检索结果-南通市图书馆

Sustained complete response of advanced hepatocellular carcinoma with metronomic capecitabine: a report of three cases

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2018年第1期38卷 429-435页

作者： Giovanni Brandi Michela Venturi Stefania De Lorenzo francesca Garuti Giorgio Frega Andrea Palloni Ingrid Garajovà francesca Abbati Gioconda Saccoccio Rita Golfieri maria Abbondanza Pantaleo maria Aurelia Barbera Department of Experimental Diagnostic and Specialty MedicineSt.Orsola-Malpighi HospitalHaematological and Oncological InstituteUniversity of Bologna9 Massarenti street40138 BolognaItaly Department of Medical and Surgical Sciences St.Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly Department of Medicine Bologna Health Authority40139 BolognaItaly Department of Digestive Diseases and Internal Medicine St.Orsola-Malpighi HospitalUniversity of Bologna40138 BolognaItaly

Background:Hepatocellular carcinoma(HCC)is one of the most frequent causes of cancer-related ***,a multitarget angiogenesis inhibitor,is an approved frontline treatment for advanced HCC in Western countries,although a complete response(CR)to treatment is infrequently ***,an oral fluoropyrimidine,has been shown to be effect in both treatment-naïve patients and those previously treated with *** date,how-ever,only one case of sustained CR to metronomic capecitabine has been *** presentation:We describe three cases of advanced HCC treated with metronomic capecitabine where a CR was *** the first case,capecitabine was administered as first line therapy;in the second case,capecitabine was used after intolerance to sorafenib;while in the third case,capecitabine was administered after sorafenib ***:Capecitabine is a potentially important treatment option for patients with advanced HCC and may even represent a cure in certain cases.

关键词： Hepatocellular carcinoma Capecitabine Metronomic capecitabine Complete response Sorafenib

Exercise-induced anaphylaxis with an Ayurvedic drug as cofactor:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2019年第5期7卷 623-627页

作者： francesca Losa Margherita Deidda Davide Firinu maria Luisa Di Martino maria Pina Barca Stefano Del Giacco Department of Medical Sciences and Public Health and Unit of Allergy and Clinical Immunology University Hospital "Duilio Casula" University of Cagliari

BACKGROUND The practice of Indian Ayurvedic medicine is spreading in Western countries and Shilajit is one of the most used drugs, for its antioxidant activities and immunomodulatory effects. Albeit Shilajit has showed a high degree of safety, it can act as cofactor of anaphylaxis, especially in condition at high risk, such as mast cell activation syndrome(MCAS). We reported this case to sensitize practitioners to investigate to the use of complementary and alternative medicine,in case of exercise-induced anaphylaxis(EIAn).CASE SUMMARY A 43-year-old woman, working as a dance teacher, developed urticaria after ingestion of rice, tuna and Shilajit, which did not respond to intramuscular corticosteroids. Subsequently, she developed dyspnoea and hypotension with loss of consciousness that arose 1 h after sexual activity. The patient did not refer personal history of atopy. Specific IgE for main food allergens resulted negative,with total IgE levels of 14 IU/L. Oral provocation test with Shilajit was not perfomed because the patient refused, but we performed prick-by-prick and patch test that resulted negative. Serum tryptase at the time of anaphylaxis was 20.6 μg/L that fell down to of 10.6 μg/L after therapy, but has remained at the high value after two days and during the follow-up. We performed an analysis of the c-KIT gene in peripheral blood, which was negative. We felt the diagnosis consistent with EIAn in a patient with a possible *** In Western countries the use of drugs from Ayurvedic medicine is more common than in the past. These substances can be cofactors of anaphylaxis in patients with risk factors.

关键词： Indian Ayurvedic medicine Anaphylaxis Exercise-induced anaphylaxis Mast cell activation syndrome Case report

Evaluation of the Efficacy of 99.9% Pure Silver Trilaminate Cups in the Prevention and Treatment of Nipple Pain and Fissures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Nursing 2023年第10期13卷 686-698页

作者： Monica Pilloni Pierina Zedda Carla Orrù Elena Fassina maria Carmela Forte Rossana Mazzulla Brunella Celestino maria francesca Marotto Manuela Neri Gian Benedetto Melis Anna maria Paoletti University Hospital of Cagliari (UHC) Cagliari Italy Department of Surgical Sciences University of Cagliari Cagliari Italy Maternal and Child Family Counselling Quartu Sant’Elena Cagliari Italy Caruso’s Medical Office Cusago Italy Hospital of Castrovillari Cosenza Italy Hospital of Cosenza Cosenza Italy Maternal and Child Family Counselling Argentano Cosenza Italy Company of National Importance and High Specialization (CNIHS) Giovanni Brotzu Cagliari Italy Women’s Wellness Foundation Cagliari Italy

Breastfeeding is drastically decreasing over time and nipple trauma constitutes one of the most significant reasons for its discontinuation. In this context, this study aimed at evaluating the effectiveness and tolerability of a topical treatment device, namely Silver Cap® (Depofarma S.P.A.), when used to prevent pain and nipple fissure formation. The medical device consists in a silver trilaminate cup to be placed on the nipple, providing physical protection and creating a moist environment. The study involved 187 women: 38 started to apply the device prior to lactation (PL group) and 149 during lactation (DL group). Aiming to collect safety and performance data, both groups were provided with questionnaires during 6 consecutive visits (120 days of follow-up). At last visit, absence of painful symptoms was reported by the 98.8% and the 100% of women in DL and PL groups, respectively. Moreover, no nipple fissures were observed and no adverse events directly correlated to use of the device were reported. According to these findings, it can be concluded that Silver Cap® is a safe and effective device for nipple pain and fissure prevention. .

关键词： Silver Cap Breastfeeding Breast Pain Nipple Fissures

Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第23期27卷 3303-3316页

作者： Carmelina Calitri Ilaria Fumi maria Giovanna Ignaccolo Elena Banino Stefania Benetti maria MaddalenaLupica francesca Fantone Mariella Pace Franco Garofalo Department of Paediatrics Infermi HospitalASLTO3Rivoli 10098Italy

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of coronavirus disease 2019(COVID-19),is responsible for the first pandemic of the 21st *** found in adults,signs and symptoms related to the disease mainly involve the respiratory tract in the paediatric ***,a considerable number of children present with gastrointestinal symptoms such as vomiting,abdominal pain,and *** purpose of this review is an accurate description,from pathogenesis to clinical presentation,diagnosis and treatment,of COVID-19 effects on the gastrointestinal system at a paediatric ***-CoV-2 can be identified in stool specimens of affected children by real-time polymerase chain reaction *** can last for several weeks after the end of the symptomatic *** signs and symptoms are generally self-limited,can correlate with blood tests and imaging alterations,and may require supportive treatment such as ***,they can precede severe disease manifestations such as the COVID-19-related multisystem inflammatory *** belonging to risk categories such as those affected by celiac disease,inflammatory bowel disease,and hepatic disease seem to not have a more severe course than the others,even if they are undergoing immunosuppressant *** follow-ups of patients with chronic diseases need to be revised during the pandemic period in order to postpone unnecessary tests,mainly endoscopic ones.

关键词： SARS-CoV-2 COVID-19 Paediatric Gastrointestinal Diarrhea Hydration

Portal vein thrombosis in cirrhosis: Why a well-known complication is still matter of debate

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第31期25卷 4437-4451页

作者： Mariella Faccia maria Elena Ainora francesca Romana Ponziani Laura Riccardi Matteo Garcovich Antonio Gasbarrini Maurizio Pompili maria Assunta Zocco Department of Internal Medicine and Gastroenterology Fondazione Policlinico Universitario A.Gemelli IRCCSCatholic University

Portal vein thrombosis(PVT)represents a well-known complication during the natural course of liver cirrhosis(LC),ranging from asymptomatic cases to lifethreating conditions related to portal hypertension and hepatic *** flow stasis,complex acquired hypercoagulable disorders and exogenous factors leading to endothelial dysfunction have emerged as key factors for PVT ***,PVT occurrence remains unpredictable and many issues regarding its natural history,prognostic significance and treatment are still *** particular although spontaneous resolution or disease stability occur in most cases of PVT,factors predisposing to disease progression or recurrence after spontaneous recanalization are not clarified as ***,PVT impact on LC outcome is still debated,as PVT may represent itself a consequence of liver fibrosis and hepatic dysfunction *** and transjugular intrahepatic portosystemic shunt are considered safe and effective in this setting and are recommended in selected cases,even if the safer therapeutic option and the optimal therapy duration are still ***,their impact on mortality rates should be addressed more *** this review we present the most debated questions regarding PVT,whose answers should come from prospective cohort studies and large sample-size randomized trials.

关键词： Portal vein thrombosis Liver cirrhosis Hypercoagulability Anticoagulation Direct oral anticoagulants

Anionic liposomes for small interfering ribonucleic acid （siRNA） delivery to primary neuronal cells： Evaluation of alpha-synuclein knockdown efficacy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2017年第10期10卷 3496-3508页

作者： Michele Schlich francesca Longhena Gaia Faustini Caitriona M. O'Driscoll Chiara Sinico Anna maria Fadda Arianna Bellucci Francesco Lai Department of Life and Environmental Sciences University of Cagliari Cagliari 09124 Italy Division of Pharmacology Department of Molecular and Translational Medicine University of Brescia Brescia 25123 Italy Pharmacodelivery Group School of Pharmacy University College Cork Cork Ireland

Alpha-synuclein （a-syn） deposition in Lewy bodies （LB） is one of the main neuropathological hallmarks of Parkinson＇s disease （PD）. LB accumulation is considered a causative factor of PD, which suggests that strategies aimed at reducing a-syn levels could be relevant for its treatment. In the present study, we developed novel nanocarriers suitable for systemic delivery of small interfering ribonucleic acid （siRNA） that were specifically designed to reduce neuronal α-syn by RNA interference. Anionic liposomes loaded with an siRNA-protamine complex for α-syn gene silencing and decorated with a rabies virus glycoprotein （RVG）-derived peptide as a targeting agent were prepared. The nanoparticles were characterized for their ability to load, protect, and deliver the functional siRNA to mouse primary hippocampal and cortical neurons as well as their efficiency to induce gene silencing in these cells. Moreover, the nanocarriers were evaluated for their stability in serum. The RVG-decorated liposomes displayed suitable characteristics for future in vivo applications and successfully induced α-syn gene silencing in primary neurons without altering cell viability. Collectively, our results indicate that RVG-decorated liposomes may be an ideal tool for further studies aimed at achieving efficient in vivo α-syn gene silencing in mouse models of PD.

关键词： rabies virus glycoprotein (RVG) peptide liposomes small interfering ribonudeic acid (siRNA) alpha-synuclein primary neuronal cells Parkinson's disease

Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2017年第7期23卷 1241-1249页

作者： francesca Romana Ponziani Maurizio Pompili Enrico Di Stasio maria Assunta Zocco Antonio Gasbarrini Roberto Flore Internal Medicine Gastroenterology and HepatologyAgostino Gemelli Hospital Biochemistry Agostino Gemelli Hospital Internal Medicine and Vascular Medicine Agostino Gemelli Hospital

To assess the rate of matrix Gla-protein carboxylation in patients with small intestinal bacterial overgrowth (SIBO) and to decipher its association with subclinical *** with suspected SIBO who presented with a low risk for cardiovascular disease and showed no evidence of atherosclerotic plaques were included in the study. A glucose breath test was performed in order to confirm the diagnosis of SIBO and vascular assessment was carried out by ultrasound examination. Plasma levels of the inactive form of MGP (dephosphorylated-uncarboxylated matrix Gla-protein) were quantified by ELISA and vitamin K2 intake was estimated using a food frequency ***-nine patients were included in the study. SIBO was confirmed in 12/39 (30.8%) patients who also presented with a higher concentration of dephosphorylated-uncarboxylated matrix Gla-protein (9.5 μg/L vs 4.2 μg/L; P = 0.004). Arterial stiffness was elevated in the SIBO group (pulse-wave velocity 10.25 m/s vs 7.68 m/s; P = 0.002) and this phenomenon was observed to correlate linearly with the levels of dephosphorylated-uncarboxylated matrix Gla-protein (β = 0.220, R2 = 0.366, P = 0.03). Carotid intima-media thickness and arterial calcifications were not observed to be significantly elevated as compared to *** is associated with reduced matrix Gla-protein activation as well as arterial stiffening. Both these observations are regarded as important indicators of subclinical atherosclerosis. Hence, screening for SIBO, intestinal decontamination and supplementation with vitamin K2 has the potential to be incorporated into clinical practice as additional preventive measures.

关键词： Small intestinal bacterial overgrowth Vitamin K Dysbiosis Atherosclerosis Cardiovascular disease risk

Aggregation properties of a therapeutic peptide for rheumatoid arthritis:A spectroscopic and molecular dynamics study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ChemPhysMater 2022年第1期1卷 62-70页

作者： Rita Cimino Marco Savioli Noemi Ferrante Carrante Ernesto Placidi Hilda Garay-Perez Matilde López-Abad Alexis Musacchio Lasa maria Del Carmen Domínguez-Horta Emanuela Gatto francesca Cavalieri Gianfranco Bocchinfuso mariano Venanzi PEPSA-LAB Department of Chemical Sciences and TechnologyUniversity of Rome Tor VergataVia della Ricerca Scientifica 100133RomeItaly Department of Physics University of Rome‘Sapienza’P.le A.Moro 500185 RomeItaly Centre for Genetic Engineering and Biotechnology PO Box 616210600HavanaCuba School of Science RMIT UniversityMelbourneVIC 3001Australia

The biological properties of therapeutic peptides,such as their pharmacokinetics and pharmacodynamics,are correlated with their structure and aggregation ***,we studied the aggregation properties of a therapeutic peptide(CIGB-814),currently in phase 2 clinical trial,for the treatment of rheumatoid arthritis over a wide range of concentrations(μM-mM).We applied spectroscopic techniques(fluorescence,circular dichro-ism,resonance,and dynamic light scattering),atomic force microscopy,and molecular dynamics simulations to determine the aggregation mechanism of *** found that the hierarchical aggregation of CIGB-814 at micromolar concentrations was initiated by the formation of peptide ***,the peptide oligomers trigger the nucleation and growth of peptide nanostructures(cac=123μM),ultimately leading to the fibrillization of CIGB-814(cac’=508μM).These results pave the way for a deeper understanding of the CIGB-814 therapeutic activity and may give important insights on its pharmacokinetics.

关键词： Molecular dynamics of peptide oligomers Peptide aggregation Peptide fibrils Peptide nanostructures Therapeutic peptides Treatment of rheumatoid arthritis

Mesenteric adenitis caused by Yersinia pseudotubercolosis in a patient subsequently diagnosed with Crohn's disease of the terminal ileum

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第24期12卷 3933-3935页

作者： Maddalena Zippi maria Chiara Colaiacomo Adriana Marcheggiano Roberta Pica Paolo Paoluzi Giancarlo Iaiani Renzo Caprilli francesca Maccioni Department of Clinical Sciences GI Unit Umberto Ⅰ Viale del Policlinico 15500161RomeItaly Department of Radiological Sciences Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly Department of Infectious Diseases Umberto Ⅰ Viale del Policlinico 155 00161RomeItaly

Although the association between inflammatory bowel disease and gastrointestinal infections has been suggested, the mechanisms involved in the pathogenesis of Crohn＇s disease （CD） are still undetermined. We report the case of a man, who presented with mesenteric adenitis initially due to a Yersinia pseudotubercolosis infection, who was later diagnosed with Crohn＇s disease. This case is in keeping with recent evidence in the literature which suggests that CD is a disease linked to abnormal immune responses to enteric bacteria in genetically susceptible individuals.

关键词： Yersinia pseudotubercolosis Crohn's disease Ileitis