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Cellular & Molecular Immunology 2021年第8期18卷 2062-2064页

作者： Ernest Adankwah Julia Seyfarth Richard Phillips marc jacobsen Department of General Pediatrics Medical FacultyUniversity Hospital DüsseldorfHeinrich-Heine-UniversityDüsseldorfGermany Department of Medical Diagnostics College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Department of Medicine School of Medicine and DentistryCollege of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana Kumasi Centre for Collaborative Research in Tropical Medicine(KCCR) KumasiGhana

Our previous study published in Cellular&Molecular Immunology(Harling et al.1)described aberrant immunological features in the pathogenesis of ***,we provided evidence supporting an impact chain regarding aberrant high interleukin(IL)-6 and IL-10 cytokine expression and respective receptor signaling affecting T-cell functions in acute *** STAT3 phosphorylation,high expression of its key regulator suppressor of cytokine signaling(SOCS)3 and spontaneous IL-6/IL-10 secretion characterized CD4^(+)T cells from tuberculosis patients.

关键词： tuberculosis cytokine STAT3

Constitutive STAT3 phosphorylation and IL-6/IL-10 co-expression are associated with impaired T-cell function in tuberculosis patients

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Cellular & Molecular Immunology 2019年第3期16卷 275-287页

作者： Kirstin Harling Ernest Adankwah Alptekin Güler Anthony Afum-Adjei Awuah Louis Adu-Amoah Ertan Mayatepek Ellis Owusu-Dabo Norman Nausch marc jacobsen Department of General Pediatrics Neonatologyand Pediatric CardiologyUniversity Children’s HospitalDuesseldorf 40225Germany Kumasi Centre for collaborative Research in Tropical Medicine(KCCR) KumasiGhana School of Public Health College of Health SciencesKwame Nkrumah University of Science and Technology(KNUST)KumasiGhana

T-cells critically contribute to protection against Mycobacterium tuberculosis infection,and impaired T-cell responses can lead to disease ***-inflammatory and immunosuppressive cytokines affect T-cells,and fine-tuned regulation of cytokine signaling via the Jak/STAT signaling pathways is crucial for appropriate T-cell *** STAT3 phosphorylation as a consequence of aberrant cytokine signaling has been described to occur in pathognomonic T-cell responses in inflammatory and autoimmune *** characterized blood samples from tuberculosis patients(n=28)and healthy contacts(n=28)from Ghana for ***-specific T-cell responses,constitutive cytokine production,and SOCS3 and pSTAT3 *** modulation of primary CD4+T-cells was performed to determine the effects of SOCS3 on T-cell functions.T-cells from tuberculosis patients expressed higher levels of IL-10 and IL-6 and lower levels of T helper type(TH)17 cytokines after ***-specific stimulation compared to healthy *** addition,tuberculosis patients had higher IL-10 and IL-6 levels in the supernatants of non-stimulated immune cells and plasma samples compared to healthy ***,aberrant cytokine expression was accompanied by high constitutive pSTAT3 levels and SOCS3 expression in *** analysis identified an IL-6/IL-10 co-expression-based principal component in tuberculosis patients that correlated with high pSTAT3 ***3 contributed to a regulatory component,and tuberculosis patients with high SOCS3 expression showed decreased TH1 cytokine expression and impaired IL-2-induced STAT5 ***3 over-expression in primary CD4+T-cells confirmed the SOCS3 inhibitory function on IL-2-induced STAT5 *** conclude that constitutive pSTAT3 and high SOCS3 expression are influential factors that indicate impaired T-cell functions in tuberculosis patients.

关键词： tuberculosis Interleukin-6 Interleukin-10 STAT3 SOCS3

Exercised blood plasma promotes hippocampal neurogenesis in the Alzheimer's disease rat brain

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Journal of Sport and Health Science 2024年第2期13卷 245-255页

作者： Cecilie Skarstad Norevik Aleksi M.Huuha Ragnhild N.RФsbjФrgen Linda Hildegard Bergersen Kamilla jacobsen Rodrigo Miguel-dos-Santos Liv Ryan Belma Skender Jose Bianco N.Moreira Asgeir Kobro-Flatmoen Menno P.Witter Nathan Scrimgeour Atefe R.Tari Cardiac Exercise Research Group(CERG) Department of Circulation and Medical ImagingNorwegian University of Science and Technology7491TrondheimNorway Department of Neurology and Clinical Neurophysiology St.Olavs University Hospital7030TrondheimNorway Institute of Oral Biology University of Oslo0372OsloNorway Department of Physiology Federal University of SergipeS~ao Cristov~ao49100-000SergipeBrazil Centre of Molecular Inflammation Research Department of Clinical and Molecular MedicineNorwegian University of Science and Technology7491TrondheimNorway Kavli Institute for Systems Neuroscience Centre for Neural Computationand Egil and Pauline Braathen and Fred Kavli Centre for Cortical MicrocircuitsNorwegian University of Science and Technology7030TrondheimNorway K.G.Jebsen Centre for Alzheimer’s Disease Norwegian University of Science and Technology7030TrondheimNorway

Background:Exercise training promotes brain plasticity and is associated with protection against cognitive impairment and Alzheimer’s disease(AD).These beneficial effects may be partly mediated by blood-borne *** we used an in vitro model of AD to investigate effects of blood plasma from exercise-trained donors on neuronal viability,and an in vivo rat model of AD to test whether such plasma impacts cognitive function,amyloid pathology,and ***:Mouse hippocampal neuronal cells were exposed to AD-like stress using amyloid-βand treated with plasma collected from human male donors 3 h after a single bout of high-intensity *** in vivo studies,blood was collected from exercise-trained young male Wistar rats(high-intensity intervals 5 days/week for 6 weeks).Transgenic AD rats(McGill-R-Thyl-APP)were inj ected 5 times/fortnight for 6 weeks at2 months or 5 months of age with either(a)plasma from the exercise-trained rats,(b)plasma from sedentary rats,or(c)*** function,amyloid plaque pathology,and neurogenesis were *** plasma used for the treatment was analyzed for 23 ***:Plasma from exercised donors enhanced cell viability by 44.1%(p=0.032)and reduced atrophy by 50.0%(p<0.001)in amyloid-β-treated *** vivo exercised plasma treatment did not alter cognitive function or amyloid plaque pathology but did increase hippocampal neurogenesis by~3 fold,regardless of pathological stage,when compared to saline-treated *** of 7 cytokines were significantly reduced in exercised plasma compared to sedentary ***:Our proof-of-concept study demonstrates that plasma from exercise-trained donors can protect neuronal cells in culture and promote adult hippocampal neurogenesis in the AD rat *** effect may be partly due to reduced pro-inflammatory signaling molecules in exercised plasma.

关键词： Cytokines High-intensity interval training Inflammation Neurons Plasma transfusion

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梅斯卡尔酒面临可持续发展挑战

商业周刊（中文版） 2024年第4期 56-63页

作者： ROWAN jacobsen RUBEN E.REYES(摄影) 不详

从瓦哈卡市到圣地亚哥马塔特兰的道路婉蜓曲折地穿过瓦哈卡广阔的中央山谷,这是一片干旱的平原,被灌木色的山丘环绕着。当一排排好像巨型绿色海葵的东西密密匝匝地插人棕色的背景色时,你就知道快到地方了。这是龙舌兰,一种带刺的多汁植... 详细信息

从瓦哈卡市到圣地亚哥马塔特兰的道路婉蜓曲折地穿过瓦哈卡广阔的中央山谷,这是一片干旱的平原,被灌木色的山丘环绕着。当一排排好像巨型绿色海葵的东西密密匝匝地插人棕色的背景色时,你就知道快到地方了。这是龙舌兰,一种带刺的多汁植物,可以用来制作特基拉酒和梅斯卡尔酒。龙舌兰是一种神奇的植物,可以在最干旱的环境中生长而无需灌溉,几千年来,它为墨西哥原住民提供食物、纤维和烈酒。

关键词：可持续发展龙舌兰背景色原住民圣地亚哥瓦哈卡墨西哥酒

Gottfried Konecny:The photogrammetric and remote sensing trend setter

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Geo-Spatial Information Science 2021年第1期24卷 13-21,I0004页

作者： Karsten jacobsen Institute of Photogrammetry and Geoinformation Leibniz University HannoverHannoverGermany

There are various publications on the 90th birthday of Gottfried *** involvement in the International Society for Photogrammetry and Remote Sensing(ISPRS)is particularly described by ***,his forward-oriented impulses in research and development at the former Institute for Photogrammetry and Engineering Survey of the(Technical)University of Hannover,today Institute for Photogrammetry and Geoinformation,Leibniz University Hannover,and some of his activities supporting developing and other countries by given shortterm courses are *** Konecny was always one of the first in pushing new *** the analytical plotter AP/C-3,he introduced analytical photogrammetry in *** on his experience with this not really operational version,he induced the company Zeiss to develop the first really operational analytical plotter Planicomp,which resulted in the end of analog photogrammetric devices and their *** the invitation of Gilbert Hobrough,a mainly hardware-based image correlator was developed for the AP/C-3 in Hannover which anticipated many of today’s *** Konecny initiated remote sensing in *** on his proposal with the Metric Camera Flight on Spacelab,the then highest resolution civil stereoscopic space images available were *** limited computer performance at his institute,a digital stereo plotter was developed,using hardware components from the cooperating Swedish company Context Vision,long before digital stereo workstations with increased and affordable computer capacity were ***,in the area of GIS,he too,pushed development in collaboration with companies and *** before the end of his time as head of the institute,and more so after he became emeritus professor,he started a series of educational workshops,particularly in developing countries,but also other countries,to support the development of photogrammetry,remote sensing and *** prom

关键词： initiated gramme hardware

Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： César H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal Claudio Carta Shuxin Zhang Celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald Cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques Alberto Camara Ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort Chris T.Evelo Alasdair J.G.Gray marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons marco Roos Annika jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National Centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain Castor AmsterdamThe Netherlands Department of Bioinformatics-BiGCaT Maastricht UniversityMaastrichtThe Netherlands University Medical Center Groningen University of GroningenGroningenThe Netherlands Maastricht Centre for Systems Biology(MaCSBio) Maastricht UniversityMaastrichtThe Netherlands Department of Computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance Centre for Digital Scholarship Leiden University LibrariesThe Netherlands Center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic Center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

Calcium isotope compositions as a means to trace carbonate recycling

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National Science Review 2022年第6期9卷 8-10页

作者： Shichun Huang Stein B.jacobsen Department of Geoscience University of Nevada Department of Earth and Planetary Sciences Harvard University

Marine carbonates, such as sedimentary carbonates and secondary carbonates formed during marine alteration processes, are returned to the mantle at subduction zones, and their fates regulate the global carbon cycle. S... 详细信息

关键词： Carbonates

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智能,无需大脑?

环球科学 2024年第5期 78-85页

作者：罗恩·雅各布森金烨(译) 不详

一团团微小的细胞能够学习,可以形成记忆,还会做出重大决定——这些都是思考能力的关键部分。但是,它们却没有大脑。没人会欣赏三角涡虫的智识。这种扁形动物长得像个逗号,我们能在全球湖泊和池塘的淤泥中找到它们蠕动的身影。它针尖大... 详细信息

一团团微小的细胞能够学习,可以形成记忆,还会做出重大决定——这些都是思考能力的关键部分。但是,它们却没有大脑。没人会欣赏三角涡虫的智识。这种扁形动物长得像个逗号,我们能在全球湖泊和池塘的淤泥中找到它们蠕动的身影。它针尖大小的头部内有一套类似于大脑的微型结构,两个眼点靠得很近,看上去像傻乎乎的卡通动物。

关键词：三角涡虫扁形动物思考能力大脑记忆

N-cluster correlations in four-and five-dimensional percolation

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Frontiers of physics 2020年第4期15卷 5-16页

作者： Xiao-Jun Tan You-Jin Deng Jesper Lykke jacobsen Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics University of Science and Technology of ChinaHefei 230026China CAS Center for Ercellence and Synergetic Innovation Center in Quantun Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Laboratoire de Physique de I'Ecole Normale Superieure ENSUniversite PSLCNRSSorbonne UniversiteUniversite de ParisParisFrance Sorbnne Universite Eecole Normale SuperieureCNRSLaborutoire de Physique(LPENS)75005 ParisFrance Institut de Physique Theorique Universite Paris SaclayCEACNRS91191 Gif-sur-YvetteFrance

We study N-cluster correlation functions in four-and five-dimensional(4D)and 5D)bond percolation by extensive Monte Carlo *** reformulate the transfer Monte Carlo algorithm for percolation[***.E 72,016126(2005)]using the disjoint-set data structure,and simulate a cylindrical geometry Ld^-1×∞,with the linear size up to L=512 for 4D and 128 for *** determine with 1 high precision all possible N-cluster exponents,for N=2 and 3,and the universal amplitude for a logarithmic correlation *** the symmetric correlator with N=2,we obtain the correlation-length critical exponent as 1/v=1.4610(12)for 4D and 1/v=1.737(2)for 5D,significantly improving over the existing *** for the other exponents and the universal logarithmic amplitude have not been reported before to our *** work demonstrates the validity of logarithmic conformal field theory and adds to the growing knowledge for high-dimensional percolation.

关键词： critical exponents percolation logarithmic conformal field theory Monte Carlo algorithm

High-throughput computational screening for twodimensional magnetic materials based on experimental databases of three-dimensional compounds

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npj Computational Materials 2020年第1期6卷 350-361页

作者： Daniele Torelli Hadeel Moustafa Karsten W.jacobsen Thomas Olsen Computational Atomic-scale Materials Design(CAMD) Department of PhysicsTechnical University of DenmarkDK-2800 Kgs.LyngbyDenmark

We perform a computational screening for two-dimensional(2D)magnetic materials based on experimental bulk compounds present in the Inorganic Crystal Structure Database and Crystallography Open Database.A recently proposed geometric descriptor is used to extract materials that are exfoliable into 2D derivatives and we find 85 ferromagnetic and 61 antiferromagnetic materials for which we obtain magnetic exchange and anisotropy parameters using density functional *** the easy-axis ferromagnetic insulators we calculate the Curie temperature based on a fit to classical Monte Carlo simulations of anisotropic Heisenberg *** find good agreement with the experimentally reported Curie temperatures of known 2D ferromagnets and identify 10 potentially exfoliable 2D ferromagnets that have not been reported *** addition,we find 18 easy-axis antiferromagnetic insulators with several compounds exhibiting very strong exchange coupling and magnetic anisotropy.

关键词： magnetic compounds ferromagnetic