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Health 2020年第10期12卷 1360-1370页

作者： Lucas Lima de Carvalho Lucas Rodrigues Claro Amanda dos Santos Cabral Marcela Pereira da Silva Mello Bruna Liane Passos Lucas Marcelly Valadares Souza Simone Fonseca Lucas Alexandre Oliveira Tellles Ravini Fernandez dos Santos Vieira dos Santos Marcia Augusta Pereira dos Santos Claudia Lima Campos Alzuguir maria Cristina Dias da Silva Antonio Eduardo Vieira dos Santos maria antonieta rubio tyrrell Eduardo Alexander Júlio César Fonseca Lucas Anna Nery School of Nursing Federal University of Rio de Janeiro Rio de Janeiro Brazil Celso Lisboa University Center Rio de Janeiro Brazil State Secretariat of Education of Rio de Janeiro Rio de Janeiro Brazil Department of Medicine in Primary Health Care Faculty of Medicine Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal and Child Nursing Faculty of Nursing State University of Rio de Janeiro Rio de Janeiro Brazil Department of Maternal-Child Nursing Faculty of Nursing Fernandez Figueira Institute of the Oswaldo Cruz Foundation State University of Rio de Janeiro Rio de Janeiro Brazil

This documentary research aimed to describe the results of an epidemiological survey that sought to determine the prevalence of Infections Related to Health Care (IRHC) in newborns admitted to a Neonatal Intensive Care Unit (NICU) at the city of Rio de Janeiro. For methodology, the existing data in the original research database were used as the primary source. The method used was the case study in a quantitative approach. The data have been statistically arranged by odds ratio, which measured the possibility of IRHC development at the 102 newborns, by exposition at the risk factors. Results: IRHC prevalence with pneumonias, sepsis, navel’s infection and ocular infections predominance rises. Prematures are 4.10 more susceptible. Twelve hours after amniotic rupture there are 1.77 more chances of infections. Babies with more than 10 days of hospitalization are 4.70 more susceptible than those with 10 days. The registers examined were incipient at the IRHC’s characterization, beginning and duration, which make the IRHC’s diagnostic/notification difficult.

关键词： Neonatal Nursing Cross Infection Data Interpretation Statistical

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Health 2020年第10期

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Fast preparation route to high-performances textured Sr-doped Ca_3Co_4O_9 thermoelectric materials through precursor powder modification

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Science China Materials 2019年第3期62卷 399-406页

作者： Miguel Angel Torres Gustavo Garcia Idoia Urrutibeascoa maria antonieta Madre Juan Carlos Diez Andres Sotelo ICMA (CSIC-Universidad de Zaragoza) Centro Stirling S. Coop. Mondragon Unibertsitatea

This work presents a short and very efficient method to produce high performance textured Ca_3Co_4O_9 thermoelectric materials through initial powders modification. Microstructure has shown good grain orientation, and low porosity while slightly lower grain sizes were obtained in samples prepared from attrition milled powders. All samples show the high density of around 96% of the theoretical *** similar characteristics are reflected in, approximately,the same electrical resistivity and Seebeck coefficient values for both types of samples. However, in spite of similar power factor(PF) at low temperatures, it is slightly higher at high temperature for the attrition milled samples. On the other hand, the processing time reduction(from 38 to 2 h) when using attrition milled precursors, leads to lower mechanical properties in these samples. All these data clearly point out to the similar characteristics of both kinds of samples, with a drastic processing time decrease when using attrition milled precursors, which is of the main economic importance when considering their industrial production.

关键词： ceramics oxides hot-pressing electrical properties power factor

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In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds:An Update

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Genomics, Proteomics & Bioinformatics 2017年第4期15卷 236-245页

作者： Ursula Catalan Laura Barrubes Rosa maria Vails Rosa Soila Laura rubio Functional Nutrition Oxidation and Cardiovascular Diseases Group(NFOC-Salut)Technological Center of Nutrition and Health(CTNS)lnstitut d'lnvestigacio Sanitaria Pere Virgili(IISPV)Faculty of Medicine and ttealth SciencesUniversitat Rovira i VirgiliReus 43201Spain Food Technology Department Universitat de Lleida-AGROTECNIO CenterLleida 25198Spain

Dietary phenolic compounds （PCs） have been receiving intercst lor their presumcd roles ill disease prevention. However, there is a lack of studies on the underlying molecular mechanisnls. In this regard, in vitro metabolomic approaches are suitable for the investigation o1 the molecular changes in response to PC exposure. Up to date, the biological effects of PCs have only been cxalnined for PCs from rosemary （Rosmarinus officinalis）, olive oil, and reSVCl-atrol using cell-based mctabolomic approach, although transcriptomic and/or proteomic studies have also been conducted in the same in vi[ro cell experiment in some cases. Our integral analysis of the reviewed studies suggest that PCs may be involved not only in basic cellular processes or macro-and micro-nutrient meta- bolism, but also in specific metabolic pathways that have been thoroughly investigated. These modulated pathways could have a clinical impact on neurodegenerativc diseases, type 2 diabetes, cancer, and cardiovascular diseases. In conclusion, the in vitro metabolomic approaches provide additional information of the molecular mechanisms involved in disease risk reduction of dietary PCs. In order to elucidate the mechanisms of action of PCs, more metabolomic cell-based studies are nccdcd and testing the physiological conjugated forms of PCs in these cell systems could be of special interest.

关键词： Cell-based Metabolomics Phenolic compounds Mechanism of action Disease prevention

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Origin of the Caribbean Plate Conference Siguenza, Spain, May 29-June 2, 2006

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Episodes 2006年第4期29卷 299-300页

作者： Keith H. James maria antonieta Lorente Honorary Departmental Fellow Institute of Geography and Earth Sciences University of Wales Aberystwyth UK Stratigraphy Professor Postgraduate Program Universidad Central de Venezuela Caracas Venezuela

An international research conference, entitled ＂Geology of the area between North and South America, with focus on the origin of the Caribbean Plate＂, took place in Siguenza, Spain, from May 29-June 2, 2006. Fifty five people from 11 countries attended the meeting, which was chaired by Drs. Albert W. Bally, Mafia antonieta Lorente and David G. Roberts. Siguenza authorities and volunteers lent a great deal of enthusiastic support, while BP, Repsol, Shell, Statoil and SEPM provided financial encouragement.

关键词：加勒比海西班牙地质环境国际研究会议行业交流

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Recurrent anal fistulae:Limited surgery supported by stem cells

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World Journal of Gastroenterology 2015年第11期21卷 3330-3336页

作者： Damian Garcia-Olmo Hector Guadalajara Ines rubio-Perez maria Dolores Herreros Paloma de-la-Quintana mariano Garcia-Arranz Hospital Fundación Jimenez Díaz Colorectal Surgery Unit University Hospital Fundación Jiménez Díaz Colorectal Surgery Unit La Paz University Hospital Cell Therapy Laboratory University Hospital Fundación Jiménez Díaz

AIM:To study the results of stem-cell therapy under a Compassionate-use Program for patients with recurrent anal ***:Under controlled circumstances,and approved by European and Spanish laws,a Compassionate-use Program allows the use of stem-cell therapy for patients with very complex anal *** had previously undergone multiple surgical interventions that had failed to resolve the fistulae,and presented symptomatic *** intervention consisted of limited surgery(with closure of the internal opening),followed by local implant of stem cells in the fistula-tract *** expanded adipose-derived stem cells were the main cell type selected for *** first evaluation was performed on the 8th postoperative week;outcome was classified as response or partial *** one year after the intervention confirmed if complete healing of the fistula was ***:Ten patients(8 male)with highly recurrent and complex fistulae were treated(mean age:49years,range:28-76 years).Seven cases were nonCrohn’s fistulae,and three were Crohn’s-associated *** surgical attempts ranged from 3to *** patients presented with preoperative incontinence(Wexner scores of 12 and 13 points).After the intervention,six patients showed clinical response on the 8th postoperative week,with a complete cessation of suppuration from the *** patients presented a partial response,with an evident decrease in suppuration.A year later,six patients(60%)remained healed,with complete reepithelization of the external *** Wexner Scores were 0 in six *** two patients with previous incontinence improved their scores from12 to 8 points and from 13 to 5 *** adverse reactions or complications related to stem-cell therapy were reported during the study ***:Stem cells are safe and useful for treating anal *** can be achieved in severe cases,sparing fecal incontinence risk,and impr

关键词： Adipose-derived stem cells Cell therapy Compassion

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Evaluation of the Permeation and Penetration of Two Formulations of Terbinafine Chlorhydrate Incorporated in Liposomes (Cream 1%) vs. a Conventional Formulation (Cream 1%), in an <i>in Vitro-ex Vivo</i>Model

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Journal of Biosciences and Medicines 2019年第8期7卷 119-133页

作者： Sanabria Kinski Annunziato maria antonieta Chacon Nicolas Inatti Alfredo Department of Nanotechnology of Laboratories Leti S.A.V. GuarenasVenezuela Department of Research and Development Laboratories Biocontrolled C.A.GuarenasVenezuela

In this trial, a topical formulation of a 1% liposome TH cream was compared to a conventional TH formulation. Permeation was evaluated through a synthetic membrane. The study provided information on the rate of diffusion and percentage of drug release and also compared the penetration dynamics in the layers of the stratum corneum of both formulations. Liposome TH cream was able to deliver the active ingredient to a larger number of SC layers, with a higher amount of drug, which is very promising for the treatment of superficial mycoses.

关键词： Antifungal Franz Diffusion Cell Tape Striping Method Liposome Terbinafine HCl Drug Carrier Systems Stratum Corneum

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Nested multiplex PCR for identification and detection of human Plasmodium species including Plasmodium knowlesi

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 280-284页

作者： maria Miguel-Oteo Adela I Jiram Thuy H Ta-Tang Marta Lanza Shamilah Hisam José Miguel rubio Malaria & Emerging Parasitic Diseases Laboratory Parasitology DepartmentNational Microbiology Centre. Instituto de Salud Carlos Ⅲ Majadahonda Unit Institut Penyelidikan PerubatanInstitute for Medical Research

Objective:To develop a new technique for diagnosis of Plasmodium knowlesi and at the same time to be able to discriminate among the diverse species of Plasmodium causing human ***:In this study the nested multiplex malaria PCR was redesigned,targeting the 18S rR NA gene,to identify the fifth human Plasmodium species,Plasmodium knowlesi,together with the other human Plasmodium(Plasmodium falciparum,Plasmodium vivax,Plasmodium ovale and Plasmodium malariae)by amplified fragment size using only two amplification processes and including an internal reaction control to avoid false ***:The technique was validated with 91 clinical samples obtained from patients with malaria compatible *** technique showed high sensitivity(100%)and specificity(96%)when it was compared to the reference method employed for malaria diagnosis in the Instituto de Salud Carlos栿and a published real-time PCR malaria ***:The technique designed is an economical,sensitive and specific alternative to current diagnosis ***,the method might be tested in knowlesi-malaria endemic areas with a higher number of samples to confirm the quality of the method.

关键词： Malaria Plasmodium knowlesi Nested multiplex PCR Molecular diagnosis

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The Mexican Environmental Flow Standard:Scope,Application and Implementation

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Journal of Environmental Protection 2014年第1期5卷 71-79页

作者： maria antonieta Gomez-Balandra maria del Pilar Saldana-Fabela Maricela Martinez-Jimenez Hydrobiology and Environmental Assessment Department Mexican Institute of Water TechnologyJiutepecMexico

With the implementation of the Official Mexican Standard NOM-011-CONAGUA-2000 [1], the water balance of 730 basins has been calculated and its water availability agreement is published. This rule points out to allocate water for the environment only as an annual volume since methods for estimating environmental flows were not standardized in the country. For this reason, The Water Agency (CONAGUA) issued the standard NMX-AA-159-SCFI-2012 [2], to assess environmental flows needed both, at the strategic level in Integrated Water Resources Management (IWRM), or as part of the Environmental Impact Assessment (EIA) of large hydraulic projects. For over ten years, this standard was developed and finally published in September 2012 [3]. It explains different methods from hydrological to holistic approaches, with examples for the country. Its application will cover the urgent need to preserve water for ecosystems in watersheds with high ecological importance and low stress for water use. In this paper, an analysis of the environmental flow standard and examples of the suggested hydrological methods are presented. For its implementation, some steps are taking place, mainly establishing environmental water reserves and building capacities. In addition, environmental allocations are becoming a common practice for all water projects, as well as setting limits to hydrological alterations by hydroelectric dams. The standard promotes the use of technical integration tools to analyze the responses of ecosystems to changes in the flow regime and adaptive management under different scenarios of water use. Although the main steps have been taken, its implementation as mandatory rule will take time.

关键词： Environmental Flows Hydrological Methods Mexican Standard

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Environmental Approaches during Planning and Construction Stages of Hydropower Projects in Mexico

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Journal of Environmental Protection 2015年第10期6卷 1186-1195页

作者： maria antonieta Gomez-Balandra maria del Pilar Saldana-Fabela Rosa Dina Llerandi-Juarez Hydrobiology and Environmental Assessment Department Mexican Institute of Water TechnologyMorelosMexico 2Discipline of Compensations Resettlements and EcologyFederal Commission of Electricity(CFE)Mexico CityMexico

During the Environmental Impact Assessment procedure (EIA) for hydropower projects, apart from the compliance with environmental standards and regulations, important environmental and ecosystem changes are foreseen from planning and construction stages. In Mexico, the EIA and environmental standards are being systematically applied and fulfilled at planning and construction stages for hydropower projects. These are mainly related to control air emissions, solid and hazardous wastes, water discharges and deal with protected species. In addition, due to land use changes, forestry compensation procedures have already been established. To comply with project approval conditions, an Environmental Management Plan (EMP) is carried out during construction;it includes mitigation measures, standards, regulations and approval conditions resulting of project review and in some cases requests from the public audience. Monitoring is carried out in the area of influence that is in the works and where it is expected that natural processes are modified. However, indicators to track these changes are minimal. This paper analyzes the regulatory and organizational frameworks to address environmental management during the planning and construction of hydropower facilities in Mexico and gives recommendations to expand the scope of the supervision and management of ecosystem changes.

关键词： Environment Hydro Project Requirement Mexico

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