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Acute propranolol infusion stimulates protein synthesis in rabbit skin wound

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Acute propranolol infusion stimulates protein synthesis in r...

第八届西南五省一市烧伤整形学术会议暨贵州省医学会烧伤整形分会2010年学术年会

作者： David L.Chinkes Celeste C.Finnerty Asle Aarsland marc g.jeschke David N.Herndon galveston Texas Shriners Hospital for Children University of Texas Medical Branch Departments of Surgery University of Texas Medical Branch Anesthesiology University of Texas Medical Branch

*** administration has been demonstrated to improve cardiac work,reduce energy expenditure and attenuate lipolysis in burned ***,its effect on wound healing has not been ***.A partial thickness skin donor site wound was created on the back and catheters were placed in the carotid artery and jugular vein in rabbits under general anesthesia.A nasogastric feeding tube was placed for enteral *** day 5 after injury stable isotope tracers were infused to determine protein and DNA kinetics in the *** hydrochloride(Baxter Healthcare Corporation,Deerfield,Ill) was injected in one group during the tracer infusion to reduce heart rate,and the other group without propranolol injection served as a *** propranolol infusion reduced heart rate by 21%.Protein fractional synthetic rate in the wound was 8.6±0.9%/day in the propranolol group,greater(pgnificantly *** rate of protein deposition(synthesis - breakdown) tended to increase in the propranolol group(5.0±1.2 vs.2.8±0.7%/day,p =.07 ***).Wound DNA fractional synthetic rates were *** protein fractional synthetic rate was correlated with%decrease in heart rate but expression of theβ-adrenergic receptors and down-stream signaling cascades in local wounds were not affected following propranolol treatment. *** infusion increased wound protein synthetic rate and tended to increase wound protein deposition rate,which might be beneficial to wound *** changes might reflect a systemic response to theβ-adrenergic blockade.

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《SHOCK》2018年第3期新观点

实用休克杂志（中英文） 2018年第2期2卷 115-117页

作者： Mile Stanojcic marc g.jeschke 朱浙祥湖南省人民医院急诊科

我很荣幸能被邀请就当前的休克问题写一篇文章，本刊出版物较为独特，它使休克成为一个大问题且具有阅读乐趣的广泛话题。所以，坐下来，放一些好的音乐，喝一杯你选择的饮料，找些时间和灵感，享受文章。

关键词：期刊编辑工作发行工作《SHOCK》

Low-protein diet accelerates wound healing in mice post-acute injury

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Burns & Trauma 2021年第1期9卷 339-350页

作者： Jonathan J.Hew Roxanne J.Parungao Craig P.Mooney Julian K.Smyth Sarah Kim Kevin H.-Y.Tsai Huaikai Shi Cassandra Chong Renee C.F.Chan Beba Attia Caroline Nicholls Zhe Li Samantha M.Solon-Biet David g.Le Couteur Stephen J.Simpson marc g.jeschke Peter K.Maitz Yiwei Wang Burns Research and Reconstructive Surgery ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Bone Biology group ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Adrenal Steroids Laboratory ANZAC Research InstituteConcord HospitalUniversity of SydneySydneyAustralia 2139 Electron Microscopy Unit Anatomical PathologyConcord HospitalSydneyAustralia 2139 Burns Unit Concord Repatriation General HospitalConcordAustralia 2139 Ageing and Alzheimer Institute and ANZAC Research Institute Concord HospitalUniversity of SydneySydneyAustralia 2139 Charles Perkins Centre and School of Life and Environmental Sciences University of SydneyAustralia 2006 Sunnybrook Research Institute TorontoOntarioCanadaM4N 3M5 School of Pharmacy Nanjing University of Chinese MedicineNanjingPR China 210023

Background:Wound healing processes are influenced by macronutrient intake(protein,carbohydrate and fat).The most favourable diet for cutaneous wound healing is not known,although highprotein diets are currently favoured *** experimental study investigates the optimal macronutrient balance for cutaneous wound healing using a mouse model and the geometric Framework,a nutrient modelling method,capable of analyzing the individual and interactive effects of a wide spectrum of macronutrient ***:Two adjacent and identical full-thickness skin excisions(1 cm^(2))were surgically created on the dorsal area of male C57BL/6 *** were then allocated to one of 12 high-energy diets that varied in protein,carbohydrate and fat *** select diets,wound healing processes,cytokine expression,energy expenditure,body composition,muscle and fat reserves were ***:Using the geometric Framework,we show that a low-protein intake,coupled with a balanced intake of carbohydrate and fat is optimal for wound *** fed a low-protein diet progressed quickly through wound healing stages with favourable wound inflammatory cytokine expression and significantly accelerated collagen *** local processes were associated with an increased early systemic inflammatory response and a higher overall energy expenditure,related to metabolic changes occurring in key macronutrient reserves in lean body mass and fat ***:The results suggest that a low-protein diet may have a greater potential to accelerate wound healing than the current clinically used high-protein diets.

关键词： Wound healing Macronutrients Cutaneous geometric Framework Mouse model Low-protein diet Nutrition

Stepping up after spinal cord injury:negotiating an obstacle during walking

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Neural Regeneration Research 2025年第7期20卷 1919-1929页

作者： Alain Frigon Charly g.Lecomte Department of Pharmacology-Physiology Faculty of Medicine and Health SciencesUniversitéde SherbrookeCentre de recherche du Centre Hospitalier Universitaire de SherbrookeSherbrookeQCCanada

Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate *** spinal cord injury,stepping over an obstacle becomes *** over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor *** information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain *** spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an ***,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关键词： biomechanics locomotion neurophysiology obstacle negotiation spinal cord injury

Remote sensing-based estimation of rice yields using various models:A critical review

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geo-Spatial Information Science 2021年第4期24卷 580-603页

作者： Daniel marc g dela Torre Jay gao Cate Macinnis-Ng School of Environment University of AucklandAucklandNew Zealand School of Biological Sciences University of AucklandAucklandNew Zealand

Reliable estimation of region-wide rice yield is vital for food security and agricultural ***-scale models have increased our understanding of rice yield and its estimation under theoretical environmental ***,they offer little infor-mation on spatial variability effects on farm-scale *** Sensing(RS)is a useful tool to upscale yield estimates from farm scales to regional *** research used RS with rice models for reliable yield *** several countries start to operatio-nalize rice monitoring systems,it is needed to synthesize current literature to identify knowledge gaps,to improve estimation accuracies,and to optimize *** paper critically reviewed significant developments in using geospatial methods,imagery,and quantitative models to estimate rice ***,essential characteristics of rice were discussed as detected by optical and radar sensors,band selection,sensor configuration,spatial resolution,mapping methods,and biophysical variables of rice derivable from RS ***,various empirical,process-based,and semi-empirical models that used RS data for spatial estimation of yield were critically assessed-discussing how major types of models,RS platforms,data assimilation algorithms,canopy state variables,and RS variables can be integrated for yield ***,to overcome current constraints and to improve accuracies,several possibilities were suggested-adding new modeling modules,using alternative canopy variables,and adopting novel modeling *** rice yields are expected to decrease due to global warming,geospatial rice yield estimation techniques are indispensable tools for climate change *** studies should focus on resolving the current limitations of estimation by precise delineation of rice cultivars,by incorporating dynamic harvesting indices based on climatic drivers,using innovative modeling approaches with machine learning.

关键词： Process-based crop model data assimilation empirical model geospatial applications remote sensing rice yield mapping yield estimation

Bioelectronic medicine in modulation of cortical spreading depolarization and beyond

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Neural Regeneration Research 2025年第2期20卷 481-482页

作者： Khaled Alok Timothy g.White Chunyan Li Department of Neurosurgery Donald and Barbara Zucker School of Medicine at Hofstra/NorthwellHempsteadNYUSA Translational Brain Research Laboratory The Feinstein Institutes for Medical ResearchManhassetNYUSA

Bioelectronic interventions,specifically trigeminal nerve st imulat ion(TNS),have attracted considerable attention in conditions where cortical spreading depolarizations(CSDs)accompanied by compromised cerebral perfusion may exacerbate neurological *** pharmacological interventions have demonstrated initial potential in addressing CSDs,a standardized treatment approach has not yet been *** objective of this perspective is to explore emerging bioelectronic methodologies for addressing CSDs,particularly emphasizing TNS,and to underscore TNS’s capacity to enhance neurovascular coupling and cerebral perfusion.

关键词： cerebral perfusion electronic

Key Milestones in HCV Discovery and Therapeutics

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The Innovation 2020年第3期1卷 54-55页

作者： Xiaoming Cheng marc g.ghany Liver Diseases Branch National Institute of DiabetesDigestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA

This year's Nobel Prize in Physiology or Medicine was awarded to three scientists,each of whom played an integral role in the identification of the hepatitis C virus(HCV)and the characterization of the disease it causes,chronic hepatitis C(CHC).Initially *** Alter,a hematologist at the Clinical Center of the National Institutes of Health in Bethesda,Maryland recognized that there were many cases of post-transfusion hepatitis,unrelated to hepatitis A virus(HAV)or hepatitis B virus(HBV),termed non-A,non-B *** Houghton,a microbiologist working at a small biotechnology company,Chiron in Emeryville,California,identified HCV as the causative agent of non-A,non-B *** discovery of the HCV,*** Rice,at Rockefeller University,New Yorkworked on constructing a replication competent clone of the virus thatwas later used to demonstrate that theHCV alone was indeed the cause of CHC.

关键词： Miles Maryland transfusion

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.g.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

Stand structure and productivity of Populus euphratica along a gradient of groundwater distances at the tarim River(NW china)

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Journal of Plant Ecology 2017年第5期10卷 753-764页

作者： Frank M.Thomas Michael jeschke Ximing Zhang Petra Lang geobotany Faculty of Regional and Environmental SciencesUniversity of TrierBehringstraße 2154296 TrierGermany Xinjiang Institute of Ecology and geography Chinese Academy of Sciences40 South Beijing Road830011 UrumqiChina

Aims Along central-Asian rivers in arid regions,lowering of the ground-water level constitutes a major threat to the riparian forests,whose tree layers are dominated by Euphrates poplar(Populus euphratica).Some of these fragile ecosystems are supplied with additional(‘eco-logical’)water for protection and *** investigated interrelationships among groundwater distance,stand structure and above-ground wood production(at the tree and the stand level)in *** stands along a groundwater gradient(distances of 2.0-12.0 m)that also included a plot supplied with‘ecological water’.Methods We measured the height,diameter at breast height and basal area of poplar trees and determined the annual above-ground wood production for the three most recent years on the basis of tree-ring analyses and allometric regressions at three sites at the upper,mid-dle and lower reaches of the tarim River,Xinjiang,NW *** Findingsthe distribution of age classes differed significantly among the plots:in accordance with their life histories,stands growing at a larger distance to the groundwater harboured a larger fraction of old trees(>80 years)and,in most cases,a smaller fraction of young trees(≤20 years).the annual above-ground wood production per ha was highest on a plot with a short groundwater distance(2.0 m;maxi-mum of the 3-year investigation period:3.0 t ha−1 a−1)and lowest,at a plot with a large distance to the water table(6.6 m;minimum:0.23 t ha^(−1)a^(−1)).However,the plot located close to the groundwater(and to the river)at the middle reaches exhibited a relatively large interannual variation in above-ground wood production,which can be attributed to interannual variations in the river *** the middle and the lower reaches,these interannual variations on plots with the most favourable water supply were even more obvious at the tree *** the fraction of mature trees(60-99 years old),no significant differences in above-ground wood production were

关键词： allometry ground water life history tree-age distribution tugai forest