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New concepts for generating interspecies chimeras using human pluripotent stem cells

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Protein & Cell 2022年第4期13卷 234-238页

作者： Alejandro de los angeles Jun Wu department of Psychiatry Yale University School of MedicineNew HavenCTUSA department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA

The worldwide paucity of transplantable organs for patients is a devastating *** different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies *** blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of *** principle,interspecies blastocyst complementation may one day allow the generation of human organs inside ***,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).

关键词： organs donor generating

JClic Crosswords in Chemistry Class

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Journal of Chemistry and Chemical Engineering 2015年第4期9卷 303-308页

作者： maria de los angeles Montiel Montoya department of Chemistry National Preparatory School No. 4 National Autonomous University of Mexico Mexico 11870 Mexico

Eight crosswords made in JClic were applied to twenty nine students from group 654, in area 2, at ENP （national preparatory school） No. 4 （a national public high school） in order to review Unit 2 and introduce the following Unit of Chemistry IV. Two surveys were applied in scholars in order to evaluate： the application of crosswords and of ICT （information and communications technology）. The results show that students like ICT because it is a relaxing mechanism to learn, JClic games were also liked by the majority due to the team work, so it induces to considerable learning.

关键词： ICT JClic amusing teaching-learning activities crosswords organic chemistry.

Movement initiation of millimeter particles on a rotating rough surface: The role of adhesion

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Particuology 2020年第6期18卷 92-99页

作者： Karina de los angeles Valenzuela Aracena Rodolfo O.Unac Irene Ippolito Ana M.Vidales INFAP CONICETDepartamento de FisicaFacultad de Ciencias Fisico Matematicas y NaturalesUniversidad Nacional de San LuisEjercito de los Andes 950D5700HHWSan LuisArgentina Universidad de Buenos Aires Facultad de IngenieriaGrupo de Medios PorososPaseo Colon 850C1063ACV Buenos AiresArgentina

We performed experiments to determine the critical moment for movement initiation of a millimeter bead on a rotating rough *** corresponding critical angular velocities were measured for glass and stainless-steel ball bearings over two different rough surfaces with glued glass beads.A basic theoretical analysis was developed to explain the observed *** the expectation of a simple approach with the presence of the obstacles offered by a rough surface could be sufficient to describe the problem,we prove here that the sole con sideration of these obstacles,and even friction,are insufficient to explain the results in the range of a few-millimeter glass *** the thermodynamic work of adhesion between surfaces is significant,the adhesion forces must be considered in the force balance for particle detachment:.This effect is a determinant for describing theoretically and numerically the dynamics of millimeter particles.

关键词： detachment Adhesion Centrifugation

Environmental Occurrence of Selenium in Waters and Related Health Significance

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Biomedical and Environmental Sciences 1997年第2期10卷 292-299页

作者： JANE L. VALENTINE(School of Public Health, University of CalIfornia at los angeles, los angeles, CA 90024, USA) School of Public Health University of California at Los Angeles 90024 USA.

Appreciable amounts of selenium in spring and well waters can be found due to geological occurrence. Concentrations of as much as 400 9000 μg/l have been reported in U. S. *** levels are 8 to 180 times the current EPA drinking water standard and approximate dietary exposures of 4900μg in selenosis regions of China. Reviews of health significance of the elevated drinking water exposures to U. S. populations revealed elevated concentrations of selenium in urine and blood. A decrease in glutathione peroxidase activity in such instances was noted. However noticeable symptoms and signs seem absent in studies reviewed. A comparison of intake levels (diet or drinking water) to urinary excretion for residents of China and the U. S. produced a correlation coefficient, r = 0. 82 (P < 0. 01 ) for the three research studies available

关键词： In Am Environmental Occurrence of Selenium in Waters and Related Health Significance

Posterior gut development in Drosophila:a model system for identifying genes controlling epithelial morphogenesis

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Cell Research 1998年第4期8卷 273-284页

作者： LENGYEL JUDITH A XUE JUN LIU (department of Molecular, Cell and developmental Biology University of California at los angeles, los angeles, CA USA, 90095-1606 USA) department of Molecular Cell and Developmental Biology University of California at Los Angeles Los Angeles CA USA 90095-1606 USA

The posterior gut of the Drosophila embryo, consisting of hindgut and Malpighian tubules, provides a simple,well-defined system where it is possible to use a genetic approach to define components essential for epithelial *** review here the advantages of Drosophila as a model genetic organism, the morphogenesis of the epithelial structures of the posterior gut, and what is known about the genetic requirements to form these *** overview, primordia are patterned by expression of hierarchies of transcription factors; this leads to localized expression of cell signaling molecules, and finally, to the least understood step: modulation of cell adhesion and cell shape. We describe approaches to identify additional genes that are required for morphogenesis of these simple epithelia, particularly those that might play a structural role by affecting cell adhesion and cell shape.

关键词： Organogenesis cell rearrangement convergent extension hindgut Malpighian tubule

OPTIMAL COARSE GRID SIZE IN DOMAIN deCOMPOSITION

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Journal of Computational Mathematics 1994年第4期12卷 291-297页

作者： Tony Chan Jian-Ping Shao(department of Mathematics, University of Califoruia, los angeles, USA) UNIV CALIF los angeles DEPT MATHLOS ANGELESCA 90024

In most domain decomposition (DD) methods, a coarse grid solve is employed to provide the global coupling required to produce an optimal method. The total cost of a method can depend sensitively on the choice of the coaxse grid size H. In this paper, we give a simple analysis of this phenomenon for a model elliptic problem and a variant of Smith's vertex space domain decomposition method [11, 3]. We derive the optimal value Hopt which asymptotically minimises the total cost of method (number of floating point operations in the sequential case and execution time in the parallel case), for subdomain solvers with different complekities. Using the value of Hopt, we derive the overall complexity of the DD method, which can be significantly lower than that of the subdomain solver

关键词： UCLA OPTIMAL COARSE GRID SIZE IN DOMAIN deCOMPOSITION CAM

Chemistry, Theater, Information and Communications Technology

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Journal of Chemistry and Chemical Engineering 2015年第3期9卷 221-226页

作者： maria de los angeles Montiel Montoya Celia Sanchez Mendoza Graciela Martinez de Jesus department of Chemistry National Preparatory School No. 4 National Autonomous University of Mexico Mexico 11870 Mexico department of Chemistry National Preparatory School No. 8 National Autonomous University of Mexico Mexico 01600 Mexico

Theater play that shows how textiles, make up, hair dyes and music players has changed along the last six decades, especially due to polymers. It is a play that has a historic, chemical and musical side that introduces the use of ICT （information and communications technology）, such as Faeebook, Moodle platform, Web sites, E-mail, Word, Publisher, PowerPoint, Videos and Digital music. Results in the conduct of the students that participated： assertiveness, self-esteem, tolerance, cooperation, responsibility and teamwork, all of them significantly contributed a meaningful learning about the polymers.

关键词： Theater ICT polymer meaningful learning.

Nutritional quality and physiological effects of halal meat:A pilot study in non-Muslim consumers

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Food Bioscience 2022年第5期49卷 738-745页

作者： Cristina Carrasco Trinidad Perez-Palacios Luis Miguel Luengo Sergio Gomez Miguel Fajardo María de los angeles Gomez Ana Beatriz Rodríguez Neuroimmunophysiology and Chrononutrition Research Group Department of Physiology(Faculty of Sciences)University of Extremadura06006BadajozSpain Research Institute of Meat and Meat Products(IProCar) University of Extremadura10003C´aceresSpain Service of Endocrinology and Nutrition University Hospital of Badajoz06006BadajozSpain Service of Clinical Analysis University Hospital of Badajoz06006BadajozSpain Service of Microbiology University Hospital of Badajoz06006BadajozSpain

despite the current controversy,red meat remains essential to the proper functioning of our *** the trend meat products available for consumers,halal meat is becoming an interesting choice,independently of their religious ***,little is known about its nutritional content and possible health *** this reason,a comparative analysis of the physical-chemical and nutritional properties between halal and non-halal meats(beef and lamb)was ***,a pilot study was performed by University of Extremadura analysing the impact of its consumption on body composition,gut microbiota,biomarkers,and antioxidant *** healthier lipid profile founded in halal meat may have had a positive impact on the weight,muscle mass,body fat and antioxidant status of the participants,without altering the gut microbiota and levels of biomarkers such as glucose,insulin,or *** research can help meat consumers to choose healthier and more eco-friendly products.

关键词： Halal meat Lipid profile Body composition gut microbiota Antioxidant status Biomarkers

On the Equivalence of Multiplicative Structures in Floer Homology and Quantum Homology

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Acta Mathematica Sinica,English Series 1999年第1期15卷 53-80页

作者： Gang Liudepartment of Mathematics,UCLA,los angeles,CA 90095 USAGang Tiandepartment of Mathematics,MIT,Cambridge,MA 02139,USA department of Mathematics UCLA Los Angeles USA department of Mathematics MIT Cambridge USA

In this paper,we will prove that Floer homology equipped with either the intrinsic or exterior product is isomorphic to quantum homology as a *** will also prove that GW-invariants in Floer homology and quantum homolo... 详细信息

关键词： Floer homology Quantum homology GW-invariants J-holomorphic curves Moduli space