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International Journal of Ophthalmology(English edition) 2021年第3期14卷 476-477页

作者： Leopoldo Spadea maria ilaria giannico Marta Armentano Ludovico Alisi Santino Pistella Department of Sense Organs Eye ClinicUniversity"LaSapienza"Rome 00185Italy

Dear Editor,We present an unusual case of acute graft rejection after photorefractive keratectomy(PRK),performed to correct high residual astigmatism after penetrating keratoplasty(PKP)for *** primary measures of succ... 详细信息

关键词： astigmatism acute keratoplasty

This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco maria Lisci Antonio maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi maria Chiara Spera Valeria De Masi Ester maria Marzo Francesca Abate Gianluca Boggio maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli mariateresa Acanfora Eleonora Gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

How toxic are gold nanoparticles？ The state-of-the-art

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Nano Research 2015年第6期8卷 1771-1799页

作者： ilaria Fratoddi Iole Venditti Cesare cametti maria Vittoria Russo Dipartimento di Chimica Universita' di Roma 'La Sapienza' Piazzale A. Moro 5 1-00185 Rome Italy Dipartimento di Fisica and INFM CNR-SOFT Universita' di Roma 'La Sapienza' Piazzale A. Moro 51-00185 Rome Italy

With the growing interest in the applications of gold nanoparticles in biotechnology and their physiological effects, possible toxicity of gold nanoparticles is becoming an increasingly important issue. A large number of studies carried out over the past few years under a variety of experimental conditions and following different protocols have produced conflicting results, leading to divergent views about the actual safety of gold nanoparticles in human applications. This work is intended to provide an overview of the most recent experimental results and thereby summarize current state-of-the-art. Rather than presenting a comprehensive review of the available literature in this field, which would be impractically broad, we have selected representative examples of both in vivo and in vitro studies, which clearly demonstrate the need for urgent and rigorous standardization of experimental protocols. Despite their significant potential, the safety of gold nanoparticles is highly controversial at this time, and important concerns have been raised that need to be properly addressed. Factors such as shape, size, surface charge, coating, and surface functionalization are expected to influence the interactions of particles with biological systems to a different extent, resulting in different outcomes and influencing the potential of gold nanoparticles for biomedical applications. Moreover, despite continuous attempts to establish a correlation between structure of the particles and their interactions with biological systems, we are still far from elucidating the toxicological profile of gold nanoparticles in an indisputable manner. This review is intended to contribute towards this goal, offering a number of suggestions on how to achieve the systematization of data on the most relevant physico-chemical parameters, which govern and control the toxicity of ~old nanot^articles at cellular and whole-organism levels.

关键词： gold nanoparticles nanospheres nanorods nanocages nanostars toxicity

A blockchain architecture for industrial applications

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Blockchain(Research and Applications) 2022年第4期3卷 1-13页

作者： Lodovica Marchesi Michele Marchesi Roberto Tonelli maria ilaria Lunesu Department of Mathematics and Computer Science University of CagliariCagliari09124Italy

Blockchain and the programs running on it,called smart contracts,are increasingly applied in all fields where trust and strong certifications are *** work focuses on industrial applications of blockchains and not on cryptocurrencies or *** use frameworks to compare public and permissioned blockchains specifically suited for industrial *** also propose a complete solution based on Ethereum to implement a decentralized application,putting together in an original way,components and patterns already used and *** solution is characterized by a set of validator nodes running the blockchain using Proof-of-Authority or similar efficient consensus algorithms,by the use of an explorer enabling users to check the blockchain state,and the source code of the smart contracts running on *** time to time,the hash digest of the last mined block is written into a public blockchain to guarantee *** right to send transactions is granted by validator nodes to users by endowing them with the Ethers mined ***,the proposed approach has the same transparency and immutability as a public blockchain,largely reducing its drawbacks.

关键词： Permissioned blockchain Industrial application Information system Software application Ethereum

Association between non-alcoholic fatty liver disease and obstructive sleep apnea

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World Journal of Gastroenterology 2020年第20期26卷 2669-2681页

作者： ilaria Umbro Valerio Fabiani Mario Fabiani Francesco Angelico maria Del Ben Department of Anatomical HistologicalForensic Medicine and Orthopedic SciencesSapienza University of RomeRome 00161Italy Department of Neurosciences Mental Health and Sensory OrgansSapienza University of RomeRome 00123Italy Department of Sense Organs Sapienza University of RomeRome 00161Italy Department of Public Health and Infectious Diseases Sapienza University of RomeRome 00161Italy Department of Clinical InternalAnesthetic and Cardiovascular SciencesSapienza University of RomeRome 00161Italy

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is an emerging liver disease and currently the most common cause of incidental abnormal liver *** pathogenesis of NAFLD is multifactorial and many mechanisms that cause fatty liver infiltration,inflammation,oxidative stress and progressive fibrosis have been *** sleep apnea(OSA)may be linked with the pathogenesis and the severity of *** To study the association between NAFLD and OSA considering also the efficacy of continuous positive airway pressure(CPAP)*** A Pub Med search was conducted using the terms"non-alcoholic fatty liver disease AND(obstructive sleep apnea OR obstructive sleep disorders OR sleep apnea)".Research was limited to title/abstract of articles published in English in the last 5 years;animal and child studies,case reports,commentaries,letters,editorials and meeting abstracts were not *** were extracted on a standardized data collection table which included:First author,publication year,country,study design,number of patients involved,diagnosis and severity of OSA,diagnosis of NAFLD,patient characteristics,results of the *** total,132 articles were initially retrieved on Pub Med search and 77 in the last five *** removal of irrelevant studies,13 articles were included in the qualitative *** was a total of 2753 participants across all the studies with a mean age between 42 and 58 *** proportion of males ranged from21%to 87.9%and the mean body mass index ranged from 24.0 to 49.9 kg/*** results of this review showed an increased prevalence of NAFLD in patients with diagnosis of OSA,even in the absence of coexisting comorbidities such as obesity or metabolic ***,the severity of NAFLD is associated with the increase in OSA *** CPAP treatment,although not always decisive,may stabilize or slow NAFLD progression with benefits on metabolic and cardiovascular *** In

关键词： Continuous positive air pressure Non-alcoholic fatty liver disease Nonalcoholic steatohepatitis Obstructive sleep apnea Obstructive sleep disorders Sleep apnea

Liver transplantation for hepatocellular carcinoma: Where do we stand?

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World Journal of Gastroenterology 2019年第21期25卷 2591-2602页

作者： Francesco Santopaolo ilaria Lenci Martina Milana Tommaso maria Manzia Leonardo Baiocchi Hepatology Unit Department of MedicinePoliclinico Universitario Tor VergataRome 00133Italy Transplant Surgery Unit Department of SurgeryPoliclinico Universitario Tor VergataRome 00133Italy

Hepatocellular carcinoma represents an important cause of morbidity and mortality worldwide. It is the sixth most common cancer and the fourth leading cause of cancer death. Liver transplantation is a key tool for the treatment of this disease in human therefore hepatocellular carcinoma is increasing as primary indication for grafting. Although liver transplantation represents an outstanding therapy for hepatocellular carcinoma, due to organ shortage, the careful selection and management of patients who may have a major survival benefit after grafting remains a fundamental question. In fact, only some stages of the disease seem amenable of this therapeutic option, stimulating the debate on the appropriate criteria to select candidates. In this review we focused on current criteria to select patients with hepatocellular carcinoma for liver transplantation as well as on the strategies (bridging) to avoid disease progression and exclusion from grafting during the stay on wait list. The treatments used to bring patients within acceptable criteria (down-staging), when their tumor burden exceeds the standard criteria for transplant, are also reported. Finally, we examined tumor reappearance following liver transplantation. This occurrence is estimated to be approximately 8%-20% in different studies. The possible approaches to prevent this outcome after transplant are reported with the corresponding results.

关键词： Hepatocellular carcinoma Liver transplantation Bridging Down-staging Milan Criteria

International transferability of macro-level safety performance functions: a case study of the United States and Italy

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Transportation Safety and Environment 2019年第1期1卷 68-78页

作者： Jaeyoung Lee Mohamed Abdel-Aty maria Rosaria de Blasiis Xuesong Wang ilaria Mattei Department of Civil Environmental and Construction EngineeringUniversity of Central Florida.4000 Central Florida Blvd.OrlandoFlorida 32816USA Department of Engineering Roma Tre University.Via Vito Volterra 6200146 RomaItaly School of Transportation Engineering Tongji University.4800 Cao’an RoadJiading DistrictShanghai 201804China Ferrovie dello Stato Italiano.Piazza della Croce Rossa 100161 RomaItaly School of Traffic and Transportation Engineering Central South University.22 Shaoshan South RoadChangsha Hunan 410075 China

Safety performance functions(SPFs),or crash-prediction models,have played an important role in identifying the factors contributing to crashes,predicting crash counts and identifying *** a great deal of time and effort is needed to estimate an SPF,previous studies have sought to determine the transferability of particular SPFs;that is,the extent to which they can be applied to data from other *** many efforts have been made to examine micro-level SPF transferability,few studies have focused on macro-level SPF *** has been little transferability analysis of macro-level SPFs in the international context,especially between western *** study therefore evaluates the transferability of SPFs for several states in the USA(Illinois,Florida and Colorado)and for *** SPFs were developed using data from counties in the United States and provincias in Italy,and the results revealed multiple common significant variables between the two *** indexes were then calculated between the *** showed that the Italy SPFs for total crashes and bicycle crashes were transferable to US data after calibration factors were applied,whereas the US SPFs for total and bicycle crashes,with the exception of the Colorado SPF,could not be transferred to the Italian *** the other hand,none of the pedestrian SPFs developed was transferable to other *** paper provides insights into the applicability of macro-level SPFs between the USA and Italy,and shows a good potential for international SPF ***,further investigation is needed of SPF transferability between a wider range of countries.

关键词： safety performance function(SPF) crash prediction model negative binomial model transferability transferability index international transferability macro-level safety macroscopic safety

Language training for oral and written naming impairment in primary progressive aphasia:a review

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Translational Neurodegeneration 2021年第3期10卷 297-330页

作者： ilaria Pagnoni Elena Gobbi Enrico Premi Barbara Borroni Giuliano Binetti maria Cotelli Rosa Manenti Neuropsychology Unit IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly Vascular Neurology Unit Department of Neurological and Vision SciencesASST Spedali CiviliBresciaItaly Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly MAC Memory Clinic and Molecular Markers Laboratory IRCCS Istituto Centro San Giovanni di Dio FatebenefratelliBresciaItaly

Background Primary progressive aphasia(PPA)is a neurodegenerative disorder characterized by a gradual,insidious and progressive loss of language abilities,with naming difficulties being an early and persistent impairment common to all three *** the absence of effective pharmacological treatments and given the progressive nature of the disorder,in the past few decades,many studies have investigated the effectiveness of language training to minimize the functional impact of word-finding difficulties in daily *** body We review language treatments most commonly used in clinical practice among patients with different variants of PPA,with a focus on the enhancement of spoken and written naming *** of gains to the ability to name untrained stimuli or to other language abilities and the maintenance of these results over time are also ***-eight studies were included in this literature review,identifying four main types of language treatment:a)lexical retrieval treatment,b)phonological and/or orthographic treatment,c)semantic treatment,and d)a multimodality approach ***,language training is able to induce immediate improvements of naming abilities in all variants of ***,despite the large variability among results,generalization and long-term effects can be recorded after the *** reviewed studies also suggest that one factor that determines the choice of a particular approach is the compromised components of the lexical/semantic processing *** The majority of studies have demonstrated improvements of naming abilities following language *** the progressive nature of PPA,it is essential to apply language treatment in the early stages of the disease.

关键词： Agrammatic variant of primary progressive aphasia Semantic variant of primary progressive aphasia Logopenic/phonological variant of PPA Naming

Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review

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World Journal of Gastroenterology 2021年第23期27卷 3303-3316页

作者： Carmelina Calitri ilaria Fumi maria Giovanna Ignaccolo Elena Banino Stefania Benetti maria MaddalenaLupica Francesca Fantone Mariella Pace Franco Garofalo Department of Paediatrics Infermi HospitalASLTO3Rivoli 10098Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),is responsible for the first pandemic of the 21st *** found in adults,signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric ***,a considerable number of children present with gastrointestinal symptoms such as vomiting,abdominal pain,and *** purpose of this review is an accurate description,from pathogenesis to clinical presentation,diagnosis and treatment,of COVID-19 effects on the gastrointestinal system at a paediatric ***-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction *** can last for several weeks after the end of the symptomatic *** signs and symptoms are generally self-limited,can correlate with blood tests and imaging alterations,and may require supportive treatment such as ***,they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory *** belonging to risk categories such as those affected by celiac disease,inflammatory bowel disease,and hepatic disease seem to not have a more severe course than the others,even if they are undergoing immunosuppressant *** follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests,mainly endoscopic ones.

关键词： SARS-CoV-2 COVID-19 Paediatric Gastrointestinal Diarrhea Hydration

Black soldier fly and gut health in broiler chickens:insights into the relationship between cecal microbiota and intestinal mucin composition

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Journal of Animal Science and Biotechnology 2020年第3期11卷 841-852页

作者： ilaria Biasato Ilario Ferrocino Sihem Dabbou Rocchina Evangelista Francesco Gai Laura Gasco Luca Cocolin maria Teresa Capucchio Achille Schiavone Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Department of Veterinary Sciences University of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Institute of Science of Food Production National Research CouncilLargo Paolo Braccini 210095 GrugliascoTOItaly

Background:The relationship between diet and intestinal microbiota and mucin composition appears to be fundamental for poultry gut *** effects of insect meal(whose role as alternative feed ingredient is now well recognized)on gut microbiota and mucin composition have recently been reported in Tenebrio molitor-fed free-range and broiler chickens,but no data are currently available for Hermetia illucens(HI)-fed *** present study evaluated the effects of dietary HI meal inclusion on cecal microbiota and intestinal mucin composition of broiler ***:A total of 256 male broiler chickens were allotted to 4 dietary treatments(control diet[C]and 5%,10%and 15%HI meal inclusion,with 8 replicate pens/treatment and 8 birds/pen)and slaughtered at 35 d of age(2 animals/pen,16 birds/diet).The cecal microbiota assessment by 16S rRNA amplicon based sequencing showed lower alpha diversity in HI15 chickens(Shannon,P<0.05)and higher beta diversity(Adonis and ANOSIM,P<0.001)in birds fed HI diets than ***,HI15 birds displayed significant increase of the relative abundance of Proteobacteria phylum(False Discovery Rate[FDR]<0.05)when compared to HI10.L-Ruminococcus(Ruminococcus from Lachnospiraceae family),Faecalibacterium,Blautia and Clostridium genera were found to be characteristic of HI5 cecal microbiota(FDR<0.05),while broiler chickens fed HI10 and HI15 diets were characterized(FDR<0.05)by Lactobacillus and Ruminococcus(HI10)and Bacteroides,Roseburia and Helicobacter genera(HI15).Periodic-acid Schiff,Alcian Blue pH 2.5 and high iron diamine staining on small and large intestine also demonstrated lower mucin staining intensity in the intestinal villi of HI10 and HI15 birds than C(P<0.05).Conclusions:Dietary HI meal utilization at low inclusion levels(i.e.,5%)positively influenced either the cecal microbiota or the gut mucin dynamics in terms of selection of potentially beneficial bacteria and increase in villi ***,high inclusion levels(in

关键词： 16S rRNA Gut health Hermetia illucens L. Histochemistry Insect meal Microbiota Mucin Poultry