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Comissioning of the lEA-R1 Nuclear Reactor New Heat Exchanger

Journal of Energy and Power Engineering 2013年第6期7卷 1058-1065页

作者： Alfredo Jose Alvim de Castro Pedro Ernesto Umbehaun marcos rodrigues de carvalho Roberto Frajndlich Douglas Alves Cassiano Nuclear Engineering Center Nuclear and Energy Research Institute (IPEN-CNEN/SP) Sao Paulo 05508-000 Brazil Engineering Modeling and Applied Social Sciences Center ABC Federal University (UFABC) S6o Bernardo do Campo09606-070 Brazil

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Litter decomposition and nutrient release for two tropical N-fixing species in Rio de Janeiro,Brazil

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Journal of Forestry Research 2022年第2期33卷 487-496页

作者： David Pessanha Siqueira Giovanna Campos Mamede Weiss de carvalho JoséGabriel de Souza Silva marcos Vinicius Winckler Caldeira deborah Guerra Barroso Laboratório de Fitotecnia Universidade Estadual do Norte Fluminense Darcy RibeiroAvenida Alberto Lamego2000Campos dos GoytacazesRio de JaneiroBrazil departamento de Ciências Florestais e da Madeira Universidade Federal do Espírito SantoAvenida Governador Lindenberg316Jerônimo MonteiroEspírito SantoBrazil department of Geosciences and Natural Resources Management University of CopenhagenRolighedsvej 23Frederisksberg CDenmark

Litter production and decomposition are critical to forest productivity,nutrient cycling,and carbon seques-tration in tropical woody ***,nutrient release and leaf litter stoichiometry in tropical legume tree plantations over the long term after outplanting are poorly understood or even *** improving our under-standing of the pattern of changes in the decomposition of N-fixing leaf litters and their possible impact on carbon stor-age,we measured litter production,mass loss and nutrient release for 240 d during litter decomposition for two tropical legume tree species(Plathymenia reticulata and Hymenaea courbaril),in Rio de Janeiro,*** production for *** was 5.689 kg ha^(−1) a^(−1) and 3.231 kg ha^(−1) a^(−1) for *** patterns of mass loss rates were similar;however,nutrient release was greater for ***,while *** showed immobilization of nutrients,especially for N,which increased by almost 20%in the early phase of decomposition followed by gradual *** from the N-fixing species did differ in nutrient chemistries over time,which was not surprising given that initial nutrient concentrations varied broadly,except for C and *** of the nutrient concentrations increased as the remaining litter mass decreased in both species,except for C and *** C:N and N:P ratios differed between the species,but N:P did not correlate to mass *** species had N-rich leaves,but *** decomposition was very likely P-limited,while *** seemed to be co-limited by N and *** results showed different patterns in nutrient release and the stoichi-ometry involved in the decomposition dynamics of the two tropical N-fixing species,even though they have similar litter decay *** species,but especially ***,may help re-establish nutrient cycling in disturbed ecosystems.

关键词： Nutrient dynamics Legume species Litter chemistry Ecological stoichiometry Tropical forest

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Dimensions of emotional distress among Brazilian workers in a COVID-19 reference hospital:A factor analytical study

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World Journal of Psychiatry 2022年第6期12卷 843-859页

作者： marcos O carvalho-Alves Vitor A Petrilli-Mazon Andre R Brunoni Andre Malbergier Pedro Fukuti Guilherme V Polanczyk Euripedes C Miguel Felipe Corchs Yuan-Pang Wang department of Psychiatry School of MedicineUniversity of Sao PauloSao Paulo 05403-010Brazil Program in Neuroscience and Behavior Department of Experimental PsychologyInstitute of PsychologyUniversity of Sao PauloSao Paulo 01060-970Brazil department and Institute of Psychiatry University of Sao PauloSao Paulo 05403-010Brazil

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic is an unprecedented challenge for public health and has caused the loss of millions of lives *** workers play a key role in averting the collapse of the health system,but the mental health of many has deteriorated during the *** studies have been devoted to identifying the needs of workers on frontline *** To investigate dimensions of common emotional symptoms and associated predictors among Brazilian workers in a COVID-19 reference *** This is an observational study of the mental health of professionals in a COVID-19 hospital in the city of São *** invited all hospital employees to respond to an online survey between July and August 2020,during the first peak of the *** of 1000 participants who completed the survey were analyzed(83.9%were women and 34.3%were aged 30 to 40).Hospital workers selfreported the presence of symptoms of depression,anxiety,trauma-related stress,and burnout through the Patient Health Questionnaire-9,the Generalized Anxiety Disorder-7,the Impact of Event Scale-Revised and the Mini-Z Burnout Assessment *** were assembled and subjected to exploratory factor analysis to reveal workers’core emotional *** linear regression models were subsequently carried out to estimate the likelihood of dimensions of distress using questions on personal motivation,threatening events,and institutional *** Around one in three participants in our sample scored above the threshold of depression,anxiety,post-traumatic stress disorder,and *** factor analysis revealed a three-factor structure that explained 58%of the total data *** distressing emotional domains were avoidance and re-experience,depression-anxiety,and sleep *** analysis revealed that institutional support was a significant protective factor for each of these dimensions(βrange=-0.41 to-0.20,P<0.001).However,partici

关键词： COVID-19 Pandemics Health personnel Mental health Psychological distress Occupational medicine

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Helicobacter pylori and EBV in gastric carcinomas:Methylation status and microsatellite instability

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World Journal of Gastroenterology 2010年第3期16卷 312-319页

作者： Adriana Camargo Ferrasi Nídia Alice Pinheiro Silvia Helena Barem Rabenhorst Otávia Luisa Caballero Maria Aparecida Marchesan rodrigues Fabrício de carvalho Celso Vieira de Souza Leite Marcia Valéria Pitombeira Ferreira marcos Aurélio Pessoa Barros Maria Inês de Moura Campos Pardini Blood Transfusion Center Botucatu Medical SchoolUNESP-Sao Paulo State University department of Pathology-Federal University of Ceara Ludwig Institute of Cancer Research department of Pathology Medical SchoolUNESP-Sao Paulo State University department of Gastroenterology Surgery Medical SchoolUNESP-Sao Paulo State University

AIM:To verify the methylation status of CDH1, DAPK, COX2, hMLH1 and CDKN2A genes and to evaluate their association with Helicobacter pylori (H. pylori)-cagA+ and Epstein Barr virus (EBV) infections in gastric ***: Methylation-specific PCR (MSP) assay was performed in 89 primary gastric carcinomas (intestinal and diffuse types). Microsatellite instability (MSI) analysis was performed using the BAT26 primer set and PCR products were analyzed with the ABI PRISM 3100 Genetic Analyzer using Genescan 3.7 software (Applied Biosystems). detection of H. pylori and genotyping were performed by PCR, using specifi c primers for ureaseC and cagA genes. The presence of EBV was assessed by in situ hybridization. Statistical analyses were performed using the χ2 or Fisher's exact ***: The most frequent hypermethylated gene was COX-2 (63.5%) followed by DAPK (55.7%), CDH1 (51%), CDKN2A (36%) and hMLH1 (30.3%). Intestinal and diffuse adenocarcinomas showed different methylation profiles and there was an association between methylation of E-CDH1 and H. pylori-cagA+ in the intestinal adenocarcinoma type. MSI was correlated with hMLH1 methylation. There was an inverse correlation between DAPK hypermethylation and ***: We found a strong association between CDH1 methylation and H. pylori-cagA+ in intestinal-type gastric cancer, association of MSI and better prognosis and an heterogeneous COX-2 overexpression.

关键词： Gastric cancer Methylation Microsatellite instability Helicobacter pylori Epstein Barr virus

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Turning Industrial Waste into a Valuable Bioproduct:Starch from Mango Kernel derivative to Oil Industry Mango Starch derivative in Oil Industry

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Journal of Renewable Materials 2019年第2期7卷 139-152页

作者： Nívia do Nascimento Marques Caroline Suzy do Nascimento Garcia Liszt Yeltsin Coutinho Madruga marcos Antônio Villetti Men de SáMoreira de Souza Filho Edson Noriyuki Ito Rosangela de carvalho Balaban Instituto de Química Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil departamento de Física Universidade Federal de Santa Maria-UFSMSanta Maria97105900Brazil Embrapa Agroindústria Tropical Fortaleza60511-110Brazil departamento de Engenharia de Materiais Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil

After industrial mango processing,tons of residues such as peels and kernels are discarded as ***,almost 60% of the mango kernel is due to starch on a dry weight ***,starch from mango(Manguifera Indica L.)kernel was applied to obtain a starch fatty ester with vinyl laurate,in DMSO,under basic ***,1H and 13C NMR confirmed that a starch ester with a degree of modification of 2.6 was *** showed that the modified starch has higher thermal stability than its precursors and higher than a vinyl laurate/starch physical *** data showed that granular shape and smooth surface on mango starch changed after chemical modification to a continuous and shapeless *** industrial reject derivative behaved as an efficient alternative environmentally friendly fluid loss controller in oil drilling fluids,even in conditions of high temperatures and high pressures(HTHP)drilling.

关键词： Mango Starch oil drilling fluid transesterification vinyl laurate

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Role of lysophosphatidic acid and its receptors in health and disease:novel therapeutic strategies

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Signal Transduction and Targeted Therapy 2021年第3期6卷 630-647页

作者： Luiz Henrique Medeiros Geraldo Tania Cristina Leite de Sampaio Spohr Rackele Ferreira do Amaral Anna Carolina carvalho da Fonseca Celina Garcia Fabio de Almeida Mendes Catarina Freitas marcos Fabio dosSantos Flavia Regina Souza Lima Institute de Ciencias BiomedicasUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil Universite de Paris PARCCINSERMF-75015 ParisFrance Institute Estadual do Cerebro Paulo Niemeyer-Secretaria de Estado de Saude Rio de JaneiroBrazil Instituto de Saiide de Nova Friburgo Universidade Federal Fluminense28625-650 Nova FriburgoBrazil

Lysophosphatidic acid(LPA)is an abundant,bioactive phospholipid,with multiple functions both in development and in pathological ***,we review the literature about the differential signaling of LPA through its specific receptors,which makes this lipid a versatile signaling *** differential signaling is important for understanding how this molecule can have such diverse effects during central nervous system development and angiogenesis;and also,how it can act as a powerful mediator of pathological conditions,such as neuropathic pain,neurodegenerative diseases,and cancer ***,we review the preclinical and clinical uses of Autotaxin,LPA,and its receptors as therapeutic targets,approaching the most recent data of promising molecules modulating both LPA production and *** review aims to summarize the most update knowledge about the mechanisms of LPA production and signaling in order to understand its biological functions in the central nervous system both in health and disease.

关键词： therapeutic clinical diseases

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Genetic Divergence among Progenies Resulting from the Crossing of Groups Coffee Timor Hybrid and Dilla ＆ Alghe

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Journal of Agricultural Science and Technology(B) 2013年第12期3卷 865-872页

作者： Janine Magalhaes Guedes Juliana Costa Rezende Joao marcos rodrigues Andrade Lara Samuel Pereira carvalho Antonio Alves Pereira Alex Mendonca de carvalho department of Agriculture-UFLA Federal University of Lavras DAG-Cx. P. 3037-37.200-000 Lavras MG Brazil Agricultural Research Company of Minas Gerais-Technological Center in South of Minas Campus UFLA Cx P. 179 37200-000Lavras MG Brazil Agricultural Research Company of Minas Gerais -Technological Center in Zona da Mata Campus UFV Cx P. 216 - 36571-000Vigosa MG Brazil

This study aimed to agronomically and morphologically characterize, as well as analyze the genetic divergence of Dilla & Alghe ? Timor hybrid progenies of the coffee germplasm bank of Minas Gerais in Brazil to improve the breeding and management schemes of the hybrids. Forty-two morpho-agronomic traits were evaluated and the generalized Mahalanobis distance was used to quantify the genetic divergence among progenies. Tocher clustering, unweighted pair-group method using arithmetic averages (UPGMA) method and canonical variation analysis were employed as clustering strategies. The Tocher and UPGMA methods have been separated the progenies into eight and five groups, respectively. Analysis of the relative contribution of each characteristic to genetic dissimilarity highlighted the characteristics of production in liters in 2009, production notes in 2009, and average uniformity of maturation in 2009 as those that contributed most to obtaining genetic divergence. The authors observed that the first three canonical variables accounted for over 99% of the total variance observed in the full set of analyzed characteristics. High variability was observed among the 15 progenies of Dilla & Alghe ? Timor hybrid progenies. The progenies MG0589 and MG0592, MG0593 and MG0589, MG0591 and MG0589, MG0589 and MG0588, MG0589 and MG0583 were the most suitable crosses for exploring the genetic variability in Dilla & Alghe ? Timor hybrid generated from the germplasm bank of Minas Gerais. Through these crossovers, it is expected to get new coffee cultivars with desirable agronomic characteristics, as resistant to Pseudomonas syringae pv. garcae and some breeds of Hemileia vastatrix.

关键词：遗传分化咖啡品种后代混合动力东帝汶 UPGMA 隧道农艺性状

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Chemical Characterization,Antibacterial and Antioxidant Activities of Essential Oils of Mentha viridis *** Mentha pulegium L.(L)

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American Journal of Plant Sciences 2015年第5期6卷 666-675页

作者： Lucilene Fernandes Silva Maria das Gracas Cardoso Luís Roberto Batista marcos de Souza Gomes Leonardo Milani Avelar rodrigues Danúbia A.de carvalho Selvati Rezende Maria Luisa Teixeira marcos Schleiden Sousa carvalho Juliana de Andrade Santiago David Lee Nelson department of Chemistry Federal University of Lavras Lavras Brazil department of Food Science Federal University of Lavras Lavras Brazil department of Agriculture Federal University of Lavras Lavras Brazil Federal University of Vales de Jequitinhonha e Mucuri Diamantina Brazil

The essential oils from Mentha viridis L. and Mentha pulegium L. were characterized by gas chromatography coupled to mass spectrometry (GC-MS). These oils were obtained by hydrodistillation and presented linalool (40.70%), carvone (13.52%) and α-terpinene (8.56%) as the principal constituents in the essential oil from Mentha viridis L. Pulegone (50.01%), menthol (31.90%) and menthone (16.56%) were the principal constituents in the essential oil from Mentha pulegium L. These essential oils (in concentrations ranging from 3.91 to 500 μL·mL-1) showed satisfactory activities against Escherichia coli, Listeria monocytogenes, Salmonella choleraesuis and Staphylococcus aureus. The antioxidant activities with 2-deoxyribose and phosphomolybdenum and the reducing power (in concentrations ranging from 0.78 to 1000 μL·mL-1) were determined. The antioxidant activity was observed for the two oils evaluated by the phosphomolybdenum and 2-deoxyribose methods, whereas the essential oil from M. viridis presented low antioxidant activity in the reducing power assay.

关键词： Mentha Linalool Pulegone Volatiles

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Mesenchymal stem cell enhances chondral defects healing in horses

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Stem Cell Discovery 2013年第4期3卷 218-225页

作者： Ana Lucia Miluzzi Yamada Armando de Mattos carvalho Andrei Moroz Elenice deffune marcos Jun Watanabe Carlos Alberto Hussni Celso Antonio rodrigues Ana Liz Garcia Alves department of Veterinary Surgery and Anesthesiology School of Veterinary Medicine and Animal Science(FMVZ)UNESPUniversidade Estadual PaulistaBotucatuBrazil Faculty of Veterinary Medicine Cuiaba UniversityCuiabaBrazil department of Morphology Institute of BiosciencesUNESPBotucatuBrazil Blood Center School of MedicineUNESPBotucatuBrazil

The purpose of this study was to evaluate the effect of intralesional Mesenchymal Stem Cells (MSC) on the treatment of experimentally induced articular chondral defects in horses, emphasizing the benefits of this application in veterinary medicine. Chondral defects were induced in the medial femoral trochlea of both hind limbs of four horses. Thirty days post induction;the horses were divided into two groups. The G1 was submitted to treatment with MSC and the G2 was the control group. Clinical evaluations, synovial fluid analysis and synovial Prostaglandin E2 (PGE2) assessment were performed prior to defects and fortnightly up to 120 and 150 days. Macroscopic, histopathological and histochemical evaluations were performed at the end of the experiment. The treatment with MSC reduced the intraarticular inflammatory process. The G1 showed lower PGE2 concentrations in the synovial fluid and greater percentage of mononuclear cells and lower percentages of lymphocytes and neutrophils. The treatment improved the macro and microscopic aspects of repair tissue. No difference was observed in the scores of lameness between the G1 and G2. The use of MSC in the treatment of chondral defects minimized joint inflammation, as confirmed by synovial fluid analysis. The treatment resulted in an improved repair tissue, verified by macroscopic examination, histochemical and histopathological analysis.

关键词： Arthroscopy Cartilage Equine Lameness Mesenchymal Stem Cells

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Analyzing Brazilian Driver’s License Authenticity by Easy Ambient Sonic-Spray Ionization Mass Spectrometry

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American Journal of Analytical Chemistry 2016年第4期7卷 342-350页

作者： deleon Nascimento Correa Eduardo Morgado Schmidt marcos Fernando Franco Jorge Jardim Zacca Werickson Fortunato de carvalho Rocha Antony de Paula Barbosa Rodrigo Borges Wanderley de Souza marcos Nogueira Eberlin ThoMSon Mass Spectrometry Laboratory Department of Analytical Chemistry Institute of Chemistry University of Campinas-UNICAMP Campinas Brazil Technical-Scientific Police Superintendency from Sao Paulo State Criminalistic Institute Sao Paulo Brazil Analítica Sao Paulo Brazil Brazilian Federal Police Scientific and Technical Department Brasília Brazil National Institute of Metrology Quality and Technology-INMETRO Duque de Caxias Brazil

Fast and unequivocal methods of questioned document analysis are essential in forensic science. Here, a desorption/ionization technique, EASI-MS, was assessed for its ability to investigate questioned driver’s licenses (DL). Two suspects DL, displaying the same personal data in the proper fields (name and ID numbers), but with different individual photos, showing similar impressions on microscopic analysis, and authentic standards documents specimens were used as test cases. Profiles from authentic DL surface were dominated by a set of few minor ions, mainly from the plasticizers bis(2-ethylhexyl)phthalate and dibutylphthalate. The seized suspect counterfeit DL on points from personal data and photo were, however, dominated by abundant diagnostic ions of m/z 463, 507, 551, 595, 639, 683, which confirmed counterfeiting. Surfynol® and Nonoxynol-9®, which are common constituents of inkjet printing, were detected in the counterfeiting areas by high-accuracy EASI(+)-FT-ICR MS. The EASI-MS technique is shown therefore to offer an attractive tool for forensic investigation of questioned documents.

关键词： Forensic Sciences Questioned Documents Ambient Mass Spectrometry Easy Ambient Sonic-Spray Ionization Mass Spectrometry EASI-MS

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