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The association of type and number of high-risk criteria with cancer-specific mortality in prostate cancer patients treated with radical prostatectomy

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CURRENT UROLOGY 2024年第2期18卷 128-132页

作者： Chierigo, Francesco Flammia, Rocco Simone Sorce, Gabriele Hoeh, Benedikt Hohenhorst, Lukas Panunzio, Andrea Tian, Zhe Saad, Fred Graefen, marcus Gallucci, Michele Briganti, Alberto Montorsi, Francesco Chun, Felix k. H. Shariat, Shahrokh F. Antonelli, Alessandro Guano, Giovanni Mantica, Guglielmo Borghesi, Marco Suardi, Nazareno Terrone, Carlo karakiewicz, Pierre I. Univ Genoa Dept Surg & Integrated Diagnost Sci Genoa Italy IRCCS Osped Policlin San Martino Genoa Italy Univ Montreal Hlth Ctr Div Urol Canc Prognost & Hlth Outcomes Unit Montreal PQ Canada IRCCS Policlin San Martino Dept Urol Genoa Italy Univ Genoa Policlin San Martino Hosp Dept Urol Largo Rosanna Benzi 10 I-16132 Genoa Italy Sapienza Rome Univ Policlin Umberto Hosp 1 Dept Maternal Child & Urol Sci Rome Italy Univ Hosp Frankfurt Dept Urol Frankfurt Germany Univ Hosp Hamburg Eppendorf Martini Klin Prostate Canc Ctr Hamburg Germany Univ Verona Azienda Osped Univ Integrata Verona Dept Urol Verona Italy IRCCS San Raffaele Sci Inst Urol Res Inst Div Expt Oncol Unit Urol Milan Italy Med Univ Vienna Comprehens Canc Ctr Dept Urol Vienna Austria Weill Cornell Med Coll Dept Urol New York NY USA Univ Texas Southwestern Dept Urol Dallas TX USA Charles Univ Prague Fac Med 2 Dept Urol Prague Czech Republic IM Sechenov First Moscow State Med Univ Inst Urol & Reprod Hlth Moscow Russia Univ Jordan Jordan Univ Hosp Dept Special Surg Div Urol Amman Jordan

Objectives: This study aimed to test the association between of type and number of D'Amico high-risk criteria (DHRCs) with cancer-specific mortality (CSM) in high-risk prostate cancer patients treated with radical prostatectomy. Materials and methods: In the Surveillance, Epidemiology, and End Results database (2004-2016), we identified 31,281 radical prostatectomy patients with at least 1 DHRC, namely, prostate-specific antigen (PSA) >20 ng/mL (hrPSA), biopsy Gleason Grade Group (hrGGG) score of 4 and 5, or clinical tumor stage >= T3 (hrcT). Multivariable Cox regression models and competing risks regression models (adjusting for other cause mortality) tested the association between DHRCs and 5-year CSM. Results: Of 31,281 patients, 14,394 (67%) exclusively harbored hrGGG, 3189 (15%) harbored hrPSA, and 1781 (8.2%) harbored hrcT. Only 2132 patients (6.8%) harbored a combination of the 2 DHRCs, and 138 (0.6%) had all 3 DHRCs. Five-year CSM rates ranged from 0.9% to 3.0% when any individual DHRC was present (hrcT, hrPSA, and hrGGG, in that order), 1.6% to 5.9% when 2 DHRCs were present (hrPSA-hrcT, hrcT-hrGGG, and hrPSA-hrGGG, in that order), and 8.1% when all 3 DHRCs were present. Cox regression models and competing risks regression confirmed the independent predictor status of DHRCs for 5-year CSM that was observed in univariable analyses, with hazard ratios from 1.00 to 2.83 for 1 DHRC, 2.35 to 5.88 for combinations of 2 DHRCs, and 7.13 for all 3 DHRCs. Conclusions: Within individual DHRCs, hrcT and hrPSA exhibited weaker effects than hrGGG did. Moreover, a dose-response effect was identified according to the number of DHRCs. Accordingly, the type and number of DHRCs allow further risk stratification within the high-risk subgroup.

关键词： High risk prostate cancer Radical prostatectomy Cancer-specific mortality Staging SEER BEAM RADIATION-THERAPY RATES

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斯塔默应跨越政治分歧选拨内阁成员

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商业周刊（中文版） 2024年第11期 24-25页

作者： marcus Ashworth 逸思(译) 不详

基尔·斯塔默应当采取类似前工党首相戈登·布朗的超越党派立场的做法来组建内阁。2007年,英国工党籍首相戈登·布朗(Gordon Brown)站在唐宁街10号的台阶上宣布,他组建的将是“人才济济的新政府”,从而传达出这样的信息:挑选最智慧、最... 详细信息

基尔·斯塔默应当采取类似前工党首相戈登·布朗的超越党派立场的做法来组建内阁。2007年,英国工党籍首相戈登·布朗(Gordon Brown)站在唐宁街10号的台阶上宣布,他组建的将是“人才济济的新政府”,从而传达出这样的信息:挑选最智慧、最优秀的人来领导国家。

关键词：内阁成员英国工党斯塔政治分歧戈登新政府首相

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汉堡“水上歌剧院”——阿尔斯特游泳馆翻新及改扩建

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当代建筑 2024年第5期 108-116页

作者：冯·格康 marcus Bredt(摄影) 玛格及合伙人建筑师事务所

位于汉堡市霍恩费尔德区的阿尔斯特游泳馆始建于1972年,由建筑师霍斯特·尼森、罗尔夫·施托默、瓦尔特·诺伊豪瑟及工程师约尔格·施莱希共同设计。直至今日,其造型独特的壳面屋顶仍属于欧洲最大型的壳结构之一。三根结构柱支撑的混凝... 详细信息

位于汉堡市霍恩费尔德区的阿尔斯特游泳馆始建于1972年,由建筑师霍斯特·尼森、罗尔夫·施托默、瓦尔特·诺伊豪瑟及工程师约尔格·施莱希共同设计。直至今日,其造型独特的壳面屋顶仍属于欧洲最大型的壳结构之一。三根结构柱支撑的混凝土屋顶由两个双曲抛物壳面组成。

关键词：建筑改造与更新游泳馆混凝土壳面屋顶

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Treatment of Vulvovaginal Candidiasis with A Strategy Based on Phototherapy (M.A.C.^® Scar Acceleration Method)

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Modern Research in Inflammation 2024年第1期13卷 1-7页

作者： marcus Vinicius de Mello Pinto karin Yuri Fernández Iturra Aline Ronis Sampaio María Elena Silva Álvarez Esteban Fortuny Celulare Institute Petrópolis Brazil Bienus Clinic Santiago Chile Fisiocare Curicó Chile Universidad Finis Terrae Santiago Chile

Candidiasis, also known as candidiasis vulvovaginitis, is an infection caused by different types of Candida fungi, the most frequent being Candida albicans. The present study reports an effective strategy, which opens new avenues for the treatment of this public health problem. The MAC® Methodology, conventional laser light-emitting (LLLT)/LED) methods are based on the biphasic response demonstrated many times in LLLT research and as with other forms of drugs, a “drug” (irradiation parameters) and a “dose” (irradiation times) and the “Arndt-Schulz Law” is often cited as a suitable model to describe the dose-dependent effects of LLLT. This method uses photopharmaceuticals, cell markers and the use of correct parameters for each case to induce the acceleration of tissue repair. The present study shows a case of a 32-year-old patient diagnosed with recurrent candidiasis 4 years ago. Eighteen sessions were performed (every other day) using a photoactivated component (Methylene blue 1% + Clotrimazole 1%) and LED phototherapy (red, blue and violet) with emission times of 60 - 260 seconds for each applicator, according to the dose recommendations of the scar acceleration method (MAC®). At the sixth treatment session there was a noticeable decrease in the itching sensation reported by the patient. In session 11 she reported feeling a great improvement, indicating that she no longer felt itching in any area after 18 sessions. The present case demonstrates new methodologies to treat common problems in the population that have a positive impact on the quality of life. This methodology has a promising future because it is non-invasive and requires a great biological transformation for inflammatory, fungal and viral control.

关键词： Treatment of vulvovaginal Candidiasis Candidiasis Candida M.A.C. MAC®

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Individual variation in dispersal associated behavioral traits of the invasive Chinese mitten crab （Eriocheir sinensis, H. Milne Edwards, 1854） during initial invasion of Lake V^inern, Sweden

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Current Zoology 2014年第3期60卷 410-416页

作者： Tomas BRODIN marcus k. DROTZ Department of Ecology and Environmental Science Umea University Sweden Lake Vanem Museum of Natural and Cultural History Framnisvsgen 2 53154 Lidkoping Sweden

Understanding and predicting species range-expansions and biological invasions is an important challenge in modem ecology because of rapidly changing environments. Recent studies have revealed that consistent within-species variation in behavior （i.e. animal personality） can be imperative for dispersal success, a key stage in the invasion process. Here we investigate the composition and correlation of two important personality traits associated with invasion success, activity and boldness, and how they are connected to sex and individual size in a newly colonised population of the Chinese mitten crab Eriocheir sinensis in Lake Vanem, Sweden. We found no effect of sex or size on behavioral expressions orE. sinensis but a clear positive correlation between boldness and activity. In addition, this study generates important baseline data for monitoring behavioral develop ment, and thereby changing ecological impact, of an invading population over time. This has implications for predicting ecological effects of invasive species as well as for managing ecological invasions.

关键词： Eriocheir sinensis Biological invasion Behavior Boldness Activity Invasion front

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2024年别跟美联储作对

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商业周刊（中文版） 2024年第1期 6-7页

作者： Mark Gilbert marcus Ashworth 逸思(译) 不详

几年来的消费价格升,使通胀率远超美联储的目标值,从而促成了连串加息。然而,在急于为其货币稳定守护者的形象重新正名的同时,决策者的热情也有可能破坏经济增长并引发失业。我们预计,紧随近几个月加息暂停而来的将是政策的放松。无论如... 详细信息

几年来的消费价格升,使通胀率远超美联储的目标值,从而促成了连串加息。然而,在急于为其货币稳定守护者的形象重新正名的同时,决策者的热情也有可能破坏经济增长并引发失业。我们预计,紧随近几个月加息暂停而来的将是政策的放松。无论如何,美联储接下来的行动对于金融市场新一年表现的决定作用将比以往任何时候都重要。

关键词：加息金融市场消费价格通胀率美联储守护者目标值

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Comparison between solid pseudopapillary neoplasms of the pancreas and pancreatic ductal adenocarcinoma with cystic changes using computed tomography

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World Journal of Radiology 2024年第6期16卷 211-220页

作者： Shuai Ren Li-Chao Qian Xiao-Jing Lv Ying-Ying Cao marcus J Daniels Zhong-Qiu Wang Li-Na Song Ying Tian Department of Radiology Jiangsu Province Hospital of Chinese MedicineThe Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Geratology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Department of Radiology NYU Langone HealthNew YorkNY 10016United States

BACkGROUND Solid pseudopapillary neoplasms of the pancreas(SPN)share similar imaging findings with pancreatic ductal adenocarcinoma with cystic changes(PDAC with cystic changes),which may result in unnecessary *** To investigate the value of computed tomography(CT)in differentiation of SPN from PDAC with cystic *** This study retrospectively analyzed the clinical and imaging findings of 32 patients diagnosed with SPN and 14 patients diagnosed with PDAC exhibiting cystic changes,confirmed through pathological *** and qualitative analysis was performed,including assessment of age,sex,tumor size,shape,margin,density,enhancement pattern,CT values of tumors,CT contrast enhancement ratios,“floating cloud sign,”calcification,main pancreatic duct dilatation,pancreatic atrophy,and peripancreatic invasion or distal *** logistic regression analysis was used to identify relevant features to differentiate between SPN and PDAC with cystic changes,and receiver operating characteristic curves were obtained to evaluate the diagnostic performance of each variable and their *** When compared to PDAC with cystic changes,SPN had a lower age(32 years vs 64 years,P0.05).The area under the receiver operating characteristic curve of the combination was 0.833(95%confidence interval:0.708-0.957)with 78.6%sensitivity,81.3%specificity,and 80.4%accuracy in differentiation of SPN from PDAC with cystic *** A larger tumor size,“floating cloud sign,”and peri

关键词： Solid pseudopapillary neoplasm Pancreas Pancreatic ductal adenocarcinoma Computed tomography Differential diagnosis

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Transplantation in autoimmune liver diseases

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World Journal of Gastroenterology 2008年第21期14卷 3388-3395页

作者： marcus Mottershead James Neuberger Liver Unit Queen Elizabeth HospitalBirmingham B15 2THUnited Kingdom

Liver transplantation remains an effective treatment for those with end-stage disease and with intractable liver-related *** shortage of organs for transplantation has resulted in the need for rationing.A variety of approaches to selection and allocation have been developed and vary from country to *** shortage of donors has meant that new approaches have to be adopted to make maximal use of the available organs;these include splitting grafts,use of extended criteria livers,livers from non-heart-beating donors and from living *** transplantation,most patients will need life-long immunosuppression,although a small proportion can have immunosuppression successfully *** immunosuppressive drugs and different strategies may allow a more targeted approach with a reduction in side-effects and so improve the patient and graft *** autoimmune diseases,transplantation is associated with significant improvement in the quality and length of *** may recur after transplantation and may affect patient and graft survival.

关键词： Liver transplantation Autoimmune disease Recurrence Immunosuppression

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Small scale adeno-associated virusvector production for preclinical gene delivery based on chloroform precipitation

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Neural Regeneration Research 2022年第1期17卷 99-100页

作者： marcus Davidsson Andreas Heuer Molecular Neuromodulation Department of Experimental Medical SciencesLund UniversityLundSweden Behavioural Neuroscience Laboratory Department of Experimental Medical SciencesLund UniversityLundSweden

Gene therapy aims to introduce genetic information into a cell-type of interest to replace,correct,silence,or modify defective *** therapy in its broadest sense can theoretically prevent,halt,or cure any condition that affects *** addition to that,the introduction and/or manipulation of genes is one of the major research areas in biological sciences,aimed to deepen our knowledge on how biological systems *** advances have made it possible to induce changes ranging from manipulations of large stretches of the genome to the change of single *** gold-standard vehicles to bring this genetic information into the target cells are viral vectors.

关键词： replace Small mankind

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Scanning probe lithography on calixarene towards single-digit nanometer fabrication

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International Journal of Extreme Manufacturing 2020年第3期2卷 104-124页

作者： marcus kaestner Ivo W Rangelow Institute of Micro-and Nanoelectronics Nanoscale Systems GroupFaculty of Electrical Engineering and Information TechnologyIlmenau University of TechnologyGustav-Kirchhoff-Str.198693 IlmenauGermany

Cost effective patterning based on scanning probe nanolithography(SPL)has the potential for electronic and optical nano-device manufacturing and other nanotechnological *** of the fundamental advantages of SPL is its capability for patterning and imaging employing the same *** is achieved with self-sensing and self-actuating cantilevers,also known as‘active'*** we used active cantilevers to demonstrate a novel path towards single digit nanoscale patterning by employing a low energy(king *** sensitivity was 80-times greater than a classical electron beam exposure at 30 *** operating the electro-exposure process in ambient conditions a novel lithographic reaction scheme based on a direct ablation of resist material(positive tone)is presented.

关键词： nanofabrication field-emission scanning probe lithography single nanometer lithography molecular resist

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