The reversal of antineoplastic drug resistance in cancer cells by β-elemene
The reversal of antineoplastic drug resistance in cancer cells by β-elemene作者机构：Department of Pharmaceutical Sciences College of Pharmacy and Health Sciences St. John’s University Department of Thoracic Surgery Peking Union Medical College Hospital
出 版 物：《癌症》 (Chinese Journal of Cancer)
年 卷 期：2015年第34卷第11期
页 面：488-495页
核心收录：
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学]
基 金：supported by St.John’s University Research Seed Grant (No. 579?1110?7002) to Zhe?Sheng Chen
主 题：Rhizoma zedoariae β?Elemene Multidrug resistance
摘 要：Multidrug resistance(MDR), deined as the resistance of cancer cells to compounds with diverse structures and mechanisms of actions, signiicantly limits the eicacy of antitumor drugs. A major mechanism that mediates MDR in cancer is the overexpression of adenosine triphosphate(ATP)?binding cassette transporters. These transporters bind to their respective substrates and catalyze their elux from cancer cells, thereby lowering the intracellular concentra?tions of the substrates and thus attenuating or even abolishing their eicacy. In addition, cancer cells can become resistant to drugs via mechanisms that attenuate apoptosis and cell cycle arrest such as alterations in the p53, check point kinase, nuclear factor kappa B, and the p38 mitogen?activated protein kinase pathway. In this review, we discuss the mechanisms by which β?elemene, a compound extracted from Rhizoma zedoariae that has clinical antitumor eicacy, overcomes drug resistance in cancer.
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