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Effects of Hedera helix *** on the understory early regeneration in an oak temperate forest in Mexico City

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Ecological Processes 2023年第1期12卷 438-449页

作者： Héctor Adrián Jiménez-Hernández Leticia Bonilla-Valencia Yuriana martínez-Orea mara Jessica Zamora-Almazan Francisco Javier Espinosa-García Silvia Castillo-Argüero Facultad de Ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico Instituto de Investigaciones en Ecosistemas y Sustentabilidad Universidad Nacional Autónoma de MéxicoMichoacánMexico

Background Hedera helix *** an invasive weed species introduced in several regions of the world,so it is relevant to study its effects on the plant community and the changes occurring after its *** established invaded(with/without removal of ***)and non-invaded(with/without removal of the understory)plots to compare some community attributes in an oak forest in Mexico City and monitored them every 2 months for 1 year,taking soil samples to compare some edaphic variables between the *** invasive species negatively affect natural regenera-tion,seedlings of native species would be less abundant in plots invaded by *** than in the non-invaded *** invasive species modify the soil microbiota through exudates and often allelochemicals,soil chemical variables would differ between invaded and non-invaded *** The abundance of native species was lower in the invaded plots,but the richness and diversity of species were not statistically *** composition of the two invaded plots was similar to each other and more alike to that of the non-invaded *** species composition of the invaded plots was associated with soil potassium and phosphorus concentrations,whereas that of the non-invaded plots was more associated with soil nitrogen *** Following the removal of ***,several native species were registered,leading to a similar species composition as in the non-invaded plots,suggesting that some vegetation recovery can be expected following *** removal in 1 year.

关键词： Ivy Invasive plant Mechanical control Diversity Species composition

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Activation of Wnt/β-catenin signaling in abdominal aortic aneurysm:A potential therapeutic opportunity?

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Genes & Diseases 2023年第3期10卷 639-642页

作者： Lídia Puertas-Umbert Saray Varona Carme Ballester-Servera Judith Alonso Silvia Aguiló Mar Orriols Ernesto martínez-martínez Antonio Rodríguez-Sinovas Josémartínez-González Cristina Rodríguez Institut de Recerca Hospital de la Santa Creu i Sant Pau(IRHSCSP) Barcelona 08025Spain Instituto de Investigación Biomédica Sant Pau Barcelona 08036Spain CIBER de Enfermedades Cardiovasculares ISCIIIMadrid 28029Spain Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas(IIBB-CSIC) Barcelona 08036Spain Facultad de Medicina Universidad Complutense de MadridInstituto de Investigación Sanitaria Gregorio MarañónMadrid 28040Spain Cardiovascular Diseases Research Group Vall d’Hebron Institut de RecercaVall d’Hebron Hospital UniversitariVall d’Hebron Barcelona Hospital CampusBarcelona 08035Spain

Abdominal aortic aneurysm (AAA) is a common degenerative vascular disease with a prevalence up to 8% in males over 60 years of age.1 This is a complex disorder characterized by permanent and focal dilation of abdominal aorta that exceeds at least 50% of the normal diameter. In these patients, the aortic diameter progressively expands boosted by smoking and aging as major risk factors. Unfortunately, aneurysm growth increases the risk of aortic rupture, a life-threatening emergency that carries a mortality rate of 80%. Despite the increasing effort of the scientific community to identify therapeutic strategies for AAA, there are currently no pharmacological tools that ameliorate aneurysm expansion, while the underlying mechanisms involved in this disease are not completely understood.

关键词： aneurysm aortic therapeutic

Silymarin Attenuates Hepatic and Pancreatic Redox Imbalance Independent of Glycemic Regulation in the Alloxan-induced Diabetic Rat Model

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Biomedical and Environmental Sciences 2020年第9期33卷 690-700页

作者： Miranda Laise mara Oliveira Agostini Livia da Cunha Lima Wanderson Geraldo de Camini fernanda Caetano Costa Daniela Caldeira Programa de Pos-graduagao em Saude e Nutricao Escola de NutricaoUniversidade Federal de Ouro PretoOuro PretoMinas Gerais 35400-000Brazil Escola de Farmacia Universidade Federal de Ouro Preto.Ouro PretoMinas Gerais 35400-000Brazil Laboratorio de Morfopatologia Departamento de Ciencias BioldgicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil Programa de Pos-graduaqao em Ciencias Bioldgicas Nucleo de Pesquisas em Ciencias BiologicasUniversidade Federal de Ouro Preto.Ouro Preto 35400-000Brazil Laboratorio de Bioquimica Metabolica Departamento de Ciencias BiologicasUniversidade Federal de Ouro PretoOuro Preto 35400-000Brazil

Objective To evaluate the efficiency of silymarin(SMN) in modulating metabolic parameters and redox status in rats with type 1 diabetes mellitus(T1 DM).Methods Diabetes was induced by intraperitoneal injection of alloxan. The diabetic rats were administered with SMN at doses of 50 and 100 mg/kg body weight/d for 30 consecutive days. The rats were divided into the following four groups: vehicle control, diabetic(alloxan-treated), DS50(alloxan +50 mg/kg body weight/d of SMN), and DS100(alloxan + 100 mg/kg body weight/d of SMN) groups. The bodyweight and food and water intake were evaluated. After 30 d, the animals were euthanized and the blood was collected for measuring the serum levels of glucose, triacylglycerol(TAG), urea, and creatinine. The liver and pancreas were collected for measuring the activities of superoxide dismutase(SOD) and catalase(CAT), and the levels of carbonylated protein(PC). The pancreas sample was also used for histological *** SMN reduced hepatic(P < 0.001) and pancreatic(P < 0.001) protein damage and creatinine levels(P = 0.0141) in addition to decreasing food(P < 0.001) and water intake(P < 0.001). However,treatment with SMN did not improve beta-cell function or decrease blood glucose levels in diabetic *** SMN improved polyphagia and polydipsia, renal function, and protected the liver and pancreas against protein damage without affecting hyperglycemia in diabetic animals.

关键词： Silymarin Silybum marianum Type 1 diabetes Oxidative stress

A stability-indicating high performance liquid chromatography method to determine apocynin in nanoparticles

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Journal of Pharmaceutical Analysis 2017年第2期7卷 129-133页

作者： Juliana Kovalczuk de Oliveira Débora fernanda Veres Ronik Jociani Ascari Rubiana mara Mainardes Najeh Maissar Khalil Department of Pharmacy Laboratory of Pharmaceutical NanotechnologyUniversidade Estadual do Centro-OesteRua Simeao Camargo Varelade Sá.85040-080 GuarapuavaBrazil Department of Biological Sciences Universidade Tecnológica Federal do ParanáRua Cerejeiras S/N85892-000 Santa HelenaPRBrazil

In this study, we developed and validated a fast, specific, sensitive, precise and stability-indicating high performance liquid chromatography（HPLC） method to determine the drug apocynin in bovine serum albumin（BSA） nanoparticles. Chromatographic analyses were performed on an RP C18 column and using a photodiode array detector at a wavelength of 276 nm. Mobile phase consisted of a mixture of acetonitrile and 1% acetic acid（60：40, v/v）, and it was eluted isocratically at a flow rate of 0.8 mL/min. The retention time of apocynin chromatographic peak was 1.65 min. The method was linear, precise, accurate and specific in the range of 5–100 μg/mL. The intra-and inter-day precisions presented relative standard deviation（RSD） values lower than 2%. The method was robust regarding changes in mobile phase proportion, but not for flow rate. Limits of detection and quantitation were 78 ng/mL and 238 ng/mL, respectively. Apocynin was exposed to acid and alkali hydrolysis, oxidation and visible light. The drug suffered mild degradation under acid and oxidation conditions and great degradation under alkali conditions. Light exposure did not degrade the drug. The method was successfully applied to determine the encapsulation efficiency of apocynin in BSA nanoparticles.

关键词： Apocynin Nanoparticles Bovine serum albumin HPLC

Chemical genetics and drug screening in Drosophila cancer models

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Journal of Genetics and Genomics 2011年第10期38卷 497-504页

作者： mara Gladstone Tin Tin Su Department of Molecular Cellular and Developmental Biology University of Colorado Boulder CO 80309-0347 USA SuviCa Inc. Box 3131 Boulder CO 80307-3131 USA

Drug candidates often fail in preclinical and clinical testing because of reasons of efficacy and/or safety. It would be time- and cost-efficient to have screening models that reduce the rate of such false positive candidates that appear promising at first but fail later. In this regard, it would be particularly useful to have a rapid and inexpensive whole animal model that can pre-select hits from high-throughput screens but before testing in costly rodent assays. Drosophila melanogaster has emerged as a potential whole animal model for drug screening. Of particular interest have been drugs that must act in the context of multi-cellularity such as those for neurological disorders and cancer. A recent review provides a comprehensive summary of drug screening in Drosophila, but with an emphasis on neurodegenerative disorders. Here, we review Drosophila screens in the literature aimed at cancer therapeutics.

关键词： Drosophila Cancer Drug screening

Molecular complexity of visual mapping: a challenge for regenerating therapy

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Neural Regeneration Research 2020年第3期15卷 382-389页

作者： mara Medori Gonzalo Spelzini Gabriel Scicolone CONICET–Universidad de Buenos Aires Instituto de Biología Celular y Neurociencias“Prof.E.De Robertis”(IBCN)Ciudad Autónoma de Buenos AiresArgentina Universidad de Buenos Aires Facultad de MedicinaDepartamento de Biología CelularHistologíaEmbriología y GenéticaCiudad Autónoma de Buenos AiresArgentina

Investigating the cellular and molecular mechanisms involved in the development of topographically ordered connections in the central nervous system constitutes an important issue in neurobiology because these connections are the base of the central nervous system normal *** dominant model to study the development of topographic maps is the projection from the retinal ganglion cells to the optic tectum/*** expression pattern of Eph/ephrin system in opposing gradients both in the retina and the tectum,labels the local addresses on the target and gives specific sensitivities to growth cones according to their topographic origin in the *** rigid precision of normal retinotopic mapping has prompted the chemoaffinity hypothesis,positing axonal targeting to be based on fixed biochemical affinities between fibers and ***,several lines of evidence have shown that the mapping can adjust to experimentally modified targets with flexibility,demonstrating the robustness of the guidance *** we discuss the complex ways the Ephs and ephrins interact allowing to understand how the retinotectal mapping is a precise but also a flexible process.

关键词： axon growth axon guidance development Eph and ephrin mapping regeneration retinal ganglion cells retino-tectal system

Determination of particulate polycyclic aromatic hydrocarbons in ambient air by gas chromatography-mass spectrometry after molecularly imprinted polymer extraction

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Journal of Environmental Sciences 2023年第2期124卷 644-654页

作者： Maria Chiara Pietrogrande Giorgia Demaria mara Russo Department of Chemical Pharmaceutical and Agraricultural SciencesUniversity of FerraraVia Fossato di Mortara 17/1944121 FerraraItaly

A solid phase extraction procedure(SPE)is described for the quantitative analysis of polycyclic aromatic hydrocarbons(PAHs)in atmospheric particulate matter(PM),as ubiquitous environmental pollutants routinely measured in air qualitymonitoring.A SPE cartridge was used based on a molecular imprinted polymer(MIP-SPE)properly tailored for selective retention of PAHs with 4 and more benzene fused *** performance of the clean-up procedure was evaluated with the specific concern of selective purification towards saturated hydrocarbons,which are the PM components mostly interfering GC analysis of target *** optimized operative conditions,the MIP-SPE provided analyte recovery close to 95%for heavier PAHs,from benzo(α)pyrene to benzo(ghi)perylene,and close to 90%for four benzene rings PAHs,with good reproducibility(RSDs:2.5%-5.9%).Otherwise,C_(17)-C_(32) n-alkanes were nearly completely *** proposed method was critically compared with Solid Phase Micro Extraction(SPME)using a polyacrylate *** methods were successfully applied to the analysis of ambient PM2.5 samples collected at an urban polluted *** the two procedures,the MIP-SPE provided the highest recovery(R%≥93%)for PAHs with 5 and more benzene rings,but lower for lighter *** contrast,SPME showed a mean acceptable R%value(∼80%)for all the investigated PAHs,except for the heaviest PAHs in the most polluted samples(R%:110%-138%),suggesting an incomplete purification from the interfering n-hydrocarbons.

关键词： Polycyclic aromatic hydrocarbons Atmospheric particle matter Molecularly imprinted polymers-solid-phase extraction Solid phase micro extraction GC/MS analysis

Winter is coming for ski resorts: Insights from the Apennines (Italy)

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Journal of Mountain Science 2024年第11期21卷 3847-3858页

作者： Giuliano BONANOMI mara GHERARDELLI Sabrina SPIGNO Mohamed IDBELLA Department of Agricultural Sciences University of Naples Federico ⅡVia Università100Portici 80055Italy CAI-Club Alpino Italiano Sectin of SalernoVia Porta di Mare 26Salerno 84121Italy CAI-Club Alpino Italiano Sectin of NapoliVia Eldorado3Napoli 80132Italy College of Agriculture and Environmental Sciences AgroBioSciences(AgBS)programMohammed Ⅵ Polytechnic UniversityBen Guerir 43150Morocco

Ski resort abandonment is more frequent due to global warming,which progressively reduces snowpack and ***,projects aiming for new resorts in the Apennines have *** economic investments are risky,especially without long-term data on snow cover *** aim,thus,is to provide the first census of abandoned ski resorts in the Apennines and compare them with the resorts currently open to understand the causes that led to their ***,we explore factors behind resort failure by analyzing the relationships between climatic,geomorphological,and economic ***,we found 101 ski resorts in the Apennines,of which 28 were open,41 closed and abandoned and 32 partially closed(i.e.,closed in more than at least 7 years in the last 10 years).The closed and partially closed resorts represent 358 km of ski slopes(44%of total available).The number of structures per resort(*** lifts,chair lifts)is higher for open compared to partially closed and closed ***,the maximum elevation reached by the resorts is higher for those open(1793 m a.s.l.)than for those partially closed(1687 m a.s.l.)and especially those closed(1577 m a.s.l.).Finally,the mean size of the resorts in terms of skiable track length is larger for open(15.7 km)than partially closed(7.1 km)and closed resorts(3.2 km).The average duration of operation for abandoned resorts is 29.5 years,varying from a maximum of 56 years to a minimum of 0 years for two sites that were never opened after *** year of abandonment is positively associated with the maximum elevation,size,and duration of ***,the duration of operation is negatively correlated with the construction *** multivariate analysis confirms and strengthens the hypothesis for the causes that lead to abandonment are *** of the closed resorts are located at low altitude and have small ski areas although some higher altitude sites have also been abando

关键词： Climate change Mountain economy Snowpack duration Winter tourism Ski resort

Ultrafast laser-driven topological spin textures on a 2D magnet

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npj Computational Materials 2022年第1期8卷 1630-1635页

作者： mara Strungaru Mathias Augustin Elton J.G.Santos Institute for Condensed Matter Physics and Complex Systems School of Physics and AstronomyThe University of EdinburghEdinburghEH93FDUK Donostia International Physics Center(DIPC) 20018Donostia-San SebastiánBasque CountrySpain Higgs Centre for Theoretical Physics The University of EdinburghEdinburghEH93FDUK

Ultrafast laser excitations provide an efficient and low-power consumption alternative since different magnetic properties and topological spin states can be triggered and manipulated at the femtosecond(fs)***,it is largely unknown whether laser excitations already used in data information platforms can manipulate the magnetic properties of recently discovered two-dimensional(2D)van der Waals(vdW)*** we show that ultrashort laser pulses(30−85 fs)can not only manipulate magnetic domains of 2D-XY CrCl_(3)ferromagnets,but also induce the formation and control of topological nontrivial meron and antimeron spin *** observed that these spin quasiparticles are created within~100 ps after the excitation displaying rich dynamics through motion,collision and annihilation with emission of spin waves throughout the *** findings highlight substantial opportunities of using photonic driving forces for the exploration of spin textures on 2D magnetic materials towards magneto-optical topological applications.

关键词： laser excitation topological