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Neural Regeneration Research 2024年第5期19卷 1150-1155页

作者： shuanglong Yi Linfang Wang margaret s.ho shiping Zhang s.hool of Life science and Technology ShanghaiTech UniversityShanghaiChina College of Life sciences University of Chinese Academy of SciencesBeijingChina

Parkinson’s disease is a progressive neurodegenerative disease characterized by motor deficits,dopaminergic neuron loss,and brain accumulation ofα-synuclein aggregates called Lewy *** in protein degradation pathways,such as autophagy,has been demonstrated in neurons as a critical mechanism for eliminating protein aggregates in Parkinson’s ***,it is less well understood how protein aggregates are eliminated in glia,the other cell type in the *** the present study,we show that autophagy-related gene 9(Atg9),the only transmembrane protein in the autophagy machinery,is highly expressed in Drosophila glia from adult *** from immunostaining and live cell imaging analysis reveal that a portion of Atg9 localizes to the trans-Golgi network,autophagosomes,and lysosomes in ***9 is persistently in contact with these *** glial atg9 reduces the number of omegasomes and autophagosomes,and impairs autophagic substrate *** suggests that glial Atg9 participates in the early steps of autophagy,and hence the control of autophagic ***,loss of glial atg9 induces parkinsonian symptoms in Drosophila including progressive loss of dopaminergic neurons,locomotion deficits,and glial *** findings identify a functional role of Atg9 in glial autophagy and establish a potential link between glial autophagy and Parkinson’s *** results may provide new insights on the underlying mechanism of Parkinson’s disease.

关键词： Atg9 autophagy glia Parkinson’s disease

A shared Neural Node for Multiple Innate Behaviors in Drosophila

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Neuroscience Bulletin 2018年第6期34卷 1103-1104页

作者： margaret s.ho s.hool of Life science and Technology ShanghaiTech University

The nervous system orchestrates diverse behaviors such as reproduction, sleep, feeding, and aggression, and selects a single behavior for execution at any given time. This requires neural mechanisms for behavioral selection sensitive to both internal physiological states and external environmental conditions. For example, hungry animals

关键词： In A shared Neural Node for Multiple Innate Behaviors in Drosophila

Neurodevelopment and degeneration

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Neuroscience Bulletin 2014年第4期30卷 539-541页

作者： margaret s.ho Department of Anatomy and Neurobiology School of MedicineTongji University

Over the past decades, continuous effort has been made to resolve unsettled matters in the emerging scene of neuronal development. Despite the rapid progress, neuroscientists remain fascinated by the intricate networks of signaling pathways and molecules conserved among species. Fundamental questions such as progenitor cell specification, compartmentalized cellular tactics, and the identification of factors involved in orchestrating the progression of development are being actively pursued. Furthermore, reversing the effects of development, neurodegeneration symbolizes an opposite force in limiting growth and has been linked to a variety of diseases. To date, a tremendous amount of work from the research community has conceptualized the central image of how nervous systems develop and are equipped to modulate animal functions, albeit with mysterious gaps in the picture that remain to be filled.

关键词： Neurodevelopment degeneration equipped

Analysis of Glial Distribution in Drosophila Adult Brains

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Neuroscience Bulletin 2016年第2期32卷 162-170页

作者： Jiayao Ou Zongbao Gao Li song margaret s.ho Research Center for Translational Medicine Shanghai East Hospital Tongji University School of Medicine Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East Hospital Tongji University School of Medicine Department of Anatomy and Neurobiology Tongji University School of Medicine

Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body（MB）, ellipsoid body（EB）,and antennal lobe（AL） in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL.

关键词： Glia Drosophila Mushroom body

Glial cells in neuronal development:recent advances and insights from Drosophila melanogaster

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Neuroscience Bulletin 2014年第4期30卷 584-594页

作者： Jiayao Ou Yijing He Xi Xiao Tian-Ming Yu Changyan Chen Zongbao Gao margaret s.ho Department of Anatomy and Neurobiology School of MedicineTongji University s.hool of Life sciences Tongji University

Gila outnumber neurons and are the most abundant cell type in the nervous system. Whereas neurons are the major carriers, transducers, and processors of information, glial cells, once considered mainly to play a passive supporting role, are now recognized for their active contributions to almost every aspect of nervous system development. Recently, insights from the invertebrate organism Drosophila melanogaster have advanced our knowledge of glial cell biology. In particular, findings on neuron-glia interactions via intrinsic and extrinsic mechanisms have shed light on the importance of gtia during different stages of neuronal development. Here, we summarize recent advances in understanding the functions of Drosophila glia, which resemble their mammalian counterparts in morphology and function, neural stem-cell conversion, synapse formation, and developmental axon pruning. These discoveries reinforce the idea that glia are substantial players in the developing nervous system and further advance the understanding of mechanisms leading to neurodegeneration.

关键词： glia neuronal development Gcm neurodegeneration neural stem cell synapse formation axon pruning

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神经胶质细胞调控黑腹果蝇生理行为研究进展

遗传 2022年第4期44卷 300-312页

作者：王孟晓何淑君上海科技大学生命科学与技术学院上海201210

生物机体的神经系统由神经元和神经胶质细胞(简称胶质细胞,glia)两部分组成。目前,对神经元的研究已经非常广泛,但是有关胶质细胞的功能研究仍然所知甚少。由于胶质细胞不具兴奋性,无法像神经元一样传递动作电位,传统观点认为胶质细胞... 详细信息

生物机体的神经系统由神经元和神经胶质细胞(简称胶质细胞,glia)两部分组成。目前,对神经元的研究已经非常广泛,但是有关胶质细胞的功能研究仍然所知甚少。由于胶质细胞不具兴奋性,无法像神经元一样传递动作电位,传统观点认为胶质细胞主要起到支撑神经元并维持其正常功能的作用。近年来,越来越多的研究结果表明,胶质细胞参与调控生物机体的各种生理行为。其中,通过黑腹果蝇(Drosophila melanogaster)研究了胶质细胞的重要性,证实胶质细胞参与调控果蝇的神经发育、营养代谢、睡眠、寿命、细胞凋亡、求偶、嗅觉和学习记忆等生理活动。本文详细总结了胶质细胞调控果蝇不同生理活动的相关研究进展,并对其功能进行了探究和展望。

关键词：果蝇神经系统神经胶质细胞发育寿命代谢行为

Wireless sequential dual light delivery for programmed PDT in vivo

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Light(science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen sun Wenkai Li Han-Joon Kim shu Uin Gan John s.ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROs)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

Inclusive quasielastic neutrino-nucleus scattering with energy density functional nuclear models

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Chinese Physics C 2024年第8期48卷 153-158页

作者： K.s.Kim soonchul Choi Hana Gil Chang ho Hyun s.hool of liberal arts and science korea aerospace universitygoyang 10540korea Center for exotic nuclear studies institute for basic sciencedaejeon 34126korea Center for extreme nuclear matters korea universityseoul 02841korea Department of physics education daegu universitygyeongsan 38453korea

In this study,we calculated the inclusive charged-current neutrino-nucleus scattering from ^(40)Ar in the quasielastic *** explore the effect of uncertainties stemming from the nuclear structure,we used the KIDs(Korea-IBs-Daegu-sKKU)nuclear energy density functional and skyrme force models,namely sLy4,skI3,and *** models were selected to have distinct behavior in terms of the density dependence of the symmetry energy and the effective mass of the *** the charged-current neutrino scattering,the single-and double-differential cross sections were calculated for various *** cross sections are reported as a function of the incident neutrino *** theoretical cross sections were compared with experimental data,and the roles of the effective mass and symmetry energy were investigated in terms of charged-current neutrino-nucleus scattering.

关键词： energy density functional neutrino-nucleus scattering symmetry energy effective mass of the nucleon

Enhancing visible-light-driven NO oxidation through molecular‐level insights of dye-loaded sea sands

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Rare Metals 2024年第2期43卷 543-554页

作者： Yu-Han Li Bang-Fu Chen sónia A.C.Carabineiro You-Yu Duan Ping Tan Wing-Kei ho Fan Dong Engineering Research Center for Waste Oil Recovery Technology and Equipment Ministry of EducationChongqing Key Laboratory of Catalysis and New Environmental MaterialsChongqing Technology and Business UniversityChongqing400067China Nanchang Institute of Technology Nanchang33044China LAQV-REQUIMTE Department of ChemistryNOVA School of Science and TechnologyUniversidade NOVA de Lisboa2829-516CaparicaPortugal College of Physics and Center of Quantum Materials and Devices Chongqing UniversityChongqing401331China Department of science and Environmental studies The Education University of Hong KongHong Kong999077China

Natural minerals,abundant and easily obtained through simple physical processing,offer a cost-effective and environmentally friendly solution for dyeing wastewater disposal and air pollution *** study investigates the photocatalytic removal of NO using natural different types of dyes,loaded on natural sand,under visible light *** examining various coating concentrations of dyes and sand weights,we discovered that sand loaded with Rhodamine B(RhB)exhibits high activity for the photo-oxidation of NO.A combination results of X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPs),Fourier transform infrared spectroscopy(FTIR)and thermogravimetric(TG)analyses confirm the presence of siO_(2),CaCO_(3),Al_(2)O_(3)and iron oxides as the main components of the ***,studying RhB-loaded individual components reveals that CaCO_(3)plays a crucial role in enhancing the NO removal *** results and theoretical calculations demonstrate the establishment of a directional charge transfer channel from CaCO_(3)to RhB,facilitating the adsorption and activation of molecular NO and O_(2).This work not only promotes the utilization of natural mineral resources but also enriches the fields of environmental photochemistry and semiconductor photocatalysis.

关键词： sand dyes Rhodamine B Photo-oxidation of NO Visible light illumination

Post-fontan circulation hepatocellular carcinoma:Open and laparoscopic hepatectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 90-93页

作者： Karin KY ho Wong hoi she simon HY Tsang Kevin s Lo Tan To Cheung Department of surgery The University of Hong Kong102 Pok Fu Lam RoadHong KongChina Department of Anaesthesiology Queen Mary Hospital102 Pok Fu Lam RoadHong KongChina

To the Editor:Fontan-associated liver disease shows increasing incidence as advances in pediatric cardiology have prolonged life expectancy in patients with single ventricle congenital heart defects[1].Their unique physiology and procedure-related sequelae present an increasingly relevant challenge in hepatic *** hereby reported a series of patients suffering from hepatocellular carcinoma(HCC)who successfully underwent open and laparoscopic hepatectomy.

关键词： hepatocellular hepatectomy surgery