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Effect of drug thera.ies on self-reported chemosensory outcomes a.ter COVID-19

World Journa. of Otorhinola.yngology-Hea. a.d Neck Surgery 2024年第2期10卷 88-96页

作者： marco a.Forna.ieri Bruno M.Cunha.Sa.uel P.Nicácio Luca. K.a.zolin JoséL.B.da.Silva.a.istides Ferna.des Neto Deusdedit Bra.dão Neto Richa.d L.Voegels Fábio D.R.Pinna Depa.tment of Surgery Londrina State UniversityLondrinaBrazil Depa.tment of Medicine Pontifical Catholic University of ParanáLondrinaBrazil Depa.tment of Otorhinola.yngology University of São PauloSao PauloBrazil Depa.tment of Otorhinola.yngology:Hea. a.d Neck Surgery Perelman School of MedicineSmell and Taste CenterUniversity of PennsylvaniaPhiladelphiaPennsylvaniaUSA

Objective:The a.m of this study wa. to a.sess the rela.ive effica.y of medica.ions used following severe a.ute respira.ory syndrome corona.irus-2(Sa.S-CoV-2)infection on self-reported a.tera.ions in ta.te a.d/or smell ***:Seven hundred a.d fourteen persons with self-reported postcorona.irus disea.e 2019(post-COVID-19)chemosensory disorders were persona.ly interviewed rega.ding specific medica.ions they were a.ministered following the a.ute pha.e of the *** dependent mea.ure—self-reported tota. recovery of chemosensory symptoms—wa. subjected to stepwise logistic *** predictors included demogra.hic a.d clinica. va.ia.les,in a.dition to specific medica.ions used to mitiga.e disea.e symptoms(i.e.,systemic corticosteroids,oselta.ivir,vita.in C,ibuprofen,hydroxychloroquine,a.ithromycin,ivermectin,nita.oxa.ide,a.ticoa.ula.ts,a.d zinc).Results:The media. time between COVID-19 symptom onset a.d the interviews wa. 81 da.s(interqua.tile ra.ge:60-104).Of the 714 subjects,249(34.9%)reported tota. recovery of their chemosensory function;437(61.2%)ha. a. lea.t one trea.ment since the beginning of the *** a.d those with more comorbidities ha. undergone more *** recovery ra.es of the trea.ed a.d nontrea.ed groups did not differ ***,respondents who ha. used nita.oxa.ide tended to ha.e a.higher ra.e of self-reported ta.te or smell *** who took ora. zinc were less likely to ***:No medica.ion employed during the first months a.ter Sa.S-CoV-2 infection ha. a.clea. positive effect on returning self-reported smell or ta.te function to norma.,a.though nitra.oxide trended in a.positive *** zinc ha. a.nega.ive effect on the reported recovery of these senses.

关键词： chemosensory disorder corona.irus infections COVID-19 drug thera.y Sa.S-CoV-2 smell loss ta.te loss

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Deep lea.ning for la.d use a.d la.d cover cla.sifica.ion from the Ecua.oria. Pa.a.o.

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Interna.iona. Journa. of Digita. Ea.th 2022年第1期15卷 1001-1017页

作者： marco Ca.telo-Ca.a. Jose a.Piedra.fernandez Rosa.a.a.a a.plied Computing Group University of AlmeriaAlmeriaSpain

The pa.a.o,pla.s a. importa.t role in our ecosystems a. They ba.a.ce the wa.er resources a.d ca. reta.n substa.tia. qua.tities of *** resea.ch wa. ca.ried out in the province of Tungura.ua.specifica.ly the Quero *** a.m is to develop a.cla.sifica.ion of the la.d use la.d cover(LULC)in the pa.a.o using sa.ellite ima.ery using severa. cla.sifiers a.d determine which one obta.ns the best performa.ce,for which three different a.proa.hes were a.plied:Pixel-Ba.ed Ima.e a.a.ysis(PBIa.,Geogra.hic Object-Ba.ed Ima.e a.a.ysis(GEOBIa.,a.d a.Deep Neura. Network(DNN).Va.ious pa.a.eters were used,such a. the Norma.ized Difference Vegeta.ion Index(NDVI),the Ba.e Soil Index(BSI),texture,a.titude,a.d *** cla.ses were used:pa.a.o,pa.ture,crops,herba.eous vegeta.ion,urba.,shrubra.nla.d,a.d forestry *** da.a.wa. obta.ned with the help of onsite technica. experts,using geo-referencing a.d reference *** the models used the highest-ra.ked wa. DNN with a. overa.l precision of 87.43%,while for the pa.a.o cla.s specifica.ly,GEOBIa.rea.hed a.precision of 95%.

关键词： Cla.sifica.ion la.d use a.d la.d cover pixel-ba.ed ima.e a.a.ysis geogra.hic object-ba.ed ima.e a.a.ysis deep neura. network

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Retinoscopes:Pa.t a.d present

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World Journa. of Methodology 2024年第3期14卷 126-140页

作者： Muta.i Musa.Ehima.e Ena.olo Ba.a.unde Isma.l Ba.e Ca.lo Sa.a.i Leopoldo Spa.ea.marco Zeppieri Depa.tment of Optometry University of BeninBenin 300283Nigeria Depa.tment of Ophtha.mology Africa Eye Laser CentreBenin 300105Nigeria Depa.tment of Ophtha.mology Centre for Sight AfricaNkpor 434101Nigeria Depa.tment of Ophtha.mology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy

Ba.KGROUND Retinoscopy is a.gua.ly the most importa.t method in the eye clinic for dia.nosing a.d ma.a.ing refra.tive *** of retinoscopy include its noninva.ive na.ure,a.ility to a.sess pa.ients of a.l a.es,a.d usefulness in pa.ients with limited coopera.ion or communica.ion *** To discuss the history of retinoscopes a.d exa.ine current litera.ure on the *** a.sea.ch wa. conducted on the PubMed a.d with the reference cita.ion a.a.ysis(https://***)da.a.a.e using the term"Retinoscopy,"with a.ra.ge restricted to the la.t 10 yea.s(2013-2023).The sea.ch string a.gorithm wa.:"Retinoscopy"(MeSH Terms)OR"Retinoscopy"(a.l Fields)OR"Retinoscopes"(a.l Fields)a.D[(a.l Fields)a.D 2013:2023(pda.)].RESULTS This systema.ic review included a.tota. of 286 *** reviewed itera.ions of the retinoscope into a.torefra.tors,infra.ed photo retinoscope,television retinoscopy,a.d the Wifi ena.led digita. *** The retinoscope ha. evolved significa.tly since its discovery,with a.significa.t improvement in its dia.nostic *** it ha. a.va.ta.es such a. non-inva.iveness a.d broa. a.plica.ility,limita.ions exist,a.d the need for skilled interpreta.ion *** ongoing resea.ch,including the integra.ion of a.tificia. intelligence,retinoscopy is expected to continue a.va.cing a.d pla.ing a.vita. role in eye ca.e.

关键词： Retinoscopy a.torefra.tor Refra.tive errors Ophtha.mology Optics a.tificia. intelligence

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Whole-eye tra.spla.ta.ion: Current cha.lenges a.d future perspectives

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 28-39页

作者： a.na.Sca.a.osio Pier Luigi Surico Vla. Tereshenko Roha. Bir Singh Ca.lo Sa.a.i Leopoldo Spa.ea.Glenda.Ca.uto Pier Ca.illo Pa.odi Ca.erina.Ga.lia.o Jona.ha. M Winogra. marco Zeppieri Depa.tment of Pla.tic Surgery University Hospital of UdineUdine 33100Italy Depa.tment of Pla.tic Surgery Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Schepens Eye Resea.ch Institute of Ma.s Eye a.d Ea. Harvard Medical SchoolBostonMA 02114United States Depa.tment of Ophtha.mology University Hospital of UdineUdine 33100Italy Eye Clinic Policlinico Umberto I"Sapienza"University of RomeRome 00142Italy Depa.tment of Medicine a.d Surgery University of Enna"Kore"Enna 94100Italy Eye Clinic Ca.a.ia.University Sa. marco Hospita. Viale Carlo Azeglio Ciampi 95121 CataniaItaly

Whole-eye tra.spla.ta.ion emerges a. a.frontier in ophtha.mology,promising a.tra.sforma.ive a.proa.h to irreversible *** a.va.cements,formida.le cha.lenges *** of donor eye via.ility post-enuclea.ion necessita.es meticulous surgica. techniques to optimize retina. integrity a.d ga.glion cell *** the inhibitory milieu of the centra. nervous system for successful optic nerve regenera.ion rema.ns elusive,prompting the explora.ion of neurotrophic support a.d immunomodula.ory *** tolera.ce,pa.a.ount for gra.t a.cepta.ce,confronts the distinc-tive immunogenicity of ocula. tissues,driving resea.ch into ta.geted immunosup-pression *** a.d lega. considera.ions underscore the necessity for stringent sta.da.ds a.d ethica. *** colla.ora.ion a.d ongoing resea.ch endea.ors a.e impera.ive to na.iga.e these ***,stem cell thera.ies,a.d precision immunomodula.ion represent promising a.enues in this ***,the a.m of this review is to critica.ly a.sess the current la.dsca.e of whole-eye tra.spla.ta.ion,elucida.ing the cha.lenges a.d a.va.cements while delinea.ing future directions for resea.ch a.d clinica. *** concerted efforts,whole-eye tra.spla.ta.ion sta.ds to revolu-tionize ophtha.mic ca.e,offering hope for restored vision a.d enha.ced qua.ity of life for those a.flicted with blindness.

关键词： Eye Tra.spla.ta.ion Optic nerve Nerve regenera.ion Immunologica. tolera.ce

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Evolutiona.y fingerprint, phylogenetic a.d forest structure of tropica. monta.e a.la.tic cloud forests a.ong a. eleva.ion gra.ient

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Journa. of Mounta.n Science 2024年第4期21卷 1259-1271页

作者： Ra.i Ferna.des Ma.Ia.O Va.essa.Leite REZENDE Cléber Rodrigo de SOUZa.Pa.rícia.Vieira.POMPEU Rubens Ma.oel dos Sa.TOS Ca.olina.Nja.me MENDES a.oysio Souza.de MOURa.Felipe Sa.ta.a.Ma.Ha.O Wa.ley a.gusto Ca.da. Ca.Va.HO marco a.rélio Leite FONTES Depa.tment of Forest Sciences Federal University of LavrasLavras 37200-900Brazil 2Environmenta. Defence a.socia.ion of Mina. Gera.s Belo Horizonte 30360-110Brazil Depa.tment of Ecology a.d Conserva.ion Federal University of LavrasLavras 37200-900Brazil Depa.tment of Forest Sciences State University of Mato Grosso do SulAquidauana 79200-000Brazil a.ência.Zetta Federal University of LavrasLavras 37200-900Brazil. Depa.tment of Na.ura. Sciences Federal University of São João del-ReiSão João del-Rei 36307-352Brazil.

Environmenta. conditions ca. cha.ge ma.kedly over geogra.hica. dista.ces a.ong eleva.ion gra.ients,ma.ing them na.ura. la.ora.ories to study the processes tha. structure *** work a.med to a.sess the influences of eleva.ion on Tropica. Monta.e Cloud Forest pla.t communities in the Bra.ilia. a.la.tic Forest,a.historica.ly neglected *** eva.ua.ed the phylogenetic structure,forest structure(tree ba.a. a.ea.a.d tree density)a.d species richness a.ong a. eleva.ion gra.ient,a. well a. the evolutiona.y fingerprints of eleva.ion-success on phylogenetic linea.es from the tree *** do so,we a.sessed nine communities a.ong a. eleva.ion gra.ient from 1210 to 2310 m *** la.ge eleva.ion *** rela.ionships between eleva.ion a.d phylogenetic structure,forest structure a.d species richness were investiga.ed through Linea. *** occurrence of evolutiona.y fingerprint on phylogenetic linea.es wa. investiga.ed by qua.tifying the extent of phylogenetic signa. of eleva.ion-success using a.genus-level molecula. *** results showed decrea.ed species richness a. higher eleva.ions a.d independence between forest structure,phylogenetic structure a.d *** a.so verified tha. there is a.phylogenetic signa. a.socia.ed with eleva.ion-success by *** concluded tha. the eleva.ion is a.socia.ed with species richness a.d the occurrence of phylogenetic linea.es in the tree communities eva.ua.ed in Ma.tiqueira.*** the other ha.d,eleva.ion is not a.socia.ed with forest structure or phylogenetic ***,closely rela.ed ta.a.tend to ha.e their higher ecologica. success in simila. ***,we highlight the fra.ility of the tropica. monta.e cloud forests in the Ma.tiqueira.Ra.ge in fa.e of environmenta. cha.ges(*** wa.ming)due to the occurrence of exclusive phylogenetic linea.es evolutiona.ily a.a.ted to environmenta. conditions(*** tempera.ure)a.socia.ed with ea.h eleva.ion ra.ge.

关键词： a.la.tic Forest Cloud forest Conserva.ion Community ecology Monta.e forests Phylogenetic diversity Phylogenetic signa.

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Prima.y liver tra.spla.ta.ion vs tra.spla.t a.ter Ka.a. portoenterostomy in children with bilia.y a.resia. a.retrospective Bra.ilia. single-center cohort

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World Journa. of Tra.spla.ta.ion 2024年第1期14卷 112-119页

作者： Melina.Utz Melere Va.berto Sa.ha.marco Fa.ina.Ca.olina.Soa.es da.Silva.Luiza.Na.er Cristine Trein a.gelica.Ma.ia.Lucchese Cristina.Ferreira.a.tonio Nocchi Ka.il Fla.ia.Heinz Feier Depa.tment of Hepa.ology a.d Liver Tra.spla.ta.ion Santa Casa de Porto AlegrePorto Alegre 90050170Brazil Depa.tment of Hepa.o-bilia.y-pa.crea.ic Surgery a.d Liver Tra.spla.ta.ion Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Brazil Depa.tment of Surgica. Oncology Santa Rita Hospital/Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil

Ba.KGROUND Bilia.y a.resia.Ba.is the most common indica.ion for pedia.ric liver tra.spla.ta.ion,a.though portoenterostomy is usua.ly performed ***,due to the high fa.lure ra.e of portoenterostomy,liver tra.spla.ta.ion ha. been a.voca.ed a. the prima.y procedure for pa.ients with *** is still unclea. if a.previous portoenterostomy ha. a.nega.ive impa.t on liver tra.spla.ta.ion *** To investiga.e the effect of prior portoenterostomy in infa.ts un-dergoing liver tra.spla.ta.ion for *** This wa. a.retrospective cohort study of 42 pedia.ric pa.ients with Ba.who underwent prima.y liver tra.spla.ta.ion from 2013 to 2023 a. a.single tertia.y center in *** with Ba.were divided into two groups:Those undergoing prima.y liver tra.spla.ta.ion without portoenterostomy a.d those undergoing liver tra.spla.ta.ion with prior *** va.ia.les were compa.ed using the Student’s t-test or the Kruska.-Wa.lis test,a.d ca.egorica. va.ia.les were compa.ed using theχ2 or Fisher’s exa.t test,a. *** Cox regression a.a.ysis wa. performed to determine risk fa.tors for porta. vein *** a.d gra.t surviva. a.a.yses were conducted with the Ka.la.–Meier product-limit estima.or,a.d pa.ient subgroups were compa.ed using the two-sided log-ra.k *** Forty-two pa.ients were included in the study(25[60%]girls),23 undergoing liver tra.spla.ta.ion without prior portoenterostomy,a.d 19 undergoing liver tra.spla.ta.ion with prior *** with prior portoenterostomy were older(12 vs 8 months;P=0.02)a. the time of liver tra.spla.ta.ion a.d ha. lower Pedia.ric End-Sta.e Liver Disea.e scores(13.2 vs 21.4;P=0.01).The ma.ority of the pa.ients(35/42,83%)underwent livingdonor liver *** group of pa.ients without prior portoenterostomy a.pea.ed to ha.e a.higher incidence of porta. vein thrombosis(39 vs 11%),but this result did not rea.h sta.istica. *** portoenterostomy

关键词： Hepa.ic portoenterostomy Bilia.y a.resia Liver tra.spla.ta.ion Pa.ient outcome a.sessment Porta. vein Surviva.

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具有Ruddlesden-Popper结构的杂化非本征铁电体(Ca.(1-x)Sm_(x))_(3)Ti_(2)O_(7)陶瓷的制备及其物理性能

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天津师范大学学报（自然科学版） 2024年第2期44卷 19-25页

作者： marco a.tonio López-a.uila.柳志旭王守宇黄聪刘卫芳天津大学理学院天津300350 天津师范大学物理与材料科学学院天津300387

为探究稀土离子掺杂对Ca.(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了Sm^(3+)掺杂的(Ca.(1-x)Sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPS、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、... 详细信息

为探究稀土离子掺杂对Ca.(3)Ti_(2)O_(7)物理性能的调控,采用固相反应法制备了Sm^(3+)掺杂的(Ca.(1-x)Sm_(x))_(3)Ti_(2)O_(7)(x=0,0.02,0.04)陶瓷样品,通过XRD、XPS、紫外-可见光吸收光谱以及第一性原理计算等方法对样品的晶体结构、光学性能、电学性能和磁学性能进行分析.结果表明:随着Sm^(3+)含量的增加,(Ca.(1-x)Sm_(x))_(3)Ti_(2)O_(7)的晶胞参数逐渐增大.Sm^(3+)掺杂导致氧空位减少,因此样品的漏电流随着Sm^(3+)掺杂量的增加而减小.同时,随着Sm^(3+)掺杂量的增加,样品的光学带隙呈现增大趋势.此外,第一性原理研究表明,Sm^(3+)掺杂可在体系中诱导出磁性能,进一步丰富了该材料的物理性能.

关键词： (Ca.(1-x)Sm_(x))_(3)Ti_(2)O_(7)陶瓷铁电性氧空位光学带隙第一性原理

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a.Structured Method of Tea.hing Epidura. Block reduces the incidence of a.cidenta. dura. puncture in inexperienced tra.nees.

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Open Journa. of a.esthesiology 2024年第4期14卷 131-135页

作者： marco Scorzoni Gia.luigi Gonnella.Ema.uele Ca.ogna.Ma.ina.Ca.pione Ga.ta.o Dra.sci Ma.teo Vela.do Giorgio Ca.ogna Depa.tment of a.esthesiology Fondazione Policlinico Gemelli IRCCS Rome Italy Depa.tment of Economics a.d La. Enna Kore University Enna Italy Europea. School of Obstetric a.esthesia Rome Italy

Ba.kground: The ra.e of a.cidenta. dura. puncture is pa.ticula.ly high during the period of tra.ning, especia.ly in novices. The structured epidura. tea.hing model (SETM) includes three sta.da.dized video lessons, the construction of a.3D epidura. module by tra.nees a.d pra.tica. tra.ning by using a. epidura. simula.or with a.d without the CompuFlo™ Epidura. instrument. In this study we report the retrospective a.a.ysis of the a.cidenta. dura. puncture ra.e of inexperienced tra.nees during their 6 months clinica. pra.tice rota.ion in obstetrics before a.d a.ter the introduction of the SETM in our Institution. Method: We eva.ua.ed the incidence of a.cidenta. dura. puncture before the introduction of the SETM methodology a.d a.terwa.ds by a.a.yzing our depa.tmenta. da.a.a.e from Februa.y 2019 to Ja.ua.y 2023. a.l epidura. blocks were executed by tra.nees who ha. never previously performed a. epidura. block a.d were a.out to begin their obstetrics rota.ion. Results: We a.a.yzed 7415 epidura.s: 3703 were performed before the introduction of the SETM methodology (control group) a.d 3712 a.terwa.ds (study group). The incidence of a.cidenta. dura. puncture wa. 0.37% for the control group a.d 0.13% for the study group (pa.ility of ma.ing a. a.cidenta. dura. puncture wa. 64% (OR: 0.36) lower for tra.nees who ha. the tra.ning tha. for those who did not. Conclusions: a.ter the introduction of the structured tea.hing method, we observed a.significa.t reduction of a.cidenta. dura. puncture during the tra.ning period. We hope tha. our observa.ion will encoura.e a.constructive discussion a.ong experts a.out the need to use sta.da.dized a.d va.ida.ed tools a. a.va.ua.le a.d in tea.hing epidura. a.esthesia.

关键词： tea.hing epidura. a.esthesia obstetrica. a.esthesia a.esthesia

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Prognostic role of pla.elet-to-lymphocyte ra.io a.d neutrophil-to-lymphocyte ra.io in pa.ients with non-meta.ta.ic a.d meta.ta.ic prosta.e ca.cer:a.meta.a.a.ysis a.d systema.ic review

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a.ia. Journa. of Urology 2024年第2期11卷 191-207页

作者： Stefa.o Sa.ciccia.marco Frisenda.Giulio Bevila.qua.Pietro Viscuso Pa.lo Ca.a.e Ettore De Bera.dinis Giova.ni Ba.tista.Di Pierro Susa.na.Ca.ta.ino Gloria.Giorgino Da.ide Rosa.i Fra.cesco Del Giudice a.essa.dro Scia.ra.Gia.na.Ma.iotti a.essa.dro Gentilucci Depa.tment of Urology Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly Depa.tment of Urology Humanitas20089 RozzanoMIItaly

Objective: To a.a.yze da.a.a.a.la.le in the litera.ure rega.ding a.possible prognostic va.ue of the pla.elet-to-lymphocyte ra.io (PLR) a.d neutrophil-to-lymphocyte ra.io (NLR) in prosta.e ca.cer (PCa. pa.ients stra.ified in non-meta.ta.ic a.d meta.ta.ic ***: a.litera.ure sea.ch process wa. performed following the Preferred Reporting Items for Systema.ic reviews a.d Meta.a.a.yses guidelines. In our meta.a.a.ysis, the pooled event ra.e estima.ed a.d the pooled ha.a.d ra.io were ca.cula.ed using a.ra.dom effect ***: Forty-two a.ticles were selected for our a.a.ysis. The pooled risk difference for non-orga. confined PCa.between high a.d low NLR ca.es wa. 0.06 (95% confidence interva. [CI]: −0.03-0.15) a.d between high a.d low PLR ca.es increa.ed to 0.30 (95% CI: 0.16-0.43). In non-meta.ta.ic PCa.ca.es, the pooled ha.a.d ra.io for overa.l morta.ity between high a.d low NLR wa. 1.33 (95% CI: 0.78-1.88) a.d between high a.d low PLR wa. 1.47 (95% CI: 0.91-2.03), wherea. in meta.ta.ic PCa.ca.es, between high a.d low NLR wa. 1.79 (95% CI: 1.44-2.13) a.d between high a.d low PLR wa. 1.05 (95% CI: 0.87-1.24).Conclusion: The prognostic va.ues of NLR a.d PLR in terms of PCa.cha.a.teristics a.d responses a.ter trea.ment show a.high level of heterogeneity of results a.ong studies. These two ra.ios ca. represent the infla.ma.ory a.d immunity sta.us of the pa.ient rela.ed to severa. conditions. a.higher predictive va.ue is rela.ed to a.high NLR in terms of risk for overa.l morta.ity in meta.ta.ic PCa.ca.es under systemic trea.ments.

关键词： Prosta.ic neopla.m Neutrophil-to-lymphocyte ra.io Pla.elet-to-lymphocytera.io Meta.a.a.ysis Ra.ica. prosta.ectomy Meta.ta.ic

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a.herence to Pha.ma.othera.y in Post-Menopa.sa. Women with Hypertension or Meta.olic Syndrome: Rea. World Experience

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Interna.iona. Journa. of Clinica. Medicine 2024年第3期15卷 145-154页

作者： Ma.ia.Ma.ello Fra.cesca.a.a.i Vincenzo Ezio Sa.tobuono a.drea.Igoren Gua.icci Cinzia.Forleo marco Ma.teo Ciccone Pa.qua.e Pa.miero Depa.tment of Ca.diology ASL BR SSN3 Brindisi Italy Ca.diova.cula. Disea.es Section Interdisciplinary Department of Medicine (DIM) University of Bari “Aldo Moro” Bari Italy

Ba.kground: a.herence to medica.ions is dependent upon a.va.iety of fa.tors, including individua. cha.a.teristics of the pa.ient, intera.tions with hea.th ca.e providers, a.d medica.ion complexity. Even though severa. studies were conducted to test intervention stra.egies, results a.e uncerta.n. a.m: The a.m of the study is to a.sess if a.ta.lored combined intervention stra.egy improves medica.ion a.herence in a.la.ge popula.ion of post-menopa.sa. women a.fected by hypertension or meta.olic syndrome. Methods: We enrolled 6833 pa.ients a.ed 50 to 69 yea.s, 85.7% with hypertension, a.d 14.3% with meta.olic syndrome. a.network between pa.ients, genera. pra.titioners, a.d ca.diologists wa. esta.lished. Interventions included educa.ion, a.equa.e informa.ion to pa.ients, a.simplified scheme of trea.ment, a.d periodic a.herence a.sessment. These were either delivered a. hea.thca.e provider supports or using modern technology. Medica.ion a.herence wa. estima.ed by the proportion of da.s covered for a.l cla.ses of drugs a.ter the index da.e. Results: Non-a.herent hypertensive women were 297 (5%), a.d those with meta.olic syndrome were 73 (7.4%) (p Conclusions: The ra.e of non-a.herence in both settings of postmenopa.sa. women wa. 7.7%, much lower tha. tha. described in the litera.ure. This ra.e wa. increa.ed in pa.ients with meta.olic syndrome;proba.ly it is rela.ed to the complexity of the thera.eutic scheme or to a.poor consciousness of the disea.e. Therefore, implementing a.ta.lored combined intervention ca. improve significa.tly pa.ients’ a.herence to medica. thera.y.

关键词： a.herence Ca.diova.cula. Prevention Postmenopa.sa. Women Hypertensive Meta.olic Syndrome

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