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Molecular identification of hepatitis B virus genotypes/subgenotypes:Revised classification hurdles and updated resolutions

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World Journal of Gastroenterology 2014年第23期20卷 7152-7168页

作者： Mahmoud Reza Pourkarim Samad Amini-Bavil-Olyaee Fuat Kurbanov marc van ranst Frank Tacke Department of Microbiology and Immunology Laboratory of Clinical and Epidemiological VirologyRega Institute for Medical ResearchKU Leuven3012 LeuvenBelgium Blood Transfusion Research Center High Institute for Research and Education in Transfusion MedicineTehran 15614Iran Department of Molecular Microbiology and Immunology Keck School of MedicineUniversity of Southern CaliforniaHarlyne J.Norris Cancer Research TowerLos AngelesCA 90033United States Division of Infectious Diseases Johns Hopkins School of MedicineBaltimoreMD 21205United States Department of Medicine Ⅲ RWTH University Hospital Aachen52074 AachenGermany

The clinical course of infections with the hepatitis B virus (HBV) substantially varies between individuals, as a consequence of a complex interplay between viral, host, environmental and other factors. Due to the high genetic variability of HBV, the virus can be categorized into different HBV genotypes and subgenotypes, which considerably differ with respect to geographical distribution, transmission routes, disease progression, responses to antiviral therapy or vaccination, and clinical outcome measures such as cirrhosis or hepatocellular carcinoma. However, HBV (sub)genotyping has caused some controversies in the past due to misclassifications and incorrect interpretations of different genotyping methods. Thus, an accurate, holistic and dynamic classification system is essential. In this review article, we aimed at highlighting potential pitfalls in genetic and phylogenetic analyses of HBV and suggest novel terms for HBV classification. Analyzing full-length genome sequences when classifying genotypes and subgenotypes is the foremost prerequisite of this classification system. Careful attention must be paid to all aspects of phylogenetic analysis, such as bootstrapping values and meeting the necessary thresholds for (sub)genotyping. Quasi-subgenotype refers to subgenotypes that were incorrectly suggested to be novel. As many of these strains were misclassified due to genetic differences resulting from recombination, we propose the term “recombino-subgenotype”. Moreover, immigration is an important confounding facet of global HBV distribution and substantially changes the geographic pattern of HBV (sub)genotypes. We therefore suggest the term “immigro-subgenotype” to distinguish exotic (sub)genotypes from native ones. We are strongly convinced that applying these two proposed terms in HBV classification will help harmonize this rapidly progressing field and allow for improved prophylaxis, diagnosis and treatment.

关键词： Hepatitis B virus Hepatitis Classification Genotype Subgenotype Phylogenetic tree

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Early prediction of major depression in chronic hepatitis C patients during peg-interferon α-2b treatment by assessment of vegetative-depressive symptoms after four weeks

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World Journal of Gastroenterology 2007年第43期13卷 5736-5740页

作者： Geert Robaeys Jozef De Bie Marieke C Wichers Liesbeth Bruckers Frederik Nevens Peter Michielsen marc van ranst Frank Buntinx Department of Gastroenterology and Hepatology Ziekenhuis Oost Limburg Genk Belgium Department of Psychiatry Ziekenhuis Oost Limburg Genk Belgium Department of Psychiatry and Neuro-psychiatry South Limburg Mental Health Research and Teaching Network EURON Maastricht University Maastricht The Netherlands Center for Statistics Limburgs Universitair Centrum Diepenbeek Belgium Department of Hepatology Katholieke Universiteit Leuven Leuven Belgium Division of Gastroenterology and Hepatology University Hospital Antwerp Belgium Laboratory of Clinical and Epidemiological Virology Department of Microbiology and Immunology Rega Institute and University Hospitals Katholieke Universiteit Leuven Leuven Belgium Department of General Practice Katholieke Universiteit Leuven Leuven Belgium and Department of General Practice Maastricht University The Netherlands

AIM: To study the predictive value of the vegetative- depressive symptoms of the Zung Depression Rating Scale for the occurrence of depression during treatment with peg-interferon α-2b of chronic hepatitis C (CHC) patients. METHODS: The predictive value of vegetative- depressive symptoms at 4 wk of treatment for the occurrence of a subsequent diagnosis of major depressive disorder (MDD) was studied in CHC patients infected after substance use in a prospective, multi- center treatment trial in Belgium. The presence of vegetative-depressive symptoms was assessed using the Zung Scale before and 4 wk after the start of antiviral treatment. RESULTS: Out of 49 eligible patients, 19 (39%) developed MDD. The area under the ROC curve of the vegetative Zung subscale was 0.73, P = 0.004. The sensitivity at a cut-point of > 15/35 was 95% (95% CI: 74-100). The positive predictive value equalled 44% (95% CI: 29-60). CONCLUSION: In this group of Belgian CHC patients infected after substance use, antiviral treatment caused a considerable risk of depression. Seven vegetativedepressive symptoms of the Zung scale at wk 4 of treatment predicted 95% of all emerging depressions, at a price of 56% false positive test results.

关键词： Interferons Hepatitis C Chronic Substance-related disorders Depression Zung self rating scale Prognosis

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An extremely rare case of delusional parasitosis in a chronic hepatitis C patient during pegylated interferon alpha-2b and ribavirin treatment

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World Journal of Gastroenterology 2007年第16期13卷 2379-2380页

作者： Geert Robaeys Jozef De Bie marc van ranst Frank Buntinx Department of Gastroenterology and Hepatology Ziekenhuis Oost Limburg Genk Belgium Department of Psychiatry Ziekenhuis Oost Limburg Genk Belgium Laboratory of Clinical and Epidemiological Virology Department of Microbiology and Immunology Rega Institute and University Hospitals Katholieke Universiteit Leuven Leuven Belgium Department of General Practice Katholieke Universiteit Leuven Leuven Belgium and Department of General Practice Maastricht University The Netherlands

During treatment of chronic hepatitis C patients with interferon and ribavirin, a lot of side effects are described. Twenty-three percent to 44% of patients develop depression. A minority of patients evolve to psychosis. To the best of our knowledge, no cases of psychogenic parasitosis occurring during interferon therapy have been described in the literature. We present a 49-year-old woman who developed a delusional parasitosis during treatment with pegylated interferon alpha-2b weekly and ribavirin. She complained of seeing parasites and the larvae of fleas in her stools. This could not be confirmed by any technical examination. All the complaints disappeared after stopping pegylated interferon alpha-2b and reappeared after restarting it. She had a complete sustained viral response.

关键词： Interferons Ribavirin Hepatitis C Chronic Parasitology Delusions

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A Novel Virus Detected In Papillomatous And Carcinomatous Lesions Of The Endangered Western Barred Bandicoot （Perameles Bougainville） Exhibits Genomic Features Of Both The Papillomaviridae And Polyomaviridae

A Novel Virus Detected In Papillomatous And Carcinomatous Le...

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24th International Papillomavirus Conference and Clinical Workshop

作者： Lucy Woolford Annabel Rector marc van ranst Andrea Ducki Mark D Bennett Philip K Nicholls Kristin S Warren Ralph A Swan Graham E Wilcox Amanda J O’Hara Murdoch University Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium Laboratory of Clinical and Epidemiological Virology Department of Microbiology and ImmunologyRega Institute for Medical Research.University of LeuvenBelgium School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia School of Veterinary and Biomedical Sciences Murdoch UniversityPerthWestern Australia

＜正＞Conservation efforts to prevent the extinction of the endangered western barred bandicoot（Perameles bougainville）are currently hindered by a progressively debilitating cutaneous and mucocutaneous papillomatosis and carcinomatosis syndrome observed in captive and wild *** this study we have detected a novel virus,tentatively designated the Bandicoot papillomatosis carcinomatosis virus type 1（BPCV1）,in lesional tissue from affected western barred bandicoots using multiply

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Computational modelling of gas–liquid–solid multiphase free surface flow with and without evaporation

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Particuology 2024年第7期90卷 218-235页

作者： Huihuang Xia marc Kamlah Institute for Applied Materials(IAM) Karlsruhe Institute of Technology(KIT)Hermann-von Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Gas–liquid–solid multiphase systems are ubiquitous in engineering applications,*** printing,spray drying and *** a numerical framework for modelling these multiphase systems is of great *** improved,resolved computational fluid dynamics-discrete element method(CFD-DEM)framework is developed to model the multiphase free surface flow with and without *** improved capillary force model is developed to compute the capillary interactions for partially floating particles at a free *** well-known benchmark cases,namely drag coefficient calculation,the single sphere settling,and drafting-kissing-tumbling of two particles are conducted to validate the resolved CFD-DEM *** turns out that the resolved CFD-DEM model developed in this paper can accurately calculate the fluid–solid interactions and predict the trajectory of solid particles interacting with the liquid *** demonstrations,namely two particles moving along a free surface when the liquid phase evaporates,and particle transport and accumulations inside an evaporating sessile droplet show the performance of the resolved model.

关键词： Capillary force Discrete element method Liquid bridge Particle transport Resolved CFD-DEM Volume of fluid

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Bound and Resonating Multiquark Configurations

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Chinese Physics Letters 2024年第8期41卷 8-12页

作者： Jean-marc Richard Institut de Physique des 2 Infinis de Lyon Université Claude Bernard(Lyon 1) CNRS-IN2P34 rue Enrico Fermi69622 VilleurbanneFrance

We review the predictions of quark models for multiquark configurations that are bound or resonant states,and compare different methods for estimating the properties of resonances.

关键词： quark Configuration resonant

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CURDIS:A template for incremental curve discretization algorithms and its application to conics

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虚拟现实与智能硬件（中英文） 2024年第5期6卷 358-382页

作者： Philippe LATOUR marc van DROOGENBROECK Montefiore Institute University of LiègeQuartier Polytech 1Allée de la découverte 104000 LiègeBelgium

We introduce CURDIS,a template for algorithms to discretize arcs of regular curves by incrementally producing a list of support pixels covering the *** this template,algorithms proceed by finding the tangent quadrant at each point of the arc and determining which side the curve exits the pixel according to a tailored *** two elements can be adapted for any type of curve,leading to algorithms dedicated to the shape of specific *** the calculation of the tangent quadrant for various curves,such as lines,conics,or cubics,is simple,it is more complex to analyze how pixels are traversed by the *** the case of conic arcs,we found a criterion for determining the pixel exit *** leads us to present a new algorithm,called CURDIS-C,specific to the discretization of conics,for which we provide all the ***,the criterion for conics requires between one and three sign tests and four additions per pixel,making the algorithm efficient for resource-constrained systems and feasible for fixed-point or integer arithmetic *** algorithm also perfectly handles the pathological cases in which the conic intersects a pixel twice or changes quadrants multiple times within this pixel,achieving this generality at the cost of potentially computing up to two square roots per *** illustrate the use of CURDIS for the discretization of different curves,such as ellipses,hyperbolas,and parabolas,even when they degenerate into lines or corners.

关键词： Computer graphics Curve discretization Conics Rasterization Ellipse drawing Conic spline Conic pencil

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Sperm function, mitochondrial activity and in vivo fertility are associated to their mitochondrial DNA content in pigs

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1550-1558页

作者： marc Llavanera Yentel Mateo‑Otero Estel Vinolas‑Vergés Sergi Bonet marc Yeste Unit of Cell Biology Department of BiologyFaculty of SciencesUniversity of GironaGirona ES‑17003Spain Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaGirona ES‑17003Spain Catalan Institution for Research and Advanced Studies(ICREA) Barcelona ES‑08010Spain

Background Despite their low abundance in sperm, mitochondria have diverse functions in this cell type, includ-ing energy production, signalling and calcium regulation. In humans, sperm mitochondrial DNA content(mtDNAc) has been reported to be negatively linked to sperm function and fertility. Yet, the association between mtDNAc and sperm function in livestock remains unexplored. For this reason, this study aimed to shed some light on the link between mtDNAc and sperm function and fertilising potential in pigs. A qPCR method for mtDNAc quantification was optimised for pig sperm, and the association of this parameter with sperm motility, kinematics, mitochondrial activity, and fertility was subsequently *** First, the q PCR method was found to be sensitive and efficient for mtDNAc quantification in pig sperm. By using this technique, mtDNAc was observed to be associated to sperm motility, mitochondrial activity and in vivo, but not in vitro, fertility outcomes. Specifically, sperm with low mtDNAc were seen to exhibit greater motility but decreased mitochondrial activity and intracellular reactive oxygen species. Interestingly, samples with lower mtD-NAc showed higher conception and farrowing rates, but similar in vitro fertilisation rates and embryo development, when compared to those with greater *** These findings enrich our comprehension of the association of mtDNAc with sperm biology, and lay the foundation for future research into employing this parameter as a molecular predictor for sperm function and fer-tility in livestock.

关键词： Fertility Mitochondria Motility mtDNA copy number qPCR Sperm

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The germline genetics of mild-to-moderate penetrance:An intriguing role of PRAME in multiple carcinogenesis

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Genes & Diseases 2024年第3期11卷 7-10页

作者： Diaddin Hamdan van Tai Nguyen Justine Paris Christophe Leboeuf Morad El Bouchtaoui marc Espie Anne Janin Geraldine Falgarone Melanie Di Benedetto Guithem Bousquet Universite de Paris Cite INSERMUMR_S942MASCOTParis F-75006France Hopital La Porte Verte Versailles F-78004France National Cancer Hospital Cancer Research and Clinical Trials CenterHaNoi100000VietNam AP-HP-Hopital Saint Louis Centre de Maladies du SeinParisF-75010France Universite Sorbonne Paris Nord Bobigny F-93000France AP-HP-Hopital Avicenne Unite de Medecine AmbulatoireBobigny F-93000France

Germline genetics of high penetrance such as BRCA genes,mutations might be sufficient for carcinogenesis,but this only explains fewer than 10%of *** assume that most cancers are the result of germline mutations of low to moderate penetrance,combined with acquired mutations due to external carcinogenic *** their accumulation over time,aging is associated with an increased risk of multiple cancer development in a given *** decades,germline genetics have been based on familial linkage studies enabling most high-penetrance genes to be *** recently,population-wide studies have led to the identification of considerable numbers of polymorphisms associated with cancer ***,most of them are of unknown functional value,thus limiting their translational application.

关键词： carcinogenesis BRCA linkage

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Piezoelectric resonant ice protection systems–Part1/2:Prediction of power requirement for de-icing a NACA 0024 leading edge

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Chinese Journal of Aeronautics 2024年第3期37卷 92-103页

作者： Valerian PALANQUE Jason POTHIN Vale′rie POMMIER-BUDINGER marc BUDINGER Institut Clement Ader University of ToulouseINSAISAE-SUPAEROMINES ALBIUPSCNRSToulouse 31055France ISAE-SUPAERO University of Toulouse10 Avenue Edouard BelinToulouse 31055France

This paper proposes a numerical method to analyze the ice protection capability and predict the power requirements of a piezoelectric resonant de-icing *** method is based on a coupled electro-mechanical finite element analysis which enables the fast computation of the modes of resonance of interest to de-ice curved surfaces and the estimation of the input voltage and current required for a given configuration(defined by its mode,actuator location,ice deposit,etc.).Eventually,the electric power to be supplied can be also *** method is applied to a NACA 0024 leading edge equipped with piezoelectric ***,two extension modes are analyzed and compared with respect to their efficiency and power ***,tests are carried out in an icing tunnel to verify the effectiveness of the piezoelectric ice protection system and the predictions of the maximal required *** system allows de-icing the leading edge in less than 2 s for a glaze ice deposit.

关键词： Ice protection system Piezoelectric Resonance mode Ice fracture Leading edge de-icing

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