicate lncRNAs in osteoporosis and that support their potential use as therapeutic ***,current evidence on lncRNAs involvement in cellular and molecular mechanisms linked to osteoporosis and its major complication,fragility fractures,is *** analyze evidence of their roles in osteogenesis,osteoclastogenesis,and bone fracture healing events from human and animal model ***,the potential of lncRNAs alterations at genetic and transcriptomic level are discussed as osteoporosis risk factors and as new circulating biomarkers for ***,we conclude debating the possibilities,persisting difficulties,and future prospects of using lncRNAs in the treatment of osteoporosis.

关键词： Osteoporosis density lncRNAs

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Recurrent anal fistulae:Limited surgery supported by stem cells

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World Journal of Gastroenterology 2015年第11期21卷 3330-3336页

作者： Damian Garcia-Olmo Hector Guadalajara ines Rubio-Perez maria Dolores Herreros Paloma de-la-Quintana mariano Garcia-Arranz Hospital Fundación Jimenez Díaz Colorectal Surgery Unit University Hospital Fundación Jiménez Díaz Colorectal Surgery Unit La Paz University Hospital Cell Therapy Laboratory University Hospital Fundación Jiménez Díaz

AIM:To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal ***:Under controlled circumstances,and approved by European and Spanish laws,a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal *** had previously undergone multiple surgical interventions that had failed to resolve the fistulae,and presented symptomatic *** intervention consisted of limited surgery(with closure of the internal opening),followed by local implant of stem cells in the fistula-tract *** expanded adipose-derived stem cells were the main cell type selected for *** first evaluation was performed on the 8th postoperative week;outcome was classified as response or partial *** one year after the intervention confirmed if complete healing of the fistula was ***:Ten patients(8 male)with highly recurrent and complex fistulae were treated(mean age:49years,range:28-76 years).Seven cases were nonCrohn’s fistulae,and three were Crohn’s-associated *** surgical attempts ranged from 3to *** patients presented with preoperative incontinence(Wexner scores of 12 and 13 points).After the intervention,six patients showed clinical response on the 8th postoperative week,with a complete cessation of suppuration from the *** patients presented a partial response,with an evident decrease in suppuration.A year later,six patients(60%)remained healed,with complete reepithelization of the external *** Wexner Scores were 0 in six *** two patients with previous incontinence improved their scores from12 to 8 points and from 13 to 5 *** adverse reactions or complications related to stem-cell therapy were reported during the study ***:Stem cells are safe and useful for treating anal *** can be achieved in severe cases,sparing fecal incontinence risk,and impr

关键词： Adipose-derived stem cells Cell therapy Compassion

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A theragenerative bio-nanocomposite consisting of black phosphorus quantum dots for bone cancer therapy and regeneration

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Bioactive Materials 2024年第5期35卷 99-121页

作者： Ashkan Bigham ines Fasolino Silvia Borsacchi Carmen Valente Lucia Calucci Gabriele Turacchio marianna Pannico Manuel Serrano-Ruiz Luigi Ambrosio maria Grazia Raucci Institute of Polymers Composites and BiomaterialsNational Research Council of Italy(IPCB-CNR)Viale John Fitzgerald Kennedy 54Mostra d’Oltremare Padiglione 2080125NaplesItaly Department of Chemical Materials and Production EngineeringUniversity of Naples Federico IIPiazzale V.Tecchio 8080125NaplesItaly Institute for the Chemistry of OrganoMetallic Compounds-ICCOM Italian National Research Council-CNRvia G.Moruzzi 156124Pis1Italy Center for Instrument Sharing of the University of Pisa(CISUP) 56126Pis1Italy Institute of Experimental Endocrinology and Oncology“G.Salvatore”(IEOS) National Research Council(CNR)Via Pietro Castellino 11180131NapoliItaly Institute of Polymers Compositesand BiomaterialsNational Research Council of Italy(IPCB-CNR)PozzuoliItaly Institute for the Chemistry of OrganoMetallic Compounds-ICCOM National Research Council-CNRSesto FiorentinoItaly Institute of Translational Pharmacology(IFT) National Research Council(CNR)Via Carducci 3267100L’Aquila(Italy).

Recently,the term theragenerative has been proposed for biomaterials capable of inducing therapeutic approaches followed by repairing/regenerating the tissue/*** study is focused on the design of a new theragenerative nanocomposite composed of an amphiphilic non-ionic surfactant(Pluronic F127),bioactive glass(BG),and black phosphorus(BP).The nanocomposite was prepared through a two-step synthetic strategy,including a microwave treatment that turned BP nanosheets(BPNS)into quantum dots(BPQDs)with 5±2 nm dimensions in *** effects of surfactant and microwave treatment were assessed in vitro:the surfactant distributes the ions homogenously throughout the composite and the microwave treatment chemically stabilizes the *** presence of BP enhanced bioactivity and promoted calcium phosphate formation in simulated body *** inherent anticancer activity of BP-containing nanocomposites was tested against osteosarcoma cells in vitro,finding that 150μg mL^(-1)was the lowest concentration which prevented the proliferation of SAOS-2 cells,while the counterpart without BP did not affect the cell growth ***,the apoptosis pathways were evaluated and a mechanism of action was *** irradiation was applied to induce further proliferation suppression on SAOS-2 cells through *** inhibitory effects of bare BP nanomaterials and nanocomposites on the migration and invasion of bone cancer,breast cancer,and prostate cancer cells were assessed in vitro to determine the anticancer potential of nanomaterials against primary and secondary bone *** regenerative behavior of the nanocomposites was tested with healthy osteoblasts and human mesenchymal stem cells;the BPQDs-incorporated nanocomposite significantly promoted the proliferation of osteoblast cells and induced the osteogenic differentiation of stem *** study introduces a new multifunctional theragenerative platform with promising potential for simultaneous bone cancer t

关键词： Bioactive glass Black phosphorus Microwave treatment Bone cancer therapy Tissue regeneration

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Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics

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Congenital Heart Disease 2022年第3期17卷 351-363页

作者： Eloisa Sassa Carvalho maria Francilene SSouza Kelly Cristina O.Abud Claudia R.P.Castro Juliano G.Penha Ana maria Thomaz Vanessa A.guimaraes Antonio Augusto Lopes Heart Institute(InCor) University of Sao Paulo School of MedicineSão PauloBrazil

Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac *** patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up ***:We analyzed a prospective cohort of 52 pediatric patients(age 3 to 35 months)looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery,defined as a systolic pressure greater than 30 mmHg by transthoracic *** corresponds to a mean pulmonary arterial pressure of>20 ***,echocardiographic and hemodynamic parameters were *** hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling *** postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio(PAP/SAP)obtained per patient during the first 6 h of postoperative ***:Among the factors that were investigated as possible predictors,perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis(p0.35 was 76%sensitive and 74%specific at predicting a systolic pulmonary arterial pressure of>30 mmHg 6 months after surgery(hazard ratio with 95%CI 8.972[2.428–33.158],p=0.002).Conclusion:The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome,and it was char

关键词： Pulmonary hypertension congenital heart disease Down syndrome pediatric cardiac surgery

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XEN^(■) implant and trabeculectomy medium-term quality of life assessment and comparison of results

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1941-1944页

作者： Ana Luisa Basilio Nuno Moura-Coelho ines Passos mariana Sa Cardoso Isabel Domingues maria Reina Rita Flores Teresa Gomes Ophthalmology Department Central Lisbon Hospital Center Lisbon 1169050Portugal

AIM: To evaluate and compare the quality of life of patients submitted to XEN~? implant or trabeculectomy and the relationship with potentially involved ***: A cross-sectional study of patients with advanced open-angle glaucoma who underwent implantation of XEN~?(group 1) and trabeculectomy(group 2) between October 2015 and February 2017. The studied variables were: age, gender, follow-up time, need of topical anti-hypertensive therapy, visual acuity and intraocular pressure(IOP). The quantification of the quality of life was attained through the Glaucoma Symptom Scale(GSS) questionnaire. RESULTS: Totally 34 eyes(34 patients) were included, 17 in each group. The mean GSS scores for group 1 were 42.6±6.8(median, 47; p25, 36.5; p75, 48.5) and for group 2 it was 41.6±7.0(median, 43; p25, 36.5; p75, 47.0; P=0.34). There was a strong negative correlation between the need for topical anti-hypertensive drugs and the GSS result in both groups(r=-0.88, P<0.01, r=-0.59, P=0.01, respectively) and a moderate negative correlation with IOP in group 1(r=-0.50, P=0.03).CONCLUSION: The analysis demonstrates the noninferiority of medium-term quality of life of one group in relation to the other(XEN~? implant and trabeculectomy). The number of topical anti-hypertensive drugs and IOP negatively influenced the quality of life.

关键词： quality of life XEN^(■) trabeculectomy

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SUMOylation Inhibition Mediated by Disruption of SUMO El-E2 Interactions Confers Plant Susceptibility to Necrotrophic Fungal Pathogens

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Molecular Plant 2017年第5期10卷 709-720页

作者： Laura Castano-Miquel Abraham Mas ines Teixeira Josep Segui Anna Perearnau Bhagyasree N. Thampi Arnaldo L. Schapire Natalia Rodrigo Gaelle La Verde Silvia Manrique maria Coca L. maria Lois Center for Research in Agricultural Genomics - CRAG Edifici CRAG-Campus UAB Bellaterra (Cerdanyola del Vall~s) 08193 Barcelona Spain

Protein modification by SUMO modulates essential biological processes in eukaryotes. SUMOylation is facilitated by sequential action of the El-activating, E2-conjugating, and E3-1igase enzymes. In plants, SUMO regulates plant development and stress responses, which are key determinants in agricultural productivity. To generate additional tools for advancing our knowledge about the SUMO biology, we have developed a strategy for inhibiting in vivo SUMO conjugation based on disruption of SUMO El-E2 interactions through expression of E1 SAE2uFDct domain. Targeted mutagenesis and phylogenetic analyses revealed that this inhibition involves a short motif in SAE2uFDct highly divergent across kingdoms. Transgenic plants expressing the SAE2UFDCt domain displayed dose-dependent inhibition of SUMO conjugation, and have revealed the existence of a post-transcriptional mechanism that regulates SUMO E2 conjugating enzyme levels. Interestingly, these transgenic plants displayed increased suscep- tibility to necrotrophic fungal infections by Botrytis cinerea and Plectosphaerella cucumerina. Early after fungal inoculation, host SUMO conjugation was post-transcriptionally downregulated, suggesting that targeting SUMOylation machinery could constitute a novel mechanism for fungal pathogenicity. These findings support the role of SUMOylation as a mechanism involved in plant protection from environmental stresses. In addition, the strategy for inhibiting SUMO conjugation in vivo described in this study might be applicable in important crop plants and other non-plant organisms regardless of their genetic complexity.

关键词： SUMQ inhibition development flowering necrotrophic fungi El-activating enzyme El-E2interaction disruption

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Recombination-Independent Mechanisms and Pairing of Homologous Chromosomes during Meiosis in Plants

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Molecular Plant 2014年第3期7卷 492-501页

作者： Olivier Da ines maria E. Gallego Charles I. White Genetique Reproduction et Developpement UMR CNRS 6293 Clermont UniversitY INSERM U1103 63171 Aubiere France

Meiosis is the specialized eukaryotic cell division that permits the halving of ploidy necessary for game- togenesis in sexually reproducing organisms, This involves a single round of DNA replication followed by two successive divisions. To ensure balanced segregation, homologous chromosome pairs must migrate to opposite poles at the first meiotic division and this means that they must recognize and pair with each other beforehand. Although understanding of the mechanisms by which meiotic chromosomes find and pair with their homologs has greatly advanced, it remains far from being fully understood. With some notable exceptions such as male Drosophila, the recognition and physical link- age of homologs at the first meiotic division involves homologous recombination. However, in addition to this, it is clear that many organisms, including plants, have also evolved a series of recombination-independent mechanisms to facili- tate homolog recognition and pairing. These implicate chromosome structure and dynamics, telomeres, centromeres, and, most recently, small RNAs. With a particular focus on plants, we present here an overview of understanding of these early, recombination-independent events that act in the pairing of homologous chromosomes during the first meiotic division,

关键词： meiosis homolog pairing chromatin centromeres telomeres.

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Glycoconjugation: An approach to cancer therapeutics

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World Journal of Clinical Oncology 2020年第3期11卷 110-120页

作者： maria I Molejon Gisela Weiz Javier D Breccia maria ines Vaccaro Institute of Earth and Environmental Sciences from La Pampa(INCITAP) National University of La PampaSchool of Natural Sciences(CONICET-UNLPam)Santa Rosa 6300La PampaArgentina Institute of Biochemistry and Molecular Medicine(UBACONICET) Department of PathophysiologySchool of Pharmacy and BiochemistryUniversity of Buenos AiresBuenos Aires C1113AADArgentina

Cancer constitutes the second leading cause of death globally and is considered to have been responsible for an estimated 9.6 million fatalities in *** treatments against gastrointestinal tumors have recently advanced,those interventions can only be applied to a minority of patients at the time of ***,new therapeutic options are necessary for advanced stages of the *** of antitumor agents,has been found to improve pharmacokinetic parameters,reduce side effects,and expand drug half-life in comparison with the parent *** addition,glycosylation of therapeutic agents has been proven to be an effective strategy for their targeting tumor tissue,thereby reducing the doses of the glycodrugs administered to *** review focusses on the effect of the targeting properties of glycosylated antitumor agents on gastrointestinal tumors.

关键词： Glycosylation Gastrointestinal cancers Antitumoral agents Therapeutic strategies Drug targeting

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High Temperature and Abscisic Acid Modified the Profile of Anthocyanins in Grape （Vitis vinifera L,）

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Journal of Life Sciences 2012年第7期6卷 758-765页

作者： Leonor Deis maria ines de Rosas Juan Bruno Cavagnaro Instituto de Biologla Agricola Mendoza Consejo Nacional de Investigaciones Cientifieas y Teenol6gicas (CON1CET) AIte Brown 500 PC. 5507 Chacras de Coria Argentina Facultad de Ciencias Agrarias Universidad Naeional de Cuyo Alte Brown 500 PC. 5507 Chacras de Coria Argentina

The predicted increase of temperature by effect of climatic change （1.5 ℃ to 4.5 ℃）, will affect some berry components. Anthocyanins and flavonols concentration are responsible of wine color. The level of anthocyanin is affected by light intensity, temperature, sugars, growth regulators and vineyard management. Abscisic acid （ABA） increases the synthesis of anthocyanin in grape. The object of study was to evaluate the effect of different temperature in berries in vitro, of two cultivars combined with ABA treatments. The treatments were control （C, water） and ABA treatment （1,000 ppm） and temperature： 25, 33 and 40 ℃. In Cabemet Sauvignon, 25 and 33 ~C did not affect anthocyanin total concentration but 40 ℃ produced a 30% decrease in anthocyanin. ABA treatment increased anthocyanin vs. C at 25 and 33 ℃, mainly due to glucosylated forms. But ABA ＋ 40 ℃ showed a 44-60% decrease in all anthocyanins forms compounds. Response of Malbec to the highest temperature （40 ℃）, at the end of ripening, was different; higher temperature produced only slight decrease of total anthocyanins concentration （decrease of 7%）. Combination of temperature ＋ ABA at 20℃ and 33℃ increased anthocyanin. But ABA ＋ 40℃ decreased glucosylated and cumarylated forms of anthocyanin.

关键词： Temperature ABA anthocyanins grape Malbec Cabernet Sauvignon.

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