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Colon cancer stem cells:Controversies and perspectives

World Journal of Gastroenterology 2013年第20期19卷 2997-3006页

作者： maria ausiliatrice puglisi Valentina Tesori Wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini Department of Internal Medicine and Gastroenterology Gemelli Hospital00168 RomeItaly Institute of Anatomy and Cell Biology Università Cattolica del Sacro Cuore00168 RomeItaly Fondazione Ricerca in Medicina ONLUS 40123 BolognaItaly

Tumors have long been viewed as a population in which all cells have the equal propensity to form new tumors,the so called conventional stochastic *** cutting-edge theory on tumor origin and progression,tends to consider cancer as a stem cell *** cells are actively involved in the onset and maintenance of colon *** review is intended to examine the state of the art on colon cancer stem cells(CSCs),with regard to the recent achievements of basic research and to the corresponding translational *** prominence is given to the hypothesized origin of CSCs and to the methods for their *** growing understanding of CSC biology is driving the optimization of novel anti-cancer targeted drugs.

关键词： Colon cancer stem cells Colorectal cancer CD133 Therapy Chemoresistance

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Update on small intestinal stem cells

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World Journal of Gastroenterology 2013年第29期19卷 4671-4678页

作者： Valentina Tesori maria ausiliatrice puglisi Wanda Lattanzi Giovanni Battista Gasbarrini Antonio Gasbarrini Department of Internal Medicine and Gastroenterology Università Cattolica del Sacro Cuore Rome Largo A. Gemelli 8 00197 Rome Italy Department of Internal Medicine Gemelli Hospital 00168 Rome Italy Institute of Anatomy and Cell Biology Università Cattolica del Sacro Cuore 00168 Rome Italy Medical Research Foundation ONLUS Galleria Falcone Borsellino 2 40123 Bologna Italy

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.

关键词： Intestinal stem cells Organoids Intestinal regeneration Lgr5 Niche

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