Patient with unresectable colorectal liver metastases and asymptomatic primary tumor:end of the debate!

作     者：Marc-Antoine Allard RenéAdam 

作者机构：Centre Hépato-BiliaireHôpital Paul BrousseAPHPVillejuifFrance Équipe ChronothérapieCancers et TransplantationUniversitéParisSaclayFrance 

出 版 物：《Hepatobiliary Surgery and Nutrition》 (肝胆外科与营养（英文）)

年 卷 期：2022年第11卷第3期

页      面：412-414页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：chemotherapy colorectal prevention 

摘      要：In patients with definitively unresectable colorectal liver metastases,whether the primary tumor should be resected prior to chemotherapy is an old *** retrospective studies(1-5)and a meta-analysis with individual data(6)had suggested that primary resection of the primary tumor followed by chemotherapy was associated with better survival than the chemotherapy-first *** prevention of complications related to the primary tumor(occlusion,perforation,bleeding)as well as a better response to chemotherapy were usual justifications to explain the superiority of primary tumor ***,the absence of any randomized study made it difficult to conclude on this question due to the numerous selection biases related to these retrospective analyses.