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Super-resolution of PROBA-V images using convolutional neural networks

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Astrodynamics 2019年第4期3卷 387-402页

作者： marcus Martens DarioIzzo Andrej Krzic Daniel Cox European SpaceAgency Noordwijk2001AZthe Netherleneds

European Space Aqency(ESA)’s PROBA-V Earth observation(EO)satellite enables us to monitor our planet at a large scale to study the interaction between vegetation and climate,and provides guidance for important decisions on our common global ***,the interval at which high-resolution images are recorded spans over several days,in contrast to the availability of lower-resolution images which is often *** collect an extensive dataset of both high-and low-resolution images taken by PROBA-V instruments during monthly periods to investigate Multi Image Super-resolution,a technique to merge several low-resolution images into one image of higher *** propose a convolutional neural network(CNN)that is able to cope with changes in illumination,cloud coverage,and landscape features which are introduced by the fact that the different images are taken over successive satellite passages at the same *** a bicubic upscaling of low resolution images taken under optimal conditions,we find the Peak Signal to Noise Ratio of the reconstructed image of the network to be higher for a large majority of different *** shows that applied machine learning has the potential to enhance large amounts of previously collected EO data during multiple satellite passes.

关键词： deep learning convolutional neural network (CNN) super-resolution imaging remote sensing Earth observation(EO)

THE HOSPITAL FORMULARY:A TYPE OF ESSENTIAL DRUG PROGRAM

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中国临床药理学杂志 1993年第1期 8-9页

作者： marcus M.Reidenberg Cornell University Medical College New York

Hospital pharmacies in the United States stock a limited number of drugs. The drugs that arestocked are selected to be able to treat all of the problems occuring in hospitalized patients. This requiresan extensive list of drugs, but far fewer than are available on the American market. Let us examinethe hospital formulary system and think of it as an example of an essential drugs program.

关键词： THE HOSPITAL FORMULARY

CONTINUING MEDICAL EDUCATION,AN IMPORTANT PART OF A COMPREHENSIVE ESSENTIAL DRUGS PROGRAM

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中国临床药理学杂志 1993年第1期 10-12页

作者： marcus M.Reidenberg Cornell University Medical College New York

An essential drugs program starts with the preparation of a list of essential drugs based on theprinciples set out in the wHO Committee report. The next step in implementing an essential drugsprogram is to arrange for every drug on the essential drugs list to be available to everyone in the populationto be covered by the program. Preparing an essential drugs list and making the drugs available

关键词： CONTINUING MEDICAL EDUCATION,AN IMPORTANT PART OF A COMPREHENSIVE ESSENTIAL DRUGS PROGRAM very

Immuno-oncology in triple-negative breast cancer

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 133-144页

作者： Anne-Sophie Heimes marcus Schmidt Department of Obstetrics and Gynecology University Medical Center MainzMainz 55131Germany

The immune system plays an important role in breast ***-negative breast cancer(TNBC)has a higher mutational load compared to other *** addition,higher levels of tumor-associated antigens suggests that immunotherapies are a promising treatment option especially for *** review discusses both the complexity of the immune system and the cancer immune-cell *** fact,a higher level of tumor-infiltrating lymphocytes is associated with an improved prognosis as well as a better response to chemotherapy in *** target structures within the cancer immune-cell cycle are the so-called“immune checkpoints”.Immune checkpoint inhibitors(ICPi)block the interaction of certain cell surface proteins that serve as“brakes”of immune *** studies have shown ICPi improved survival in early as well as advanced ***,this has the price of increasing,mainly,immune-mediated *** strengthen tumor-specific T cell-mediated immunity by“releasing the brake”of the immune *** combination with chemotherapy,ICPi are already approved for *** a further step,individualized vaccination strategies against tumor-associated neoantigens represent another promising approach.A liposome-formulated intravenous RNA vaccine encoding different tumor-associated antigens is currently being studied in TNBC and leads to neoantigen-specific immune *** novel strategies will improve the prognosis of patients with triple-negative breast cancer.

关键词： Tumor infiltrating lymphocytes cancer-immunity-cycle immune checkpoint inhibitors vaccination,tumor-associated antigens neoantigens

Assessment of the spatial extent of permafrost in the Upper Indus Basin(UIB)

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Journal of Mountain Science 2023年第6期20卷 1508-1525页

作者： wasim HASSAN G.JEELANI A.P.DIMRI marcus NüSSER Department of Earth Sciences University of KashmirSrinagar 190006India School of Environmental Sciences Jawaharlal Nehru UniversityNew Delhi 110067India Department of Geography South Asia Institute(SAI)Heidelberg UniversityHeidelberg 69115Germany Heidelberg Centre for the Environment(HCE) Heidelberg UniversityHeidelberg 69120Germany

Climate change differentially influences the frozen ground,a major dynamic component of the cryosphere,on a local and regional *** the warming climate with pronounced effects reported at higher altitudes,the characterization of the frozen ground is very important in the Upper Indus Basin(UIB),an important and critical region with respect to climate and hydro-glaciological *** this study,the efficiency and reliability of the surface frost number model are assessed in delineating the spatial extent of different classes of frozen ground in the *** daily MODIS land surface temperature(LST)with ground surface temperature(GST)and surface geomorphological expressions as ground validation datasets are used jointly in efficiently determining the extent of different classes of frozen ground(continuous and discontinuous permafrost and seasonal frost).The LST and GST resonate with each other in the annual cycle of temperature variation,however,with mean annual LST exhibiting an offset(cold bias)of 5 to 7℃relative to mean *** study shows that the highest permafrost extent is observed in areas where the lowest thinning rates of glacier ice are reported and vice *** surface frost number model categorizes an area of 38%±3%and 15%±3%in the UIB as permafrost and seasonal frost,*** on the altitude model,the lower limit of alpine permafrost is approximated at a mean altitude of 4919±590 m *** the *** present study acts as preliminary work in the data sparse and inaccessible regions of the UIB in characterizing the frozen and unfrozen ground and may act as a promising input data source in glaciohydro-meteorological models for the Himalaya and *** addition,the study also underlines the consideration of this derelict cryospheric climatic variable in defining and accounting for the sustainable development of socio-economic systems through its intricate ramification on agricultural activity,landscape stability and infrastruc

关键词： Upper Indus Basin Land surface temperature Ground surface temperature Surface frost number Permafrost Seasonal frost

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Effects of a phase transition on two-pion interferometry in heavy ion collisions at √SNN=2.4-7.7 GeV

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Science China(Physics,Mechanics & Astronomy) 2023年第3期66卷 88-97页

作者： Pengcheng Li Jan Steinheimer Tom Reichert Apiwit Kittiratpattana marcus Bleicher Qingfeng Li Institut fur Theoretische Physik Johann Wolfgang Goethe Universitat FrankfurtFrankfurt am Main 60438Germany School of Science Huzhou UniversityHuzhou 313000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China Frankfurt Institute for Advanced Studies Frankfurt am Main 60438Germany GSI Helmholtzzentrum f¨urSchwerionenforschung GmbH Darmstadt 64291Germany Helmholtz Research Academy Hesse for FAIR(HFHF) GSI Helmholtz Center for Heavy Ion PhysicsCampus FrankfurtFrankfurt am Main 60438Germany Center of Excellence in High Energy Physics&Astrophysics School of PhysicsSuranaree University of TechnologyNakhon Ratchasima 30000Thailand

Hanbury-Brown-Twiss(HBT) correlations for charged pions in central Au+Au collisions at √SNN=2.4-7.7 GeV(corresponding to beam kinetic energies in the fixed target frame from Elab=1.23 to 30 GeV/nucleon) are calculated using the ultra-relativistic quantum molecular dynamics model with different equations of state(EoSs).The effects of a phase transition at high baryon densities are clearly observed in the explored HBT *** results show that the available data on the HBT radii,RO/RSand R^(2)_(O)-R^(2)_(S),in the investigated energy region favor a relatively stiff EoS at low beam energies,which then turns into a soft EoS at high collision energies consistent with astrophysical constraints on the high-density EoS of quantum chromodynamics(QCD).The specific effects of two different phase transition scenarios on RO/RSand R^(2)_(O)-R^(2)_(S)are investigated.A phase transition with a significant softening of the EoS below four times the nuclear saturation density can be excluded using HBT *** results highlight that the pion’s RO/RSand R^(2)_(O)-R^(2)_(S)are sensitive to the stiffness of the EoS and can be used to constrain and understand the QCD EoS in a high baryon density region.

关键词： heavy ion collisions HBT correlation equation of state

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Mg anode interface engineering in KNO_(3) electrolyte with sodium 5-sulfosalicylate as an additive for enhanced performance of Mg-air batteries

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Journal of Magnesium and Alloys 2024年第9期12卷 3646-3660页

作者： Guanhua Lin Yaqing Zhou Sandrine Zanna Antoine Seyeux Philippe marcus Jolanta Swiatowska Chimie ParisTech-CNRS PSL UniversityInstitut de Recherche de Chimie Paris11 rue Pierre et Marie CurieParis 75005France International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China

The Mg-air batteries face limitations with pronounced hydrogen evolution and low anodic utilization efficiency from Mg anodes in conventional NaCl *** corrosion performance,surface composition,and discharge properties of commercial purity Mg anodes were thoroughly investigated in KNO_(3)electrolytes with and without sodium 5-sulfosalicylate and compared to NaCl *** addition of sodium 5-sulfosalicylate to KNO_(3)-based electrolyte results in efficient inhibition of H_(2)evolution,consequently enhancing anodic utilization efficiency to 84%and specific capacity to 1844 mAh/g,compared to NaCl(24%and 534 mAh/g,respectively)under discharge condition of 10 mA/cm^(2)in half ***,the chelating ability of sodium 5-sulfosalicylate can significantly improve the Mg surface dissolution kinetics and discharge product deposition rate at the Mg anode/electrolyte interface,yielding formation of a thinner discharge layer as confirmed by time-of-flight secondary ion mass *** discharge voltage is increased to 1.60 V,compared to 1.35 V in KNO_(3)at 0.5 mA/cm^(2)in full ***,higher concentration of sodium 5-sulfosalicylate can accelerate Mg anode dissolution,impeding the improvement of anodic utilization efficiency,specific capacity,and energy ***,determining optimal additive concentration and current density is crucial for enhancing the discharge properties of Mg-air batteries and mitigating excessive Mg dissolution in chloride-free electrolytes.

关键词： Mg-air batteries Chloride-free electrolytes Discharge properties Structure of surface layer

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Transforming nanoscale VO_(2)(B) into a scalable sodium-ion electrode

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Nano Research 2024年第10期17卷 8809-8818页

作者： Yunkai Luo Swetha Chandrasekaran Bintao Hu Randy Chen marcus worsley Bruce Dunn Department of Materials Science and Engineering University of CaliforniaLos AngelesCA 90095USA Lawrence Livermore National Laboratory CA 94550USA

The intermittent nature of renewable energies requires highly reliable grid-level energy storage approaches.A critical consideration in developing this technology is the areal capacity which determines battery performance and influences the cost of battery *** related importance is finding new ways of developing scalable *** recent years,threedimensional(3D)printing of conductive scaffolds has emerged as an alternative to overcome the scalability limitations of commercial tape cast *** research carried out in the current study demonstrates a successful scalability pathway for nanoscale VO_(2)(B),a desirable cathode for sodium-ion batteries which has a nano-flower morphology with a crystallite sizewe were able to achieve mass loading of over 100 mg·cm^(-2) and still possess an areal capacity of 10 mAh·cm^(-2) at a current density of 5 mA·cm^(-2).Moreover,after 1000 cycles,these electrodes retained 75% to 80% of their initial *** at high loading levels,the electrodeposited VO_(2)(B)exhibits pseudocapacitive material signatures such as a box-like voltammetry response,linear galvanostatic response,and no phase change upon *** scalability of the VO_(2)(B)electrode is demonstrated in a series of experiments which show the areal capacity to scale upon increase in both mass loading and electrode thickness,with only small changes in specific *** study establishes that nanoscale materials can be scaled up to achieve thick electrodes without compromising their electrochemical properties.

关键词： nano VO_(2)(B) sodium-ion battery scalable electrodes three-dimensional(3D)printed scaffold additive manufacturing

Lymph node ratio in resected pancreatic head cancers: time for a broader clinical implementation?

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Hepatobiliary Surgery and Nutrition 2024年第2期13卷 374-375页

作者： Ernesto Sparrelid Poya Ghorbani marcus Holmberg Division of Surgery and Oncology Department of Clinical ScienceIntervention and TechnologyKarolinska InstitutetKarolinska University HospitalStockholmSweden Department of Surgery and Oncology Sankt Görans HospitalStockholmSweden

Lymph node ratio(LNR)has emerged as a promising predictor for survival outcome after surgery in different tumor types(1,2).The concept of evaluating LNR as a prognostic factor also after pancreatic surgery has been described in several publications(3,4).Most of the previous reports on LNR in this setting are single-center studies with rather small cohorts and/or mixed histological tumor types,possibly limiting the generalizability of the *** if the role of LNR in pancreatic cancer has been acknowledged,it is still regarded as having mostly academical implications when comparing results from different studies and is probably rarely being used as a tool in clinical decision-making world-wide.

关键词： Pancreas cancer surgery lymph node ratio(LNR)