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BIOCELL 2022年第1期46卷 37-49页

作者： MAURA benedetti maria ELISA GIULIANI MARICA MEZZELANI ALESSANDRO NARDI LUCIA PITTURA STEFANIA GORBI FRANCESCO REGOLI Dipartimento di Scienze della Vitaedell’Ambiente UniversitàPolitecnica delle MarcheAncona60131Italy

Oxidative stress is a critial condition derived from the imbalance between the genention of reactive oxygen species and the sophisticated network of antioidant *** pollut ants and envronmental factors can afet this system through connected mechanisms,indirect relationships,and cascade effects from pre-transcriptional to catalytic level,by either enhancing intracellular ROS formation or impairing antioxidant *** review summariaces the current kmnowledge on the pro oxidant challenges from emerging environmental stressors threatening marine organisms,such as pharmaceutials microplastics and dimate related ocean *** will be placed on oxidative pathways,including signaling proteins and transcription factors involved in regulation of antioxidant *** insights and lack of knowdedge will be pointed out by presenting single and combined efects of multiple stessors,unraveling questions to be adresed by future resarch in marine ectoicology.

关键词： Antioxidant Pharmaceuticals Microplastics/Nanoplastics Ocean acidification Thermal stress

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Musculoskeletal disorders in nursing staff

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World Journal of Methodology 2025年第2期15卷 9-14页

作者： Agapi Kolovou Asterios N Gkougkoulias Nikolaos Stefanou Elena Manuela Samaila maria Tsekoura marianna Vlychou Charalampos Matzaroglou Zoe H Dailiana Department of Orthopaedic Surgery Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Department of Radiology Faculty of MedicineSchool of Health SciencesUniversity of ThessalyLarissa 41500ThessaliaGreece Orthopaedic and Trauma Center University of VeronaVerona 37134Italy Department of Physiotherapy School of Health Rehabilitation SciencesUniversity of PatrasPatra 26504DytikíElládaGreece

Nursing staff provides patient care in an occupational environment that often imposes challenges that affect significantly the musculoskeletal ***-related musculoskeletal disorders are common in nursing stuff and have a negative impact in their professional and daily *** the current editorial,the duties of nursing staff,the types of musculoskeletal disorders,the predis-posing factors(including factors related to professional tasks/ergonomics and to working schedules,psychological,social and individual factors)and their impact on working ability and quality of life nursing staff are summarized and pre-ventive measures are proposed.

关键词： Musculoskeletal disorders Nursing staff Predisposing factors Ergonomics Prevention

The Use of Spatial Sampling Designs in Business Surveys

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Open Journal of Statistics 2014年第5期4卷 345-354页

作者： maria Michela Dickson Roberto benedetti Diego Giuliani Giuseppe Espa Department of Economics and Management University of Trento Trento Italy Department of Economics University “G. D’annunzio” Pescara Italy Department of Social Science University “Sapienza” Roma Italy

An innovative use of spatial sampling designs is here presented. Sampling methods which consider spatial locations of statistical units are already used in agricultural and environmental contexts, while they have never been exploited for establishment surveys. However, the rapidly increasing availability of geo- referenced information about business units makes that possible. In business studies, it may indeed be important to take into account the presence of spatial autocorrelation or spatial trends in the variables of interest, in order to have more precise and efficient estimates. The opportunity of using the most innovative spatial sampling designs in business surveys, in order to produce samples that are well spread in space, is here tested by means of Monte Carlo experiments. For all designs, the Horvitz-Thompson estimator of the population total is used both with equal and unequal inclusion probabilities. The efficiency of sampling designs is evaluated in terms of relative RMSE and efficiency gain compared with designs ignoring the spatial information. Furthermore, an evaluation of spatially balancing samples is also conducted.

关键词： Spatial Sampling Design Business Surveys Horvitz-Thompson Estimator Spatial Balance

Carcinosarcoma of the breast:Facing the challenge of a rare nosologic entity

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World Journal of Clinical Cases 2025年第2期13卷 14-20页

作者： Aikaterini Mastoraki maria Tsamopoulou Foivos-Konstantinos Stamatis Alexios Strimpakos Ero Mouchtouri Christiana Panagi Evgenia Mela Sotiria Mastoraki Aristotelis Kechagias Dimitrios Schizas Department of Surgery National and Kapodistrian University of AthensLaikon General HospitalAthens 11527Greece Department of Surgery National and Kapodistrian University of AthensAthens 11527Greece Department of Medical Oncology Hygeia HospitalAthens 15123Greece Department of Radiology Henry Dunant Hospital CenterAthens 11526Greece Department of Surgery Athens Metropolitan HospitalAthens 15562Greece

Carcinosarcoma(CS),also known as metaplastic breast carcinoma with mesenchymal differentiation,is one of the five distinct subtypes of metaplastic breast *** is considered as a mixed,biphasic neoplasm consisting of a carcinomatous component combined with a malignant nonepithelial element of mesenchymal origin without an intermediate transition *** cellular origin of this neoplasm remains controversial,most researchers declare that neoplastic cells derive from a cellular structure with potential biphasic *** recent research on the therapeutic strategies against CS neoplastic disorders,surgical resection appears the only potentially curative *** CS metastasize by the lymphatic route,axillary assessment with sentinel lymph node biopsy and/or axillary lymph node dissection is always ***,the tumor also presents a hematogenous metastatic pattern including pleural,pulmonary,liver,brain and less commonly bone ***,surgical removal of breast CS does not necessarily ensure patient’s long-term ***,alternative therapies,such as radio-and chemotherapy proved insufficient and 5-year survival rate is ***,there is evidence that following surgery,the combination of radio and chemotherapy is associated with a better prognosis than either treatment *** aim of this review is to evaluate the results of surgical treatment for breast CS with special reference to the extent of its histological *** features,histogenesis,morphological and immunochemical findings are discussed,while the role of current diagnostic and therapeutic management of this aggressive neoplasm is emphasized.

关键词： Carcinosarcoma Breast Diagnostic approach Therapeutic management Prognostic parameters

Distribution and fate of DCX/PSA-NCAM expressing cells in the adult mammalian cortex： A local reservoir for adult cortical neuroplasticity？

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Frontiers in Biology 2016年第3期11卷 193-213页

作者： Richard Konig Bruno benedetti Peter Rotheneichner Anna O' Sullivan Christina Kreutzer maria Belles Juan Nacher Thomas M. Weiger Ludwig Aigner Sebastien Couillard-Despres Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS) Paracelsus Medical University Salzburg Austria Institute of Molecular Regenerative Medicine Paracelsus Medical University Salzburg Austria Department of Physiology and Medical Physics Innsbruck Medical University Innsbruck Austria Institute of Experimental Neuroregenerat ion Paracelsus Medical University Salzburg Austria Department of Otorhinolaryngology Head and Neck Surgery Paracelsus Medical University Salzburg Salzburg Austria Neurobiology Unit Interdisciplinary Research Structure ffor Biotechnology and Biomedicine Valencia. Universitat de Valencia.Comunitat Valenciana Spain Division of Cellular and Molecular Neurobiology Department of Cell Biology University of Salzburg Salzburg Austria

Abstract The expression of early developmental markers such as doublecortin （DCX） and the polysialylated-neural cell adhesion molecule （PSA-NCAMIp has been used to identify immature neurons within canonical neurogenic niches. Additionally, DCX/PSA-NCAM ＋ immature neurons reside in cortical layer II of the paleocortex and in the paleo- and entorhinal cortex of mice and rats, respectively. These cells are also found in the neocortex of guinea pigs, rabbits, some afrotherian mammals, cats, dogs, non-human primates, and humans. The population of cortical DCX/PSA-NCAM ＋ immature neurons is generated prenatally as conclusively demonstrated in mice, rats, and guinea pigs. Thus, the majority of these cells do not appear to be the product of adult proliferative events. The immature neurons in cortical layer II are most abundant in the corlLices of young individuals, while very few DCX/PSA-NCAM ＋ cortical neurons can be detected in aged mammals. Maturation of DCX/PSA-NCAM ＋ cells into glutamatergic and GABAergic neurons has been proposed as an explanation for the age-dependent reduction in their population over time. In this review, we compile the recent information regarding the age-related decrease in the number of cortical DCX/PSA-NCAM ＋ neurons. We compare the distribution and fates of DCX/PSA-NCAM ＋ neurons among mammalian species and speculate their impact on cognitive function. To respond to the diversity of adult neurogenesis research produced over the last number of decades, we close this review by discussing the use and precision of the term ＂adult non-canonical neurogenesis.＂

关键词： aging cognition doublecortin piriform cortex plasticity neurogenesis

Bringing chiral functionality to in vivo applications of nanomaterials

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Light(Science & Applications) 2022年第6期11卷 1038-1039页

作者： maria Mukhina Department of Molecular and Cellular Biology Harvard UniversityCambridgeMA 02138USA

Chirality is a universal property of an endless number of objects in the *** is rapidly expanding to find ways to introduce chirality to artificial *** a recent publication in Light:Science and Applications,Das et *** successfully used capping with chiral ligand molecules to obtain chiral carbon *** authors provide a theoretical model to describe the origin of chirality in carbon dots as arising due to exciton coupling in a pair of chiral *** to non-toxic chemical composition and sizes as small as 2-5 nm,the chiral carbon dots have the potential to outperform other chiral nanostructures in numerous biomedical ***,similarly to chiral drugs,their chiral toxicity must be well understood before the carbon dots are brought to living systems.

关键词： chiral sizes expanding

Evaluating transmission towers potentials during ground faults

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第2期9卷 182-189页

作者： maria VINTAN Department of Electrical Engineering School of Engineering "Lucian Blaga" University of Sibiu Sibiu 550025 Romania

During ground faults on transmission lines,a number of towers near the fault are likely to acquire high potentials to *** tower voltages,if excessive,may present a hazard to humans and *** paper presents analytical methods in order to determine the transmission towers potentials during ground faults,for long and short *** author developed a global systematic approach to calculate these voltages,which are dependent of a number of *** of the most important factors are:magnitudes of fault currents,fault location with respect to the line terminals,conductor arrangement on the tower and the location of the faulted phase,the ground resistance of the faulted tower,soil resistivity,number,material and size of ground *** effects of these factors on the faulted tower voltages have been also examined for different types of power lines.

关键词： Overhead transmission lines Ground fault Tower potential

Inflammation induces zebrafish regeneration

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Neural Regeneration Research 2021年第9期16卷 1693-1701页

作者： maria Iribarne Center for Zebrafish Research Department of Biological Sciences Center for Stem Cells and Regenerative Medicine University of Notre DameNotre DameINUSA

Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Upon damage, mammals can only efficiently restore a few tissues including the liver, skin, epithelia of the lung, kidney, and gut. In contrast, lower vertebrates such as zebrafish possess an extraordinary regeneration ability, which restores the normal function of a broad spectrum of tissues including heart, fin, brain, spinal cord, and retina. This regeneration process is either mediated by the proliferation of resident stem cells, or cells that dedifferentiate into a stem cell-like. In recent years, evidence has suggested that the innate immune system can modulate stem cell activity to initiate the regenerative response to damage. This review will explore some of the newer concepts of inflammation in zebrafish regeneration in different tissues. Understanding how inflammation regulates regeneration in zebrafish would provide important clues to improve the therapeutic strategies for repairing injured mammalian tissues that do not have an inherent regenerative capacity.

关键词： cytokines immune system macrophage microglia regeneration stem cells zebrafish

Optimized design and integration of energy storage in Solar-Assisted Ground-Source Heat Pump systems

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Building Simulation 2023年第10期16卷 1933-1948页

作者： maria Ferrara Enrico Fabrizio Department of Energy Politecnico di TorinoTurin10121Italy

The integrated use of multiple renewable energy sources to increase the efficiency of heat pump systems,such as in Solar Assisted Geothermal Heat Pumps(SAGHP),may lead to significant benefits in terms of increased efficiency and overall system performance especially in extreme climate contexts,but requires careful integrated optimization of the different system *** particular,thermal storages take a fundamental role in optimizing the integration of renewable energy sources and the system *** work investigates the potential design optimization of a SAGHP system in a mountain site by exploring many different alternatives to optimize the mutual relationship between the solar field,the geothermal field and the water thermal *** is done through an original simulation-based multi-objective optimization framework considering energy efficiency and economic feasibility,which allows appraising the impact of the different design alternatives on the overall system performance and on the dynamics of the different system *** identify a set of optimized system configurations that optimize the integrated exploitation of the different thermal sources showing a potential increase of the overall system performance leading to 34%lower global cost compared to the initial *** robustness of the optimal design solutions is reported with respect to the current context of high economic uncertainty.

关键词： thermal storage geothermal energy heat pumps building simulation artificial intelligence cost optimization energy flexibility