Gut homeostasis, injury, and healing: New therapeutic targets
作者机构：Department of Biomedical SciencesUniversity of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States Department of SurgeryUniversity of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States Department of PathologyUniversity of North Dakota School of Medicine and Health SciencesGrand ForksND 58202United States
出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)
年 卷 期：2022年第28卷第17期
页 面：1725-1750页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
主 题：Intestine Mucosa Repair Restitution Sheet migration Stomach ulcer
摘 要：The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis,which depends upon the balance between mucosal injury by destructive factors and healing via protective *** persistence of noxious agents such as acid,pepsin,nonsteroidal anti-inflammatory drugs,or Helicobacter pylori breaks down the mucosal barrier and injury *** upon the size and site of the wound,it is healed by complex and overlapping processes involving membrane resealing,cell spreading,purse-string contraction,restitution,differentiation,angiogenesis,and vasculogenesis,each modulated by extracellular ***,the gut does not always heal,leading to such pathology as peptic ulcers or inflammatory bowel *** available therapeutics such as proton pump inhibitors,histamine-2 receptor antagonists,sucralfate,5-aminosalicylate,antibiotics,corticosteroids,and immunosuppressants all attempt to minimize or reduce injury to the gastrointestinal *** recent studies have focused on improving mucosal defense or directly promoting mucosal *** investigations have sought to enhance mucosal defense by stimulating mucus secretion,mucosal blood flow,or tight junction ***,new attempts to directly promote mucosal repair target proteins that modulate cytoskeleton dynamics such as tubulin,talin,Ehm^(2),filamin-a,gelsolin,and flightless I or that proteins regulate focal adhesions dynamics such as focal adhesion *** article summarizes the pathobiology of gastrointestinal mucosal healing and reviews potential new therapeutic targets.
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