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Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales

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World Journal of Gastroenterology 2020年第47期26卷 7538-7549页

作者： Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka marek Cybulski Witold Jeleniewicz Andrzej Stepulak Department of Gastroenterology Medical University of LublinLublin 20-954Jaczewskiego 8Poland Department of Biochemistry and Molecular Biology Medical University of LublinLublin 20-093Chodzki 3Poland Department of Biochemistry and Molecular Biology Medical Univeristy of LublinLublin 20-093Chodźki 3Poland

BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial *** a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,*** To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the *** indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each *** for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD *** operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and *** MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly *** and PLR correlated with assessed indirect and direct markers of liver ***,NLR and PLR correlated with MELD *** level in NAFLD patients was significantly higher in comparison to *** correlated with indirect markers of liver fibrosis and NAFLD fibrosis *** values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(0

关键词： Hematological markers Alcoholic liver cirrhosis Nonalcoholic fatty liver disease Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Mean platelet volume-to-platelet-ratio

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Convolutional neural network-assisted recognition of nanoscale L1_(2) ordered structures in face-centred cubic alloys

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npj Computational Materials 2021年第1期7卷 60-68页

作者： Yue Li Xuyang Zhou Timoteo Colnaghi Ye Wei Andreas marek Hongxiang Li Stefan Bauer Markus Rampp Leigh T.Stephenson Max-Planck Institut für Eisenforschung GmbH Max-Planck-Straße 140237 DüsseldorfGermany Max Planck Computing and Data Facility Gießenbachstraße 285748 GarchingGermany State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing100083 BeijingChina Max Planck Institute for Intelligent Systems Max-Planck-Ring 472076 TübingenGermany

Nanoscale L12-type ordered structures are widely used in face-centered cubic(FCC)alloys to exploit their hardening capacity and thereby improve mechanical *** fine-scale particles are typically fully coherent with matrix with the same atomic configuration disregarding chemical species,which makes them challenging to be *** distribution maps(SDMs)are used to probe local order by interrogating the three-dimensional(3D)distribution of atoms within reconstructed atom probe tomography(APT)***,it is almost impossible to manually analyze the complete point cloud(>10 million)in search for the partial crystallographic information retained within the ***,we proposed an intelligent L1_(2)-ordered structure recognition method based on convolutional neural networks(CNNs).The SDMs of a simulated L1_(2)-ordered structure and the FCC matrix were firstly *** simulated images combined with a small amount of experimental data were used to train a CNN-based L1_(2)-ordered structure recognition ***,the approach was successfully applied to reveal the 3D distribution of L1_(2)–typeδ′–Al3(LiMg)nanoparticles with an average radius of 2.54 nm in a FCC Al-Li-Mg *** minimum radius of detectable nanodomain is even down to 5Å.The proposed CNN-APT method is promising to be extended to recognize other nanoscale ordered structures and even more-challenging short-range ordered phenomena in the near future.

关键词： alloys ordered cubic

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面向流动控制的高维优化求解器——探索性梯度法

面向流动控制的高维优化求解器——探索性梯度法

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第十二届全国流体力学学术会议

作者：李逸清杨志刚 marek Morzyński Bernd R.Noack 机电工程与自动化学院哈尔滨工业大学(深圳) 上海地面交通工具风洞中心同济大学

本文介绍了Explorative gradient method (EGM)(Li et al.,JFM,2022)这一优化算法在三个不同流动控制问题上的应用。这三个流动问题分别是3圆柱组合流体弹球、6圆柱组合流体弹球以及带有7个分布式吹气槽的35°倾角Ahmed body汽车模型。... 详细信息

本文介绍了Explorative gradient method (EGM)(Li et al.,JFM,2022)这一优化算法在三个不同流动控制问题上的应用。这三个流动问题分别是3圆柱组合流体弹球、6圆柱组合流体弹球以及带有7个分布式吹气槽的35°倾角Ahmed body汽车模型。基于直接数值模拟,圆柱组合流体弹球分别利用3个和6个旋转圆柱作为输入激励。EGM以净能耗为优化目标,在3维和6维参数空间内分别实现了29%和14%净减阻。在Ahmed body模型背部的定常射流强度和方向构成了10维参数空间,EGM以气动阻力系数为目标函数基于雷诺平均法(RANS)仿真数据集实现减阻17%。该结果进一步得到了大涡模拟(LES)的验证。船尾结构作为一种有效的减阻策略,在上述3维、6维以及10维的三个流动控制问题中均得到了验证。同时,EGM算法展现了在流动控制优化问题上的优势,可以将流动控制优化的仿真或者实验成本量级从O(1000)降低至O(100)。

关键词：优化主动控制减阻尾流

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神秘的新型重奇异Z_(cs)态

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Science Bulletin 2021年第20期66卷 2045-2046页

作者： marek Karliner Jonathan L.Rosner School of Physics and Astronomy Tel Aviv UniversityTel Aviv 69978Israel Enrico Fermi Institute and Department of Physics University of ChicagoChicago IL 60637USA

For nearly forty years after the advent of the quark model [1,2],the only observed hadrons were mesons consistent with being a quark-antiquark(qq) pair and baryons consistent with being composed of three quarks(qqq). There was no reason why more ‘‘exotic" configurations, such as qqqq(tetraquarks) or qqqqq(pentaquarks), could not exist. Indeed, such a possibility was mentioned in the pioneering papers [1,2] and they had been predicted by such schemes as s–t channel duality in baryon-antibaryon scattering [3], the bag model of quark confinement [4–6], and binding of hadrons into molecules [7,8].

关键词： quark 1,2 mentioned

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What do parameterized Om(z) diagnostics tell us in light of recent observations?

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Research in Astronomy and Astrophysics 2018年第6期18卷 49-58页

作者： Jing-Zhao Qi Shuo Cao marek Biesiada Teng-Peng Xu Yan Wu Si-Xuan Zhang Zong-Hong Zhu Department of Astronomy Beijing Normal University Department of Astrophysics and Cosmology Institute of Physics University of Silesia

In this paper, we propose a new parametrization for Om(z) diagnostics and show how the most recent and significantly improved observations concerning the H(z) and SN Ia measurements can be used to probe the consistency or tension between the ΛCDM model and observations. Our results demonstrate that H0 plays a very important role in the consistency test of ΛCDM with H(z)data. Adopting the Hubble constant priors from Planck 2013 and Riess, one finds considerable tension between the current H(z) data and ΛCDM model and confirms the conclusions obtained previously by others. However, with the Hubble constant prior taken from WMAP9, the discrepancy between H(z) data and ΛCDM disappears, i.e., the current H(z) observations still support the cosmological constant scenario. This conclusion is also supported by the results derived from the Joint Lightcurve Analysis(JLA) SN Ia sample. The best-fit Hubble constant from the combination of H(z)+JLA(H00 = 68.81+1.5-1.49 km s-1 Mpc-1) is very consistent with results derived both by Planck 2013 and WMAP9, but is significantly different from the recent local measurement by Riess.

关键词： cosmology: theory cosmology: observations cosmology: cosmological parameters

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Near-Wall Flow in the Blade Cascades Representing Last Rotor Root Sections of Large Output Steam Turbines

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Journal of Thermal Science 2021年第1期30卷 220-230页

作者： ŠIMURDA David FÜRST Jiří HÁLA Jindřich LUXA Martin BOBČÍK marek NOVÁK Ondřej SYNÁČJaroslav Institute of Thermomechanics of the Czech Academy of Sciences Prague 18200Czech Republic Dpt.of Technical Mathematics Faculty of Mechanical EngineeringCTU in PraguePrague 12000Czech Republic Doosan Skoda Power Pilsen 30100Czech Republic

This paper investigates the flow past two variants of root section profile cascades for a last stage rotor considering three-dimensional flow structures in the near-wall *** were drawn based on RANS numerical simulations of both variants and on the experimental data obtained by the 3 D traversing in the exit flow field of one of the *** of 3 D structures at two different regimes and its influence on aerodynamic characteristics of the blade cascades was *** distributions of Mach number along the profiles were compared with 2 D optical measurements and its distortion due to the presence of the sidewall was *** interaction between main vortical structures was described and its influence on the loading of the blades,mechanical energy losses and exit flow angle was *** results showed that for a front loaded blade the vortical structures appeared earlier and at a larger extent than for an aft loaded ***,due to different Mach number distribution,contribution of end wall flow to the energy losses was lower in the case of the aft loaded *** influence of the near wall flow on the loading was found to be rather weak while the deviation of the exit flow angle appeared to be comparable for both of the variants.

关键词： turbine blade cascade secondary flow near wall flow supersonic flow CFD experiment

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■衰变末态中的奇异五夸克态与■超子激发态（英文）

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Science Bulletin 2021年第13期66卷 1256-1257页

作者： marek Karliner Jonathan L.Rosner School of Physics and Astronomy Tel Aviv University Enrico Fermi Institute and Department of Physics University of Chicago

Besides the observed quark-antiquark and three-quark states,the quark model predicts other states with integral charges,such as ■ （tetraquarks） and ■ （pentaquarks）.In 2015,the LHCb Collaboration observed J/ψp r...

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Role of cyclooxygenase-2 gene polymorphisms in pancreatic carcinogenesis

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World Journal of Gastroenterology 2011年第36期17卷 4113-4117页

作者： Renata Talar-Wojnarowska Anita Gasiorowska marek Olakowski Pawel Lampe Beata Smolarz Hanna Romanowicz-Makowska Ewa Malecka-Panas Department of Digestive Tract Diseases Medical University22 Kopcinskiego90-153 LodzPoland Department of Digestive Tract Surgery Silesian Medical University14 Medykow40-752 KatowicePoland Laboratory of Molecular Genetics Institute of Polish Mother's Memorial Hospital281/289 Rzgowska93-338 LodzPoland

AIM:To evaluate the clinical significance of-765G/C and-1195G/A cyclooxygenase-2 (COX-2) gene polymorphisms in patients with pancreatic cancer (PC).METHODS:The study included 201 patients:85 with PC and 116 healthy controls.-765G/C and-1195G/A COX-2 gene polymorphisms were studied in DNA isolated from blood *** associations of the analyzed genotypes and clinical data at diagnosis were ***:We found an increased frequency of the homozygous-1195AA COX-2 genotype in patients with PC (53.7%) compared with the control group (21%) (P 3 cm was observed (P < 0.05).Analyzed polymorphisms were unrelated to the patients' sex and age,nor to the presence of regional or distant ***:These preliminary results indicate that the-1195G/A COX-2 polymorphism may play an important role in PC prognosis and carcinogenesis.

关键词：基因多态性 COX 胰腺癌致癌作用临床意义频率分布肿瘤发生基因型

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Nonlinear Integrated Optical Waveguides in Chalcogenide Glasses

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光学学报 2003年第S1期23卷 363-364页

作者： Yinlan Ruan Barry Luther-Davies Weitang Li Andrei Rode marek Samoc The Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 AustraliaThe Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 AustraliaThe Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 AustraliaThe Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 AustraliaThe Australian Photonics Cooperative Research Center Laser Physics Centre The Australian National University Canberra ACT 0200 Australia

This paper reports on the study and measurement of the third order optical nonlinearity in bulk sulfide-based chalcogenide glasses; The fabrication process of the ultrafast laser deposited As-S-(Se)-based chalcogenide... 详细信息

关键词： in of on rate In be were Nonlinear Integrated Optical Waveguides in Chalcogenide Glasses for

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Cerium dioxide as a new reactive sorbent for fast degradation of parathion methyl and some other organophosphates

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Journal of Rare Earths 2014年第4期32卷 360-370页

作者： Pavel Janos Pavel Kuran Martin Kormunda Vaclav Stengl Tomas Matys Grygar marek Dosek Martin Stastny Jakub Ederer Vera Pilarova Lubos Vrtoch Faculty of the Environment University of Jan Evangelista Purkyne Faculty of Science University of Jan Evangelista Purkyne Institute of Inorganic Chemistry AS CR v.v.i.

Cerium dioxide was used for the first time as reactive sorbent for the degradation of the organophosphate pesticides para-thion methyl, chlorpyrifos, dichlofenthion, fenchlorphos, and prothiofos, as well as of some chemical warfare agents-nerve gases soman and O-ethyl S-[2-（diisopropylamino） ethyl] methylphosphonothioate （VX）. CeO2 specimens were prepared by calcination of basic cerous carbonate obtained by precipitation from an aqueous solution. The CeO2 samples containing certain amounts （1 wt.%-5 wt.%） of the neighboring lanthanides （La, Pr, Nd） were prepared in a similar way from pure lanthanide salts. It was shown that ceria accelerated markedly the decomposition of parathion methyl causing the cleavage of the P-O-aryl bond in the pesticide molecule. A similar reaction mechanism was proposed for the degradation of other organophosphate pesticides and nerve agents. The degradation times （reaction half-times） were in an order of minutes in the presence of CeO2, compared to hours or days under common environ-mental conditions. The reaction in suitable organic solvents allowed conversions of about 90%for parathion methyl loading of 20 mg pesticide/g CeO2 within 2 h with a reactant half-life in the order of 0.1 min. The key parameter governing the degradation efficiency of CeO2 was the temperature during calcination. At optimum calcination temperature （about 773.15 K）, the produced ceria retained a sufficiently high surface area, and attained an optimum degree of crystallinity （related to a number of crystal defects, and thus poten-tial reactive sites）. The presence of other lanthanides somewhat decreased the reaction rate, but this effect was not detrimental and permitted the possible use of chemically impure ceria as a reactive sorbent. A fast organophosphate degradation was demonstrated not only in non-polar solvents （such as heptane）, but also in polar aprotic solvents （acetonitrile, acetone） that are miscible with water. This opens new possibilities for designi

关键词： cerium dioxide carbonate precursor lanthanides organophosphate pesticide parathion methyl chemical warfare agents hydrolysis non-aqueous solvents rare earths

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