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Trends in treatment and overall survival among patients with proximal esophageal cancer

World Journal of Gastroenterology 2019年第47期25卷 6835-6846页

作者： Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen margreet van putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen Department of Internal Medicine Division of Medical OncologyGROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Research Netherlands Comprehensive Cancer Organization(IKNL)Eindhoven 5612 HZNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Pathology and Data Analytics Leeds Institute of Medical Research at St James”sUniversity of LeedsLeeds LS97TFUnited Kingdom Department of Medical Oncology University Medical Center UtrechtUtrecht 3584 CXNetherlands Department of Radiation Oncology(MAASTRO clinic) GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6229 ETNetherlands Department of Internal Medicine Division of GastroenterologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands Department of Radiotherapy RadiotherapiegroepDeventer 7416 SENetherlands Department of Medical Oncology Amsterdam University Medical CentersUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiotherapy Insituut VerbeetenTilburg 5042 SBNetherlands Department of Medical Oncology Leiden University Medical CenterLeiden 2333 ZANetherlands Department of Surgery Catharina Hospital EindhovenEindhoven 5623 EJNetherlands Department of Public Health Erasmus Medical Center RotterdamRotterdam 3015 GDNetherlands

BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital ***-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been *** trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease *** optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life *** To establish trends in treatment and OS in patients with proximal esophageal *** In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer *** proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the *** in radiotherapy,chemotherapy,and surgery,and OS were *** were stratified by presence of distant *** Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment *** In total,2783 patients were *** the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,*** metastatic disease,the use of chemotherapy and radiotherapy increased over *** OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on ***

关键词： Esophagus Esophageal cancer Proximal Cervical Upper thoracic Trends Treatment Survival Outcome

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Quantifying source-sink relationships in leaf-color modified rice genotypes during grain filling

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Journal of Integrative Agriculture 2024年第9期23卷 2923-2940页

作者： Zhenxiang Zhou Paul CStruik Junfei Gu Peter E.L.van der putten Zhiqin Wang Jianchang Yang Xinyou Yin Centre for Crop Systems Analysis Department of Plant SciencesWageningen University&ResearchWageningen 6700 AKThe Netherlands College of Agriculture Yangzhou UniversityYangzhou 225009China

Leaf-color modification can affect canopy photosynthesis,with potential effects on rice yield and yield *** source-sink relationships through crop management is often used to improve crop *** study investigated whether and how modifying leaf color alters source-sink relationships and whether current crop cultivation practices remain applicable for leaf-color modified *** collected data of total biomass and nitrogen(N)accumulation in rice genotypes of four genetic backgrounds and their leaf-color modified variants(greener or yellower)were analyzed,using a recently established modelling method to quantify the source-sink(im)balance during grain *** all leaf-color variants,only one yellower-leaf variant showed a higher source capacity than its normal *** was associated with greater post-flowering N-uptake that prolonged the functional leaf-N duration,and this greater post-flowering N-uptake was possible because of reduced pre-flowering N-uptake.A density experiment showed that current management practices(insufficient planting density accompanied by abundant N application)are unsuitable for the yellower-leaf genotype,ultimately limiting its yield ***-color modification affects source-sink relationships by regulating the N trade-off between pre-and post-flowering uptake,as well as N translocation between source and sink *** best exploit leaf-color modification for improving crop productivity,adjustments of crop management practices are required.

关键词： source-sink relationship biomass nitrogen Oryza sativa leaf-color modification

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Effects of plant-soil feedback on tree seedling growth under arid conditions

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Journal of Plant Ecology 2011年第4期4卷 193-200页

作者： Seline S.Meijer Milena Holmgren Wim H.van der putten Resource Ecology Group Wageningen UniversityPO Box 476700 AA WageningenThe Netherlands University College Dublin Forestry Agriculture&Food Science CentreUniversity College DublinBelfieldDublin 4Ireland World Agroforestry Centre(ICRAF) PO Box 30798LilongweMalawi Department of Terrestrial Ecology Netherlands Institute of Ecology(NIOO-KNAW)PO Box 506708 PB WageningenThe Netherlands Laboratory of Nematology Wageningen UniversityPO Box 81236700 ES WageningenThe Netherlands

Plants are able to influence their growing environment by changing biotic and abiotic soil *** soil conditions in turn can influence plant growth conditions,which is called plant–soil ***–soil feedback is known to be operative in a wide variety of ecosystems ranging from temperate grasslands to tropical rain ***,little is known about how it operates in arid *** examined the role of plant–soil feedbacks on tree seedling growth in relation to water availability as occurring in arid ecosystems along the west coast of South *** In a two-phased greenhouse experiment,we compared plant–soil feedback effects under three water levels(no water,10%gravimetric moisture and 15%gravimetric moisture).We used sterilized soil inoculated with soil collected from northwest Peru(Prosopis pallida forests)and from two sites in north-central Chile(Prosopis chilensis forest and scrublands without ***).Important Findings Plant–soil feedbacks differed between plant species and soil origins,but water availability did not influence the feedback ***–soil feedbacks differed in direction and strength in the three soil origins ***–soil feedbacks of plants grown in Peruvian forest soil were negative for leaf biomass and positive for root *** contrast,feedbacks were neutral for plants growing in Chilean scrubland soil and positive for leaf biomass for those growing in Chilean forest *** results show that under arid conditions,effects of plant–soil feedback depend upon ***,the results suggest that plant–soil feedback can influence trade-offs between root growth and leaf biomass investment and as such that feedback interactions between plants and soil biota can make plants either more tolerant or vulnerable to *** on dissecting plant–soil feedbacks into aboveground and belowground tissue responses,we conclude that plant–soil feedback can enhance plant colonization in some arid eco

关键词： biomass allocation dry forest facilitation Prosopis South America water pulse

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数据挖掘推动客户数据驱动车辆的开发进程

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同济大学学报（自然科学版） 2021年第S1期49卷 1-10页

作者： WEGENER Jan van putten Sebastiaan NEUBECK Jens WAGNER Andreas 斯图加特大学汽车工程学院德国斯图加特70049 奥迪股份公司德国英戈尔施塔特85049 斯图加特汽车工程与车辆发动机研究所德国斯图加特70049

对于汽车等面向消费者的行业,数据驱动的产品开发是一项关键的系统工程。数据驱动方法的前提是数据本身,由于现代车辆的联网能力不断提高,使得汽车制造商能够以内部总线信号的形式记录并储存客户数据。由于这些数据并不用于外部,只用于... 详细信息

对于汽车等面向消费者的行业,数据驱动的产品开发是一项关键的系统工程。数据驱动方法的前提是数据本身,由于现代车辆的联网能力不断提高,使得汽车制造商能够以内部总线信号的形式记录并储存客户数据。由于这些数据并不用于外部,只用于内部通信以保证车辆的安全性和功能性,这给这些数据的应用带来了一定的困难,因此汽车行业的主要问题在于如何利用数据挖掘技术从这些数据中提取客户需求及相关信息。为此,对上述数据应用问题进行了文献调研,并在此基础上开展数据挖掘的模拟研究,以确定现有数据挖掘过程在需求获取领域的适用性;进而提出一种扩展程序,使得数据挖掘技术能够应用于相关客户数据之中,从而加快车辆开发的进程。

关键词：车辆开发数据驱动数据挖掘跨行业数据挖掘标准流程数据驱动需求获取

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Bowel intussusception caused by a percutaneously placed endoscopic gastrojejunostomy catheter: A case report

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World Journal of Gastrointestinal Surgery 2022年第6期14卷 621-625页

作者： Maarten WJ Winters Sjoerd Kramer Albert HA Mazairac Ewoud H Jutte Paul G van putten Department of Gastroenterology and Hepatology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands Department of Radiology Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands Department of Surgery Medical Center LeeuwardenLeeuwarden 8934 ADNetherlands

BACKGROUND In adults,bowel intussusception is a rare diagnosis and is mostly due to an organic bowel *** rare cases,this is a complication of a percutaneously placed endoscopic gastro(jejunostomy)*** SUMMARY We describe a case of a 73-year-old patient with a history of myocardial infarction,chronic idiopathic constipation and Parkinson’s *** the admission of his Parkinson’s medication,a percutaneous endoscopic gastrostomy with jejunal extension(PEG-J)was *** patient presented three times at the emergency department of the hospital with intermittent abdominal pain with nausea and *** were no distinctive abnormalities from the physical and laboratory *** abdominal computed tomography scan showed a small bowel *** push endoscopy,a jejunal bezoar at the tip of the PEG-J catheter was found to be the cause of small bowel *** intussusception was resolved after removing the bezoar during push *** Endoscopic treatment of bowel intussusception caused by PEG-J catheter bezoar.

关键词： Bowel intussusception Percutaneous endoscopic gastrojejunostomy Bezoar Percutaneous endoscopic gastrostomy Case report

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Asymptotic Harmonic Behavior in the Prime Number Distribution

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Applied Mathematics 2014年第16期5卷 2547-2557页

作者： Maurice H. P. M. van putten Sejong University Seoul South Korea

We consider on x > 0, where the sum is over all primes p. If Φ is bounded on x > 0, then the Riemann hypothesis is true or there are infinitely many zeros . The first 21 zeros give rise to asymptotic harmonic behavio... 详细信息

关键词： Prime Number Distribution Summation Regularization

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CT Output Dose Performance-Conventional Approach versus the Dose Equilibrium Method

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2018年第1期7卷 15-26页

作者： Ahmad Albngali Andy Shearer Wil van der putten Brendan Tuohy Niall Colgan Department of Physics National University of Ireland Galway Ireland Department of Medical Physics and Clinical Engineering Galway University Hospitals Galway Ireland

Current output dose measurement in CT is based on (CTDI). The conventional methodology of CT dosimetric performance characterization is not appropriate to modern CT scanners with helical scanning modes, dose modulation, array detectors and multiple slice planes or cone-beam irradiation geometries. AAPM TG 111 report recognizes the shortfall of the CTDI methods and recommends a new technique that more accurately characterizes the dose profile from modern CT scanners, which utilizes a short conventional ion chamber rather than a pencil chamber. We developed and characterize a in-house phantom design using a three separate anatomical regions of clinical scan sequences (Head, chest and abdomen), and determined the equilibrium dose in our dose equilibrium phantom, measured if the attenuation of the beam is the equal to that of CTDI Perspex phantom and compare CTDI dose estimations using a standard pencil chamber to the dose equilibrium phantom measurements. This methodology allows measurements of the accumulated dose for any clinical scan length and allowing measurement of the equilibrium dose. Using the new methodology, we determined that the CTDI approach can underestimate the dose by 25% to 35% and all of our dose values from the water phantom and farmer chamber were independently verified with TLD measurements.

关键词： Computed Tomography Dixon Method Farmer Chamber CT Dosimetry

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Hollow-core antiresonant terahertz fiber-based TOPAS extruded from a 3D printer using a metal 3D printed nozzle

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Photonics Research 2021年第8期9卷 1513-1521页

作者： WANVISA TALATAISONG JON GORECKI LIEKE D.van putten RAND ISMAEEL JAMES WILLIAMSON KATIE ADDINALL DANIEL SCHWENDEMANN MARTYNAS BERESNA VASILIS APOSTOLOPOULOS GILBERTO BRAMBILLA ptoelectronics Research Centre University of SouthamptonSouthamptonS0171BJUK School of Physics Suranaree University of TechnologyNakhon Ratchasima30000Thailand School of Physics and Astronomy University of SouthamptonSouthamptonS0171BJUK National Oceanography Centre SouthamptonS0143ZHUK Centre for Precision Technologies University of HuddersfieldHuddersfieldHD13DHUK lnstitute for Material Science and Plastics Processing University of Applied Sciences Eastern SwitzerlandRapperswil8640Switzerland

We report the use of a terahertz(THz)transparent material,cyclic olefin copolymer(COC or TOPAS),for fabricating a hollow-core antiresonant fiber that provides an electromagnetic wave guidance in the THz regime.A novel fabrication technique to realize a hollow-core antiresonant polymer optical fiber(HC-ARPF)for THz guidance is proposed and *** fiber is directly extruded in a single-step procedure using a conventional fused deposition modeling 3 D *** fiber geometry is defined by a structured nozzle manufactured with a metal 3 D printer,which allows tailoring of the nozzle design to the various geometries of microstructured optical *** possibility to use the HC-ARPF made from TOPAS for guiding in the THz region is theoretically and experimentally assessed through the profile of mode simulation and time-frequency diagram(spectrogram)analysis.

关键词： fiber printer resonant

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Plant responses to variable timing of aboveground clipping and belowground herbivory depend on plant age

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Journal of Plant Ecology 2018年第5期11卷 696-708页

作者： Minggang Wang T.Martijn Bezemer Wim Hvan der putten E.Pernilla Brinkman Arjen Biere Department of Terrestrial Ecology Netherlands Institute of Ecology(NIOO-KNAW)Droevendaalsesteeg 106708 PB WageningenThe Netherlands Institute of Biology Section Plant Ecology and PhytochemistryLeiden UniversityPO Box 95052300 RA LeidenThe Netherlands Laboratory of Nematology Wageningen UniversityP.O.Box 81326700 ES WageningenThe Netherlands

Aims Plants use different types of responses such as tolerance and induced defense to mitigate the effects of *** direc-tion and magnitude of both these plant responses can vary with plant ***,most studies have focused on aboveground herbivory,whereas important feeding occurs ***,we tested the hypothesis that plant tolerance and defense following shoot damage or root herbivory depends on plant *** In order to test our hypothesis,we exposed the perennial grass spe-cies Holcus lanatus to defoliation and root nematode inoculation at three growth stages(young,intermediate and old plants),and exam-ined responses of plant traits related to tolerance(regrowth follow-ing defoliation)and defense(leaf and root nitrogen and phenolics).Important Findings Defoliation overall reduced plant shoot and root biomass as well as foliar concentrations of phenolics regardless of plant age at *** contrast,defoliation increased foliar N concentrations,but only when defoliation occurred at intermediate and old plant *** with root-feeding nematodes reduced root N concentra-tions after a prolonged period of growth,but only when nematodes had been inoculated when plants were *** relative shoot re-growth rate of plants increased immediately after defoliation but this was independent of the plant age at which defoliation occurred,*** not stronger in plants that were defoliated at a more advanced age,as ***,relative root growth rates increased shortly after defoliation,but this was only observed for plants defoli-ated when they were *** conclude that plant responses to aboveground and belowground herbivory in traits related to both defense and tolerance are affected by plant age,but do not gener-ally change with plant age.

关键词： plant age above-belowground interaction root-feeding nematodes Holcus lanatus defoliation

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教堂里的书店

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建筑实践 2014年第3期 110-115页

作者：张静 Hans Westerink Joop van putten

2013年7月13日周六,Waanders In de Broeren向公众敞开了大门。这个创新商店的理念建立在一座十五世纪教堂(Broerenkerk)的里面,包括三个楼层以及商店室内设计。因为这个全新功能的加入,兹沃勒(Zwolle)这座城市保留住了这处独特的文化... 详细信息

2013年7月13日周六,Waanders In de Broeren向公众敞开了大门。这个创新商店的理念建立在一座十五世纪教堂(Broerenkerk)的里面,包括三个楼层以及商店室内设计。因为这个全新功能的加入,兹沃勒(Zwolle)这座城市保留住了这处独特的文化遗址。BK.建筑事务所的两位建筑师Jos Burger和Wouter Keijizer为这个教堂做了改建设计,并完成了整个施工过程。在教堂内建一个商店的设计理念基于两个元素,一个是教堂的历史价值,另外就是新增加的空间。有时,这两点甚至可以说是相互矛盾的。第一次踏入这

关键词：历史价值建筑师兹沃勒

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