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From liver to hormones:The endocrine consequences of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1073-1095页

作者： Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio María del Carmen Durand-Vásquez Luciana del Pilar Rafael-Robles Jhean Gabriel Gonzáles-Yovera María Alejandra Quispe-Flores Luis Alberto Concepción-Urteaga Alejandro Román-González José paz-Ibarra Marcio José Concepción-Zavaleta Non-communicable Diseases Endocrinology Research LineHospital de Apoyo ChepénChepén 13871Peru Department of Endocrinology Hospital Víctor Lazarte EchegarayTrujillo 13006Peru Department of Endocrinology Clínica Javier PradoLima 15046Peru Department of Gastroenterology Hospital Nacional Guillermo Almenara IrigoyénLima 15018Peru Department of Endocrinology Hospital de Emergencias GrauLima 15001Peru Internal Medicine Hospital Regional Docente de TrujilloTrujillo 13011Peru Department of Endocrinology Hospital Universitario de San Vicente FundaciónMedellin 050010Colombia Internal Medicine Universidad de AntioquiaMedellín 050010Colombia School of Medicine Universidad Nacional Mayor de San MarcosLima 15081Peru Department of Endocrinology Hospital Nacional Edgardo Rebagliati MartinsLima 15072Peru Carrera de Medicina Humana Universidad Científica del SurLima 15067Peru

Hepatocrinology explores the intricate relationship between liver function and the endocrine *** liver diseases such as liver cirrhosis can cause endocrine disorders due to toxin accumulation and protein synthesis *** its importance,assessing endocrine issues in cirrhotic patients is frequently *** article provides a comprehensive review of the epidemiology,pathophysiology,diagnosis,and treatment of endocrine disturbances in liver *** review was conducted using the PubMed/Medline,EMBASE,and Scielo databases,encompassing 172 *** cirrhosis is associated with endocrine disturbances,including diabetes,hypoglycemia,sarcopenia,thyroid dysfunction,hypogonadotropic hypogonadism,bone disease,adrenal insufficiency,growth hormone dysfunction,and secondary *** optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and continuous glucose monitoring system,*** can be assessed through imaging and functional tests,while other endocrine disorders are evaluated using hormonal assays and imaging *** options include metformin,glucagon-like peptide-1 analogs,sodium-glucose co-transporter-2 inhibitors,and insulin,which are effective and safe for diabetes *** standards are followed for managing hypoglycemia,and hormone replacement therapy is often necessary for other endocrine *** transplantation can address some of these problems.

关键词： Diabetes mellitus Hypoglycemia Thyroid diseases Hypogonadism Metabolic bone diseases Liver cirrhosis

A comprehensive review of genetic causes of obesity

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World Journal of Pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Concepcion-Zavaleta Juan Eduardo Quiroz-Aldave Maria del Carmen Durand-Vasquez Elman Rolando Gamarra-Osorio Juan del Carmen Valencia de la Cruz Claudia Mercedes Barrueto-Callirgos Susan Luciana Puelles-Leon Elena de Jesus Alvarado-Leon Frans Leiva-Cabrera Francisca Elena Zavaleta-Gutierrez Luis Alberto Concepcion-Urteaga Jose paz-Ibarra Universidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Division of Medicine Hospital de Apoyo ChepénChepenPeru Division of Family Medicine Hospital de Apoyo ChepénChepenPeru Division of Endocrinology Hospital Victor Lazarte EchegarayTrujilloPeru Division of Pediatrics Hospital de Apoyo ChepenChepenPeru Division of Internal Medicine Hospital de Apoyo ChepenChepenPeru Division of Genetics Universidad Nacional de TrujilloTrujilloPeru Division of Neonatology Hospital Belen de TrujilloTrujilloPeru Division of Internal Medicine Universidad Nacional de TrujilloTrujilloPeru Department of Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Background Obesity is a multifactorial chronic disease with a high,increasing worldwide *** causes account for 7%of the cases in children with extreme *** sources This narrative review was conducted by searching for papers published in the PubMed/MEDLINE,Embase and SciELO databases and included 161 *** search used the following search terms:"obesity","obesity and genetics","leptin","Prader-Willi syndrome",and"melanocortins".The types of studies included were systematic reviews,clinical trials,prospective cohort studies,cross-sectional and prospective studies,narrative reviews,and case *** The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body ***,several important aspects of the pathophysiology of obesity remain *** causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this *** are three therapeutic levels:lifestyle modifications,pharmacological treatment,and bariatric *** Genetic study technologies are in constant development;however,we are still far from having a personalized approach to genetic causes of obesity.A significant proportion of the affected individuals are associated with genetic causes;however,there are still barriers to its approach,as it continues to be underdiagnosed.

关键词： Leptin Melanocortin Obesity Prader-Willi syndrome Precision medicine

Building the DREAM interactome

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Science China(Life Sciences) 2011年第8期54卷 786-792页

作者： marcos RIVAS Diego VILLAR paz GONZLEZ Xosé M.DOpazO Britt MELLSTROM José R.NARANJO Department of Molecular and Cellular Biology National Center of BiotechnologyConsejo Superior Investigaciones Cientificas Centro Investigacion Biomedica En Red de Enfermedades Neurodegenerativas-Centro Nacional de Biotecnologia

DREAM/calsenilin/KChIP3 is a calcium binding protein of the neuronal calcium sensor *** interacts with DRE(downstream regulatory element) sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular *** from different laboratories has identified a growing list of interacting proteins that constitutes the DREAM *** knowledge of these interactions has greatly contributed to the understanding of the various physiological functions of DREAM.

关键词： calsenilin KChIP3 protein-protein interaction

Acoustic Impact Studies (AIS) of Wind Farms in Uruguay: A Methodology Proposal

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Journal of Environmental Protection 2017年第10期8卷 1178-1193页

作者： Alice Elizabeth González Nicolás Rezzano Tizze Pablo Gianoli Kovar Martín paz Urban marcos Raúl Lisboa Department of Environmental Engineering IMFIA-Faculty of Engineering Universidad de la República Montevideo Uruguay

The fast growing development of wind power in Uruguay has encouraged research on many issues regarding environmental acoustics, especially those related to wind turbines operation. As every new power generation device of 10 MW or larger has to have an environmental license approval before building it, a methodology for Acoustic Impact Studies (AIS) was needed. This paper presents a methodology proposal to carry out AIS, taking into account the peculiarities of the Uruguayan status. Determining the area where the studies should be done, demands for the base line of sound pressure levels, predicting sound pressure levels during the operation of future wind farm and main lines for the environmental management plan are included in this proposal. Uruguayan current national guidelines to noise pollution levels are also presented.

关键词： Acoustic Impact Study Acoustic Impact Assessment Wind Farms Wind Turbine Environmental Impact Assessment

Building the DREAM interactome

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Building the DREAM interactome

第十七届国际钙结合蛋白与钙在健康和疾病中作用会议

作者： marcos RIVAS Diego VILLAR paz GONZLEZ Xosé M.DOpazO Britt MELLSTROM José R.NARANJO Department of Molecular and Cellular Biology National Center of BiotechnologyConsejo Superior Investigaciones Cientificas Madrid 28049 Spain Centro Investigacion Biomedica En Red de Enfermedades Neurodegenerativas-Centro Nacional de Biotecnologia Madrid 28049Spain

＜正＞DREAM/calseniIin/KChIP3 is a calcium binding protein of the neuronal calcium sensor *** interacts with DRE （downstream regulatory element） sites in the DNA to regulate transcription and with many proteins to exert specialized functions in different subcellular *** from different laboratories has identified a growing list of interacting proteins that con-

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墨西哥城环境文化中心

现代装饰 2023年第4期 54-59页

作者： Rafael Ponce Ortiz Margarita Gorbea Angeles Cesar Avila OscarDiaz Gaspar Abigail Esparza Diego Buenode la.paz Valerio Lopez Acevedo Margarita Gorbea(摄影) marcos Betanzos(摄影) 范嘉苑(编译) 不详

“环境文化中心”作为墨西哥城Bosquede Chapultepec第二部分的全新文化、景观和环境节点,是由Gabriel Orozco操刀的“查普特佩克自然与文化”总体规划的一部分。该项目方案在墨西哥城政府与联邦政府共同举办的公开竞赛中脱颖而出,得以... 详细信息

“环境文化中心”作为墨西哥城Bosquede Chapultepec第二部分的全新文化、景观和环境节点,是由Gabriel Orozco操刀的“查普特佩克自然与文化”总体规划的一部分。该项目方案在墨西哥城政府与联邦政府共同举办的公开竞赛中脱颖而出,得以落成。环境文化中心是一座被植物花园包围的展馆,展现出自然主义设计与民族植物学相结合的理念。设计参考了墨西哥盆地山谷的多样化生态系统和自然景观,包括温带森林、草原、湿地和植被等,并与查普特佩克现有的植被、地形和设施进行细致整合,由此最大化地增加环境文化中心作为城市森林的巨大潜力。

关键词：墨西哥城设计参考温带森林民族植物学自然景观生态系统自然与文化总体规划

Diagnosis and management of small bowel neuroendocrine tumors:A state-of-the-art

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World Journal of Methodology 2022年第5期12卷 381-391页

作者： Jhean Gabriel Gonzáles-Yovera Pela J Roseboom Marcio Concepción-Zavaleta Isamar Gutiérrez-Córdova Esteban Plasencia-Dueñas María Quispe-Flores Anthony Ramos-Yataco Carlos Alcalde-Loyola Frederick Massucco-Revoredo Josépaz-Ibarra Luis Concepción-Urteaga Division of Gastroenterology María Auxiliadora HospitalLima 15801Peru Division of Emergency Medicine Regional Academic Hospital of TrujilloTrujillo 13011Peru Division of Endocrinology Stella Maris ClinicLima 15084Peru Division of Gastroenterology Guillermo Almenara Irigoyen National HospitalLima 12590Peru Division of Endocrinology Guillermo Almenara Irigoyen National HospitalLima 12590Peru Division of Internal Medicine Ricardo Cruzado Rivarola HospitalIca 110301Peru School of Medicine National University of TrujilloTrujillo 13007Peru Department of Medicine School of MedicineNational University of San MarcosLima 15001Peru Division of Internal Medicine School of MedicineNational University of TrujilloTrujillo 13011Peru

This review provides an update on the epidemiology,pathophysiology,symptoms,diagnosis and treatment of neuroendocrine neoplasms(NENs)of the small bowel(SB).These NENs are defined as a group of neoplasms deriving from neuroendocrine *** are currently the most common primary tumors of the SB,mainly involving the ileum,making the SB the most frequently affected part of the gastrointestinal *** NENs by definition are located between the ligament of Treitz and the ileocecal *** are characterized by small size and induce an extensive fibrotic reaction in the small intestine including the mesentery,resulting in narrowing or twisting of the *** manifestations of bowel functionality are related to the precise location of the primary *** majority of them are non-functional NENs and generally asymptomatic;in an advanced stage,NENs present symptoms of mass effect by non-specific abdominal pain or carcinoid syndrome which appears in patients with liver metastasis(around 10%).The main manifestations of the carcinoid syndrome are facial flushing(94%),diarrhea(78%),abdominal cramps(50%),heart valve disease(50%),telangiectasia(25%),wheezing(15%)and edema(19%).Diagnosis is made by imaging or biochemical tests,and the order of request will depend on the initial diagnostic hypothesis,while confirmation will always be *** patients with a localized SB NEN with or without near metastasis in the mesentery are recommended for curative *** and distant spread may be susceptible to several therapeutic strategies,such as chemotherapy,somatostatin analogs and palliative resection.

关键词： Neuroendocrine Tumor Small bowel Small intestine Gastrointestinal disease Treatment Survival

Environmental geochemistry studies and health risk assessment to identify priority areas for remediation of polluted soils in the Santa Maria de la.paz (S.L.P., Mexico) mining district

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Chinese Journal Of Geochemistry 2006年第B8期25卷 61-61页

作者： Israel Razo Fernando Diaz-Barriga Javier Castro marcos Monroy Universidad Autonoma de San Luis Potosi/Instituto de Metalurgia/San Luis Potosi S.L.P. (Mexico)