检索结果-南通市图书馆

Potential of polyphenols in curbing quorum sensing and biofilm formation in Gramnegative pathogens

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2021年第6期11卷 231-243页

作者： Arnica f Lal Shaminder Singh francisco C.franco,jr. Sonam Bhatia Department of Pharmaceutical Science SHALOM Institute of Health and Allied SciencesSam Higginbottom University of AgricultureTechnology and SciencesNainiPrayagrajIndia regional Centre for Biotechnology NCR Biotech Science Cluster3rd MilestoneFaridabad-Gurugram ExpresswayFaridabad-121001HaryanaIndia Chemistry Department De La Salle Univers2401 Taft Ave.Manila 0922Philippines

Polyphenols are the secondary metabolic products of plants and are considered as active constituents to possess therapeutic *** date,a vast number of scientific literature addressed the potential of polyphenols as bio-efficient compounds owing to their structural *** to the presence of several hydroxyl groups,they are metabolized quickly due to conjugation reaction and thus,readily produce toxic metabolites as a defense material against many pathogens,reflecting their safety *** review focuses on the anti-quorum sensing and biofilm inhibition activity of polyphenols,which display their potential to treat bacterial infections by combating the virulence caused by pathogenic ***,for mitigating quorum sensing-controlled pathogenesis,the use of polyphenol-based phytochemicals holds immense potential to cure *** application of polyphenol as sensitizing agent/adjuvant therapeutics which act in synergism with antibiotics is highly remarkable.

关键词： Polyphenols Quorum sensing Biofilm recombinant polyphenolic compounds Sensitizers Antibiotic resistance

Strawberry sweetness and consumer preference are enhanced by specific volatile compounds

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Horticulture research 2021年第1期8卷 870-884页

作者： Zhen fan Tomas Hasing Timothy S.Johnson Drake M.Garner Michael L.Schwieterman Christopher r.Barbey Thomas A.Colquhoun Charles A.Sims marcio f.r.resende Vance M.Whitaker Horticultural Sciences Department University of FloridaIFAS Gulf Coast Research and Education CenterWimaumaFLUSA Elo Life Systems DurhamNCUSA Department of Environmental Horticulture and Plant Innovation Center Institute of Food and Agricultural SciencesUniversity of FloridaGainesvilleFLUSA Plenty Unlimited Inc.South San FranciscoCA 94080USA food Science and Human Nutrition Department University of FloridaGainesvilleFLUSA Horticultural Sciences Department University of FloridaGainesvilleFLUSA

Breeding crops for improved flavor is challenging due to the high cost of sensory evaluation and the difficulty of connecting sensory experience to chemical *** main goal of this study was to identify the chemical drivers of sweetness and consumer liking for fresh strawberries(fragaria×ananassa).fruit of 148 strawberry samples from cultivars and breeding selections were grown and harvested over seven years and were subjected to both sensory and chemical *** panel consisted of at least 100 consumers,resulting in more than 15,000 sensory data points per *** sugars,two acids and 113 volatile compounds were *** liking was highly associated with sweetness intensity,texture liking,and flavor intensity,but not sourness *** least square analyses revealed 20 volatile compounds that increased sweetness perception independently of sugars;18 volatiles that increased liking independently of sugars;and 15 volatile compounds that had positive effects on *** learning-based predictive models including sugars,acids,and volatiles explained at least 25%more variation in sweetness and liking than models accounting for sugars and acids *** compounds such asγ-dodecalactone;5-hepten-2-one,6-methyl;and multiple medium-chain fatty acid esters may serve as targets for breeding or quality control attributes for strawberry products.A genetic association study identified two loci controlling ester production,both on linkage group 6 ***-segregating makers in these regions can be used for increasing multiple esters *** study demonstrates a paradigm for improvement of fruit sweetness and flavor in which consumers drive the identification of the most important chemical targets,which in turn drives the discovery of genetic targets for marker-assisted breeding.

关键词： volatile sugar esters

A phased approach to enable hybrid simulation of complex structures

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 63-77页

作者： Billie f.Spencer jr. Chia-Ming Chang Thomas M.frankie Daniel A.Kuchma Pedro f.Silva Adel E.Abdelnaby Department of Civil Engineering University of Illinois at Urbana-Champaign Nathan M.& Anne M.Newmark Endowed Chair Earthquake Engineering research &Test Center Guangzhou University Associate Professor Wiss JanneyElstner AssociatesInc. Department of Civil and Environmental Engineering University of Illinois at Urbana-Champaign Department of Civil and Environmental Engineering George Washington University Department of Civil Engineering University of Memphis Assistant Professor

Hybrid simulation has been shown to be a cost-effective approach for assessing the seismic performance of structures. In hybrid simulation,critical parts of a structure are physically tested,while the remaining portions of the system are concurrently simulated computationally,typically using a finite element model. This combination is realized through a numerical time-integration scheme,which allows for investigation of full system-level responses of a structure in a cost-effective manner. However,conducting hybrid simulation of complex structures within large-scale testing facilities presents significant challenges. for example,the chosen modeling scheme may create numerical inaccuracies or even result in unstable simulations; the displacement and force capacity of the experimental system can be exceeded; and a hybrid test may be terminated due to poor communication between modules(e.g.,loading controllers,data acquisition systems,simulation coordinator). These problems can cause the simulation to stop suddenly,and in some cases can even result in damage to the experimental specimens; the end result can be failure of the entire experiment. This study proposes a phased approach to hybrid simulation that can validate all of the hybrid simulation components and ensure the integrity largescale hybrid simulation. In this approach,a series of hybrid simulations employing numerical components and small-scale experimental components are examined to establish this preparedness for the large-scale experiment. This validation program is incorporated into an existing,mature hybrid simulation framework,which is currently utilized in the Multi-Axial full-Scale Sub-Structuring Testing and Simulation(MUST-SIM) facility of the George E. Brown Network for Earthquake Engineering Simulation(NEES) equipment site at the University of Illinois at Urbana-Champaign. A hybrid simulation of a four-span curved bridge is presented as an example,in which three piers are experimentally controlle

关键词： hybrid simulation seismic performance evaluation phased approach curved bridge MUST-SIM facility

Assessment and Perceived Impact of Coastal resource Management (CrM) Programs in the Southern Part of Masbate Island, Philippines

在线全文

学校读者我要写书评

暂无评论

Journal of Geoscience and Environment Protection 2023年第3期11卷 87-103页

作者： Benedicto B. Balilo jr. Angelo P. Candelaria ronnel r. Dioneda Sr. CS/IT Department College of Science Bicol University Legazpi City Philippines

Coastal resource Management (CrM) are activities that achieve sustainable use and management of valuable resources in coastal areas. This study presents the perceived impact of the coastal resource management (CrM) interventions implemented by the Bureau of fisheries and Aquatic resources (BfAr) under the fishCOrAL Project in the Municipality of Milagros, Masbate. The respondents are members of fisherfolk organizations, Bantay Dagat (BD), and community members. The CrM projects include mangrove planting, the establishment of marine protected area (MPA) markers, the construction of a watchtower, and the establishment of Bantay Dagat (BD). respondents were convinced that the interventions affected their daily living, especially mangrove planting projects. Members of fisherfolk organizations carried out the project in Barangays Jamorawon, Magsalangi, and Tagbon. In terms of knowledge, attitude, and practices (KAP), these could be attributed to the respondent’s appreciation of the intervention, which contributed to the protection of the area from flood, storm surge, and tsunami, support for livelihood, the presence of marine animals (i.e., shrimp and crabs), and apprehension of illegal fishing activities. Destructive fishing, domestic waste, and natural calamities are some identified causes of aquatic ecosystem destruction. In terms of socioeconomic, respondents are provided additional income ranging from Php 1,500.00 - 2,000.00 per month, and fish stocks have also increased. The distribution of fishnets and Banca, livelihood, protection of marine resources, and commitment of legal authorities to enforce related fishery policies are among the CrM activities with a sound impact on the community.

关键词： Non-Livelihood CrM Bureau of fisheries and Aquatic resources LGU Milagros Impact Assessment

The reversal of antineoplastic drug resistance in cancer cells by β-elemene

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

癌症 2015年第11期34卷 488-495页

作者： Guan-Nan Zhang Charles r.Ashby jr. Yun-Kai Zhang Zhe-Sheng Chen Huiqin Guo Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St. John’s University Department of Thoracic Surgery Peking Union Medical College Hospital

Multidrug resistance(MDr), deined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, signiicantly limits the eicacy of antitumor drugs. A major mechanism that mediates MDr in cancer is the overexpression of adenosine triphosphate(ATP)?binding cassette transporters. These transporters bind to their respective substrates and catalyze their elux from cancer cells, thereby lowering the intracellular concentra?tions of the substrates and thus attenuating or even abolishing their eicacy. In addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa B, and the p38 mitogen?activated protein kinase pathway. In this review, we discuss the mechanisms by which β?elemene, a compound extracted from rhizoma zedoariae that has clinical antitumor eicacy, overcomes drug resistance in cancer.

关键词： rhizoma zedoariae β?Elemene Multidrug resistance

Mesenchymal stem cell therapy for acute radiation syndrome: Innovative medical approaches in military medicine

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Medical Colleges of PLA(China) 2014年第3期29卷 186-195页

作者： Erik B.Eaton jr. Timothy r.Varney United States Army Medical research Institute of Chemical Defense 3100 Ricketts Point Road Aberdeen Proving GroundMaryland 21010 US United States Army Medical research Institute of Chemical Defense 3100 Ricketts Point Road Aberdeen Proving Ground Maryland 21010 US

After a radiological or nuclear event, acute radiation syndrome(ArS) will present complex medical challenges that could involve the treatment of hundreds to thousands of patients. Current medical doctrine is based on limited clinical data and remains inadequate. Efforts to develop medical innovations that address ArS complications are unlikely to be generated by the industry because of market uncertainties specific to this type of injury. A prospective strategy could be the integration of cellular therapy to meet the medical demands of ArS. The most clinically advanced cellular therapy to date is the administration of mesenchymal stem cells(MSCs). results of currently published investigations describing MSC safety and efficacy in a variety of injury and disease models demonstrate the unique qualities of this reparative cell population in adapting to the specific requirements of the damaged tissue in which the cells integrate. This report puts forward a rationale for the further evaluation of MSC therapy to address the current unmet medical needs of ArS. We propose that the exploration of this novel therapy for the treatment of the multivariate complications of ArS could be of invaluable benefit to military medicine.

关键词： Acute radiation syndrome Mesenchymal stem cell Cell therapy Hematopoietic syndrome Gastrointestinal syndrome radiation injury

The occlusal plane in the facial context:inter-operator repeatability of a new three-dimensional method

在线全文

学校读者我要写书评

暂无评论

International Journal of Oral Science 2012年第1期4卷 34-37页

作者： riccardo rosati Alberto rossetti marcio De Menezes Virgilio f ferrario Chiarella Sforza Department of Human Morphology Universita` degli Studi di MilanoMilano 20133Italy

The repeatability of a non-invasive digital protocol proposed to evaluate the three-dimensional（3D） position of the occlusal plane in the face is *** virtual models and soft tissue facial morphology of 20 adult subjects were digitally integrated using a 3D stereophotogrammetric imaging *** digital 3D coordinates of facial and dental landmarks were obtained by two different ***＇s（facial） and occlusal（dental） planes were individuated,and their 3D relationships were *** repeatability of the protocol was investigated and showed no significant differences in repeated *** angle between occlusal and Camper＇s planes was smaller than 26 in the frontal and horizontal *** the sagittal projection,the angle was observed to be,on average,4.9 *** determined occlusal plane pitch,roll and yaw values show good agreement with previously published data obtained by different *** current non-invasive method was repeatable,without inter-operator differences and can facilitate assessment of healthy subjects.

关键词： healthy subjects occlusal plane stereophotogrammetry three-dimensional analysis

Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2015年第7期42卷 373-382页

作者： Xiaodong Sun Changsheng Xing Xiaoying fu Jie Li Baotong Zhang Henry f.frierson jr. Jin-Tang Dong Winship Cancer Institute Department of Hematology and Medical OncologyEmory University School of Medicine Department of Pathology Tianjin University of Traditional Chinese Medicine Department of Pathology University of Virginia Health System

The phosphatase and tensin homolog （PTEN） and the zinc finger homeobox 3 （ZfHX3）/AT-motif binding factor 1 （ATBf1） genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in human prostate cancer and by the formation of mouse prostatic intraepithelial neoplasia （mPIN） or tumor by their deletions in mouse prostates. However, whether ZfHX3/ATBf1 deletion together with PTEN deletion facilitates prostatic tumorigenesis is unknown. In this study, we simultaneously deleted both genes in mouse prostatic epithelia and performed histological and molecular analyses. While deletion of one Pten allele alone caused low-grade （LG） mPIN as previously reported, concurrent deletion of Zfhx3/Atbfl promoted the progression to high-grade （HG） mPIN or early carcinoma. ZJhx3/Atbfl and Pten deletions together increased cell proliferation, disrupted the smooth muscle layer between epithelium and stroma, and increased the number of apoptotic cells. Deletion of both genes also accelerated the activation of Akt and Erkl/2 oncoproteins. These results suggest an additive effect of ZfHX3/ATBf1 and PTEN deletions on the development and progression of prostate neoplasia.

关键词： ZfHX3 ATBfI PTEN Prostate cancer mPIN

在线全文

学校读者我要写书评

暂无评论

Marketing / Dalian :