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Patient with unresectable colorectal liver metastases and asymptomatic primary tumor:end of the debate!

Hepatobiliary Surgery and Nutrition 2022年第3期11卷 412-414页

作者： marc-antoine allard RenéAdam Centre Hépato-Biliaire Hôpital Paul BrousseAPHPVillejuifFrance Équipe Chronothérapie Cancers et TransplantationUniversitéParisSaclayFrance

In patients with definitively unresectable colorectal liver metastases,whether the primary tumor should be resected prior to chemotherapy is an old *** retrospective studies(1-5)and a meta-analysis with individual data(6)had suggested that primary resection of the primary tumor followed by chemotherapy was associated with better survival than the chemotherapy-first *** prevention of complications related to the primary tumor(occlusion,perforation,bleeding)as well as a better response to chemotherapy were usual justifications to explain the superiority of primary tumor ***,the absence of any randomized study made it difficult to conclude on this question due to the numerous selection biases related to these retrospective analyses.

关键词： chemotherapy colorectal prevention

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Systolic and Diastolic Strain Measurements Show Left Ventricular Dysfunction in Women with Turner Syndrome

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Congenital Heart Disease 2021年第4期16卷 357-368页

作者： allard T.van den Hoven Sultan Yilmazer Lidia R.Bons Roderick W.Jvan Grootel L.W.Geenen An M.van Berendoncks Anthonie L.Duijnhouwer Hans-marc J.Siebelink Jolien W.Roos-Hesselink Annemien E.van den Bosch Department of Congenital Cardiology Erasmus MCRotterdamNetherlands Department of Cardiology Radboud University Medical CenterNijmegenNetherlands Department of Cardiology Leiden University Medical CenterRotterdamNetherlands

Aim:This study aimed to describe the systolic left ventricular global longitudinal strain(LvGLS)and left ventricular peak early diastolic strain rate(Sre)in adult women with Turner syndrome(TS)and to determine its relationship with exercise capacity and clinical ***:In this cross-sectional cohort study,consecutively included adult TS women underwent an electrocardiogram,transthoracic echocardiogram(TTE)and cardiopulmonary exercise test(CPET)on the same *** and Sre were measured using 2D speckle tracking analysis(STE)and compared with age-matched healthy female ***:Ninety-four adult women(age 36±13 years)with TS and 32 healthy age-matched female controls were *** with TS had a significantly impaired/reduced systolic LvGLS(–17.82±2.98%vs.–21.80±1.85%,p0.001),compared to healthy female ***,TS women had reduced diastolic function as measured by conventional echocardiographic parameters:A higher A-wave(p<0.001),lower E/A-ratio(p=0.001),longer deceleration time(p=0.006),and a higher E/E’-ratio(p<0.001).Women with TS also had a significantly reduced maximal workload(p=0.033),reduced oxygen uptake(p<0.001)and a reduced maximal heart rate(p<0.001)during *** linear regression analysis revealed that Age,karyotype and QT-duration were significantly associated with Sre,but not with LvGLS,in the TS ***:Systolic and diastolic strain and exercise capacity were significantly reduced in TS women compared to healthy *** correlation between strain itself and exercise capacity could be demonstrated,but correlations with conventional TTE parameters and baseline characteristics were found.

关键词： Turnersyndrome speckletracking echocardiography strain exercise capacity

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Primary Prevention of Cardiovascular Disease

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Cardiovascular Innovations and Applications 2016年第B9期1卷 379-389页

作者： Danny J.Eapen William M.Schultz Robert E.Heinl Nima Ghasemzadeh Tina Varghese Diana E.Kurian Christina E.Mathai Pratik Sandesara Bryan R.Kindya marc P.allard-Ratick Neal K.Bhatia Ijeoma Isiadinso Laurence Sperling Department of Medicine Emory UniversityAtlantaGAUSA Department of Pharmacy Houston Methodist HospitalHoustonTXUSA Department of Medicine University of South FloridaTampaFLUSA

Cardiovascular disease(CVD)is the leading cause of death *** article focuses on current guidelines for the primary prevention of CVD and addresses management of key risk *** modifi cation,weight loss,exercise,and tobacco use cessation are specifi c areas where focused efforts can successfully reduce CVD risk on both an individual and a societal *** c areas requiring management include dyslipidemia,hypertension,physical activity,diabetes,aspirin use,and alcohol *** preventive efforts have major public health *** the global population continues to grow,health care expenditures will also rise,with the potential to eventually overwhelm the health care *** it is imperative to apply our collective efforts on CVD prevention to improve the cardiovascular health of individuals,communities,and nations.

关键词： cardiovascular disease primary prevention tobacco diabetes dyslipidemia aspirin alcohol exercise

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