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B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1251-1268页

作者： Cefan Zhou Xiaoting Zhu Nanxi Liu Xueying Dong Xuewen Zhang Huili Huang Yu Tang Shicheng Liu Mengyu Hu Ming Wang Xiaoling Deng Shi Li Rui Zhang Yuan Huang Hao Lyu Shuai Xiao Sang Luo Declan William Ali marek michalak Xing-Zhen Chen Zhentian Wang Jingfeng Tang National“111”Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei University of TechnologyWuhan 430068China Membrane Protein Disease Research Group Department of PhysiologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAB T6G2R3Canada Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province) Hubei Key Laboratory of Industrial MicrobiologyHubei University of TechnologyWuhanChina Department of Systems Biology for Medicine School of Basic Medical SciencesFudan Universityand Shanghai Fifth People’s HospitalFudan UniversityShanghai 200433China Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China Ningxia Key Laboratory of Stem Cell and Regenerative Medicine General Hospital of Ningxia Medical UniversityNingxia 750001China Department of Biological Sciences University of AlbertaEdmontonAB T6G2R3Canada Department of Biochemistry University of AlbertaEdmontonAB T6G2R3Canada

Abnormal activation of Wnt/β-catenin-mediated transcription is closely associated with the malignancy of pancreatic *** with sequence similarity 83 member A(FAM83A)was shown recently to have oncogenic effects in a variety of cancer types,but the biological roles and molecular mechanisms of FAM83A in pancreatic cancer need further ***,we newly discovered that FAM83A binds directly toβ-catenin and inhibits the assembly of the cytoplasmic destruction complex thus inhibiting the subsequent phosphorylation and ***83A is mainly phosphorylated by the SRC non-receptor kinase family member BLK(B-lymphoid tyrosine kinase)at tyrosine 138 residue within the DUF1669 domain that mediates the FAM83A-β-catenin ***,FAM83A tyrosine 138 phosphorylation enhances oncogenic Wnt/β-catenin-mediated transcription through promotingβ-catenin-TCF4 interaction and showed an elevated nucleus translocation,which inhibits the recruitment of histone deacetylases by *** also showed that FAM83A is a direct downstream target of Wnt/β-catenin signaling and correlates with the levels of Wnt target genes in human clinical pancreatic cancer ***,the inhibitory peptides that target the FAM83A-β-catenin interaction significantly suppressed pancreatic cancer growth and metastasis in vitro and in *** results revealed that blocking the FAM83A cascade signaling defines a therapeutic target in human pancreatic cancer.

关键词： FAM83A elevated phosphorylation

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Security Strategy of Digital Medical Contents Based on Blockchain in Generative AI Model

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Computers, Materials & Continua 2025年第1期82卷 259-278页

作者： Hoon Ko marek R.Ogiela Division of Computer Science and Engineering Sunmoon UniversityAsan31460Republic of Korea AGH University of Krakow Cryptography and Cognitive Informatics LaboratoryKrakow30-059Poland

This study presents an innovative approach to enhancing the security of visual medical data in the generative AI environment through the integration of blockchain *** combining the strengths of blockchain and generative AI,the research team aimed to address the timely challenge of safeguarding visual medical *** participating researchers conducted a comprehensive analysis,examining the vulnerabilities of medical AI services,personal information protection issues,and overall security *** multi faceted exploration led to an indepth evaluation of the model’s performance and ***,the correlation between accuracy,detection rate,and error rate was *** analysis revealed insights into the model’s strengths and limitations,while the consideration of standard deviation shed light on the model’s stability and performance *** study proposed practical improvements,emphasizing the reduction of false negatives to enhance detection rate and leveraging blockchain technology to ensure visual data integrity in medical *** blockchain to generative AI-created medical content addresses key personal information protection *** utilizing the distributed ledger system of blockchain,the research team aimed to protect the privacy and integrity of medical data especially medical *** approach not only enhances security but also enables transparent and tamperproof ***,the use of generative AI models ensures the creation of novel medical content without compromising personal information,further safeguarding patient *** conclusion,this study showcases the potential of blockchain-based solutions in the medical field,particularly in securing sensitive medical data and protecting patient *** proposed approach,combining blockchain and generative AI,offers a promising direction toward more robust and secure medical content *** research and advancements

关键词： Digitalmedical content medical diagnostic visualization security analysis generativeAI blockchain vulnerability pattern recognition

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Towards an evaluation of alcoholic liver cirrhosis and nonalcoholic fatty liver disease patients with hematological scales

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World Journal of Gastroenterology 2020年第47期26卷 7538-7549页

作者： Agata michalak Halina Cichoz-Lach Malgorzata Guz Joanna Kozicka marek Cybulski Witold Jeleniewicz Andrzej Stepulak Department of Gastroenterology Medical University of LublinLublin 20-954Jaczewskiego 8Poland Department of Biochemistry and Molecular Biology Medical University of LublinLublin 20-093Chodzki 3Poland Department of Biochemistry and Molecular Biology Medical Univeristy of LublinLublin 20-093Chodźki 3Poland

BACKGROUND Seeking potentially novel blood markers of liver fibrosis and steatosis is constantly of crucial *** a growing number of studies in this field of hepatology,a certain role of hematological indices in the course of liver disorders has not been fully elucidated,*** To evaluate a diagnostic accuracy of neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR)and mean platelet volume-to-platelet-ratio(MPR)in the course of alcoholic liver cirrhosis(ALC)and nonalcoholic fatty liver disease(NAFLD).METHODS One hundred forty-two patients with ALC,92 with NAFLD and 68 persons in control group were enrolled in the *** indices(NLR,PLR and MPR),indirect and direct markers of liver fibrosis(aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index,fibrosis-4,gamma-glutamyl transpeptidase to platelet ratio,procollagen Ⅰ carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,platelet-derived growth factor AB,laminin)were measured in each *** for end-stage liver disease(MELD)score in ALC group and NAFLD fibrosis score together with BARD score were calculated in NAFLD *** operating characteristic(ROC)curves and area under the curve(AUC)values were applied to assess the sensitivity and specificity of examined markers and to evaluate proposed cut-offs of measured indices in the course of ALC and *** MPR and NLR values in ALC patients were significantly higher in comparison to control group;PLR level was significantly *** and PLR correlated with assessed indirect and direct markers of liver ***,NLR and PLR correlated with MELD *** level in NAFLD patients was significantly higher in comparison to *** correlated with indirect markers of liver fibrosis and NAFLD fibrosis *** values and proposed cut-offs for NLR,PLR and MPR in ALC patients were:0.821(>2.227),0.675(0

关键词： Hematological markers Alcoholic liver cirrhosis Nonalcoholic fatty liver disease Neutrophil-to-lymphocyte ratio Platelet-to-lymphocyte ratio Mean platelet volume-to-platelet-ratio

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Red blood cell distribution width derivatives in alcohol-related liver cirrhosis and metabolic-associated fatty liver disease

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World Journal of Gastroenterology 2022年第38期28卷 5636-5647页

作者： Agata michalak Małgorzata Guz Joanna Kozicka marek Cybulski Witold Jeleniewicz Tomasz Lach Halina Cichoż-Lach Department of Gastroenterology Medical University of LublinLublin 20-954Poland Department of Biochemistry and Molecular Biology Medical University of LublinLublin 20-093Poland Department of Orthopedics and Traumatology Medical University of LublinLublin 20-954Poland

BACKGROUND Looking for undiscovered blood markers of liver fibrosis and steatosis still remains an issue worth *** are still plenty of unresolved issues related to the actual role of hematological indices as potential markers of liver *** To study red blood cell distribution width(RDW),RDW-to-platelet ratio(RPR)and RDW-to-lymphocyte ratio(RLR) in alcohol-related liver cirrhosis(ALC) and metabolic-associated fatty liver disease(MAFLD).METHODS The study group was composed of 302 people:142 patients with ALC and 92 with MAFLD;68 persons were included as ***,RPR and RLR were measured in each *** and direct parameters of liver fibrosis were also assessed [aspartate transaminase to alkaline transaminase ratio,aspartate transaminase to platelet ratio index(APRI),fibrosis-4(FIB-4),gamma-glutamyl transpeptidase to platelet ratio(GPR),procollagen I carboxyterminal propeptide,procollagen Ⅲ aminoterminal propeptide,transforming growth factor-α,plateletderived growth factor AB,laminin].MELD score in ALC patients and nonalcoholic fatty liver disease(NAFLD) fibrosis score together with BARD score were obtained in the MAFLD *** achieved results were compared to *** a correlation between assessed markers was *** value of each investigated parameter and its suggested cut-off in the research group RESULTS RDW,RPR and RLR values turned out to be significantly higher in ALC and MAFLD groups compared to controls(ALC:P<0.0001;NAFLD:P<0.05,P<0.0001 and P<0.0001,respectively).RPR correlated positively with MELD score(P<0.01) and indirect indices of liver fibrosis(FIB-4 and GPR;P<0.0001) in ALC patients;negative correlations were found between PDGF-AB and both:RDW and RPR(P<0.01 and P<0.0001,respectively).RPR correlated positively with NAFLD fibrosis score and APRI(P<0.0001) in the MAFLD group;a positive relationship was observed between RDW and FIB-4,too(P<0.05).AUC values and suggested cut-offs for RDW,RPR and RLR in ALC

关键词： Hematological indices Alcohol-related liver cirrhosis Metabolic-associated liver disease Red blood cell distribution width Red blood cell distribution width-to-platelet ratio Red blood cell distribution width-to-lymphocyte ratio

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Non-linear Constitutive Model for the Oligocarbonate Polyurethane Material

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Chinese Journal of Polymer Science 2014年第12期32卷 1666-1677页

作者： marek Pawlikowski Warsaw University of Technology Institute of Mechanics and Printing

The polyurethane, which was the subject of the constitutive research presented in the paper, was based on oligocarbonate diols Desmophen C2100 produced by Bayer？. The constitutive modelling was performed with a view to applying the material as the inlay of intervertebral disc prostheses. The polyurethane was assumed to be non-linearly viscohyperelastic, isotropic and incompressible. The constitutive equation was derived from the postulated strain energy function. The elastic and rheological constants were identified on the basis of experimental tests, i.e. relaxation tests and monotonic uniaxial tests at two different strain rates, i.e. λ= 0.1 min-1 and λ= 1.0 min-1. The stiffness tensor was derived and introduced to Abaqus？finite element（FE） software in order to numerically validate the constitutive model. The results of the constants identification and numerical implementation show that the derived constitutive equation is fully adequate to model stress-strain behavior of the polyurethane material.

关键词： Constitutive model Viscoelastic material Stress relaxation Finite elements.

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Statistical variation of characteristics of random packed beds of Raschig rings:The influence of the sample size

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Particuology 2021年第3期19卷 50-61页

作者： PawełNiegodajew Maciej marek Czestochowa University of Technology Department of Thermal Machineryal.Armii Krajowej 2142-200 CzestochowaPoland

Many studies on random packed beds have been dedicated to local porosity(void fraction)or orientation distribution of ***,despite the random nature of the considered packings,very little attention has been devoted to examination whether the number of particles used in experiments/simulations is sufficiently large to get reproducible *** reproducibility of the key packing parameters depends on the size of the population of particles(sample size)and ordering effects induced by the confining *** work investigates quantitatively the influence of the sample size on the statistical variation of the packed bed *** beds of Raschig rings were generated with a sequential algorithm and three column diameters were *** has been found that in the case of the orientation distribution the results depend strongly on the sample size,especially for slender columns,while the porosity profiles are well-reproducible characteristics even for relatively small packings of *** complementary results for full cylinders are also included.

关键词： Random packing Raschig rings Full cylinders Particle orientation Porosity Reproducibility

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Shape Optimization of the Turbomachine Channel by a Gradient Method - Accuracy Improvement

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Journal of Thermal Science 2003年第3期12卷 239-244页

作者： marek Rabiega Institute of Turbomachinery Technical University of Lodz219/223 Wolczanska St93-005 LodzPoland

An algorithm of the gradient method of the channel shape optimization has been built on the basis of 3D equations of mass, momentum and energy conservation in the fluid flow. The gradient of the functional that is posed for minimization has been calculated by two methods, via sensitivities and - for comparison - by the finite difference approximation. The equations for sensitivities have been generated through a differentiate-then-discretize approach. The exemplary optimization of the blade shape of the centrifugal compressor wheel has been carried out for the inviscid gas flow governed by Euler equations with a non-uniform mass flow distribution as the inlet boundary condition. Mixing losses have been minimized downstream the outlet of the centrifugal wheel in this exemplary optimization. The results of the optimization problem accomplished by the two above-mentioned methods have been presented. In the case sparse grids have been used, the method with the gradient approximated by finite differences has been found to be more consistent. The discretization accuracy has turned out to be crucial for the consistency of the gradient method via sensitivities.

关键词： numerical fluid dynamics shape optimization turbomachine channels

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Effect of particle polydispersity on micromechanical properties and energy dissipation in granular mixtures

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Particuology 2014年第5期12卷 91-99页

作者： Joanna Wiacek marek Molenda Institute of Agrophysics Polish Academy of SciencesDoswiadczalna 420-290 Lublin 27Poland

A series of numerical tests was conducted to study the micromechanical properties and energy dissipation in polydisperse assemblies of spherical particles subjected to uniaxial compression. In general, distributed particle size assemblies with standard deviations ranging from 0% to 80% of the particle mean diameter were examined. The microscale analyses included the trace of the fabric tensor, magnitude and orien- tation of the contact forces, trace of stress, number of contacts and degree of mobilization of friction in contacts between particles. In polydisperse samples, the average coordination numbers were lower than in monodisperse assemblies, and the mobilization of friction was higher than in monodisperse assemblies due to the non-uniform spatial rearrangement of spheres in the samples and the smaller displacements of the particles. The effect of particle size heterogeneity on both the energy density and energy dissipation in systems was also investigated.

关键词： Polydisperse packing Discrete element method Micromechanics Energy dissipation

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Representative elementary volume analysis of polydisperse granular packings using discrete element method

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Particuology 2016年第4期14卷 88-94页

作者： Joanna Wiacek marek Molenda Institute of Agrophysics Polish Academy of Sciences Doswiadczalna 4 20-290 l.ublin Poland

The representative elementary volume （REV） for three-dimensional polydisperse granular packings was determined using discrete element method simulations. Granular mixtures of various sizes and particle size distributions were poured into a cuboid chamber and subjected to uniaxial compression, Findings showed that the minimum REV for porosity was larger compared with the REV for parameters such as coordination number, effective elastic modulus, and pressure ratio. The minimum REV for porosity and other parameters was found to equal 15,10, and 5 times the average grain diameter, respectively. A study of the influence of sample size on energy dissipation in random packing of spheres has also confirmed that the REV size is about 15 times the average grain diameter. The heterogeneity of systems was found to have no effect on the REV for the parameters of interest for the narrow range of coefficient of uniformity analyzed in this paper. As the REV approach is commonly applied in both experimental and numerical studies, determining minimum REV size for polydisperse granular packings remains a crucial issue.

关键词： Representative elementary volume Polydisperse packing Discrete element method Sample size effect

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Temporal inequalities for sequential multi-time actions in quantum information processing

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Frontiers of physics 2014年第5期9卷 629-633页

作者： marek Zukowski Institute for Theoretical Physics and Astrophysics Uniwersytet Gdanski PL-80-952 Gdadsk Poland Hefei National Laboratory of Physical Sciences at the Mieroscale University of Science and Technology of China Hefei 230026 China

A new kind of temporal inequalities are discussed, which apply to algorithmic processes, involving a finite memory processing unit. They are an alternative to the Leggett-Grag ones, as well as to the modified ones by Brukner et al. If one considers comparison of quantum anti classical processes involving systems of finite memory （of the same capacity in both cases）, the inequalities give a clear message why we can expect quantum speed-up. In a classical process one always has clearly defined values of possible measurements, or in terms of the information processing language, if we have a sequential computations of some function depending on data arriving at each step on an algorithm, the function always has a clearly defined value. In the quantum case only the final value, after the end of the algorithm, is defined. All intermediate values, in agreement with Bohr＇s complementarity, cannot be ascribed a definite value.

关键词： temporal inequalities quantum information

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