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Application of Kaiser Sepsis Calculator in culture-positive infants with early onset sepsis

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World Journal of Pediatrics 2021年第4期17卷 429-433页

作者： Gretchen Kopec marc Collin Anirudha Das Department of Neonatology University of Illinois College of MedicinePeoria campusPeoriaUSA Department of Neonatology MetroHealth Medical CenterClevelandUSA Department of Neonatology Cleveland Clinic Children’s Hospital9500 Euclid AvenueClevelandOH44195USA

Background Kaiser Sepsis Calculator(KSC)reduces antibiotic use,testing and intravenous infiltrates but there are concerns about the missed early onset sepsis(EOS)*** sought to apply the KSC score for culture-positive infants retrospectively in infants born in the last 10 years in our *** In a retrospective cohort study,the comparison groups were divided into Group A(no antibiotics recommended by KSC)and Group B(antibiotics recommended).Results Overall,17/24(71%)infants would have been started on antibiotics per KSC but 7/24(29%)would *** initial EOS risk was not significantly different between the groups(Group A *** B:0.44 vs.0.76,P=0.41),but the final risk score was(0.33 vs.9.41,P<0.001).In Group A(no antibiotics),3/7 infants became symptomatic between 9 and 42 *** There may be a potential delay in starting antibiotics in infants that are asymptomatic at birth while using KSC.

关键词： Early onset sepsis EOS Kaiser Sepsis Calculator Neonatal sepsis Neonate Newborn Blood culture

PERMEABILITY COMPUTATION ON A REPRESENTATIVE VOLUME ELEMENT （RVE） OF. UNIDIRECTIONAL DISORDERED FIBER ARRAYS

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Journal of Computational Mathematics 2016年第3期34卷 223-239页

作者： Karim Hitti Stephanie Feghali marc Bernacki Department of Mathematics Faculty of Sciences University of Balamand Lebanon Notre Dame University-Louaize Faculty of Natural and Applied Sciences Department of Mathematics and Statistics Lebanon Lebanese University Faculty of Sciences II Mathematics Department P.O. Box 90656 Fanar-Matn Lebanon Mines-ParisTech PSL-Research University CEMEF- Centre de mise en forme des matdriaux CNRS UMR 7635 CS 10207 rue Claude Daunesse 06904 Sophia Antipolis Cedex France

An efficient method to compute the permeability of disordered fibrous arrays is pro- posed. A stabilized mixed finite element method is used with an immersed domain ap- proach to represent the porous material at its microscopic scale. Therefore, the Stokes e- quations are solved in the whole domain （including solid part） using a penalization method. The accuracy is controlled by refining the mesh around the fluid-solid interface defined by a level-set function. Using homogenization techniques, the permeability of an RVE is obtained. Furthermore, a new method to generate disordered fibers in function of the porosity, Ф, and other microstructural parameters is proposed and a study of the effect of inter-fiber spacing on K：, the permeability tensor, is performed using parallel computation and over 460 simulations were carried RVEs consisting of over 555 fibers. This task was achieved out in two-dimensional

关键词： Permeability Fibrous Media Finite Element Method Level-set.

Geometry optimization of a barrel silicon pixelated tracker

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Chinese Physics C 2017年第8期41卷 118-124页

作者：刘清源王萌 marc Winter School of Physics and Key Laboratory of Particle Physics and Particle Irradiation(MOE) Shandong UniversityJinan 250100China Universite de Strasbourg IPHC-CNRS23 rue du Loess67037 StrasbourgFrance

We have studied optimization of the design of a barrel-shaped pixelated tracker for given spatial boundaries. The optimization includes choice of number of layers and layer spacing. Focusing on tracking performance only,momentum resolution is chosen as the figure of merit. The layer spacing is studied based on Gluckstern＇s method and a numerical geometry scan of all possible tracker layouts. A formula to give the optimal geometry for curvature measurement is derived in the case of negligible multiple scattering to deal with trajectories of very high momentum particles. The result is validated by a numerical scan method, which could also be implemented with any track fitting algorithm involving material effects, to search for the optimal layer spacing and to determine the total number of layers for the momentum range of interest under the same magnetic field. The geometry optimization of an inner silicon pixel tracker proposed for BESIII is also studied by using a numerical scan and these results are compared with Geant4-based simulations.

关键词： tracker geometry optimization optimal spacing numerical scan least squares kalman filter initialization BESIII silicon pixel tracker

Optimal flow conditions of a tracheobronchial model to reengineer lung structures

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Acta Mechanica Sinica 2017年第2期33卷 284-294页

作者： Stefano Casarin Federico Aletti Giuseppe Baselli marc Garbey LASIE UMR CNTS Univeristy of La Rochelle La Rochelle France Houston Methodist Hospital Research Institute Houston TX USA Dipartimento di Elettronica Informazione e Bioingegneria Politecnico di Milano Milan Italy

The high demand for lung transplants cannot be matched by an adequate number of lungs from donors. Since fully ex-novo lungs are far from being feasible, tissue engineering is actively considering implantation of engineered lungs where the devitalized structure of a donor is used as scaffold to be repopulated by stem cells of the receiving patient. A decellularized donated lung is treated inside a bioreactor where transport through the tracheobronchial tree (TBT) will allow for both deposition of stem cells and nourishment for their subsequent growth, thus developing new lung tissue. The key concern is to set optimally the boundary conditions to utilize in the bioreactor. We propose a predictive model of slow liquid ventilation, which combines a one-dimensional (1-D) mathematical model of the TBT and a solute deposition model strongly dependent on fluid velocity across the tree. With it, we were able to track and drive the concentration of a generic solute across the airways, looking for its optimal distribution. This was given by properly adjusting the pumps’ regime serving the bioreactor. A feedback system, created by coupling the two models, allowed us to derive the optimal pattern. The TBT model can be easily invertible, thus yielding a straightforward flow/pressure law at the inlet to optimize the efficiency of the bioreactor.

关键词： Bioreactor Lung rehabilitation Network flow Tissue engineering Transport of solute

＂LOCK＂ing up allergic responses with a Polish probiotic

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Cellular & Molecular Immunology 2016年第2期13卷 263-264页

作者： Yuying Liu marc Rhoads Department of Pediatrics Division of Gastroen-terology The University of Texas Health ScienceCenter at Houston Medical School HoustonTexas 77030 USA

Three relatively new lactobacillus species that were developed from fecal samples of a 26-year-old woman （LOCK0900）, a 6-year-old girl （LOCK 0908）, and a 5-year-old boy （LOCK 0919） have been studied by Kozakova ... 详细信息

关键词：内皮缩血管肽类乳杆菌属有益菌种

A Novel Virus Detected In Papillomatous And Carcinomatous Lesions Of The Endangered Western Barred Bandicoot （Perameles Bougainville） Exhibits Genomic Features Of Both The Papillomaviridae And Polyomaviridae

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A Novel Virus Detected In Papillomatous And Carcinomatous Le...

Gut homeostasis, injury, and healing: New therapeutic targets

24th International Papillomavirus Conference and Clinical Workshop

作者： Lucy Woolford Annabel Rector marc.van ranst Andrea Ducki Mark D Bennett Philip K Nicholls Kristin S Warren Ralph A Swan Graham E Wilcox Amanda J O’Hara Murdoch University Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia

＜正＞Conservation efforts to prevent the extinction of the endangered western barred bandicoot（Perameles bougainville）are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild *** this study we have detected a novel virus,tentatively designated the Bandicoot papillomatosis carcinomatosis virus type 1（BPCV1）,in lesional tissue from affected western barred bandicoots using multiply

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World Journal of Gastroenterology 2022年第17期28卷 1725-1750页

作者： Sema Oncel marc D Basson Department of Biomedical Sciences University of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States Department of Surgery University of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States Department of Pathology University of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States

The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective *** persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury *** upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular ***,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel *** available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal *** recent studies have focused on improving mucosal defense or directly promoting mucosal *** investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction ***,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion *** article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets.

关键词： Intestine Mucosa Repair Restitution Sheet migration Stomach ulcer

Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome

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World Journal of Gastroenterology 2022年第7期28卷 732-744页

作者： Jean-marc Sabaté Franck Iglicki Department of Gastroenterology Hôpital AvicenneAP-HPSorbonne Paris NordBobigny 93000France INSERM U-987 Pathophysiology and Clinical Pharmacology of PainAmbroise ParéHospitalBoulogne-Billancourt 92100France allée Léon Gambetta Clichy 92110France

BACKGROUND Bifidobacterium longum 35624 has shown efficacy in improving irritable bowel syndrome(IBS)symptoms compared with placebo in double-blind randomized ***,few data are available from real-life clinical practice or from studies that used Rome IV criteria to diagnose *** To assess the effect of *** 35624 on IBS severity and quality of life in a reallife *** From November 2018 to January 2020,278 patients with IBS(according to Rome IV criteria)were enrolled in a prospective,open-label,multicenter observational study by private practice gastroenterologists to received one capsule of *** 35624(10^(9) colony-forming units)per day for 30 *** in the study was independently proposed to patients during spontaneous *** severity(assessed by the IBS severity scoring system)and patient quality of life(assessed by the IBS quality of life questionnaire)were compared between the inclusion visit(baseline)and the visit at the end of 30 d of *** characteristics of patients were described at *** variables comparisons between inclusion and end-of-treatment visits were performed using the t-test and Kruskal-Wallis *** variables comparisons were performed using theχ^(2) *** total of 233 patients,with a mean age of 51.4 years and composed of 71.2%women,were included in the *** these patients,48.1%had moderate IBS and 46.4%had severe *** a 30-d treatment period with one *** 35624 capsule per day,a significant decrease in IBS severity was observed compared to baseline(mean±SD,IBS severity scoring system scores:208±104 vs 303±81,P<0.001)and 57%of patients moved to lower severity categories or achieved *** quality of life of patients was also improved by the treatment(IBS Quality of Life questionnaire score:68.8±20.9 vs 60.2±20.5;P<0.001)and 63.8%of patients were satisfied with the *** Thirty days of treatment with *** 35624

关键词： Irritable bowel syndrome Probiotics Bifidobacterium longum Quality of life Severity of illness index Abdominal pain

Therapeutic anticoagulation for splanchnic vein thrombosis in acute pancreatitis: A national survey and case-vignette study

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World Journal of Gastroenterology 2023年第21期29卷 3328-3340页

作者： Noor J Sissingh Jesse V Groen Hester C Timmerhuis marc G Besselink Bas Boekestijn Thomas L Bollen Bert A Bonsing Frederikus A Klok Hjalmar C van Santvoort Robert C Verdonk Casper H J van Eijck Jeanin E van Hooft Jan Sven D Mieog Department of Gastroenterology and Hepatology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Research and Development St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Amsterdam UMCLocation University of AmsterdamAmsterdam 1081 HZNetherlands Amsterdam Gastroenterology Endocrinology Metabolism Amsterdam 1105 AZNetherlands Department of Radiology Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Radiology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Medicine-Thrombosis and Hemostasis Leiden University Medical CentreLeiden 2333 ZANetherlands Department of Surgery University Medical Centre UtrechtUtrechtUtrecht 3584 CXNetherlands Department of Gastroenterology and Hepatology St.Antonius HospitalNieuwegein 3420 EMNetherlands Department of Surgery Erasmus Medical CentreRotterdam 3015 GDNetherlands

BACKGROUND Splanchnic vein thrombosis(SVT)is a major complication of moderate and severe acute *** is no consensus on whether therapeutic anticoagulation should be started in patients with acute pancreatitis and *** To gain insight into current opinions and clinical decision making of pancreatologists regarding SVT in acute *** A total of 139 pancreatologists of the Dutch Pancreatitis Study Group and Dutch Pancreatic Cancer Group were approached to complete an online survey and case vignette *** threshold to assume group agreement was set at 75%.RESULTS The response rate was 67%(n=93).Seventy-one pancreatologists(77%)regularly prescribed therapeutic anticoagulation in case of SVT,and 12 pancreatologists(13%)for narrowing of splanchnic vein *** most common reason to treat SVT was to avoid complications(87%).Acute thrombosis was the most important factor to prescribe therapeutic anticoagulation(90%).Portal vein thrombosis was chosen as the most preferred location to initiate therapeutic anticoagulation(76%)and splenic vein thrombosis as the least preferred location(86%).The preferred initial agent was low molecular weight heparin(LMWH;87%).In the case vignettes,therapeutic anticoagulation was prescribed for acute portal vein thrombosis,with or without suspected infected necrosis(82%and 90%),and thrombus progression(88%).Agreement was lacking regarding the selection and duration of long-term anticoagulation,the indication for thrombophilia testing and upper endoscopy,and about whether risk of bleeding is a major barrier for therapeutic *** In this national survey,the pancreatologists seemed to agree on the use of therapeutic anticoagulation,using LMWH in the acute phase,for acute portal thrombosis and in the case of thrombus progression,irrespective of the presence of infected necrosis.

关键词： Acute pancreatitis Splanchnic vein thrombosis Therapeutic anticoagulation Bleeding Recanalization Outcomes