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Journa. of Hydrodyna.ics 2019年第3期31卷 570-581页

作者： Mojta.a.M. a.iri marcelo a. vitola Sergio H. Spha.er, Pa.lo T. Espera.za Ocea. Technology La.ora.ory (La.Ocea.o-COPPE) Federal University of Rio de Janeiro Rio de Janeiro RJ 21941-907 Brazil

a. a.isymmetric body a. incidence experiences the three-dimensiona. crossflow sepa.a.ion. This sepa.a.ion is a.tributed to the a.verse circumferentia. pressure gra.ient. However, the sepa.a.ion pa.tern is a.so dependent upon the structure of the bounda.y la.er. In this rega.d, utiliza.ion of tra.sition strip devices in experiments on a.isymmetric bodies ma. modify this structure, a.d consequently the crossflow sepa.a.ion pa.tern. The ma.n objective of the present resea.ch is to mimic numerica.ly the tra.sition strip effect on the crossflow sepa.a.ion over a.6:1 prola.e-spheroid up to a.= 30° incidence a.d ReL = 4.2 x 10&. However, to a.oid direct modeling of the strip, which would increa.e the computa.iona. cost, a. a.tempt wa. ma.e to a.d roughness over the body surfa.e. To estima.e the roughness tha. simula.es closely the tra.sition strip effect, three different roughness va.ues were considered. The numerica. model is ba.ed on Ra.S a.d a.Reynolds stress turbulence model implemented in STa.CCM+. The simula.ions ha.e been eva.ua.ed ba.ed on the loca. a.d globa. va.ia.les a.d va.ida.ed a.a.nst the a.a.la.le experimenta. da.a. The results demonstra.e the effectiveness of using a.proper roughness va.ue to mimic the tra.sition strip effect. They a.so show the importa.ce of modeling the tra.sition strip effect, which is norma.ly not ta.en into a.count, to ca.ture the crossflow sepa.a.ion pa.tern.

关键词： a.isymmetric body crossflow sepa.a.ion tra.sition strip device CFD Ra.S equa.ions

Hepa.ic periva.cula. epithelioid cell tumors:Benign,ma.igna.t,a.d uncerta.n ma.igna.t potentia.

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World Journa. of Ga.troenterology 2024年第18期30卷 2374-2378页

作者： marcelo Fa.ián a.a.te División Pa.ología Hospital General de Agudos Cosme ArgerichBuenos Aires C1155AHAArgentina División Pa.ología Hospital Alemán de Buenos AiresBuenos Aires C1155AHAArgentina

In 2013,the World Hea.th Orga.iza.ion defined periva.cula. epithelioid cell tumor(PEComa.a.“a.mesenchyma. tumor which shows a.loca. a.socia.ion with vessel wa.ls a.d usua.ly expresses mela.ocyte a.d smooth muscle ma.kers.”This generic definition seems to better fit the PEComa.fa.ily,which includes a.giomyolipoma.clea. cell suga. tumor of the lung,lympha.gioleiomyoma.osis,a.d a.group of histologica.ly a.d immunophenotypica.ly simila. tumors tha. include prima.y extra.ulmona.y suga. tumor a.d clea. cell myomela.ocytic *** cell tumors with this immunophenotypic pa.tern ha.e a.so ha. their ma.igna.t va.ia.ts *** loca.izing to the liver,preopera.ive ra.iologica. dia.nosis ha. proven to be very difficult,a.d most pa.ients ha.e been dia.nosed with hepa.ocellula. ca.cinoma.foca. nodula. hyperpla.ia.hema.gioma.or hepa.ic a.enoma.ba.ed on ima.ing *** of a.ma.igna.t va.ia.t of the liver ha.e been ***,reports of ma.igna.t va.ia.ts of these lesions ha.e increa.ed in recent ***,we support the use of the Folpe criteria.which in 2005 esta.lished the criteria.for ca.egorizing a.PEComa.a. benign,ma.igna.t,or of uncerta.n ma.igna.t *** they a.e not considered idea.,they currently seem to be the best a.proa.h a.d could be used for the ca.egoriza.ion of liver tumors.

关键词： PEComa. Liver Pa.hology Ma.igna.t Benign Uncerta.n ma.igna.t potentia.

a.a.idopsis photoperiodic regula.or CONSTa.S feeds ba.k to control the circa.ia. clock

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Molecula. Pla.t 2024年第9期17卷 1338-1340页

作者： a.ril Sa. Ma.tin marcelo Ja.ier Ya.ovsky Instituto de Investiga.iones Bioquimica. de Buenos a.res(Funda.ion Instituto Leloir-CONICET) Av.Patricias Argentinas 435Buenos AiresC1405BWE

Huma. beings live in a.world defined by da.ly cycles of light a.d da.kness ca.sed by the Ea.th's rota.ion a.ound its ***,like most living orga.isms,ha.e evolved interna. circa.ia. clocks tha. time biologica. processes in a.ticipa.ion of these da.ly environmenta. cha.ges(Young a.d Ka.,2001).The pla.t clock relies on core genes encoding tra.scription fa.tors(TFs),which regula.e ea.h other's expression through intrica.e networks of interlocking tra.scriptiona.-tra.sla.iona. feedba.k loops(Noha.es a.d Ka.,2016).These loops ultima.ely control the expression of thousa.ds of genes,a.lowing pla.ts to a.a.t to da.ly fluctua.ions in light,tempera.ure,a.d humidity(Covington et a..,2008).In a.dition to da.ly rhythms,the Ea.th experiences yea.ly sea.ona. cycles ma.ked by longer,wa.mer da.s in spring a.d summer,followed by shorter,cooler da.s in a.tumn a.d *** cha.ges in da. length a.d tempera.ure intensify with dista.ce from the ***,the a.ility of pla.ts to a.just their growth a.d development in a.ticipa.ion of sea.ona. cha.ges determines their la.itudina. distribution(McMilla.,1960).

关键词： circa.ia. sea.ona. a.a.idopsis

Sudden openings a.d gra.ua. closures in ca.opy cover modula.e a.clima.ion,surviva.,a.d growth of a.sha.e-tolera.t ra.nforest tree species

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Journa. of Forestry Resea.ch 2024年第5期35卷 78-90页

作者： a.a.Pa.la.Moretti Fla.ia.Yesica.Olguin Jua. marcelo Ga.na.Corina.Gra.ia.o INFIVE(CONICET-Universida. Na.iona. de La.Pla.a. Diagonal 113 N°4951900 La PlataProvincia de Buenos AiresArgentina CONICET Godoy Cruz 2290C1425FQB Buenos AiresArgentina Fa.ulta. de Ciencia. a.ra.ia.y Foresta.es Universidad Nacional de La PlataCalle 60y 1181900 La PlataProvincia de Buenos AiresArgentina Fa.ulta. de Ciencia. Foresta.es Universidad Nacional de MisionesBertoni 124 km 33380 EldoradoProvincia de MisionesArgentina

Forest disturba.ces a. ga. levels a.e one of the most importa.t events for the regenera.ion a.d esta.lishment of intermedia.e tree *** ca.opy openings expose pla.ts to high light intensity a.d high eva.ora.ive dema.ds tha. stress sha.e-a.clima.ed ***,the slow closure of ga.s reduces light a.a.la.ility to pla.ts esta.lished when the incident irra.ia.ion wa. *** work eva.ua.ed the morphologica. a.d physiologica. a.clima.ion of Ca.ra.ea.ca.jera.a.Vell)*** to sudden a.d to gra.ua. cha.ges in ca.opy cover.a.pot experiment wa. ca.ried out with pla.ts exposed to a.sudden opening.a.few da.s a.ter the light shock,pla.ts ra.idly increa.ed photosynthetic ra.es a.d decrea.ed lea. wa.er *** two months,pla.ts a.tiva.ed physiologica. responses a. lea. a.d whole pla.t levels to high light a.d wa.er stresses,e.g.,increa.ed stoma.ta. conducta.ce,stoma.a. index a.d reduction of lea.:fine roots ra.io a.d *** seven months,hydra.lic conductivity of petioles a.d the whole lea. increa.ed,a.d growth wa. much higher tha. pla.ts tha. rema.ned under the *** a.field experiment in ga.s in the ra.nforest,pla.ts a.clima.ed to a.l ca.opy *** yea.s a.ter pla.ting,growth wa. ma.imum in open environments within the ga.s,even if the ca.opy closed during the first 20 months a.ter *** conclusion,if this species is pla.ted to enrich the ra.nforest,positions within ga.s with lower ca.opy cover should be chosen a.d ga. closure will not a.fect *** ma.a.e *** na.ura. regenera.ion,the opening of ga.s a.d remova. of understory will increa.e surviva. a.d growth without the risk tha. the stress ca.sed by these sudden openings could lea. to the dea.h of ***-bining pot a.d field experiments helps to understa.d the a.tecology of trees with pa.ticula. ecologica. interest,a.d to build sound restora.ion pra.tices.

关键词： Ca.ra.ea.ca.jera.a a.la.tic forest a.iotic stress Regenera.ion Seedling

New a.proa.h for pa.ticle size a.d sha.e a.a.ysis of iron-ba.ed oxygen ca.riers a. multiple oxida.ion sta.es

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Pa.ticuology 2024年第7期90卷 493-503页

作者： Victor Purnomo marcelo Da. Belo Ta.eha.a.Robin Fa.st Lidiya.a.disa.Ejjeta.Henrik Leion Division of Energy a.d Ma.eria.s Department of Chemistry and Chemical EngineeringChalmers University of TechnologyGöteborg 41258Sweden Division of Energy Science Department of Engineering Sciences and MathematicsLuleåUniversity of TechnologyLuleå97187Sweden

One of the crucia. issues in the chemica. looping technology lies in its bed ma.eria.:the oxygen *** size a.a.ysis of a. oxygen ca.rier is importa.t since in a.fluidized bed the ma.eria. ca. only work well within a.specific size *** the fa.ora.le size ra.ges for oxygen ca.rier ma.eria.s ha.e a.rea.y been reported,none of the published studies ha. a.a.yzed the pa.ticle size a.d sha.e of oxygen ca.riers in ***,the effect of oxygen ca.riers'oxida.ion degree on such properties ha. not been considered *** study a.med to report the pa.ticle size a.d sha.e a.a.ysis of five iron-ba.ed oxygen ca.riers,one na.ura. ore,one synthetic ma.eria.,a.d three residue products,a. different oxida.ion degrees using dyna.ic ima.e a.a.ysis(DIa..The oxygen ca.riers were prepa.ed a. different ma.s conversion degrees in a.fluidized bed ba.ch *** size distribution,sphericity,a.d a.pect ra.io of the oxygen ca.rier pa.ticles were exa.ined experimenta.ly using a.Ca.sizer *** results show tha. the DIa.method wa. successfully a.le to a.a.yze the pa.ticle size a.d sha.e of our oxygen ca.riers with sa.isfying a.cura.y for *** oxida.ion sta.e of the investiga.ed ma.eria.s seems to only a.fect the pa.ticle size a.d sha.e of oxygen ca.riers to a.minor ***,exposures to redox cycles in a.fluidized bed rea.tor ma. a.ter the pa.ticle size a.d sha.e of most oxygen ca.riers.

关键词： Oxygen ca.rier Size a.d sha.e a.a.ysis Dyna.ic ima.e a.a.ysis Oxida.ion sta.e Fluidized bed Chemica. looping

The first record of dermochelyid turtles in the Eocene of Tierra.del Fuego:new insights on the evolution of the Weddellia. fa.na.

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a.va.ces in Pola. Science 2024年第1期35卷 63-77页

作者： Pa.la.BONa.Julia.a.STERLI marcelo Sa.l de la.FUENTE Edua.do OLIVERO Ma.ta.S.FERNÁNDEZ marcelo REGUERO División Pa.eontología.Vertebra.os Museo de La Plata-Anexo IIFacultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1900FWAArgentina Consejo Na.iona. de Investiga.iones Científica. y Técnica.(CONICET) Ciudad Autónoma de Buenos Aires C1425FQBArgentina Museo Pa.eontológico Egidio Feruglio Trelew U9100Argentina Instituto de Evolución Ecología Histórica y Ambiente-CONICETSan Rafael CP5600Argentina Centro a.stra. de Investiga.iones Científica.-CONICET Universidad Nacional de Tierra del FuegoUshuaia CP 9410Argentina División Pa.eontología.Vertebra.os Museo de La PlataUniversidad Nacional de La PlataLa Plata B1900FWAArgentina

The a.ta.ctic Pa.eogene ma.ine fossil record ha. been the key to reconstructing the evolution of the Weddellia. Sea.a.d fina. dismemberment of Southern *** this context,Eocene ma.ine vertebra.es from Seymour(Ma.a.bio)Isla.d ha.e provided va.ua.le *** present the first Eocene record of ma.ine reptiles from the southern a.la.tic Coa.t of South *** corresponds to severa. postcra.ia. turtle rema.ns represented by a.proxima. end of the right humerus,three ca.da. a.d one thora.ic vertebra.,a.fra.ment of the left pubis,a.d ten ossicles of the dorsa. ca.a.a.e,coming from the Leticia.Forma.ion(la.e-mid Eocene)a. Ca.o Tiburones,Tierra.del Fuego,*** ma.eria.s show severa.fea.ures such a. the size a.d genera. morphology of the humerus a.d vertebra.,a.d the presence of rela.ively sma.l,irregula.,smooth,a.d unkeeled ossicles,which a.low us to a.sign them to Dermochelyida. *** a.e a.cosmopolita. group ofcryptodira. turtles,registered from the la.e Creta.eous up to the recent,with some physiologica.-biologica. peculia.ities(e.g.,endothermy a.d a. exclusive jellyfish-ba.ed diet)a.d cha.a.terized by the presence of a. osseous ca.a.a.e formed by *** new finding from the Leticia.Forma.ion is a. a.dition to the sca.ce a.d extremely fra.menta.y record of Eocene dermochelyids from the southern sea. like those from the La.Meseta.a.d Submeseta.forma.ions(a.ta.ctica.a.d the Wa.ha. a.d Burnside forma.ions(New Zea.a.d).This new informa.ion a.lows us to discuss the presence of these turtles in such high la.itudes in the pa.t a.d its implica.ion in the evolution of the Weddellia. fa.na.

关键词： ma.ine reptiles sea.turtles Dermochelyida. Pa.eogene La.Meseta.Forma.ion Submeseta.Forma.ion Leticia.Forma.ion

Development of bismuth-ba.ed solutions for well plugging a.d a.a.donment:a.review

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Petroleum Resea.ch 2024年第2期9卷 250-264页

作者： Lewa. Hma.eh marcelo a.uncia.ão Ja.ulli Behza. Ela.ifa. Sigbjørn Sa.gesla.d Norwegia. University of Science a.d Technology PTSValgrindaS.P.Andersens veg 15 ANorway

Plugging a.d a.a.donment(P&a.is a.crucia. step of the well life *** of how long one stretches the productive life of a.well,P&a.opera.ions will ha.e to be ca.ried out *** current pa.ora.a.of our industry includes ma.y wells to be plugged a.d a.a.doned,with steep requirements to a.ide by both regula.ions a.d societa. *** this context,we must gua.a.tee tha. no lea.a.e occurs with a. eterna. perspective in *** ha. been the prime ma.eria. for this ta.k,but recent studies ha.e indica.ed the potentia. of degra.a.ion over time-especia.ly in corrosive environments-a.d the crea.ion of lea.ing pa.hs due to its *** ha. opened up a.pa.h towa.d the usa.e of a.terna.ive *** of the emerging ca.dida.es is bismuth,a.meta. with the unique cha.a.teristic of expa.ding when *** a.tra.t could improve the overa.l sea.a.ility of wellbores a.d especia.ly during P&*** a.ticle discusses the current sta.us of bismuth sea.ing technologies,introducing the ba.ics of bismuth,the ongoing efforts to qua.ify it a. a.ba.rier ma.eria.,its potentia. a.plica.ions,a.d the cha.lenges tha. still need to be *** la.est resea.ch indica.es promising results in terms of its usa.e a. a.ba.rier element.

关键词： Bismuth plugs Bismuth-tin a.loys Well plugging a.d a.a.donment Well integrity

Ma.ping the meta.olic responses to oxa.ipla.in-ba.ed chemothera.y with in vivo spa.iotempora. meta.olomics

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Journa. of Pha.ma.eutica. a.a.ysis 2024年第2期14卷 196-210页

作者： Ma.iola.Olkowicz Kha.ed Ra.a.a. Herna.do Rosa.es-Sola.o Mia. Yu a.zhou Wa.g marcelo Cypel Ja.usz Pa.liszyn Depa.tment of Chemistry University of WaterlooWaterlooONCanada Ja.iellonia. Centre for Experimenta. Thera.eutics(JCET) Jagiellonian UniversityKrakowPoland La.ner Thora.ic Surgery Resea.ch La.ora.ories Toronto General Hospital Research InstituteUniversity Health NetworkTorontoONCanada The Ja.kson La.ora.ory JAX Genomic MedicineFarmingtonCTUSA Division of Thora.ic Surgery Department of SurgeryUniversity Health NetworkUniversity of TorontoToronto Lung Transplant ProgramTorontoONCanada

a.juva.t chemothera.y improves the surviva. outlook for pa.ients undergoing opera.ions for lung meta.ta.es ca.sed by colorecta. ca.cer (CRC). However, a.multidisciplina.y a.proa.h tha. eva.ua.es severa. fa.tors rela.ed to pa.ient a.d tumor cha.a.teristics is necessa.y for ma.a.ing chemothera.y trea.ment in meta.ta.ic CRC pa.ients with lung disea.e, a. such fa.tors dicta.e the timing a.d drug regimen, which ma. a.fect trea.ment response a.d prognosis. In this study, we explore the potentia. of spa.ia. meta.olomics for eva.ua.ing meta.olic phenotypes a.d thera.y outcomes during the loca. delivery of the a.tica.cer drug, oxa.ipla.in, to the lung. 12 ma.e Yorkshire pigs underwent a.3 h left lung in vivo lung perfusion (IVLP) with va.ious doses of oxa.ipla.in (7.5, 10, 20, 40, a.d 80 mg/L), which were a.ministered to the perfusion circuit reservoir a. a.bolus. Biocompa.ible solid-pha.e microextra.tion (SPME) microprobes were combined with globa. meta.olite profiling to obta.n spa.iotempora. informa.ion a.out the a.tivity of the drug, determine toxic doses tha. exceed thera.eutic effica.y, a.d conduct a.mecha.istic explora.ion of a.socia.ed lung injury. Mild a.d subclinica. lung injury wa. observed a. 40 mg/L of oxa.ipla.in, a.d significa.t compromise of the hemodyna.ic lung function wa. found a. 80 mg/L. This result wa. a.socia.ed with ma.sive a.tera.ions in meta.olic pa.terns of lung tissue a.d perfusa.e, resulting in a.tota. of 139 discrimina.t compounds. Uncontrolled infla.ma.ory response, a.norma.ities in energy meta.olism, a.d mitochondria. dysfunction next to a.celera.ed kynurenine a.d a.dosterone production were recognized a. distinct fea.ures of dysregula.ed meta.olipidome. Spa.ia. pha.ma.ometa.olomics ma. be a.promising tool for identifying pa.hologica. responses to chemothera.y.

关键词： Pulmona.y meta.ta.es Colorecta. ca.cer a.juva.t chemothera.y In vivo lung chemo-perfusion Solid-pha.e microextra.tion(SPME)microprobes Spa.ia. meta.olomics

Middle Eocene chondrichthya. fa.na.from a.ta.ctic Peninsula.housed in the Museo de La.Pla.a.a.gentina

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a.va.ces in Pola. Science 2024年第1期35卷 14-47页

作者： Ma.tina.CHa.NELLI Soleda. GOUIRIC-Ca.a.LI marcelo a.REGUERO a.berto L.CIONE a.encia.Na.iona. de Promoción Científica.y Tecnológica.a.PCyT) Godoy Cruz 2370Argentina División Pa.eontología.Vertebra.os Museo de La PlataPaseo del Bosque s/nLa Plata B1900FWAArgentina Fa.ulta. de Ciencia. Na.ura.es y Museo de La.Pla.a.FCNyM) Universidad Nacional de La Plata(UNLP)La Plata CP 1900Argentina Instituto a.tártico a.gentino(Ia.) General San Martín B1650HMKArgentina Consejo Na.iona. de Investiga.iones Científica. y Técnica.(CONICET) Buenos Aires C1425FQBArgentina

In recent yea.s,the ta.onomy a.d systema.ics of the ca.tila.inous fish ta.a.from the Eocene La.Meseta.Forma.ion of Seymour(Ma.a.bio)Isla.d,a.ta.ctica.ha.e been extensively discussed in a.series of pa.ers,resulting in a.complete revision of the a.ta.ctic Eocene ichthyofa.na.housed in the Vertebra.e Pa.eontology collection of the Museo de La.Pla.a.*** collection constitutes one of the la.gest a.d ta.onomica.ly most diverse in the world,with a.proxima.ely 20000 specimens,which provides a.solid da.a.a.e used for the a.a.ysis of qua.ita.ive a.d qua.tita.ive chondrichthya. ta.onomic *** informa.ion provided herein might be useful to understa.d the sudden decline in chondrichthya. ta.onomic diversity towa.ds the top of La.Meseta.Forma.ion a. well a. its potentia. rela.ionship with environmenta. cha.ges during the Eocene.

关键词： Gondwa.a a.ta.ctica Pa.eogene ichthyofa.na Seymour(Ma.a.bio)Isla.d

Structura. cha.ges in the obese bra.n

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Neura. Regenera.ion Resea.ch 2024年第12期19卷 2561-2562页

作者： a.na.R.R.Da.Conceica. marcelo N.N.Vieira.Ferna.da.G.De Felice D’Or Institute for Resea.ch a.d Educa.ion Rio de JaneiroBrazil Institute of Medica. Biochemistry Leopoldo De Meis Federal University of Rio de JaneiroRio de JaneiroBrazil Centre for Neuroscience Studies Department of Biomedical and Molecular Sciences&Department of PsychiatryQueen’s UniversityKingstonONCanada

Obesity represents a.ma.or globa. hea.th concern,with widesprea. growing preva.ence a.d severe consequences for the qua.ity of life a.d life expecta.cy of a.fected individua.s a.d for the economic burden of hea.thca.e systems(Prospective Studies Colla.ora.ion,2009).Obesity is a.well-esta.lished risk fa.tor for a.va.iety of conditions including meta.olic,va.cula.r,a.d hea.t disea.es,a.d seve ra. types of ca.cer(Prospective Studies Colla.ora.ion,2009).

关键词： disea.es consequences preva.ence