Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales

作     者：Agata Michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka Marek Cybulski Witold Jeleniewicz Andrzej Stepulak 

作者机构：Department of GastroenterologyMedical University of LublinLublin 20-954Jaczewskiego 8Poland Department of Biochemistry and Molecular BiologyMedical University of LublinLublin 20-093Chodzki 3Poland Department of Biochemistry and Molecular BiologyMedical Univeristy of LublinLublin 20-093Chodźki 3Poland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第47期

页      面：7538-7549页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hematological markers Alcoholic liver cirrhosis Nonalcoholic fatty liver disease Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Mean platelet volume-to-platelet-ratio 

摘      要：BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial *** a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,*** To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the *** indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each *** for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD *** operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and *** MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly *** and PLR correlated with assessed indirect and direct markers of liver ***,NLR and PLR correlated with MELD *** level in NAFLD patients was significantly higher in comparison to *** correlated with indirect markers of liver fibrosis and NAFLD fibrosis *** values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(2.227),0.675(0