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Consumption of Dairy and Metabolic Syndrome Risk in a Convenient Sample of Mexican College Applicants

Food and Nutrition Sciences 2013年第1期4卷 56-65页

作者： Michelle A. Mosley Flavia C. D. Andrade Celia Aradillas-garcia margarita teran-garcia Department of Food Science and Human Nutrition University of Illinois Urbana USA Department of Kinesiology and Community Health University of Illinois Urbana USA Facultad de Medicina Universidad Autónoma de San Luis Potosi San Luis Potosí Mexico.

The rise in metabolic syndrome (MetS) is accompanied by a decrease in milk and dairy consumption and an increase in sugar-sweetened beverage (SSB) consumption, with SSB possibly displacing dairy products in the diet. Our main objective was to determine whether young individuals not meeting the dairy recommendations of 3 servings per day were at greater risk for MetS. In a cross-sectional design, a food frequency questionnaire was answered by Mexican college applicants (n = 339). Medical examination at a primary health care center and evaluation for presence of MetS risk factors was completed as part of an ongoing collaborative project. Relative risk analyses were used to assess the impact of meeting or not the dairy recommendations for the presence of MetS. The MetS prevalence was 10. Three-fourths (76%) of participants were not meeting the daily recommendations. Individuals who failed to meet dairy recommendations were at 2.9 times greater risk for MetS when controlling for age, sex, family history of cardiovascular disease and type 2 diabetes, and physical activity. We did not found that SSB were displacing dairy products in the diet. Still, our data support the importance of meeting daily dairy recommendations for the prevention of MetS in young adults.

关键词： Dairy Intake Young Adults Metabolic Syndrome Risk Obesity Prevention

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FTO genotype is associated with body mass index and waist circumference in Mexican young adults

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Open Journal of Genetics 2013年第1期3卷 44-48页

作者： margarita teran-garcia Itzel Vazquez-Vidal Flavia C. D. Andrade Michelle Mosley Eduardo Medina-Cerda Celia Aradillas-garcia Department of Food Science and Human Nutrition University of Illinois Champaign USA Department of Kinesiology and Community Health University of Illinois Champaign USA Health Center University Autonomous of San Luis Potosí San Luis Potosí Mexico School of Medicine University Autonomous of San Luis Potosí San Luis Potosí Mexico

Individual variations in the fat mass and obesity-associated (FTO) gene have been associated with obesity and BMI in diverse populations, but there are no reports in young Mexicans. We explored the association of a common FTO single-nucleotide polymorphism (SNP, rs805704) with obesity-related phenotypes in Mexican young adults. The FTO-SNP was genotyped using the fluorescent polarization method in college-age, apparently healthy subjects from the “UP AMIGOS” cohort (n = 251, 18 - 25 yrs). Homozygotes for the A allele (15%, n = 38) were heavier (1.6 kg/m2 and6.2 kg) and had a larger waist circumference (WC,4.8 cm) than G allele carriers. The FTO genotype was associated with BMI, weight and WC independently of age and sex and explained 2.7 to 3.1% of the variance in obesity-related phenotypes. The FTO genotype was also associated with fasting glucose (P = 0.0283). No other associations were found in the additive model. Despite our small sample size, we found that the FTO-rs805704 genotype influences obesity-related phenotypes young Mexicans. Previously observed FTO associations with fasting glucose were replicated. Previously reported associations with other metabolic traits likely represent the long-term consequences of obesity.

关键词： FTO Obesity Genetic Risk Young Mexicans

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Magnetic lipid nanovehicles synergize the controlled thermal release of chemotherapeutics with magnetic ablation while enabling non-invasive monitoring by MRI for melanoma theranostics

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Bioactive Materials 2022年第2期7卷 153-164页

作者： Lorena garcia-Hevia Inigo Casafont Jessica Oliveira Nuria teran Monica L.Fanarraga Juan Gallo Manuel Banobre-Lopez Advanced(Magnetic)Theranostic Nanostructures Lab.International Iberian Nanotechnology Laboratory Avda.Mestre Jose Veiga s/n4715-330BragaPortugal Grupo de Nanomedicina.Universidad de Cantabria-IDIVAL Herrera Oria s/n39011SantanderSpain

Nowadays,a number of promising strategies are being developed that aim at combining diagnostic and therapeutic capabilities into clinically effective ***,the combination of a modified release provided by an organic encapsulation and the intrinsic physico-chemical properties from an inorganic counterpart opens new perspectives in biomedical ***,a biocompatible magnetic lipid nanocomposite vehicle was developed through an efficient,green and simple method to simultaneously incorporate magnetic nanoparticles and an anticancer drug(doxorubicin)into a natural *** theranostic performance of the final magnetic formulation was validated in vitro and in vivo,in melanoma *** systemic administration of the proposed magnetic hybrid nanocomposite carrier enhanced anti-tumoral activity through a synergistic combination of magnetic hyperthermia effects and antimitotic therapy,together with MRI reporting *** application of an alternating magnetic field was found to play a dual role,(i)acting as an extra layer of control(remote,on-demand)over the chemotherapy release and(ii)inducing a local thermal ablation of tumor *** combination of chemotherapy with thermotherapy establishes a synergistic platform for the treatment of solid malignant tumors under lower drug dosing schemes,which may realize the dual goal of reduced systemic toxicity and enhanced anti-tumoral efficacy.

关键词： Drug delivery systems Theranosis Magnetic hyperthermia Magnetic resonance imaging Melanoma

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