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Antibiotics and probiotics in chronic pouchitis:A comparative proteomic approach

World Journal of Gastroenterology 2010年第1期16卷 30-41页

作者： Silvia Turroni Beatrice Vitali marco candela Paolo Gionchetti Fernando Rizzello Massimo Campieri Patrizia Brigidi Department of Pharmaceutical Sciences University of Bologna Department of Internal Medicine and Gastroenterology University of BolognaPolyclinic S.Orsola

AIM:To profile protein expression in mucosal biopsies from patients with chronic refractory pouchitis following antibiotic or probiotic treatment,using a comparative proteomic approach. METHODS:Two-dimensional polyacrylamide gel electrophoresis and matrix-assisted laser desorption/ ionization-time of flight mass spectrometry were used to characterize the changes related to antibiotic therapy in the protein expression profiles of biopsy samples from patients with chronic refractory *** same proteomic approach was applied to identify differentially expressed proteins in the non-inflamed pouch before and after probiotic administration. RESULTS:In the first set of 2D gels,26 different proteins with at least 2-fold changes in their expression levels between the pouchitis condition and antibiotic-induced remission were *** the second set of analysis,the comparison between mucosal biopsy proteomes in the normal and probiotic-treated pouch resulted in 17 significantly differently expressed *** these,8 exhibited the same pattern of deregulation as in the pouchitis/pouch remission group. CONCLUSION:For the first time,2D protein maps of mucosal biopsies from patients with ileal pouch-anal anastomosis were provided,and differentially expressed proteins following antibiotic/probiotic treatment were identified.

关键词： Chronic disease Pouchitis Antibiotics Probiotics Proteins Gene expression

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Potential role of the gut microbiota in synthetic torpor and therapeutic hypothermia

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World Journal of Gastroenterology 2017年第3期23卷 406-413页

作者： Claudia Sisa Silvia Turroni Roberto Amici Patrizia Brigidi marco candela Matteo Cerri Department of Biomedical and Neuromotor Sciences University of Bologna40126 BolognaItaly Unit of Microbial Ecology of Health Department of Pharmacy and BiotechnologyUniversity of Bologna40126 BolognaItaly

Therapeutic hypothermia is today used in several clinical settings, among them the gut related diseases that are influenced by ischemia/reperfusion injury. This perspective paved the way to the study of hibernation physiology, in natural hibernators, highlighting an unexpected importance of the gut microbial ecosystem in hibernation and torpor. In natural hibernators, intestinal microbes adaptively reorganize their structural configuration during torpor, and maintain a mutualistic configuration regardless of long periods of fasting and cold temperatures. This allows the gut microbiome to provide the host with metabolites, which are essential to keep the host immunological and metabolic homeostasis during hibernation. The emerging role of the gut microbiota in the hibernation process suggests the importance of maintaining a mutualistic gut microbiota configuration in the application of therapeutic hypothermia as well as in the development of new strategy such as the use of synthetic torpor in humans. The possible utilization of tailored probiotics to mold the gut ecosystem during therapeutic hypothermia can also be taken into consideration as new therapeutic strategy.

关键词： Therapeutic hypothermia Gut microbiota Hibernation Dysbiosis Synthetictorpor

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Inflammation and colorectal cancer, when microbiota-host mutualism breaks

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World Journal of Gastroenterology 2014年第4期20卷 908-922页

作者： marco candela Silvia Turroni Elena Biagi Franck Carbonero Simone Rampelli Carla Fiorentini Patrizia Brigidi Department of Pharmacy and Biotechnology University of Bologna Department of Food Science University of Arkansas Department of Therapeutic Research and Medicines Evaluation

Structural changes in the gut microbial community have been shown to accompany the progressive development of colorectal *** this review we discuss recent hypotheses on the mechanisms involved in the bacteria-mediated carcinogenesis,as well as the triggering factors favoring the shift of the gut microbiota from a mutualistic to a pro-carcinogenic *** possible role of inflammation,bacterial toxins and toxic microbiota metabolites in colorectal cancer onset is specifically *** the other hand,the strategic role of inflammation as the keystone factor in driving microbiota to become carcinogenic is *** a common outcome of different environmental and endogenous triggers,such as diet,aging,pathogen infection or genetic predisposition,inflammation can compromise the microbiota-host mutualism,forcing the increase of pathobionts at the expense of health-promoting groups,and allowing the microbiota to acquire an overall pro-inflammatory *** inflammation in the gut,and favoring the bloom of toxigenic bacterial drivers,these changes in the gut microbial ecosystem have been suggested as pivotal in promoting *** this context,it will become of primary importance to implement dietary or probiotics-based interventions aimed at preserving the microbiota-host mutualism along aging,counteracting deviations that favor a pro-carcinogenic microbiota asset.

关键词： Colorectal cancer Inflammation Gut microbiome Co-abundance groups

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Longitudinal analysis of inflammation and microbiota dynamics in a model of mild chronic dextran sulfate sodium-induced colitis in mice

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World Journal of Gastroenterology 2014年第8期20卷 2051-2061页

作者： Luigia De Fazio Elena Cavazza Enzo Spisni Antonio Strillacci Manuela Centanni marco candela Chiara Praticò Massimo Campieri Chiara Ricci Maria Chiara Valerii Department of Biological Geological and Environmental SciencesBiology UnitUniversity of BolognaVia Selmi 340126 BolognaItaly Department of Pharmacy and Biotechnology University of BolognaVia 640126 BolognaItaly Department of Medical and Surgical Sciences University of BolognaVia Massarenti 940138 BolognaItaly Department of Clinical and Experimental Sciences University of BresciaSpedali Civili 125121 BresciaItaly

AIM: To characterize longitudinally the inflammation and the gut microbiota dynamics in a mouse model of dextran sulfate sodium (DSS)-induced colitis.

关键词： Colitis, Dysbiosis Dextran sulfate sodium Inflammation Cyclooxygenase 2

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