检索结果-南通市图书馆

Pull the fuzes:Processing protein precursors to generate apoplastic danger signals for triggering plant immunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Communications 2024年第8期5卷 113-136页

作者： Daniele Del Corpo Daniele Coculo Marco Greco Giulia De Lorenzo Vincenzo lionetti Department of Biology and Biotechnology“Charles Darwin ”Sapienza University of RomeRomeItaly

The apoplast is one of the first cellular compartments outside the plasma membrane encountered by phytopathogenic microbes in the early stages of plant tissue *** have developed sophisticated surveillance mechanisms to sense danger events at the cell surface and promptly activate ***,a fine tuning of the activation of immune pathways is necessary to mount a robust and effective defense *** endogenous proteins and enzymes are synthesized as inactive precursors,and their post-translational processing has emerged as a critical mechanism for triggering alarms in the *** this review,we focus on the precursors of phytocytokines,cell wall remodeling enzymes,and *** physiological events that convert inactive precursors into immunomodulatory active peptides or enzymes are *** review also explores the functional synergies among phytocytokines,cell wall damage-associated molecular patterns,and remodeling,highlighting their roles in boosting extracellular immunity and reinforcing defenses against pests.

关键词： apoplast immunity activation post-translational processing cell wall proteases pro-peptides proenzymes phytocytokines cell-wall remodeling enzymes phytopathogenic microbes plant immunity

The surprising‘Coeliac Chinese box’from Italy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gastroenterology Report 2021年第5期9卷 478-479,I0003页

作者： chiara maria Trovato Monica Montuori Annalisa Morelli Elena lionetti Giulia Naspi-Catassi Ilaria Laudadio Francesco Valitutti Carlo Catassi Maternal and Child Health Department Pediatric Gastroenterology and Liver UnitSapienza—University of RomeRomeItaly Department of Pediatrics Marche Polytechnic UniversityAnconaItaly Department of Molecular Medicine Sapienza-University of RomeRomeItaly Pediatric Unit AOU San Giovanni di Dio e Ruggi di AragonaSalernoItaly European Biomedical Research Institute of Salerno SalernoItaly Mucosal Immunology and Biology Research Center Division of Pediatric Gastroenterology and NutritionMassachusetts General HospitalBostonMassachusettsUSA

Background Coeliac disease(CD)-an autoimmune systemic disorder elicited by gluten in genetically predisposed individuals-can be considered a major public-health *** prevalence is increasing in areas such as Asian *** global seroprevalence of CD is 1.4%,the highest being in Europe and Oceania,and very low in Southern America;however,few data are available for Asian countries,especially for China[1].

关键词：乳糜泻 Asian 令人

Helicobacter pylori infection and atopic diseases:Is there a relationship? A systematic review and meta-analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第46期20卷 17635-17647页

作者： Elena lionetti Salvatore Leonardi Angela Lanzafame maria Teresa Garozzo Martina Filippelli Stefania Tomarchio Viviana Ferrara Carmelo Salpietro Alfredo Pulvirenti Ruggiero Francavilla Carlo Catassi Department of Pediatrics University of Catania95100 CataniaItaly Department of Pediatrics Unit of Pediatric Genetics and ImmunologyUniversity of Messina98125 MessinaItaly Department of Clinical and Molecular Biomedicine University of Catania95100 CataniaItaly Department of Developmental Medicine University of Bari70124 BariItaly Department of Pediatrics Università Politecnica delle Marche60123 AnconaItaly

AIM: To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori (H. pylori), atopy and allergic diseases.

关键词： Atopy Allergic diseases Helicobacter pylori Hygiene hypothesis Infection

High-Lard and High-Fish Oil Diets Differ in Their Effects on Insulin Resistance Development, Mitochondrial Morphology and Dynamic Behaviour in Rat Skeletal Muscle

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2013年第9期4卷 105-112页

作者： Lillà lionetti Raffaella Sica maria Pia Mollica Rosalba Putti Department of Biology University of Naples “Federico II” Naples Italy Department of Biology University of Naples “Federico II” Naples Italy.

Fish oil (mainly omega 3 polyunsaturated fatty acids), differently from lard (mainly saturated fatty acids) has been suggested to have anti-inflammatory effects associated with amelioration of insulin sensibility. An important role in skeletal muscle insulin resistance development has been recently attributed to mitochondrial dynamic behavior. Mitochondria are dynamic organelles that frequently undergo fission/fusion processes and a shift toward fission process has been associated with skeletal muscle mitochondrial dysfunction and insulin resistance development. The present work aimed to evaluate if the replacement of lard with fish oil in high-fat diet positively affect skeletal muscle mitochondrial dynamic behavior in association with the improvement of insulin-resistance. Body weight gain, systemic insulin-resistance (glucose/insulin ratio), serum TNFα levels and skeletal muscle lipid content were assessed in rats fed a high-lard or high-fish-oil diet for 6 weeks. In skeletal muscle sections, immunohistochemical analysis were performed to detect the presence of insulin receptor substrate 1 (IRS1) and tyrosine phosphorylated IRS1 (key factor in insulin signalling pathway) as well as to detect the main proteins involved in mitochondrial fusion (MFN2 and OPA1) and fission (DRP1 and Fis1) processes. Skeletal muscle mitochondrial ultrastructural features were assessed by electron microscopy. High-fish oil feeding induced lower body weight gain, systemic inflammation and insulin-resistance development as well as skeletal muscle lipid accumulation compared to high-lard feeding. Skeletal muscle sections from high-fish oil fed rats exhibited a greater number of immunoreactive fibers for MFN2 and OPA1 proteins as well as weaker immunostaining for DRP1 and Fis1 compared to sections from high-lard fed rats. Electron microscopy observations suggested a prominent presence of fission events in L rats and fusion events in F rats. The positive effect of the replacement of lard wi

关键词： High-Fish Oil Diet High-Lard Diet Skeletal Muscle Mitochondrial Fusion Mitochondrial Fission Insulin-Resistance

Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第40期18卷 5729-5733页

作者： Salvatore Leonardi Andrea Domenico Praticò Elena lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa Department of Pediatrics University of Catania

AIM： To compare intradermal （ID） and intramuscular （IM） booster doses, which have been used in healthy and high risk subjects, such as healthcare workers, haemodialysis patients, human immunodeficiency virus patients, and renal transplant recipients unresponsive to initial hepatitis B vaccination, in celiac individuals. METHODS： We conducted our study on 58 celiac pa- tients, vaccinated in the first year of life, whose blood analysis had showed the absence of protective hepati- tis B virus （HBV） antibodies. All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year. In all patients we randomly performed an HBV vaccine booster dose by ID or IM route. Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine （Engerix B） 2 μg by the ID route, while 28 celiac patients were revaccinated with Engerix B 10 μg by the IM route. Four weeks after every boost- er dose, the anti-hepatitis B surface （HBs） antibody titer was measured by an enzyme-linked immune- adsorbent assay. We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose. The cut off value for a negative anti-HBs antibody titer was 10 IU/*** with values between 10 and 100 IU/L were considered ＂low responders＂ while patients with an antibody titer higher than 1000 IU/L were considered ＂high responders＂. RESULTS： No significant difference in age, gender, du- ration of illness, and years of gluten intake was found between the two groups. We found a high percent- age of ＂responders＂ after the first booster dose （ID = 76.7%, IM = 78.6%） and a greater increase after the third dose （ID = 90%, IM = 96.4%） of vaccine in both groups. Mloreover we found a significantly higher num- ber of high responders （with an anti-HBs antibody titer 〉 1000 IU/L） in the ID （40%） than in the IM （7.1%） group, and this difference was evident after the firs

关键词： Hepatitis B virus Non responders Intradermal route Intramuscular route Celiac disease

Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2021年第38期27卷 6374-6386页

作者： Roberto Peltrini Mauro Podda Simone Castiglioni maria Michela Di Nuzzo Michele D'Ambra Ruggero lionetti Maurizio Sodo Gaetano Luglio Felice Mucilli Salomone Di Saverio Umberto Bracale Francesco Corcione Department of Public Health University of Naples Federico IINapoli 80131Italy Department of Emergency Surgery Cagliari University Hospital"Duilio Casula"Azienda Ospedaliero-Universitaria di CagliariCagliari 09100Italy Department of Medical Oral and Biotechnological SciencesUniversity G.D’Annunzio Chieti-PescaraPescara 65100Italy Department of General Surgery University of InsubriaASST Sette LaghiVarese 21100Italy

Indocyanine green(ICG)fluorescence imaging is widely used in abdominal *** implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical *** that setting,ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic *** purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer *** type of use has been separately addressed and the evidence was *** rectal resection,ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic *** addition,ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from *** intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is *** is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the *** further studies are need to investigate the real clinical benefits,these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications.

关键词： Indocyanine green Fluorescence imaging Near infrared Rectal cancer Total mesorectal excision Anastomotic leakage

Hepatitis B vaccine by intradermal route in non responder patients:An update

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第30期20卷 10383-10394页

作者： Martina Filippelli Elena lionetti Alessia Gennaro Angela Lanzafame Teresa Arrigo Carmelo Salpietro Mario La Rosa Salvatore Leonardi Department of Medical and Pediatric Science University of Catania95100 CataniaItaly Department of Pediatric Sciences University of Messina98100 MessinaItaly

Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus (HBV) infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90% of general population. Individuals who develop an anti-HBs titer less than 10 mIU/mL after primary vaccination cycle are defined “no responders”. Many factors could cause a non response to the HBV vaccination, such as administration of the vaccine in buttocks, impaired vaccine storage conditions, drug abuse, smoking, infections and obesity. Moreover there are some diseases, like chronic kidney disease, human immunodeficiency virus infection, chronic liver disease, celiac disease, thalassaemia, type I diabetes mellitus, down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects. To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection. Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route. This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients. A comprehensive review of the literature using PubMed database, with appropriate terms, was undertaken for articles in English published since 1983. The literature search was undertaken in September 2013.

关键词： Hepatitis B virus Vaccine Intradermal route Non responders Update

Two rare cases of benign hyperlipasemia in children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2014年第1期2卷 16-19页

作者： Elena lionetti Ruggiero Francavilla Salvatore Leonardi Stefania Tomarchio Alessia Gennaro chiara Franzonello Mario La Rosa Department of Medical and Pediatric Science University of Catania 95123 Catania Italy Department of Paediatrics University of Bari 70100 Bari Italy

Gullo's syndrome is a newly identified condition characterized by a chronic elevation of pancreatic amylase and/or lipase in the absence of pancreatic disease. Until now, only one case of benign isolated hyperlipasemia in children has been recorded. We describe two children with benign and not familial increase of serum lipase. Case 1: a six year old girl presented with occasional discovery of serum lipase elevation. Medical history was silent for pancreatic hyperenzymemia. The screening for possible causes for elevated lipase(genetic, autoimmune and infectious diseases) was normal. The serum lipase increased three fold over the upper limit(193 U/L; reference range 0-60 U/L), with daily fluctuation of values. Both ultrasound scan and magnetic resonance imaging were normal. The genetic mutation associated with chronic pancreatitis was negative. We followed up this patient for two years with blood tests every six months and she did not show any signs or symptoms of pancreatic disease, except for the high level of lipase serum. Case 2: an eight year old girl complained of nausea, vomiting and severe abdominal pain in theepigastric region after eating for the last two weeks. Full blood count, electrolytes, C-reactive protein, liver and renal function were normal. Serum lipase was 96 U/L(reference range 0-60 U/L). The screening for the possible causes of pancreatic disease was negative. Endoscopy of the upper gastrointestinal tract, ultrasound, computed tomography scan and magnetic resonance imaging were normal. One year after the presentation of the symptoms, the patient became asymptomatic although the level of serum lipase continued to be high.

关键词： Amylase Lipase Pancreatic hyperenzymemia Gullo’s syndrome Benign hyperlipasemia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

熟悉继电器可获最佳效能

电子设计技术 1997年第1期 46-47+49-53页

作者： Dong lionetti

古老的继电器在过去几年内经历过一些变化。设计师们用光电耦合固体继电器(SSR)补充了普通的SSR,向人们熟知的机电继电器(EMR)提出了挑战。熟悉这些SSR的动作,可以有效地防止线路故障发生,获得最佳的效能。

关键词：继电器线圈电器电流电气设备触点闭合