Analysis of Glial Distribution in Drosophila Adult Brains

作     者：Jiayao Ou Zongbao Gao Li Song Margaret S.Ho 

作者机构：Research Center for Translational Medicine Shanghai East Hospital Tongji University School of Medicine Key Laboratory of Arrhythmias of the Ministry of Education of China Shanghai East Hospital Tongji University School of Medicine Department of Anatomy and Neurobiology Tongji University School of Medicine 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2016年第32卷第2期

页      面：162-170页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from the National Basic Research Program of China(973 Program 2013CB945602) the National Natural Science Foundation of China(31270825 and 31171043) 

主　　题：Glia Drosophila Mushroom body 

摘      要：Neurons and glia are the two major cell types in the nervous system and work closely with each other to program neuronal interplay. Traditionally, neurons are thought to be the major cells that actively regulate processes like synapse formation, plasticity, and behavioral output. Glia, on the other hand, serve a more supporting role. To date, accumulating evidence has suggested that glia are active participants in virtually every aspect of neuronal function. Despite this, fundamental features of how glia interact with neurons, and their spatial relationships, remain elusive. Here, we describe the glial cell population in Drosophila adult brains. Glial cells extend and tightly associate their processes with major structures such as the mushroom body（MB）, ellipsoid body（EB）,and antennal lobe（AL） in the brain. Glial cells are distributed in a more concentrated manner in the MB. Furthermore, subsets of glia exhibit distinctive association patterns around different neuronal structures. Whereas processes extended by astrocyte-like glia and ensheathing glia wrap around the MB and infiltrate into the EB and AL, cortex glia stay where cell bodies of neurons are and remain outside of the synaptic regions structured by EB or AL.