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Evaluation of oxidative stress levels in obesity and diabetes by the free oxygen radical test and free oxygen radical defence assays and correlations with anthropometric and laboratory parameters

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World Journal of Diabetes 2020年第5期11卷 193-201页

作者： Mihnea-Alexandru Găman Mirela Elena Epîngeac Camelia cristina Diaconu Amelia maria Găman "Carol Davila"University of Medicine and Pharmacy Bucharest 050474Romania Department of Hematology Center of Hematology and Bone Marrow TransplantationFundeni Clinical InstituteBucharest 022328Romania Department of Pathophysiology University of Medicine and Pharmacy of CraiovaCraiova 200349Romania Internal Medicine Clinic Clinical Emergency Hospital of BucharestBucharest 014461Romania Clinic of Hematology Filantropia City HospitalCraiova 200143Romania

BACKGROUND Obesity and diabetes are associated with high levels of oxidative *** Romanian patients with obesity and(or)diabetes,this association has not been sufficiently *** To evaluate oxidative stress in obese and(or)diabetic subjects and to investigate the possible correlations between oxidative stress and anthropometric/biochemical *** Oxidative stress was evaluated from a single drop of capillary *** oxygen species(ROS)were evaluated using the free oxygen radical test(FORT).The free oxygen radical defence(FORD)assay was used to measure antioxidant *** FORT levels were higher in obese subjects(3.04±0.36 mmol/L H2O2)vs controls(2.03±0.14 mmol/L H2O2)(P<0.0001).FORD levels were lower in obese subjects(1.27±0.13 mmol/L Trolox)vs controls(1.87±1.20 mmol/L Trolox)(P=0.0072).Obese diabetic subjects had higher FORT values(3.16±0.39 mmol/L H2O2)vs non-diabetic counterparts(2.99±0.33 mmol/L H2O2)(P=0.0233).In obese subjects,FORT values correlated positively with body mass index(BMI)(r=0.48,P=0.0000),waist circumference(WC)(r=0.31,P=0.0018),fasting plasma glucose(FPG)(r=0.31,P=0.0017),total cholesterol(TC)(r=0.27,P=0.0068)and uric acid(r=0.36,P=0.0001).FORD values correlated negatively with BMI(r=-0.43,P=0.00001),WC(r=-0.28,P=0.0049),FPG(r=-0.25,P=0.0130),TC(r=-0.23,P=0.0198)and uric acid(r=-0.35,P=0.0002).In obese diabetic subjects,FORT values correlated positively with BMI(r=0.49,P=0.0034)and TC(r=0.54,P=0.0217).FORD values were negatively associated with BMI(r=-0.54,P=0.0217)and TC(r=-0.58,P=0.0121).CONCLUSION Oxidative stress levels,as measured by the FORT and FORD assays,were higher in obese subjects vs *** levels were elevated in diabetic obese patients vs obese non-diabetic patients and controls.

关键词： Oxidative stress Obesity Diabetes Reactive oxygen species Antioxidants Dyslipidaemia

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A Pilot Test for A One-year Cognitive Training Intervention in Elderly Adults with Mild Cognitive Impairment

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Biomedical and Environmental Sciences 2020年第10期33卷 796-802页

作者： MENDOZA-HOLGADO cristina LOPEZ-ESPUELA Fidel MORAN Jose maria RONCERO-MARTIN Raul LAVADO-GARCIA Jesus ALIAGA Ignacio PUERTO-PAREJO Luis Manuel LEAL-HERNANDEZ Olga VERA Vicente PEDRERA-CANAL maria Nursing Department Metabolic Bone Disease Research GroupUniversity of ExtremaduraNursing and Occupational Therapy CollegueAvd.Universidad s/n10003-CaceresSpain Facultad de Odontologia Universidad ComplutenseMadridSpain

In Spain,the proportion of elderly individuals has increased to 19.1%.By 2068,the proportion of elderly individuals is estimated to increase to 29.4% given the largest birth cohorts in Spain’s history(Instituto Nacional de Estadistica,INE).This challenge needs a supportive plan,as economic and caring problems may occur because of age-related health problems,including cognitive decline and dementia[1].

关键词： elderly Pilot Training

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Autoimmune gastritis presenting as iron deficiency anemia in childhood

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World Journal of Gastroenterology 2014年第42期20卷 15780-15786页

作者： cristina Gon?alves maria Emília Oliveira Ana M Palha Anabela Ferr?o Anabela Morais Ana Isabel Lopes Gastroenterology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre Pathology Department University Hospital Santa Maria Lisbon Academic Medical Centre Hematology Unit Pediatric Department University Hospital Santa Maria Lisbon Academic Medical Centre

AIM: To characterize clinical, laboratorial, and histological profile of pediatric autoimmune gastritis in the setting of unexplained iron deficiency anemia investigation.

关键词： Autoimmune gastritis Iron deficiency anemia Children

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Trypanosoma rangeli:growth in mammalian cells in vitro and action of a repositioned drug(17-AAG)and a natural extract(Artemisia *** oil)

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BIOCELL 2019年第1期43卷 13-19页

作者： Ana Laura CIMADOR Emeli Luciana GALANTE Lucila Ibel MUNOZ Patricia Silvia ROMANO Antonella Denisse LOSINNO maria cristina VANRELL Facultad de Farmacia y Bioquimica Universidad Juan Agustin Maza.MendozaArgentina Facultad de Ciencias Medicas Universidad Nacional de Cuyo.MendozaArgentina Laboratorio de Biologia de Trypanosoma cruzi y la celula hospedadora-Instituto de Histologia y Embriologia“Dr.Mario H.Burgos”IHEM-CONICET-Universidad Nacional de Cuyo.Mendoza Argentina

Trypanosoma rangeli and *** are both parasitic unicellular species that infect *** ***,the causative agent of Chagas disease,*** is an infective and non-pathogenic parasite for humans,but pathogenic for vectors from the Rhodnius *** both species can coexist in different hosts and overlap their infective cycles but very little is known about the infection of *** in mammalian cells,we decided to characterize both the development of this parasite in cell culture and the effect of therapeutic agents with potential trypanocidal action on *** found that *** exhibits a cycle of infection in Vero cells similar to that for *** and that the repurposed drug,17-AAG,and the natural extract Artemisia *** oil produce a toxic effect on epimastigotes showing a trypanocidal action from the fifth day of *** treatments also affected the infection of trypomastigotes and reduced the capacity of replication of amastigotes of *** ***/*** coinfection cases have been reported,the finding of drugs with potential activity against both species could be significant in the ***,studies of susceptibility of both species to drugs could also help to know the different mechanisms of pathogenicity in humans displayed by *** that are absent in ***.

关键词： Life-cycle Treatment Trypanosoma rangeli

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Cuboidal vs equiaxed:The role of nanopowder assembly during BaTiO_(3)ceramic pressing step

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Journal of Materials Science & Technology 2024年第22期189卷 13-24页

作者： Vlad Alexandru Lukacs Radu Stirbu Oana Andreea Condurache Lavinia Petronela Curecheriu Mirela Airimioaei cristina Elena Ciomaga George Stoian Gabriel Caruntu Liliana Mitoseriu maria Teresa Buscaglia Dielectrics Ferroelectrics&Multiferroics GroupFaculty of Physics“Al.I.Cuza”University of Iasi11 Carol I Bv.700506 IasiRomania Electronic Ceramics Department Jozef Stefan InstituteLjubljana 1000Slovenia Faculty of Chemistry “Al.I.Cuza”University of Iasi11 Carol I Bv.700506 IasiRomania Department of Exact and Natural Sciences Institute of Interdisciplinary Research“Al.I.Cuza”University of Iasi11 Carol I Bv.700506 IasiRomania National Institute of Research and Development for Technical Physics 700050 IasiRomania Departement of Chemistry&Biochemistry Central Michigan UniversityMount PleasantMI 48859United States Institute of Condensed Matter Chemistry and Technologies for Energy CNRVia de Marini 616149 GenoaItaly

The functional properties of BaTiO_(3)ceramics,produced by using the same pressing/sintering strategy from nanopowders with two distinct morphologies(cuboidal/equiaxed nanoparticles)and similar particle sizes,are comparatively *** sintered ceramics exhibit similar nanoscale structures,with faceted crystalline grains and crystalline inclusions,clean grain boundaries and well-defined 90°lamellar domains extending in some entire grains or finer nanodomains inside grain *** differences in the functional behavior originating from the different nanopowder morphology are described in terms of the nanoparticle assembly during the pressing *** numerically simulated green body densification indicated a more efficient assembly resulting in higher density for the cubic particles(0.90 vs.0.84 relative density)and a more homogeneous pore distribution in the spherical-derived *** a result of the higher density after sintering,the functional properties are enhanced in cuboid-originated *** comparison,the ceramic produced from cubic nanoparticles sintered at T_(1)/T_(2)=1250/800℃shows higher permittivity(room temperature value of∼2100-cubic vs.∼1700-rounded),enhanced ferroelectric characteristics(cubic:P_(s)=8.57μC cm^(-2),P_(r)=0.95μC cm^(-2),and E_(c)=2.3 kV cm^(-1),with respect to P_(s)=6.06μC cm^(-2),P_(r)=0.4μC cm^(-2),and E_(c)=1.4 kV cm^(-1),for spherical-derived ones,measured at E_(max)=29.3 kV cm^(-1))and a stronger dc-field dependence of their permittivity of∼12%(cubic)***∼2%(spherical),for a dc-applied field in the range of-15 kV cm^(-1)

关键词： Electroceramics Pressing Morphology Compaction BaTiO_(3)

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Hepatitis B:Epidemiology and prevention in developing countries

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World Journal of Hepatology 2012年第3期4卷 74-80页

作者： Elisabetta Franco Barbara Bagnato maria Giulia Marino cristina Meleleo Laura Serino Laura Zaratti Department of Public Health University Tor Vergata PhD Program for Methodologies in Preventive Medicine and Therapy University Tor Vergata Specialization School for Hygiene and Preventive Medicine University Tor Vergata

Hepatitis B virus(HBV)infection is a serious global public health *** infection may be transmitted through sexual intercourse,parenteral contact or from an infected mother to the baby at birth and,if contracted early in life,may lead to chronic liver disease,including cirrhosis and hepatocellular *** the basis of the HBV carrier rate,the world can be divided in 3 regions of high,medium and low *** major concern is about high endemicity countries,where the most common route of infection remains vertical transmission from mother to *** of all pregnant women and passive immunization with human hepatitis B immunoglobulin are not affordable for many developing *** infection rate can be reduced by modifying behavior,improving individual education,testing all blood donations,assuring asepsis in clinical practice and screening all pregnant ***,availability of a safe and efficacious vaccine and adoption of appropriate immunization strategies are the most effective means to prevent HBV infection and its *** unsolved problem for poorest countries,where the number of people currently infected is high,is the cost of the vaccine.A future challenge is to overcome the social and economic hurdles of maintaining and improving a prevention policy worldwide to reduce the global burden of the disease.

关键词： Hepatitis B Developing countries Endemicity Seroprevalence Vaccine

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Esterification of Aspen Wood with Maleic Anhydride

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南京林业大学学报(自然科学版) 1997年第3期21卷 105-111页

作者： maria cristina TIMAR and maria Daniela MIHAI (“Transilvania” University of Brasov, Department of Wood Technology, ROMANIA) 罗马尼亚布拉索夫大学木材工业系

ＥｓｔｅｒｉｆｉｃａｔｉｏｎｏｆＡｓｐｅｎＷｏｏｄｗｉｔｈＭａｌｅｉｃＡｎｈｙｄｒｉｄｅＭａｒｉａＣｒｉｓｔｉｎａＴＩＭＡＲａｎｄＭａｒｉａＤａｎｉｅｌａＭＩＨＡＩ（“Ｔｒａｎｓｉｌｖａｎｉａ”Ｕｎｉｖｅｒｓｉｔ... 详细信息

ＥｓｔｅｒｉｆｉｃａｔｉｏｎｏｆＡｓｐｅｎＷｏｏｄｗｉｔｈＭａｌｅｉｃＡｎｈｙｄｒｉｄｅＭａｒｉａＣｒｉｓｔｉｎａＴＩＭＡＲａｎｄＭａｒｉａＤａｎｉｅｌａＭＩＨＡＩ（“Ｔｒａｎｓｉｌｖａｎｉａ”ＵｎｉｖｅｒｓｉｔｙｏｆＢｒａｓｏｖ，Ｄｅｐａｒｔｍ...

关键词： Aspen wood Maleic anhydride Esterification

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Renin-angiotensin system in the pathogenesis of liver fibrosis

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World Journal of Gastroenterology 2009年第21期15卷 2579-2586页

作者： Regina maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana cristina Simoes e Silva Department of Pediatrics Faculty of MedicineFederal University of Minas Gerais Laboratory of Hypertension Department of Physiology and BiophysicsInstitute of Biological SciencesFederal University of Minas Gerais Laboratory of Immunopharmacology Department of Biochemistry and ImmunologyInstitute of Biological SciencesFederal University of Minas Gerais

Hepatic fibrosis is considered a common response to many chronic hepatic injuries. It is a multifunctional process that involves several cell types, cytokines, chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem. In spite of many studies regarding the development of fibrosis, the understanding of the pathogenesis remains obscure. The hepatic tissue remodeling process is highly complex, resulting from the balance between collagen degradation and synthesis. Among the many mediators that take part in this process, the components of the Renin angiotensin system （RAS） have progressively assumed an important role. Angiotensin （Ang） II acts as a profibrotic mediator and Ang-（1-7）, the newly recognized RAS component, appears to exert a counter-regulatory role in liver tissue. We briefly review the liver fibrosis process and current aspects of the RAS. This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis, focusing on the putative role of the ACE2-Ang-（1-7）- Mas receptor axis.

关键词： Hepatic fibrosis Renin angiotensin system Angiotensin II Angiotensin-(1-7) Receptor Mas Angiotensin converting enzyme 2

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Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice

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World Journal of Gastroenterology 2006年第40期12卷 6464-6472页

作者： Alfredo Santana Carlos Medina maria cristina Paz-Cabrera Federico Díaz-Gonzalez Esther Farré Antonio Salas Marek W Radomski Enrique Quintero Gastroenterology Department and Research Unit Hospital Universitario de Canarias Tenerife Spain Reumathology Department Hospital Universitario de Canrias Tenerife Spain Pathology Department Hospital Mutua de Terrassa Barcelona Spain Institute of Molecular Medicine University of Texas Houston-Texas United States

AIM: To study whether matrix metalloproteinase-9 (MMP-9) is a key factor in epithelial damage in the dextran sodium sulphate (DSS) model of colitis in ***: MMP-9-deficient and wild-type (wt) mice were given 5% DSS in drinking water for 5 d followed by recovery up to 7 d. On d 5 and 12 after induction of colitis, gelatinases, MMP-2 and MMP-9, were measured in homogenates of colonic tissue by zymography and Western blot, whereas tissue inhibitor of metalloproteinases (TIMPs) were measured by reverse zymography. The gelatinolytic activity was also determined in supernatants of polymorphonuclear leukocytes (PMN) isolated from mice blood. Moreover, intestinal epithelial cells were stimulated with TNF-α to study whether these cells were able to produce MMPs. Finally, colonic mucosal lesions were measured by microscopic examination. RESULTS: On d 5 of colitis, the activity of MMP-9 was increased in homogenates of colonic tissues (0.24 ± 0.1 vs 21.3 ± 6.4, P < 0.05) and PMN from peripheral blood in wt (0.5 ± 0.1 vs 10.4 ± 0.7, P < 0.05), but not in MMP-9-deficient animals. The MMP-9 activity was also up-regulated by TNF-α in epithelial intestinal cells (2.5 ± 0.5 vs 14.7 ± 3.0, P < 0.05). Although colitis also led to increase of TIMP-1 activity, the MMP-9/TIMP-1 balance remained elevated. Finally, in the MMP-9-deficient colitic mice both the extent and severity of intestinal epithelialinjury were significantly attenuated when compared with wt mice. CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9. This suggests that intestinal injury induced by DSS is modu-lated by MMP-9 and that inhibition of this gelatinase may reduce inflammation.

关键词： Matrix metalloproteinases MMP-9-deficient Dextran sodium sulphate Inflammatory bowel disease Experimental colitis

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Molecular evaluation of glutathione S transferase family genes in patients with sporadic colorectal cancer

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World Journal of Gastroenterology 2018年第39期24卷 4462-4471页

作者： Gabriela Helena Rodrigues-Fleming Glaucia maria de Mendonca Fernandes Anelise Russo Patrícia Matos Biselli-Chicote Joao Gomes Netinho Erika cristina Pavarino Eny maria Goloni-Bertollo Genetics and Molecular Biology Research Unit-UPGEM Sao Jose do Rio Preto Medical SchoolFAMERPSao Jose do Rio PretoSP 15090-000Brazil Department of Surgery and Coloproctology Sao Joes do Rio Preto Medical SchoolFAMERPSao Joes do Rio PretoSP 15090-000Brazil

AIM To evaluate the association between polymorphismsin glutathione S transferases(GSTs) and the risk of sporadic colorectal cancer(SCRC), tumor progression and the survival of *** A case-control study of 970 individuals from the Brazilian population was conducted(232 individuals from the case group with colorectal cancer and 738 individuals from the control group without a history of cancer). PCR multiplex and PCR-RFLP techniques were used to genotype the GST polymorphisms. The tumors were categorized according to the TNM classification: tumor extension(T), affected lymph nodes(N), and presence of metastasis(M). Logistic regression, multiple logistic regression and survival analysis were used to analyze the data. The results are presented in terms of odds ratio(OR) and 95% confidence interval(CI). The level of significance was set at 5%(P ≤ 0.05).RESULTS Age equal to or over 62 years(OR = 8.79; 95%CI: 5.90-13.09, P < 0.01) and female gender(OR = 2.91; 95%CI: 1.74-4.37; P < 0.01) were associated with increased risk of SCRC. Analysis of the polymorphisms revealed an association between the GSTM1 polymorphisms and a risk of SCRC(OR = 1.45; 95%CI: 1.06-2.00; P = 0.02), as well as between GSTT1 and a reduced risk of the disease(OR = 0.65; 95%CI: 0.43-0.98; P = 0.04). An interaction between the presence of the wild-type allele of GSTP1 Ile105 Val polymorphism and tobacco consumption on risk of SCRC(OR = 2.33; 95%CI: 1.34-4.05; P = 0.05) was observed. There was an association between the GSTM1 null genotype and the presence of advanced tumors(OR = 2.33; 95%CI: 1.23-4.41; P = 0.009), as well as increased risk of SCRC in the presence of a combination of GSTT1 non-null/GSTM1 null genotypes(OR = 1.50; 95%CI: 1.03-2.19; P = 0.03) and GSTT1 non-null/GSTM1 null/GSTP1 Val~*(OR = 1.85; 95%CI: 1.01-3.36, P = 0.04). Combined GSTT1 non-null/GSTM1 null genotypes(OR = 2.40; 95%CI: 1.19-4.85; P = 0.01) and GSTT1 non-null/GSTM1 null/GSTP1 Val~*(OR = 2.92; 95%CI: 1.05-8.12; P

关键词： Colorectal neoplasms Smoking Alcohol Glutathione S transferase Genetic polymorphisms

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